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29 results on '"abstract report"'

1. Influence of cytochrome P-450 inhibitors on the inhalative uptake of methyl chloride and methylene chloride in male B6C3F1 mice

Author

Ottenwalder, H., Jager, R., Thier, R., Bolt, H. M., Ottenwalder, H., Jager, R., Thier, R., and Bolt, H. M.

Abstract

Dichloromethane (DCM) is thought to be metabolized in vivo by two independent pathways: a glutathione (GSH) dependent pathway that yields CO2 and a cytochrome P-450 mediated one that yields both CO and CO2 (Gargas et al 1986). With a physiologically based pharmacokinetic (PB-PK) model, Andersen et al (1987) calculate the quantitative parameters for both metabolic pathways. Using the kinetic parameters thus obtained and the results of two carcinogenicity studies with rodents (Serota et al 1986; NTP 1985), the authors then estimate the tumour risk for humans.

Published
1989

3. First proof that vitamin E is major lipid-soluble, chain-breaking antioxidant in human blood plasma

Author

Anne Joyce, Graham W. Burton, and Keith U. Ingold

Subjects
blood and hemopoietic system, Antioxidant, antioxidant, Human blood, Chemistry, medicine.medical_treatment, Vitamin E, General Medicine, alpha tocopherol, Lipid Metabolism, Antioxidants, lipids, Biochemistry, Chain (algebraic topology), Solubility, medicine, Humans, abstract report, plasma, Chromatography, Liquid
Published
1982

4. The antimutagenic effect of an extract of the mussel Mytilus edulis

Subjects
Ames test, Benzo[a]pyrene, Heredity, Mutagenesis, 4 Nitroquinoline 1 oxide, In vitro study, Animal experiment, Invertebrate, Nitrofural, Mussel, Biology, Abstract report
Abstract

Chemicals/CAS: 4 nitroquinoline 1 oxide, 56-57-5; benzo[a]pyrene, 50-32-8; nitrofural, 59-87-0

Published
1981

5. The antimutagenic effect of an extract of the mussel Mytilus edulis

Author

G.J. Vink, I.E. Mattern, W.B. van der Zwaan, and Medisch Biologisch Laboratorium TNO

Subjects
Heredity, Toxicology, Ames test, Abstract report, chemistry.chemical_compound, Antimutagenic Effect, Botany, Genetics, medicine, In vitro study, Food science, Animal experiment, Invertebrate, Nitrofural, Biology, biology, 4 Nitroquinoline 1 oxide, Mussel, biology.organism_classification, Mytilus, Benzo[a]pyrene, chemistry, Benzo(a)pyrene, Mutagenesis, Pyrene, medicine.drug
Abstract

Chemicals/CAS: 4 nitroquinoline 1 oxide, 56-57-5; benzo[a]pyrene, 50-32-8; nitrofural, 59-87-0

Published
1981

7. N-alkane neurotoxicity in cultured cerebral cells

Author

Hooisma, J., Dam, E.W., and Medisch Biologisch Laboratorium TNO

Subjects
Nervous system, 2,5 Hexanediol, Intoxication, In vitro study, Newborn, Nerve cell, 2 Hexanone, Abstract report, 2,4 Hexanedione, Acetonylacetone, Central nervous system, 2 Hexanol, Neurotoxicity, Rat, Cell culture, Biology, Hexane
Abstract

Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3

Published
1981

8. Use of Umbra pygmaea and Mytilus edulis to detect mutagens in the aquatic environment

Author

G.J. Vink, R.N. Hooftman, I.E. Mattern, P.B. Davis, and Medisch Biologisch Laboratorium TNO

Subjects
Mesylic acid methyl ester, Heredity, Toxicology, Chromosome aberration, Abstract report, Polychlorinated biphenyl, chemistry.chemical_compound, Mutagenicity, Genetics, Animal experiment, Biology, biology, Fin, Ethyl ester, biology.organism_classification, Mytilus, Mesylic acid ethyl ester, Benzo[a]pyrene, Fish, Benzo(a)pyrene, chemistry, Biochemistry, Aquatic environment, Water pollution, Environmental chemistry, Pyrene, %22">Fish , Gill, Triaziquone, Aroclor
Abstract

