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Psychedelic substances such as psilocybin have recently gained attention for their potential therapeutic benefits in treating depression and other mental health problems. However, individuals with bipolar disorder (BD) have been excluded from most clinical trials due to concerns about manic switches or psychosis. This study aimed to systematically examine the effects of recreational psychedelic use in individuals with BD. Using the Timeline Followback (TLFB) method, we assessed mood symptoms, substance use, and other mental health-related variables in the month before and three months following participants' most recent psychedelic experience. Results showed a significant reduction in depressive symptoms and cannabis use, an increase in the number of days without mental health symptoms, and an increase in the number of days with hallucinogen use. Importantly, no significant changes in (hypo)manic, psychotic, or anxiety symptoms were observed. These findings suggest that psychedelics may hold potential as a safe and effective treatment for BD, though further research, including randomized controlled trials, is needed. • Exploring the effects of recreational psychedelic use in bipolar disorder • Psychedelic use subjectively decreased days experiencing depressive symptoms. • Using a calendar method, psychedelic use decreased days of reported cannabis use. • Psychedelic use subjectively increased days experiencing no mental health symptoms. • Psychedelic use slightly increased hallucinogen use but not manic or psychotic symptoms. [ABSTRACT FROM AUTHOR]

Internalising symptoms are elevated in autism compared to the general population. Few studies have investigated emotional dysregulation (ED) as a potential mediator between specific transdiagnostic processes and anxiety and depression symptoms in autistic youth. In a sample of 94 autistic young people aged 5–18 years referred to a specialist clinic for an autism evaluation, we tested the effects of ED as a mediator between cognitive inflexibility (CI), intolerance of uncertainty (IU) and alexithymia with anxiety and depression symptoms, using structural equation modelling. Effect sizes were compared to a non-autistic comparison group (n = 84). CI and alexithymia did not significantly predict depression symptoms in autistic young people, directly nor via ED. Relationships between CI/alexithymia and depression were fully mediated by ED in the non-autistic sample. There was a direct effect of CI on anxiety in the non-autistic group but not in those with a diagnosis. IU predicted depression symptoms in the autism group; and ED mediated this relationship only in those who did not receive a diagnosis. IU directly predicted anxiety in both groups and this relationship did not occur via ED. The finding of a direct pathway from IU to anxiety and depression in autistic youth is consistent with the literature. The finding that CI did not predict anxiety or depression in those with autism is novel, as was the finding that ED mediated relationships between alexithymia and anxiety/depression symptoms in both samples. The findings may have important implications for the delivery of psychological interventions for autistic youth. [ABSTRACT FROM AUTHOR]

Few studies have investigated whether and which anxiety and affective disorders are associated with the risk of venous thromboembolism. We aimed to examine whether anxiety disorder, depression, and bipolar disorder increase the risk of venous thromboembolism, independent of socioeconomic confounders and each other, in a UK general population. This is a prospective cohort study using UK Biobank. Participants were excluded if they were diagnosed with venous thromboembolism before the baseline assessment, if they were first diagnosed with anxiety disorder, depression, or bipolar disorder thereafter, or if they had missing sociodemographic data. Diagnosed anxiety disorder, depression, and bipolar disorder were ascertained through hospital admission data and incident venous thromboembolism, pulmonary embolism, and deep vein embolism were ascertained through both hospital admission and death certificate data. Hazard ratios were calculated, adjusted for sociodemographic confounders and comorbid anxiety and affective disorders. Our main analysis included 455,705 participants, of whom 53.6 % were female, with a mean age (standard deviation) of 56.6 (8.1) years. Anxiety disorder, depression, and bipolar disorder were associated with venous thromboembolism both before and after adjusting for sociodemographic confounders. After adjustment for comorbid anxiety and affective disorders, depression (HR: 2.00; 95 % CI: 1.68–2.38) and bipolar disorder (HR: 2.08; 95 % CI: 1.28–3.37) remained associated with venous thromboembolism, but anxiety did not (HR: 1.17; 95 % CI: 0.88–1.57). Similar results were found for pulmonary embolism and deep vein embolism. Depression and bipolar disorder were associated with the risk of venous thromboembolism. Further research is required to understand the mechanism underlying their increased risk. • The association between anxiety and venous thromboembolism (VTE) was not independent of comorbid affective disorders. • Depression and bipolar disorder were associated with VTE independent of other anxiety and affective disorders. • People with depression and bipolar disorders are a higher risk group for VTE. [ABSTRACT FROM AUTHOR]

Bipolar disorder (BD) presents with a wide range of symptoms that vary among relatives, casting doubt on categorical illness models. To address this uncertainty, we investigated the heritability and genetic relationships between categorical and dimensional models of BD in a family sample. This retrospective study included participants (n = 397 Females, n = 329 Males, mean age 47 yr) in the Amish-Mennonite Bipolar Genetics (AMBiGen) study from North and South America that were assigned categorical mood disorder diagnoses ("narrow" or "broad") by structured psychiatric interview and completed the Mood Disorder Questionnaire (MDQ), which assesses lifetime history of manic symptoms and associated impairment. MDQ-dimensions were analyzed by Principal Component Analysis (PCA). Heritability and genetic overlaps between categorical diagnoses and MDQ-dimensions were estimated with SOLAR-ECLIPSE within 432 genotyped participants. Individuals diagnosed with BD (n = 124) endorsed more MDQ items (61 %) than those with other mood disorders (26 %) or with no mood disorder (9 %), as expected. PCA suggested a three-component model for the MDQ, capturing 60 % of the variance. Heritability of the MDQ and its principal components was significant but modest (20–30 %, p < 0.001). Genetic correlations between MDQ measures and categorical diagnoses (ρG = 0.62–1.0; p < 0.001) were stronger than phenotypic correlations (ρP = 0.11–0.58; p < 0.001). Recruitment through probands with BD resulted in increased prevalence of BD in this sample, limiting generalizability. Unavailable genetic data reduced sample size for some analyses. Findings support a genetic continuity between dimensional and categorical models of BD and suggest that the MDQ is a useful phenotype measure for genetic studies of BD. • Mood Disorder Questionnaire (MDQ) heritability was 30 % (p < 0.001), evenly distributed across its three principal components • Strong and significant genetic correlations were found between categorical diagnoses and most MDQ measures • Results support a genetic continuity between dimensional and categorical models of bipolar disorder [ABSTRACT FROM AUTHOR]

