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3 results on '"axially substituted"'

1. Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque

Author

Yuriy Gerasymchuk, Wojciech Kałas, Jacek Arkowski, Łukasz Marciniak, Dariusz Hreniak, Edyta Wysokińska, Leon Strządała, Marta Obremska, Larysa Tomachynski, Viktor Chernii, and Wiesław Stręk

Subjects
axially substituted, water soluble, zirconium phthalocyanines, SiO2 nanocarriers, photosensitizers, ROS generation, Organic chemistry, QD241-441
Abstract

A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO2 nanocarriers (SiO2-(CH2)3-NH2NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO2 conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO2 as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease.

Published
2021
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2. Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque

Author

Wojciech Kałas, Jacek Arkowski, Łukasz Marciniak, Wieslaw Strek, Yuriy Gerasymchuk, Viktor Chernii, Dariusz Hreniak, Leon Strządała, Larysa Tomachynski, Edyta Wysokińska, and Marta Obremska

Subjects
Indoles, medicine.medical_treatment, Pharmaceutical Science, Photodynamic therapy, SiO2 nanocarriers, Isoindoles, Conjugated system, water soluble, axially substituted, Article, Analytical Chemistry, lcsh:QD241-441, Mice, chemistry.chemical_compound, lcsh:Organic chemistry, Coordination Complexes, Drug Discovery, medicine, zirconium phthalocyanines, Animals, Photosensitizer, Physical and Theoretical Chemistry, chemistry.chemical_classification, Drug Carriers, Reactive oxygen species, Photosensitizing Agents, Organic Chemistry, photosensitizers, Silicon Dioxide, medicine.disease, cell cultures, Plaque, Atherosclerotic, macrophages, RAW 264.7 Cells, Atheroma, photodynamic therapy, Photochemotherapy, chemistry, Chemistry (miscellaneous), Phthalocyanine, Biophysics, Molecular Medicine, ROS generation, Zirconium, atherosclerosis, Nanocarriers, Conjugate
Abstract

A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO2 nanocarriers (SiO2-(CH2)3-NH2NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO2 conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO2 as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease.

Published
2021

3. Gallato Zirconium (IV) Phtalocyanine Complex Conjugated with SiO 2 Nanocarrier as a Photoactive Drug for Photodynamic Therapy of Atheromatic Plaque.

Author

Gerasymchuk, Yuriy, Kałas, Wojciech, Arkowski, Jacek, Marciniak, Łukasz, Hreniak, Dariusz, Wysokińska, Edyta, Strządała, Leon, Obremska, Marta, Tomachynski, Larysa, Chernii, Viktor, and Stręk, Wiesław

Subjects
*PHOTODYNAMIC therapy, *DRUG therapy, *ZIRCONIUM, *REACTIVE oxygen species, *LIGHT sources
Abstract

A new conjugate of gallato zirconium (IV) phthalocyanine complexes (PcZrGallate) has been obtained from alkilamino-modified SiO2 nanocarriers (SiO2-(CH2)3-NH2NPs), which may potentially be used in photodynamic therapy of atherosclerosis. Its structure and morphology have been investigated. The photochemical properties of the composite material has been characterized. in saline environments when exposed to different light sources Reactive oxygen species (ROS) generation in DMSO suspension under near IR irradiation was evaluated. The PcZrGallate-SiO2 conjugate has been found to induce a cytotoxic effect on macrophages after IR irradiation, which did not correspond to ROS production. It was found that SiO2 as a carrier helps the photosensitizer to enter into the macrophages, a type of cells that play a key role in the development of atheroma. These properties of the novel conjugate may make it useful in the photodynamic therapy of coronary artery disease. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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