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The effect of grain size and crystal orientation on the tensile deformation behavior of Ti-3Al-4.5V-5Mo titanium alloy was studied by using scanning electron scanning electron, X diffraction instrument and theoretical calculation. The results of tensile test of the wires in different states have verified that there are obvious macroscopic yield points on true stress-true strain curves of 720-840 ℃ annealing structures, and then a stress drop occurs. When the crystal orientation of α phase all shows fiber texture of different wires, the grain size determines the macroscopic yield stress of the wire. The larger the grain size is, the lower macroscopic yield stress is. Compared with fiber texture, the existence of fiber texture of α phase generates larger plastic deformation in α phase, the internal stress in β phase, increased, and the macroscopic yield strength of the alloy decreased.

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