There is an urgent need to aid in what will be an ongoing educational recovery in the wake of the COVID-19 pandemic. One avenue for supporting students with and at-risk for emotional and behavioral disorders (e.g., internalizing and externalizing behaviors) is implementation of tiered systems, which emphasize evidence-based practices to prevent and respond to academic, behavioral, and social and emotional well-being needs. We conducted this study to quantify cross-sectional differences between the academic years before (prepandemic: 2018–2019 and 2019–2020) and immediately following the pandemic onset (after-pandemic onset: 2021–2022) in students' levels of internalizing and externalizing behaviors and referrals for special education eligibility determination. We analyzed data from the Student Risk Screening Scale for Internalizing and Externalizing (SRSS-IE) and district-provided special education data from 22 U.S. elementary schools collected as part of regular practices. Schools were from two midwestern districts implementing an integrated tiered system of support—the Comprehensive, Integrated, Three-tiered (Ci3T) model of prevention—district-wide. Results indicated some statistically significant but very small-magnitude differences in internalizing and externalizing behaviors relative to the pandemic with few exceptions (e.g., fall externalizing scores slightly lower in fall after the pandemic onset). Effect sizes suggested students with disabilities and students of color were very similar and did not indicate differential pandemic impact. We discussed limitations, which centered primarily on issues of generalizability, and encouraged other researchers to examine shifts in student performance in other locales, in schools not yet implementing tiered systems, and in subsequent years following the pandemic onset. [ABSTRACT FROM AUTHOR]

Students identified with emotional and behavioral disorders (EBDs) often have difficulty with social adjustment and academic achievement, engaging in problem behaviors such as defiance, rule-breaking, and truancy, yet one particularly challenging behavior is aggression. Researchers assert that verbal aggression (VA) is the most frequent form of aggression in schools; however, little is known about student perceptions of VA among students with EBD. We surveyed 144 U.S. secondary students with EBD finding infrequent reporting to teachers about VA victimization. According to students, the most effective teacher responses to a report of VA victimization were moving the victim away from the perpetrator, providing advice, and punishing the aggressor. Students reported that the content of teacher instruction about VA most often included reporting victimization to a teacher, avoiding the aggressor, and ignoring the verbally aggressive behavior. We discuss implications for teacher education and practice including what strategies deter VA and effective teacher responses to victimization. We conclude with recommendations for future research such as examining risk and protective factors for VA involvement, assessing whether students' attitudes and beliefs contribute to VA, and conducting longitudinal studies. [ABSTRACT FROM AUTHOR]

Fragmented rapid eye movement (REM) sleep disrupts the overnight resolution of emotional distress, a process crucial for emotion regulation. Emotion dysregulation, which is common across psychiatric disorders, is often associated with sleep disturbances. This systematic review explores how REM sleep and nightmares affect emotion processing and regulation in individuals with psychiatric disorders where emotion dysregulation is a key concern, suggesting novel sleep-related treatment pathways. We performed a PRISMA-compliant systematic search of the PUBMED, Web of Science, and EBSCO databases from January 1994–February 2023. This systematic review targeted studies on REM sleep, nightmares, and emotion regulation in a postpubescent clinical population with affective dysregulation. The quality of the studies was assessed via the Newcastle‒Ottawa Scale (NOS), adapted for cross-sectional studies. From the 714 screened records, 28 articles met the inclusion criteria and focused on REM sleep, dreams, or nightmares in individuals with mood disorders (k = 8), anxiety disorders (k = 1), posttraumatic stress disorder (PTSD) (k = 16), non-suicidal self-injury (NSSI), personality disorders (k = 2), and autism (k = 1). Fifteen studies used objective sleep measures, seventeen used self-reported assessments, six included treatment components, eight investigated nightmares, and three examined dreams. NOS scores ranged from moderate to high. REM sleep disturbances represent a transdiagnostic feature across psychiatric disorders and are crucial for emotion regulation. Nightmares are associated with suicidal behaviour and emotion dysregulation. Targeted sleep interventions may improve emotion regulation and mental health outcomes. Future research should explore the role of REM sleep in disorder prognosis to develop tailored interventions. • REM disturbances contribute to emotion dysregulation in MDD, PTSD, and suicidality. • REM density may mark hypofrontality in MDD and poor emotional processing in MDD/PTSD. • REM fragmentation impairs fear extinction and emotional memory consolidation in PTSD. • Nightmares impair trauma processing in PTSD and are linked to suicidality in PTSD/MDD. • Targeted therapies for REM disturbances may enhance emotion regulation in mental disorders. [ABSTRACT FROM AUTHOR]

One of the common symptoms of mood disorders is insomnia, and the recovery processes can be negatively impacted by a lack of restorative sleep. Although factors related to restorative sleep in healthy subjects have been investigated, evaluations of these factors in patients with depression have been rarely done. Patients with depression are known to have sleep-wake state discrepancy, which can further influence their restorative sleep beyond that associated with depressive symptoms. Thus, we investigated restorative sleep in depressed patients in our current study, and attempted to identify associated factors, with a particular focus on sleep-wake state discrepancy. In the 91 participants evaluated in this cross-sectional study, all subjects filled out questionnaires on their symptoms prior to undergoing polysomnography (PSG). Sleep duration and restorative sleep were evaluated on the morning after the PSG. The association between restorative sleep and various factors was then examined using multiple regression analysis. A negative association with restorative sleep was found through multiple regression analysis for depressive symptoms (β = −0.055, p = 0.007), daytime sleepiness (β = −0.106, p = 0.020), and overestimation of wake after sleep onset (β = −0.006, p = 0.030). By subjectively and objectively assessing sleep, addressing depressive symptoms, and implementing appropriate sleep hygiene, clinicians could be able to improve restorative sleep in depressed patients. • Insomnia is the most common residual symptom of depression. • Many patients with depression experience non-restorative sleep. • Overestimation of wake time after sleep onset reduces restorative sleep. • Depressive symptoms and daytime sleepiness lower restorative sleep. • Addressing sleep-wake state discrepancy may improve restorative sleep in depression. [ABSTRACT FROM AUTHOR]

There is a clear association between relational dissatisfaction in romantic relationships and elevated mental health issues such as depression and anxiety. The association can run in both directions and adds complexity to both relationship and individual difficulties. One of the most studied relationship therapy approaches, emotion-focused therapy (EFT) for couples, focuses on the interactional cycle between partners and also stresses the importance of soothing individual vulnerabilities in order to transform troublesome relational interactions. Thus far, there has not been an attempt to describe a systematic framework for using EFT to work with couples with co-morbid mental health issues. This paper aims to address this gap. It builds upon both recent work in transdiagnostic EFT for individuals, and the EFT for couples framework as optimal scaffolding for a transdiagnostic EFT approach that targets relational issues as well as depression- and anxiety-related presentations in couples. The paper outlines several ways how individual's chronic emotional vulnerability has the potential to rise to clinical levels of distress and complicate a romantic relationship. The paper then outlines specific therapeutic strategies how to work with individual's emotional vulnerability and symptom distress it may bring, in the context of the couple relationship. The individual's emotional vulnerability work is tracked along with relational interactions, in an effort to provide healing and transformational interactions and emotional experiences. A case example from a current research project is outlined to illustrate the use of specific therapeutic strategies and the clinical application of the transdiagnostic EFT approach to couple therapy. [ABSTRACT FROM AUTHOR]

