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112,688 results on '"ascorbic acid"'

28. Pharmacological Ascorbate for Lung Cancer

Author

National Cancer Institute (NCI), National Institutes of Health (NIH), Holden Comprehensive Cancer Center, McGuff Pharmaceuticals, Inc., and Muhammad Furqan, Assistant Professor

Published
2024

35. Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (REMAP-CAP)

Author

Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore, and Lennie Derde, Dr.

Published
2024

42. Vitamin C in Post-cardiac Arrest (VITaCCA)

Author

Gelderse Vallei Hospital, Sint Franciscus Gasthuis, Tergooiziekenhuizen, Amphia Hospital, Erasmus Medical Center, Noordwest Ziekenhuisgroep, Maasstad Hospital, OLVG, and Angelique Spoelstra-de Man, M.D., Ph.D.

Published
2024

49. Dietary intake of vitamin C and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project.

Author

Sassano, Michele, Seyyedsalehi, Monireh, Collatuzzo, Giulia, Pelucchi, Claudio, Bonzi, Rossella, Ferraroni, Monica, Palli, Domenico, Yu, Guo-Pei, Zhang, Zuofeng, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Zaridze, David, Maximovich, Dmitry, Martín, Vicente, Castano-Vinyals, Gemma, Vioque, Jesús, González-Palacios, Sandra, Ward, Mary, Malekzadeh, Reza, Pakseresht, Mohammadreza, Hernández-Ramirez, Raul, López-Cervantes, Malaquias, Negri, Eva, Turati, Federica, Rabkin, Charles, Tsugane, Shoichiro, Hidaka, Akihisa, Lagiou, Areti, Lagiou, Pagona, Camargo, M, Curado, Maria, Boccia, Stefania, La Vecchia, Carlo, and Boffetta, Paolo

Subjects
Case–control, Consortium, Diet, Gastric cancer, Pooled analysis, Vitamin C, Male, Humans, Female, Ascorbic Acid, Stomach Neoplasms, Diet, Fruit, Vegetables, Case-Control Studies, Eating, Risk Factors
Abstract

BACKGROUND: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. METHODS: Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables. The dose-response relationship was evaluated using mixed-effects logistic models with second-order fractional polynomials. RESULTS: Individuals in the highest quartile of dietary vitamin C intake had reduced odds of GC compared with those in the lowest quartile (OR: 0.64; 95% CI: 0.58, 0.72). Additional adjustment for fruit and vegetables intake led to an OR of 0.85 (95% CI: 0.73, 0.98). A significant inverse association was observed for noncardia GC, as well as for both intestinal and diffuse types of the disease. The results of the dose-response analysis showed decreasing ORs of GC up to 150-200 mg/day of vitamin C (OR: 0.54; 95% CI: 0.41, 0.71), whereas ORs for higher intakes were close to 1.0. CONCLUSIONS: The findings of our pooled study suggest that vitamin C is inversely associated with GC, with a potentially beneficial effect also for intakes above the currently recommended daily intake (90 mg for men and 75 mg for women).

Published
2024

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