Grzegorz Wysocki,1 Michał Czapla,2– 4 Bartosz Uchmanowicz,5 Piotr Fehler,4 Katarzyna Aleksandrowicz,4 Łukasz Rypicz,6 Irena Wolska-Zogata,7 Izabella Uchmanowicz4,5 1LUX MED Medical Center, Warsaw, Poland; 2Department of Emergency Medical Service, Wroclaw Medical University, Wroclaw, Poland; 3Group of Research in Care (GRUPAC), Faculty of Health Science, University of La Rioja, Logroño, Spain; 4Institute of Heart Diseases, University Hospital, Wroclaw, Poland; 5Department of Nursing and Obstetrics, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland; 6Department of Population Health, Faculty of Health Sciences, Wroclaw Medical University, Wrocław, Poland; 7Department of the Sociology of the Public Sphere, University of Wroclaw, Wroclaw, PolandCorrespondence: Michał Czapla, Department of Emergency Medical Service, Wroclaw Medical University, ul. Parkowa 34, Wroclaw, 51-616, Poland, Email michal.czapla@umw.edu.plIntroduction: Ankylosing spondylitis (AS) is a chronic, progressive disease, often with multiple complications, with periods of exacerbation and remission. The onset of the disease usually affects people under 30 years of age. The disease impairs physical, psychological, and social functioning, leading to disability. Therefore, patients with AS face the challenge of adapting to life with the condition and deteriorating quality of life (QoL).Objective: This study aimed to assess the impact of disease acceptance on quality of life in patients with AS.Material and Methods: The study was conducted in the Department of Rheumatology and Internal Diseases of the University Hospital in Wrocław among 110 patients (67 men and 43 women) with the diagnosis of AS, aged 20– 89 years (M=48.44 years, SD± 12.55). The study used the Acceptance of Illness Scale (AIS), the WHOQoL-BREF Quality of Life Scale, and a self-constructed questionnaire of clinical and sociodemographic data.Results: Respondents rated the quality of life as good and moderate (M = 3.49 points, SD=± 0.84). The mean AIS score was 27.44 (SD=± 8.67). AIS scores are positively correlated with all QoL domains and perception of quality of life and health (p< 0.001). The strongest correlation was in the physical domain (r=0.71), while the weakest correlation was observed in the social domain (r=0.329). AIS and QoL measures showed significant relationships with selected sociodemographic data (eg, gender, age, education, and occupational activity) and correlated with selected disease data (eg, type of treatment used, duration of disease, or comorbidities).Conclusion: AIS in patients with AS condition correlated positively with their QoL in all domains. Both disease acceptance and quality of life are influenced by specific sociodemographic and disease-related data. Prevention of complications and the type of treatment for AS (primarily biological treatment) can be essential in improving patients’ quality of life.Keywords: ankylosing spondylitis, health-related quality of life, quality of life, acceptance of illness