Chemicals/CAS: aroclor, 12767-79-2; benzo[a]pyrene, 50-32-8; mesylic acid ethyl ester, 62-50-0; mesylic acid methyl ester, 66-27-3; triaziquone, 68-76-8

Published
1981

10. α Adrenoceptor mediated vasoconstriction in the pithed rat induced by stimulation of subclasses of ganglionic muscarinic receptors

Author

Davidesko, D., Timmermans, P.B.M.W.M., Wilffert, B., Van Zwieten, P.A., Methods in Medicines evaluation & Outcomes research (M2O), and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
pirenzepine, prazosin, nonhuman, [4 [(3 chlorophenyl)carbamoyloxy] 2 butynyl]trimethylammonium, animal experiment, autonomic nervous system, rauwolscine, unclassified drug, muscarinic receptor, alpha 2 adrenergic receptor, cardiovascular system, vasoconstriction, n,n dimethylnipecotic acid, rat, abstract report
Published
1983

11. Localization of α- and β-adrenoceptors

Author

Wilffert, B., Methods in Medicines evaluation & Outcomes research (M2O), and Reproductive Origins of Adult Health and Disease (ROAHD)

Subjects
prazosin, drug interaction, alpha adrenergic receptor, noradrenalin, beta adrenergic receptor, animal experiment, autonomic nervous system, blood pressure, adrenal medulla, heart, atenolol, spinal animal, rauwolscine, endocrine system, cardiovascular system, heart rate, 1,1 dimethyl 4 phenylpiperazinium iodide, rat, propranolol, abstract report
Published
1981

12. Competition between neuromuscular contacts in tissue culture, induced by stimulation

Author

Magchielse, T. and Medisch Biologisch Laboratorium TNO

Subjects
Tissue culture, Neuromuscular synapse, Embryo, Tubocurarine chloride, Ciliary ganglion, Autonomic nervous system, In vitro study, Animal experiment, Neuromuscular transmission, Biology, Chicken, Abstract report
Abstract

Chemicals/CAS: tubocurarine chloride, 57-94-3, 57-95-4, 8006-51-7

Published
1981

13. The mutagenicity of isoniazid in salmonella and its effects on DNA repair and synthesis in human fibroblasts

Author

Wade, D.R., Lohman, P.H.M., and Medisch Biologisch Laboratorium TNO

Subjects
Salmonella typhimurium, Mouse, Adverse drug reaction, DNA repair, Toxicology, Abstract report, Chemical mutagenesis, Mutagenicity, Salmonella, Genetics, Hydrazine, Isoniazid, Pharmacokinetics, Biology, Manganese, DNA synthesis, In vitro study, Soft tissue, Normal human, Human cell, Fibroblast, Rat, Cell culture, Liver microsome, Human
Abstract

Chemicals/CAS: hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; manganese, 16397-91-4, 7439-96-5

Published
1980

15. Tiapride bij tardieve dyskinesie: de duivel met Beëlzebub uitdrijven?

Author

Nolen, W.A., Moleman, P., Loonen, A.J.M., and Interdisciplinair Centrum voor Psychopathologie en Emotieregulatie

Subjects
neuroleptic agent, sulpiride, adverse drug reaction, letter, musculoskeletal system, intoxication, neurotoxicity, abstract report, human, therapy, psychological aspect, nervous system, tiapride, haloperidol h 3, central nervous system, flupentixol h 3, unclassified drug, drug therapy, drug efficacy, drug indication, dopaminergic system, drug contraindication, dogmatal, tardive dyskinesia, placebo, metoclopramide
Published
1982

16. The mutagenicity of isoniazid in salmonella and its effects on DNA repair and synthesis in human fibroblasts

Subjects
Salmonella typhimurium, Manganese, DNA synthesis, Mouse, Adverse drug reaction, DNA repair, In vitro study, Soft tissue, Abstract report, Chemical mutagenesis, Normal human, Human cell, Mutagenicity, Salmonella, Hydrazine, Isoniazid, Fibroblast, Rat, Pharmacokinetics, Cell culture, Liver microsome, Biology, Human
Abstract