Introduction: Transcutaneous auricular vagus nerve stimulation (taVNS) is a promising technique for modulating vagal afferent fibers non-invasively and has shown therapeutic potential in neurological, cognitive, and affective disorders. While previous research highlights its efficacy, the safety profile of taVNS has been less extensively examined. Methods: This study therefore aimed to systematically investigate side effects of taVNS in a large pooled dataset consisting of n = 488 participants, utilizing a standardized questionnaire to assess ten reported side effects. Analyses included effects of stimulation type (interval vs. continuous), stimulation duration, stimulation intensity and participant characteristics (age and gender) as potential modulators. Results: The findings support the safety of taVNS, with minimal and mild side effects reported across participants (M = 1.86, SD = 1.36). Although participants receiving sham stimulation were 32.4% less likely to report unpleasant feelings compared to participants receiving taVNS, this effect was driven primarily by low-end ratings (specifically, a rating of 1, indicating not at all when experiencing the corresponding side effect), thus suggesting limited clinical relevance. Interval stimulation notably reduced the likelihood of some side effects, particularly for neck pain, dizziness and unpleasant feelings, suggesting potential for optimizing taVNS protocols. Stimulation intensity and duration showed few statistically significant, but clinically minimal (i.e., very small) effects. Conclusion: Overall, these findings demonstrate a favorable safety profile of taVNS, with mostly mild and transient effects, supporting its use as a suitable non-invasive tool in both research and clinical applications. [ABSTRACT FROM AUTHOR]

Offspring of parents with bipolar disorder (BD) or major depressive disorder (MDD) are at high biological risk (HR) of these disorders given their significant heritability. Thus, studying neural correlates in youths at HR-MDD and HR-BD appears essential to understand the development of mood disorders before their onset. Resting-state amplitudes of low-frequency fluctuations (ALFF) and fractioned ALFF (fALFF) shows moderate to high test-retest reliability which makes it a great tool to identify biomarkers. However, this avenue is still largely unexplored. Using the Healthy Brain Network biobank, we identified 150 children and adolescents HR-MDD, 50 HR-BD and 150 not at risk of any psychiatric disorder (i.e., the control group). We then examined differences in relative ALFF/fALFF signals during resting-state. At a corrected threshold, participants HR-MDD displayed lower resting-state ALFF signals in the dorsal caudate nucleus compared to the control group. The HR-BD group showed increased fALFF values in the primary motor cortex compared to the control group. Therefore, robust differences were noted in regions that could be linked to important symptoms of mood disorders, namely psychomotor retardation, and agitation. At an uncorrected threshold, differences were noted in the central opercular cortex and the cerebellar. The database is a community-referred cohort and heterogeneous in terms of children's psychiatric diagnosis and symptomatology, which may have altered the results. ALFF and fALFF results for the comparison between both HR groups and the control group overlapped, suggesting good convergence. More studies measuring ALFF/fALFF in HR are needed to replicate these results. [ABSTRACT FROM AUTHOR]

Depression is one of the most widespread diseases worldwide, with the highest rates of disability. Considering its chronic course, over the years several treatment options have been developed and validated, however still with high relapse rates. Therefore, in recent years, the so-called third wave psychotherapies have been developed for the treatment of psychiatric disorders. Among these, the Metacognitive therapy (MCT) has proven to be effective in treating depression. The aim of this review is to evaluate the efficacy of MCT as monotherapy or adjunctive treatment in reducing depressive symptoms in patients suffering from major depression or dysthymia. From bibliographic research in PubMed until December 2023, we retrieved 12 original studies meeting our research criteria. The total sample of patients undergoing metacognitive therapy (MCT) included 376 individuals, while the control groups comprised 300 subjects, with a gender ratio of the participants of 0.48 %. The results show that metacognitive therapy is an effective approach in reducing depressive symptoms in patients with a diagnosis of depression or dysthymia when used as add-on therapy, with an efficacy comparable to CBT and superior to pharmacotherapy and as monotherapy, with an efficacy comparable to therapy with antidepressants compared to the control group and compared to cognitive-behavioral therapy with higher rates of reduction of depressive symptoms after treatment and at six months. Preliminary data also indicate its efficacy in terms of reduction of depressive symptoms in elderly people, suggesting its possible use in this population. The methodological heterogeneity in terms of treatment protocols of MCT and treatment control as well as the clinical heterogeneity of the sample employed may have limited the generalizability of the results. The results suggest that the use of MCT, both as monotherapy and as an add-on treatment, is a valid therapeutic option for major depression, even at the later stages. However, further studies are needed for deeper our comprehension of the efficacy of MCT in depression. • MCT, both as monotherapy and as an add-on treatment, reduces depressive and anxiety symptoms with high efficacy. • Studies demonstrate stable recovery rates up to 3 years post-treatment, suggesting lasting benefits of MCT. • MCT appears beneficial for non-responders to pharmacotherapy and those with poor drug tolerance, providing a viable alternative. • Future research should focus on refining MCT protocols, assessing its efficacy across diverse populations. [ABSTRACT FROM AUTHOR]

Despite evidence regarding prevalence and correlates of cannabis use (CU) and cannabis use disorder (CUD) in major depressive disorder (MDD) and bipolar disorder (BD) in adults, little is known about this topic among adolescents. Data are from the 2001–2004 National Comorbidity Survey–Adolescent Supplement, an in-person, cross-sectional epidemiologic survey of mental disorders. Participants included adolescents, ages 13–18 years, with MDD (n = 354 with CU, n = 70 with CUD, n = 688 with no CU), BD (n = 79 with CU, n = 32 with CUD, n = 184 with no CU), or adolescents without mood disorders (n = 1413 with CU, n = 333 with CUD, n = 6970 with no CU). Analyses examined prevalence and correlates of CU and CUD within MDD and BD groups. CU was most prevalent in adolescents with MDD followed by adolescents with BD then controls. CUD was most prevalent in adolescents with BD followed by adolescents with MDD then controls. In covariate-adjusted ordinal logistic regression models, within MDD and BD, CU and CUD groups had significantly higher odds of lifetime suicidal ideation/attempts, as well as other significant indicators of clinical severity. Based on changes in cannabis acceptance, potency, and availability in the two decades since this study was conducted, present findings may underestimate adverse cannabis associations. CU and CUD are both associated with adverse clinical characteristics in a community-based sample of adolescents with MDD and BD. Evidence that risks of cannabis use extend across the spectrum of use is important for adolescents with MDD and BD, in whom cannabis-related consequences tend to be more severe. • Cannabis use is elevated in adolescents with mood disorders, yet largely understudied. • Cannabis use was most prevalent in MDD, followed by BD. • Cannabis use disorder (CUD) was most prevalent in BD, followed by MDD. • MDD and BD groups with cannabis use/CUD showed more severe clinical characteristics. • This study indicates that cannabis risks may extend across the spectrum of use. [ABSTRACT FROM AUTHOR]

