1. The Current Landscape of Prostate-Specific Membrane Antigen (PSMA) Imaging Biomarkers for Aggressive Prostate Cancer.
- Author
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Al Saffar, Haidar, Chen, David C., Delgado, Carlos, Ingvar, Jacob, Hofman, Michael S., Lawrentschuk, Nathan, Perera, Marlon, Murphy, Declan G., and Eapen, Renu
- Subjects
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CANCER invasiveness , *PROSTATE-specific membrane antigen , *UNNECESSARY surgery , *COMPUTED tomography , *PROSTATE tumors , *TUMOR markers , *POSITRON emission tomography , *EVALUATION of medical care , *OVERALL survival - Abstract
Simple Summary: The review explores the critical role of prostate-specific membrane antigen (PSMA) PET/CT imaging in diagnosing, staging, and treating prostate cancer. PSMA PET/CT offers superior diagnostic capabilities for identifying prostate cancer's spread, with potential as a prognostic indicator for the disease's recurrence and survival. It highlights PSMA's variability in expression, impacting personalised treatment plans, notably in radioligand therapy with [177Lu] Lu-PSMA-617. This technology enhances treatment strategies, improves outcomes, and reduces unnecessary interventions, marking a significant advancement in personalised prostate cancer management. The review examines the vital role of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) in the diagnosis, staging, and treatment of prostate cancer (PCa). It focuses on the superior diagnostic abilities of PSMA PET/CT for identifying both nodal and distant PCa, and its potential as a prognostic indicator for biochemical recurrence and overall survival. Additionally, we focused on the variability of PSMA's expression and its impact on personalised treatment, particularly the use of [177Lu] Lu-PSMA-617 radioligand therapy. This review emphasises the essential role of PSMA PET/CT in enhancing treatment approaches, improving patient outcomes, and reducing unnecessary interventions, positioning it as a key element in personalised PCa management. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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