Chemicals/CAS: hydrazine, 10217-52-4, 13775-80-9, 18500-32-8, 302-01-2, 7803-57-8; isoniazid, 54-85-3, 62229-51-0, 65979-32-0; manganese, 16397-91-4, 7439-96-5

Published
1980

17. Chemical protection against X-irradiation by an orally administered compound

Author

Vos, O. and Medisch Biologisch Laboratorium TNO

Subjects
Radiation protection, Ld 50, Unclassified drug, Mouse, Oral drug administration, N (1 adamantylmethyl)thioglycolamidine, Cysteine, Animal experiment, Biology, Mercaptamine, Abstract report, X ray
Abstract

Chemicals/CAS: cysteine, 4371-52-2, 52-89-1, 52-90-4; mercaptamine, 156-57-0, 60-23-1; n (1 adamantylmethyl)thioglycolamidine, 60833-81-0

Published
1980

18. N-alkane neurotoxicity in cultured cerebral cells

Subjects
Nervous system, 5 Hexanediol, Intoxication, In vitro study, Newborn, Nerve cell, 2 Hexanone, Abstract report, Acetonylacetone, 4 Hexanedione, Central nervous system, 2 Hexanol, Neurotoxicity, Rat, Cell culture, Biology, Hexane
Abstract

Chemicals/CAS: 2 hexanone, 591-78-6; acetonylacetone, 110-13-4; hexane, 110-54-3

Published
1981

19. Report of a workshop on bacterial in vitro mutagenicity test systems

Subjects
Methylnitronitrosoguanidine, Unclassified drug, Mouse, Benzoflavone, 4 Nitroquinoline, Dimethylnitrosamine, Abstract report, Polychlorinated biphenyl, Vinylidene chloride, Bacterium, Drug activation, Aflatoxin, Aroclor 1254, Hamster, Diethylnitrosamine, N (2 fluorenyl)acetamide, Animal experiment, Biology, Cyclophosphamide, Drug metabolism, 2 Aminoanthracene, Clophen a50, Methodology, In vitro study, Mesylic acid ethyl ester, Benzo[a]pyrene, Drug screening, Mutagenesis, Mitomycin c, 2 Nitrofluorene, Nitrosomorpholine, Rat, Liver microsome, Mutagen testing
Abstract

Bacterial systems for the screening of chemical substances for mutagenic potential are receiving widespread attention. Now that many laboratories have introduced these test systems and a large number of substances has been tested, discrepancies in the results have become apparent. To discuss this problem, a workshop was organized at Neuherberg (Munchen) from March 6 to 9, 1977. The workshop was attended by 35 participants who had experience with the test systems, representing various European research institutes and industrial laboratories. The main points under discussion were the following. Comparison of data, with the help of data collecting forms that had been sent previously to the participants. Evaluation of the test systems that are at present in use, with emphasis on the metabolic activation system. Drafting of recommendations for the performance of the tests. Collection of new developments and future needs in this field. Chemicals/CAS: 2 aminoanthracene, 613-13-8; 2 nitrofluorene, 607-57-8; aflatoxin, 1402-68-2; aroclor 1254, 11097-69-1; benzo[a]pyrene, 50-32-8; clophen a50, 8068-44-8; cyclophosphamide, 50-18-0; diethylnitrosamine, 55-18-5; dimethylnitrosamine, 62-75-9; mesylic acid ethyl ester, 62-50-0; methylnitronitrosoguanidine, 70-25-7; mitomycin C, 50-07-7, 74349-48-7; n (2 fluorenyl)acetamide, 27215-65-2, 53-96-3; nitrosomorpholine, 59-89-2; vinylidene chloride, 25323-30-2, 75-35-4

Published
1978

22. Use of the polyethylene glycol (PEG) as a fusogen for sperm-egg interactions

Author

Chakraborty, J., Budd, C. A., Constantinou, Andreas I., and Constantinou, Andreas I. [0000-0003-0365-1821]