Background: Depression is associated with a range of adverse physical health outcomes. We aimed to quantify the association between depression and the subsequent rate of accrual of long-term physical health conditions in middle and older age. Methods and findings: We included 172,556 participants from the UK Biobank (UKB) cohort study, aged 40–71 years old at baseline assessment (2006–2010), who had linked primary care data available. Using self-report, primary care, hospital admission, cancer registry, and death records, we ascertained 69 long-term physical health conditions at both UKB baseline assessment and during a mean follow-up of 6.9 years. We used quasi-Poisson models to estimate associations between history of depression at baseline and subsequent rate of physical condition accrual. Within our cohort, 30,770 (17.8%) had a history of depression. Compared to those without depression, participants with depression had more physical conditions at baseline (mean 2.9 [SD 2.3] versus 2.1 [SD 1.9]) and accrued additional physical conditions at a faster rate (mean 0.20 versus 0.16 additional conditions/year during follow-up). After adjustment for age and sex, participants with depression accrued physical morbidities at a faster rate than those without depression (RR 1.32, 95% confidence interval [CI] [1.31, 1.34]). After adjustment for all sociodemographic characteristics, the rate of condition accrual remained higher in those with versus without depression (RR 1.30, 95% CI [1.28, 1.32]). This association attenuated but remained statistically significant after additional adjustment for baseline condition count and social/lifestyle factors (RR 1.10, 95% CI [1.09, 1.12]). The main limitation of this study is healthy volunteer selection bias, which may limit generalisability of findings to the wider population. Conclusions: Middle-aged and older adults with a history of depression have more long-term physical health conditions at baseline and accrue additional physical conditions at a faster rate than those without a history of depression. Our findings highlight the importance of integrated approaches to managing both mental and physical health outcomes. Author summary: Why was this study done?: Mood disorders like depression are increasingly viewed as whole-body conditions affecting multiple systems across the brain and body. People with depression are more likely to have long-term physical health conditions, such as diabetes and arthritis, than people without depression. Previous studies have compared people with and without depression in terms of how many long-term physical health conditions they develop over time, however, most studies count 15 or fewer conditions, whereas recent research recommends counting more than 50 conditions. What did the researchers do and find?: We used data from over 170,000 people in middle and older age who participated in the UK Biobank study. At the start of the study, 18% of the group had previously been diagnosed with depression. We followed up the group for an average of 7 years after the start of the study, using general practitioner and hospital data to identify new diagnoses of 69 long-term physical health conditions. At the start of the study, people without a previous diagnosis of depression had an average of 2 long-term physical health conditions, whilst people with a previous diagnosis of depression had an average of 3 such conditions. On average, based on people who were the same age and sex, people with a previous diagnosis of depression gained long-term physical health conditions at a 30% faster rate than people without a previous diagnosis of depression. What do these findings mean?: A previous diagnosis of depression is a marker of risk for the subsequent development of long-term physical health conditions during middle and older age. Existing healthcare systems are largely designed to treat individual conditions, instead of individual people with multiple conditions, and they especially struggle to treat people with both physical and mental health conditions. We need healthcare services to take an integrated approach to caring for people who have both depression (or other mental health conditions) and long-term physical health conditions. Using data from the UK Biobank, Kelly J Fleetwood and colleagues investigate the association between depression and the rate of accrual of long-term physical health conditions during middle and older age. [ABSTRACT FROM AUTHOR]

Background: There is a lack of valid instruments for assessing spiritual resources and distress in the context of psychiatry and psychotherapy. To fill this gap, the newly developed Spiritual Distress and Resources Questionnaire (SDRQ) was studied in patients with affective disorders. The purpose of this study was to examine the psychometric properties of the SDRQ. Methods: The SDRQ was administered to 177 patients with affective disorders. Measurement properties including reliability, structural validity and construct validity were analysed. In addition, a sub-sample of 41 participants completed the SDRQ a second time to assess test-retest reliability. Results: Exploratory factor analysis confirmed that the 22 items of the SDRQ could be grouped into four subscales: spiritual distress, spiritual coping, immanence and transcendence. The spiritual distress, transcendence, immanence and spiritual coping subscales showed high internal consistency as indicated by Cronbach's alpha coefficients (0.83–0.88). The construct validity of the SDRQ was supported by meaningful and significant correlations with established measures in the field. In particular, higher levels of spiritual distress were strongly associated with higher scores on the Hospital Anxiety and Depression Scale. Conclusion: The results of this study suggest that the SDRQ is a reliable, valid and user-friendly screening tool for assessing spiritual distress, spiritual resources and spiritual coping in patients with affective disorders. The use of the SDRQ may be useful to adequately address and integrate spiritual aspects in a multimodal care approach. [ABSTRACT FROM AUTHOR]

Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit responsible for passivity. After ketamine washout, this circuit exhibits hyposensitivity to futility, leading to long-term increased perseverance. Pharmacological, chemogenetic, and optogenetic manipulations show that norepinephrine and astrocytes are necessary and sufficient for ketamine's long-term perseverance-enhancing aftereffects. In vivo calcium imaging revealed that astrocytes in adult mouse cortex are similarly activated during futility in the tail suspension test and that acute ketamine exposure also induces astrocyte hyperactivation. The cross-species conservation of ketamine's modulation of noradrenergic-astroglial circuits and evidence that plasticity in this pathway can alter the behavioral response to futility hold promise for identifying new strategies to treat affective disorders. [Display omitted] • Zebrafish "give up" when behavior is futile, analogous to learned helplessness • Brief exposure to ketamine causes long-term suppression of giving up • Ketamine induces plasticity in the NE-astroglial system to enhance perseverance • Astrocyte activation may be a critical component of ketamine's effects across species Duque et al. show that astroglial calcium is recruited at active-to-passive transitions during learned-helplessness-like assays in both zebrafish and mice and that a variety of antidepressant compounds have consistent effects across both species. Ketamine, applied transiently, causes acute norepinephrine-mediated astrocytic hyperactivation followed by prolonged suppression to promote lasting behavioral resilience. [ABSTRACT FROM AUTHOR]

BACKGROUND: Virtual reality (VR) is a useful therapeutic tool in various patient populations. Patients with cancer may benefit from VR during chemotherapy to address concerns like negative affect, stress, and physical side effects. OBJECTIVES: The aim of this study was to evaluate the effects of VR on pain, stress, and affect in patients with cancer receiving chemotherapy. METHODS: Ninety patients were randomized into control and study groups. The study group received a 12-minute VR session while undergoing chemotherapy. Participants took surveys measuring stress, pain, affect, cybersickness, and satisfaction, and heart rates were measured before and halfway through. FINDINGS: There were statistically significant decreases in stress and pain among patients using VR. Positive affect was significantly elevated, and negative affect was significantly reduced. Heart rate measurements indicated reduced stress. Most patients reported high satisfaction with VR and experienced no feelings of cybersickness. [ABSTRACT FROM AUTHOR]

