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The purpose of the research is to study the efficacy of the drug in the form of spray based on Fipronil, Moxidectin and Pyriproxyfen against canine acarosis.Materials and methods. The assessment of the acaricidal effect of multicomponent drug against canine acarosis was carried out on the basis of the All-Russian Scientific Research Institute of Infectious Diseases (VNIIP), a branch of the Federal State Budgetary Institution FSC VIEV RAS, as well as the veterinary clinic GLOBALVET CLINIC LLC (Moscow) in 2020–2022. 82 dogs were used in the experiments, including those spontaneously infected with Otodectes cynotis (38 sp.), Sarcoptes canis (28 sp.), and Demodex canis (16 sp.). The animals were divided into experimental and control groups. To the infected animals of the experimental groups, the drug was applied in the form of spray to the affected areas of the body at the rate of 1 ml per 10 cm2, 2–4 times with an interval of 7 days. The dogs in the control group were treated at the end of the experiment. The efficacy of the drug was taken into account by examining and recording the number of ticks in animals before and 3, 11, 25, 40 and 60 days after treatment. The results were processed statistically using Microsoft Excel.Results and discussion. On the 11th day, all animals showed extinction of clinical signs, healing of affected skin areas and scratches, and the appearance of new hair in areas of alopecia; microscopy of scrapings revealed single mites, deformed larvae and eggs. Microscopy of skin scrapings on the 25th day revealed single mites in 5 dogs affected by demodicosis. On the 40th day, upon examination and acarological examination of animal skin scrapings, no S. canis, O. cynotis and D. canis mites were found. The research results showed 100% efficacy of the drug.

The purpose of the research: to study the efficacy of the insectoacaricidal preparation "Neoterica Protecto 4" against ixodidoses and other acaroses of animals. Materials and methods. 252 dogs and 158 cats of different ages and breeds naturally infected with Ixodes ticks and Notoedres cati, Demodex canis and Sarcoptes canis, as well as 35 decorative rabbits infected with acaroses caused by Psoroptes cuniculi and Sarcoptes scabiei varietas cuniculi were used. All animals were divided into experimental and control groups. For animals of experimental groups, the preparation was used according to the instructions for use, animals of control group the preparation did not receive. Determination of the rate of onset of the "knockdown" state and the height of the tick lifting on the treated tissue from cotton coarse calico size 10 × 70 cm was carried out on 30 Ixodes ticks. Results and discussion. 100 % therapeutic efficacy of preparation «Neoterica Protecto 4» in the control of ixodid ticks and acaroses of animals (otodectosis, psoroptosis, sarcoptosis, demodecosis and notoedrosis), high preventive acaricidal efficacy for 60 days, and found that the preparation has a pronounced «knockdown effect», the time of onset of the «knockdown» state averages 2.35 minutes at an average lifting altitude 37.56 cm.