Subjects
drug efficacy, nonhuman, spermatozoon, fertilization, macrogol, egg, animal cell, abstract report, female genital system, mouse, male genital system
Abstract

95

Published
1982

23. Localization of α- and β-adrenoceptors

Subjects
prazosin, drug interaction, alpha adrenergic receptor, noradrenalin, beta adrenergic receptor, animal experiment, autonomic nervous system, blood pressure, adrenal medulla, heart, atenolol, spinal animal, rauwolscine, endocrine system, cardiovascular system, heart rate, rat, propranolol, abstract report, 1 dimethyl 4 phenylpiperazinium iodide
Published
1981

24. Chemical problems in the analysis of wastes

Author

H. Compaan, C. Pries, and Centraal Laboratorium TNO

Subjects
Environmental Engineering, Waste management, Health, Toxicology and Mutagenesis, Eenvironmental chemical, Public Health, Environmental and Occupational Health, Methodology, General Medicine, General Chemistry, Environment, Pollution, Abstract report, Environmental Chemistry, Environmental science
Abstract

A survey is given of the analytical procedure and some specific problems related to the analysis of chemical wastes.

Published
1981

25. Use of Umbra pygmaea and Mytilus edulis to detect mutagens in the aquatic environment

Subjects
Mesylic acid methyl ester, Heredity, Fin, Mesylic acid ethyl ester, Abstract report, Polychlorinated biphenyl, Benzo[a]pyrene, Fish, Mutagenicity, Water pollution, Gill, Triaziquone, Animal experiment, Aroclor, Chromosome aberration, Biology
Abstract

Chemicals/CAS: aroclor, 12767-79-2; benzo[a]pyrene, 50-32-8; mesylic acid ethyl ester, 62-50-0; mesylic acid methyl ester, 66-27-3; triaziquone, 68-76-8

Published
1981

26. Tiapride bij tardieve dyskinesie: de duivel met Beëlzebub uitdrijven?

Subjects
therapy, sulpiride, nervous system, tiapride, haloperidol h 3, central nervous system, flupentixol h 3, unclassified drug, drug therapy, drug indication, drug contraindication, intoxication, tardive dyskinesia, neurotoxicity, abstract report, human, metoclopramide
Published
1982

27. Modification of the early and late delayed radiation response of the rat spinal cord by chemotherapeutic agents

Author

A.J. van der Kogel and Radiobiologisch Instituut

Subjects
Cancer Research, medicine.medical_specialty, animal experiment, Central nervous system, methotrexate, cytarabine, intramuscular drug administration, Medicine, rat, Radiology, Nuclear Medicine and imaging, abstract report, Radiation injury, Radiation, business.industry, spinal cord, central nervous system, Spinal cord, Surgery, intravenous drug administration, medicine.anatomical_structure, Oncology, Anesthesia, Cytarabine, Methotrexate, business, intrathecal drug administration, Radiation response, radiation injury, medicine.drug
Abstract

Chemicals/CAS: cytarabine, 147-94-4, 69-74-9; methotrexate, 15475-56-6, 59-05-2, 7413-34-5

Published
1981
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28. Mutagenicity of antitumour platinum compounds

Author

L. Cocchiarella, I.E. Mattern, C.G. van Kralingen, and Medisch Biologisch Laboratorium TNO

Subjects
Platinum derivative, Heredity, Unclassified drug, Platinum compounds, Polychlorinated biphenyl, Toxicology, Abstract report, Ames test, chemistry.chemical_compound, chemistry, Mutagenicity, Genetics, Organic chemistry, Biology, Oroclor
Published
1980
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29. Localization of α- and β-adrenoceptors

Subjects
prazosin, drug interaction, alpha adrenergic receptor, noradrenalin, beta adrenergic receptor, animal experiment, autonomic nervous system, blood pressure, adrenal medulla, heart, atenolol, spinal animal, rauwolscine, endocrine system, cardiovascular system, heart rate, rat, propranolol, abstract report, 1 dimethyl 4 phenylpiperazinium iodide
Published
1981

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