An increasing number of studies are investigating the links between autism and borderline personality disorder. Studies report overlapping differences and the challenges in differentiating between these two diagnostic labels. In practice, there are many people, especially autistic women, who feel that they were misdiagnosed with borderline personality disorder. This study aimed to explore the experiences of autistic adults who were previously diagnosed with borderline personality disorder. This is an interpretive phenomenological study. Data were collected using one-to-one, semi-structured interviews. Interview audio-recordings were transcribed and analysed using an interpretive phenomenological analysis. Ten people participated. All recalled autistic differences since childhood that went unnoticed. In most cases, borderline personality disorder was felt to have been a misdiagnosis. This misdiagnosis carried stigma, introduced diagnostic overshadowing and led to harmful experiences for our participants. While they did not identify with the diagnosis, they felt powerless to challenge it. In contrast, receiving an autism diagnosis was 'life changing'. While this did not solve everything for them, it was deeply validating. It also allowed them to be their true authentic selves, shifting the focus away from 'treatment' and changing who they are to suit others, towards acceptance of their differences and neurotype. This significantly improved their mental health. Autistic people face many barriers to receiving an autism diagnosis. Often, they may be misdiagnosed with borderline personality disorder instead. For our study, we interviewed 10 autistic adults who had previously been diagnosed with borderline personality disorder. This helped us to better understand their experiences. They explained how borderline personality disorder is quite stigmatised and may suggest that people are to blame for their differences in behaviour. They found the treatments they had to try for borderline personality disorder to be harmful. For example, these treatments promoted 'masking'. Previous research showed that masking can be harmful for autistic people, linking it to risk of suicide. This diagnosis also led to healthcare professionals neglecting them and discounting their beliefs. Once they were diagnosed with borderline personality disorder, it was hard to access an autism assessment. When they did receive their autism diagnoses, this was much more positive. This diagnosis was validating. It also improved their mental health, as they were no longer expected to mask – their differences were now accepted. They still felt that autism was stigmatised in society. However, this was very different to the stigma around borderline personality disorder. They felt autism stigma was more about their competence as people, whereas borderline personality disorder stigma was about how they were broken and might be harmful to others. This study is important because it allows their stories to be heard by researchers and healthcare professionals alike. Adding their voices helps to humanise them, promoting positive change in mental health services. More research is now needed. [ABSTRACT FROM AUTHOR]

Purpose: Postpartum mood disorders affect many women following childbirth. Prescribing medication for depression and anxiety is one strategy for the effective treatment of postpartum mood disorders. Left untreated, mothers experiencing these disorders and their infants face increased risks of adverse health outcomes. Little is known about how diagnosis and treatment of postpartum mood disorders changed during COVID-19. Methods: We used a retrospective pooled cross-sectional design in a sample of privately-insured postpartum women in U.S. claims data from January 1, 2016 to December 31, 2020. We measured changes in diagnoses of anxiety and depression and changes in prescription fills and days supplied of classes of medications used to treat these conditions (antidepressants, benzodiazepines, and z-drugs). We used ordinary least squares (OLS) regression for each outcome variable during the pre-pandemic period and forecast expected outcomes the observation period. Forecasted and actual values of the outcomes were then compared. Results: Following the onset of the COVID-19 pandemic in March 2020, diagnoses of depression and anxiety were not significantly higher among privately insured postpartum women in the United States. The proportion of privately-insured postpartum women filling a benzodiazepine prescription increased by 15.2%. Conclusions: We find diagnosis of postpartum mood disorders did not increase after the onset of the COVID-19 pandemic, however, fills of benzodiazepines increased among privately-insured postpartum women. Given prior evidence of increased depressive and anxiety symptoms among postpartum women during COVID-19, this suggests increased barriers to appropriate diagnoses and treatment for depression during this period. [ABSTRACT FROM AUTHOR]

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder often accompanied by mood disorders such as seasonal affective disorder (SAD), characterized by seasonal mood and behavioral changes. Although a genetic link between ADHD and SAD has been proposed, research on their relationship remains limited. An online questionnaire survey was conducted to explore the relationship between ADHD traits and seasonal mood changes. The Adult ADHD Self-Report Scale (ASRS) and the Seasonal Pattern Assessment Questionnaire (SPAQ), measured by the General Seasonality Score (GSS), were used. From a sample of 3000 participants, a significant correlation was found between ASRS and GSS (r = 0.42, p < 0.001). Potential ADHD subjects had significantly higher GSS scores than non-ADHD subjects (mean 10.2 vs. 6.7, p < 0.001). The prevalence of potential SAD during winter was higher among potential ADHD participants: 8.5% in potential ADHD participants, and 2.0% in non-ADHD participants (p < 0.001). Further analyses indicated that possible ADHD participants experienced significant seasonal changes in body weight, sleep duration, and food preferences. Additional analyses using GSS as a covariate showed that changes in body weight and sleep duration were not solely due to GSS, whereas changes in food preference were significantly associated with GSS. This study demonstrated that individuals with ADHD traits are more susceptible to seasonal mood variations. Additionally, ADHD traits were significantly associated with seasonal changes in body weight, sleep patterns, and food preferences. These findings underscore the importance of considering seasonal factors in clinical settings to improve the quality of life for individuals with ADHD. [ABSTRACT FROM AUTHOR]

Background: Rates of cannabis use disorder (CUD) have increased disproportionately among Veterans Administration (VA) patients with psychiatric disorders compared to patients with no disorder. However, VA patient samples are not representative of all U.S. adults, so results on disproportionate increases in CUD prevalence could have been biased. To address this concern, we investigated whether disproportionate increases in the prevalence of cannabis outcomes among those with psychiatric disorders would replicate in nationally representative samples of U.S. adults. Methods: Data came from two national surveys conducted in 2001-2002 (n = 43,093) and 2012-2013 (n = 36,309). Outcomes were any past-year non-medical cannabis use, frequent non-medical use (≥3 times weekly), and DSM-IV CUD. Psychiatric disorders included mood, anxiety and antisocial personality disorders. Logistic regression was used to generate predicted prevalences of the outcomes, prevalence differences calculated and additive interactions compared differences between those with and without psychiatric disorders. Results: Cannabis outcomes increased more among those with psychiatric disorders. The difference in prevalence differences included any past-year non-medical cannabis use, 2.45% (95%CI = 1.29-3.62); frequent non-medical cannabis use, 1.58% (95%CI = 0.83-2.33); CUD, 1.40% (95%CI = 0.58-2.21). For most specific disorders, prevalences increased more among those with the disorder. Conclusions: In the U.S. general population, rates of cannabis use and CUD increased more among adults with psychiatric disorders than other adults, similar to findings from VA patient samples. Results suggest that although VA patients are not representative of all U.S. adults, findings from this important patient group can be informative. Greater clinical and policy attention to CUD is warranted for adults with psychiatric disorders. [ABSTRACT FROM AUTHOR]

Objective: To descriptively analyse Australian public sector General Mental Health Services (GMHS) expenditure, ambulatory, and inpatient services, including key performance indicators (KPIs) in comparison with other subspeciality mental health services (MHS). Method: We descriptively analysed data published by the Australian Institute of Health and Welfare (AIHW), including inpatient, ambulatory services, expenditure, and KPIs. Results: From 2017–18 to 2021–22, per capita expenditure for Australian GMHS (18–64) rose by an average annual inflation-adjusted change of 2%. Overall bed numbers remained static, with non-acute beds declining, and commensurate expansion of acute beds. Community GMHS had high outpatient utilisation, with high rates of schizophrenia, schizoaffective disorder, and bipolar affective disorders as primary diagnoses in mid-life. From 2017–18 to 2021–22, GMHS inpatient and ambulatory episodes had decreasing rates of significant improvement and increasing rates of significant deterioration. Conclusions: Although GMHS has the highest overall population and service utilisation, there has been static bed availability and relatively small increases in expenditure which are occurring concurrently with worsening clinical outcomes. Evidence-based modelling of GMHS and outcomes is required to inform future service improvement. [ABSTRACT FROM AUTHOR]

Childhood trauma is a significant environmental stressor linked to mood disorder. It can affect not only the individuals directly involved but also the next generation through the intergenerational transmission of trauma. This study aimed to investigate, for the first time, the co-occurrence of childhood trauma in youths with mood disorders and their parents. We assessed 443 individuals, 100 youths with DSM-5 mood disorders, 100 youths healthy controls (HCs), 92 s' parents and 161 adult HCs. History of childhood trauma was obtained using the Childhood Trauma Questionnaire (CTQ). The distribution patterns of childhood trauma subtypes was estimated through a multivariate model. Intraclass correlations (ICC) were calculated to account for the familial clustering of the sample. We found significantly higher scores for Patients as compared to Young-HC in all the subtypes of childhood trauma (p < 0.05). Considering Parents and Adult-HC groups, Physical abuse (p = 0.001) and Emotional neglect showed higher scores in Parents (p < 0.001). Regarding the familial clustering of the sample, emotional (p < 0.001) and sexual abuse (p = 0.001), and emotional (p = 0.3) and physical neglect (p = 0.003) showed statistical significance, but only emotional abuse reveled a medium level ICC (0.25). Our study highlights the effect of intergenerational transmission of childhood trauma on the diagnosis of mood disorders in youths. Our findings underscore the significance of systematically assessing childhood trauma, in particular emotional abuse, in youths with mood disorders and their parents. Additionally, there is urgent need for evidence-based preventive measures aimed at promoting positive parenting strategies and emotionally supportive environments for children. • Childhood trauma is linked to mood disorders and can affect future generations. • Youths with mood disorders scored higher in all childhood trauma types than controls. • Parents showed higher physical abuse and emotional neglect scores than adult controls. • Emotional abuse had the highest intergenerational transmission impact on mood disorders. • Consistent trauma type in parents and children suggests a cycle of maltreatment. [ABSTRACT FROM AUTHOR]

Over the last two decades, ketamine has gained significant interest in psychiatry as a potential treatment for major depressive disorder (MDD), especially in individuals who are resistant to traditional therapies or are at a high risk of suicide. Task-based functional magnetic resonance imaging (fMRI) studies can provide insight into how ketamine alters brain function and contributes to its antidepressant properties. This mini-review followed the MOOSE guidelines for systematic reviews of observational studies. We conducted a literature search in PubMed, Web of Science, and Scopus aiming at identifying fMRI studies investigating the effect of ketamine on brain function in MDD. Eight articles were included in the study. Results showed that ketamine affects brain activity in MDD, especially in the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex, and amygdala. Interestingly, the majority of the reviewed studies showed a correlation between the changes in brain activity induced by ketamine and improvements in clinical depressive symptoms. These correlations involved the prefrontal cortex, ACC, and cortico-cerebellar circuits. Lack of longitudinal data on the lasting effects of ketamine on brain activity and the small number of studies. This review identifies key research areas that can enhance our understanding of ketamine's effects on the brain in MDD. It calls for studies on ketamine's mechanisms of action, long-term impact, dose-response optimization, and comparisons with other fast-acting antidepressants. Addressing these areas can optimize ketamine's therapeutic use and reveal new treatment targets. • The mechanism behind ketamine's antidepressant effect in MDD remains unknown. • Task-based fMRI studies show that ketamine affects brain areas in MDD. • Ketamine alters activity in the ACC and DLPFC. • Ketamine-induced brain changes correlate with clinical improvements. • Results need to be replicated in bigger studies with longitudinal designs. [ABSTRACT FROM AUTHOR]

Affective and anxiety disorders including major depression disorder (MDD), post-traumatic stress disorder (PTSD), and social anxiety disorder (SAD) are characterized by network dysconnectivity. Network controllability quantifies the capability of specific brain regions to impact functional dynamics based on the underlying structural connectome. This study aimed to investigate transdiagnostic and illness-specific network controllability alterations across these three disorders. The study enrolled 233 currently untreated and non-comorbid subjects, including 68 MDD patients, 51 PTSD patients, 46 SAD patients, and 68 healthy controls (HCs). White matter network controllability was compared among the four groups, and its associations with symptom severity and duration of untreated illness were evaluated. Compared with HCs, patients with PTSD, MDD and SAD exhibited reduced average controllability in the somatomotor, subcortical, and default mode network, notably in brain regions such as the superior frontal gyrus, postcentral gyrus, paracentral gyrus, pallidum, posterior cingulate, and putamen. MDD and SAD patients exhibited reduced average controllability in the left lateral occipital gyrus and bilateral accumbens. SAD patients showed reduced average controllability in the dorsal attention network. These controllability changes did not correlate with illness duration or symptom severity. The cross-sectional design limits causal inference, and adjusting for age and sex differences may not completely eliminate their influence on the results. The present study revealed shared and specific alterations of network controllability in MDD, PTSD, and SAD, suggesting reduced ability of specific brain regions/networks in driving the brain system into different functional states across these disorders. • Study on currently untreated, non-comorbid individuals across MDD, PTSD and SAD • Network controllability quantifies ability of brain regions to impact function. • PTSD, MDD and SAD shared controllability deficits in multiple networks/brain areas. • MDD/SAD shared controllability decreases in lateral occipital gyrus & accumbens. • SAD showed unique controllability reduction in dorsal attention network. [ABSTRACT FROM AUTHOR]

Background: Firearm violence is the leading cause of death and is a major source of morbidity for children in the United States. While gunshot wounds (GSWs) are known to cause lasting psychological repercussions beyond physical injury, these effects are not well documented compared with the physical implications. Our study explores the association between accidental gunshot-related fractures in children and subsequent psychiatric outcomes. Question/purpose: Relative to non-GSW-related fractures, do children sustaining an accidental GSW-related fracture experience higher risk of mental illness and psychiatric disorders? Methods: This study utilized the TriNetX US Collaborative Network as it provides comprehensive inpatient and outpatient data, longitudinal follow-up, and complete medical records across different facilities, closely reflecting real-world patient outcomes in orthopaedic practice. We retrospectively evaluated children diagnosed with an accidental GSW-related fracture and compared mental health diagnoses to children who experienced non-GSW-related fractures. Between January 1, 2003, and March 1, 2023, a total of 5071 children in the United States without preexisting anxiety, mood, psychotic, substance use, or insomnia disorders were reported to have experienced an accidental GSW-related fracture. Among these patients, 55% (2773) had a follow-up period of at least 1 year and met the inclusion criteria for the exposure cohort. In the non-GSW-related fracture cohort, a total of 61% (985,070) of children among 1,613,891 without the preexisting aforementioned conditions had a minimum follow-up period of 1 year and met the inclusion criteria. A total of 2769 children were successfully matched in each cohort using a greedy nearest neighbor propensity score–matching algorithm. Matching was based on age, gender, race, fracture location, and BMI, as these characteristics were identified through a regression analysis as potentially associated with psychiatric outcomes (p < 0.01). The mean ± SD age was 15 ± 4 years, and 16% (451) in the GSW cohort were girls. In the non-GSW cohort 17% (474) were girls. With respect to race and ethnicity, 62% (1709 in the GSW cohort; 1679 in the non-GSW cohort) were Black and 14% (384 in the GSW cohort; 386 in the non-GSW cohort) were Hispanic. Outcomes of interest were recorded for up to 3 years after the index event. Results: The accidental GSW-related fracture cohort experienced a greater hazard of developing anxiety disorders (HR 3.8 [95% confidence interval (CI) 3.2 to 4.6]; p < 0.001), substance use disorders (HR 3.6 [95% CI 3.0 to 4.2]; p < 0.001), mood disorders (HR 2.4 [95% CI 1.9 to 3.1]; p < 0.001), non-mood psychotic disorders (HR 2.4 [95% CI 1.5 to 3.9]; p < 0.001), and insomnia (HR 1.8 [95% CI 1.4 to 2.3]; p < 0.001). Conclusion: Orthopaedic surgeons should implement early psychiatric screenings and integrate mental health support for children with gunshot-related fractures to address elevated risk of anxiety disorders, psychotic disorders, mood disorders, substance abuse, and insomnia. Future studies should focus on identifying effective interventions that mitigate these long-term psychological outcomes, with an emphasis on practical, targeted approaches in clinical care. Level of Evidence: Level III, prognostic study. [ABSTRACT FROM AUTHOR]

Background: The brain reward circuitry is thought to underlie the co-occurrence of attention-deficit/hyperactivity disorder (ADHD) and substance use disorder (SUD) and to possibly impact mood disorders. This study aimed to establish if any difference existed in the severity of depression symptomology between SUD comorbidity with and without ADHD. Methods: A multi-centre, cross-sectional comparison study design drew study participants from substance use treatment facilities within South Africa. The participants were screened for ADHD and depression, with the selective application of a confirmatory ADHD diagnostic interview. The participants were diagnostically grouped according (SUD + ADHD, SUD − ADHD) to an application of a 2 x 2 x 3 ANOVA model. Results: A significant main effect of ADHD diagnosis and gender on depressive symptoms was identified. Post hoc analysis revealed that only male ADHD subjects had significantly higher scores on the Beck scale than non-ADHD males. Conclusions: Co-occurring disorder (COD) prevalence rates were higher than most other South African studies. The aggravation of ADHD on mood disorder symptom severity is consistent with the existing literature; however, further investigation is warranted to determine if the interaction of gender remains only significant for men with a lager sample size. The identified COD prevalence rate may contrast with other South Africa studies, emphasising the need for comprehensive psychiatric comorbidity screening in SUD treatment settings. [ABSTRACT FROM AUTHOR]

Although the construct of social maladjustment has been used for the last six decades, relatively little research has addressed secular trends in socially maladjusted behaviors over time, and even fewer studies have addressed trends for students identified with emotional disturbance (ED). The purpose of this study was to use two U.S. nationally representative cross-sectional cohorts, one sampled in 1998 (n = 1,509) and one sampled in 2020 (n = 1,513), to examine long-term trends in the socially maladjusted behaviors of students with ED and their peers without disabilities. Results indicated that (a) socially maladjusted behaviors were significantly lower for the 2020 cohort compared with 1998 cohort, (b) the decrease from 1998 to 2020 was significantly more pronounced for students with ED compared with peers without disabilities, and (c) only adolescent students demonstrated significant decreases in socially maladjusted behaviors. Potential explanations, limitations of the study, and implications for schools are discussed. [ABSTRACT FROM AUTHOR]

Systems of oppression, adult violence exposure, and adverse childhood experiences interact to contribute to traumatic-stress related disorders, which manifest in affective, cognitive, and interpersonal challenges. This paper focuses specifically on emotional/physiological dysregulation as a central driver of trauma-related difficulties. The ability to recognize, assess, and intervene with children and adults for whom the capacity to regulate is compromised is critical in social work practice. This paper seeks to a) describe the role of (dys)regulation in social work practice and to b) apply this understanding to interventions that aim to address trauma-related challenges. Consistent with social work's mission, we focus on the application of these approaches to socially and economically marginalized populations from low-resourced communities. We discuss current trauma-informed concepts and models that focus on regulation as an important accompaniment to traditional cognitive-centered or insight-oriented approaches. Furthermore we argue that how to be with clients (e.g., our presence in relationship/alliance) is as important to client outcomes as what we do with clients. We present case examples to illustrate the use of interventions informed by leading theoretical models including Window of Tolerance, Polyvagal theory, and the Neurosequential Model of Therapeutics. Implications for teaching and practice are discussed. [ABSTRACT FROM AUTHOR]

Most organisms, including humans, show daily rhythms in many aspects of physiology and behavior, and abnormalities in the rhythms are potential risk factors for various diseases. Mood disorders such as depression are no exception. Accumulating evidence suggests strong associations between circadian disturbances and the development of depression. Numerous studies have shown that interventions to circadian rhythms trigger depression-like phenotypes in human cases and animal models. Conversely, mood changes can affect circadian rhythms as symptoms of depression. Our preliminary data suggest that the phosphorylation signal pathway of the clock protein may act as a common pathway for mood and clock regulation. We hypothesize that mood regulation and circadian rhythms may influence each other and may share a common regulatory mechanism. This review provides an overview of circadian disturbances in animal models and human patients with depression. • Strong associations between circadian disturbances and the development of depression. • Interventions to circadian rhythms trigger depression-like phenotypes. • Mood changes can affect circadian rhythms as symptoms of depression. • Mood regulation and circadian rhythms may influence each other. • Neural circuits associated with mood and light. [ABSTRACT FROM AUTHOR]

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Copyright of International Journal of New Chemistry is the property of International Journal of New Chemistry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: Postpartum mood disorders are heterogenous disorders and comprise postpartum psychosis and postpartum depression. Evidence is accumulating that systemic monocyte/macrophage activation, low-grade inflammation and (premature senescence related) T cell defects increase the risk for mood disorders outside pregnancy by affecting the function of microglia and T cells in the emotional brain (the cortico-limbic system) leading to inadequate mood regulation upon stress. Areas covered: The evidence in the literature that similar immune dysregulations are present in postpartum mood disorders. Results: The physiological postpartum period is characterized by a rapid T cell surge and a mild activation of the monocyte/macrophage system. Postpartum mood disorder patients show a diminished T cell surge (including that of T regulatory cells) and an increase in low grade inflammation, that is, an increased inflammatory state of monocytes/macrophages and higher levels of serum pro-inflammatory cytokines. Expert opinion: Anti-inflammatory agents (e.g. COX-2 inhibitors) and T cell boosting agents (e.g. low-dose IL-2 therapy) should be further investigated as treatment. The hypothesis should be investigated that postpartum mood disorders are active episodes (triggered by changes in the postpartum immuno-endocrine milieu) in ongoing, dynamically fluctuating aberrant neuro-immune-endocrine trajectories leading to mood disorders in women (inheritably) vulnerable to these disorders. [ABSTRACT FROM AUTHOR]

This abstract delves into the intricate nature of impulsivity and its ramifications across psychiatric disorders, leveraging advancements in neuroimaging and psychological studies. It elucidates diverse facets of impulsivity, encompassing response, choice, and tendencies, emphasizing its pivotal role in executive functioning and social development. The intricate interplay of hormonal influences, specifically cortisol, adrenaline, and testosterone, is meticulously examined, unveiling associations between elevated cortisol levels, excessive adrenaline release, and heightened impulsivity. The ventromedial prefrontal cortex (VMPFC) assumes a central role in decision-making and emotional regulation, demonstrating correlations with conditions, such as antisocial behavior and mood disorders. Substantial contributions from neurotransmitters like dopamine and serotonin to impulsive behavior underscore the imperative need for genetic and neurochemical investigations to identify factors crucial for effective management. Interconnections between stress, impulsivity, and decision-making are accentuated, particularly in mood disorders. Hormones, such as leptin and ghrelin, in conjunction with the hypothalamic–pituitary–adrenal axis, play pivotal roles in conditions like major depressive disorder. Concurrently, leptin resistance exerts influence over appetite and mood regulation. The nexus between impulsivity and substance use disorders emphasizes the intricate involvement of neurobiological, neurotransmitter, and genetic components, guiding targeted interventions. Recognition of gender-specific impulsive behaviors and hormonal influences is imperative for tailoring treatment plans. Advocating a comprehensive approach that integrates hormonal assessments with clinical evaluations, taking into account the neurobiological context, is essential. While serotonin systems show promise for treating impulsive aggressiveness, challenges encompass intricate hormonal interactions, ethical considerations, limited treatment options, and the necessity for individualized approaches. Addressing these intricacies is pivotal for advancing knowledge and formulating effective interventions for Impulsive Control Disorders. [ABSTRACT FROM AUTHOR]

Epidemiological evidence from the past 20 years indicates that environmental chemicals brought into the air by the vaporization of volatile organic compounds and other anthropogenic pollutants might be involved, at least in part, in the development or progression of psychiatric disorders. This evidence comes primarily from occupational work studies in humans, with indoor occupations being the most important sources of airborne pollutants affecting neural circuits implicated in mood disorders (e.g., major depressive disorder and bipolar disorder). The current mini review brings together recent findings of indoor airborne pollution from different fields of research, including genetics, neuropathology, and neuroimaging, for gauging underlying physiological mechanisms leading to emotional disturbances that impact nearly all aspects of human behavior. A better understanding of how indoor airborne pollutants affect brain neurons to augment clinical symptoms associated with psychiatric disorders will undoubtedly be useful in the subsequent treatment of patients with major depressive and/or bipolar disorders. This article is part of the themed issue, "Understanding the Link Between Environmental Pollutants, Brain & Behavior." [ABSTRACT FROM AUTHOR]

Background: The basolateral complex of the amygdala is a crucial neurobiological site for Pavlovian conditioning. Investigations into volumetric alterations of the basolateral amygdala in individuals with major depressive disorder (MDD) have yielded conflicting results. These may be reconciled in an inverted U-shape allostatic growth trajectory. This hypothesized trajectory unfolds with an initial phase of volumetric expansion, driven by enhanced dendritic arborization and synaptic plasticity. The increase in volume is followed by a reduction phase, as glucocorticoid exposure cumulatively results in excitotoxic damage, reflecting allostatic load. Methods: 7T magnetic resonance brain imaging was conducted on a total of 84 participants (mean age 38 ± 12 years), comprising 20 unmedicated and 20 medicated individuals with MDD, 21 individuals suffering from bipolar disorder and 23 healthy controls. We employed FreeSurfer 7.3.2 for automatic high-resolution segmentation of nine amygdala subnuclei. We conducted analyses of covariance, with volumes of the basolateral complex, the lateral nucleus and, exploratively, the whole amygdala, as dependent variables, while controlling for the total intracranial volume and sex. Quadratic regressions were computed within the MDD group and in relevant subgroups to investigate the presence of a U-shaped relationship between the number of preceding major depressive episodes or the duration of the disease since the first episode and the dependent variables. Results: Diagnostic groups did not exhibit statistically significant differences in the volumes of the basolateral amygdala (left F (3,75) = 0.66, p >.05; right F (3,76) = 1.80, p >.05), the lateral nucleus (left F (3,75) = 1.22, p >.05; right F (3,76) = 2.30, p >.05)), or the whole amygdala (left F (3,75) = 0.48, p >.05; right F (3,76) = 1.58, p >.05). No quadratic associations were observed between surrogate parameters of disease progression and any of the examined amygdala volumes. There were no significant correlations between subregion volumes and clinical characteristics. Conclusion: We found no evidence for the hypothesis of an inverted U-shaped volumetric trajectory of the basolateral amygdala in MDD. Future research with larger sample sizes, including the measurement of genetic and epigenetic markers, will hopefully further elucidate this compelling paradigm. [ABSTRACT FROM AUTHOR]

AbstractPurposeMaterials and methodsResultsConclusionMood disorders frequently coexist with borderline personality pathology (BPP), presenting considerable clinical challenges. Affective temperaments (AT) play a role in modulating mood disorders and influence the manifestation of illness. BPP and AT share common characteristics, such as emotional instability, impulsivity, and difficulties in interpersonal relationships. However, research on the relationship between BPP and AT remains limited. This study employed network analysis to explore the network structure between BPP and AT in a cohort of patients with mood disorders.A total of 720 patients with mood disorders (major depressive disorder, n = 267; bipolar affective disorder, n = 453) were included in the analysis. The Personality Assessment Inventory-Borderline Features Scale (PAI-BOR) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto questionnaire short version (TEMPS-A) were utilized. Network analysis was conducted to identify central symptoms and network structures across the five AT dimensions and 24 BPP items.The BPP and TEMPS-A items were intricately interwoven, with no distinct groupings. The most significant symptoms identified were “Mood shifts” and “Cyclothymic temperament.” Additionally, irritable temperament was strongly linked to "Little control over anger," while anxious temperament was closely associated with "Worry about people leaving.”The overlap of BPP and AT in the network, without a clear separation, suggests a significant interconnection between these clinical concepts. The centrality of “Mood shifts” and “Cyclothymic temperament” in this network underscores the importance of targeting these symptoms in the treatment of patients with prominent BPP and AT. [ABSTRACT FROM AUTHOR]