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3 results on '"biological negotiation"'

1. Biohybrid Nanoparticles to Negotiate with Biological Barriers

Author

Mohammadi, M, Corbo, C, Molinaro, R, Lakey, J, Mohammadi, MR, Lakey, JRT, Mohammadi, M, Corbo, C, Molinaro, R, Lakey, J, Mohammadi, MR, and Lakey, JRT

Abstract

Incapability of effective cross-talk with biological environments has partly impaired the in vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could be engineered through regulating their interactions with in vivo niches. Inspired by communications in biological systems, endowing a “biological identity” to synthetic NPs is one approach to control their biodistribution, and immunonegotiation profiles. This synthetic-biological combination is referred to as biohybrid NPs, which comprise both i) engineerable, readily producible, and trackable synthetic NPs as well as ii) biological moieties with the capability to cross-talk with immunological barriers. Here, the latest understanding on the in vivo interactions of NPs, biological barriers they face, and emerging methods for quantitative measurements of NPs' biodistribution are reviewed. Some key biomolecules that have emerged as negotiators with the immune system in the context of cancer and autoimmunity, and their inspirations on biohybrid NPs are introduced. Critical design considerations for efficient cross-talk between NPs and innate and adaptive immunity followed by hybridization methods are also discussed. Finally, clinical translation challenges and future perspectives regarding biohybrid NPs are discussed.

Published
2019

2. Biohybrid Nanoparticles to Negotiate with Biological Barriers

Author

Claudia Corbo, M. Rezaa Mohammadi, Roberto Molinaro, Jonathan R. T. Lakey, Mohammadi, M, Corbo, C, Molinaro, R, and Lakey, J

Subjects
inorganic chemicals, Biodistribution, protein coronas, Nanoparticle, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biomaterials, protein corona, mental disorders, biological negotiation, Animals, Humans, General Materials Science, Tissue Distribution, Precision Medicine, biological barrier, health care economics and organizations, Phagocytes, Chemistry, technology, industry, and agriculture, Gene Transfer Techniques, Immunity, personalized medicine, General Chemistry, respiratory system, 021001 nanoscience & nanotechnology, 0104 chemical sciences, bioinspired material, Nanoparticles, 0210 nano-technology, Biotechnology
Abstract

Incapability of effective cross-talk with biological environments has partly impaired the in vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could be engineered through regulating their interactions with in vivo niches. Inspired by communications in biological systems, endowing a “biological identity” to synthetic NPs is one approach to control their biodistribution, and immunonegotiation profiles. This synthetic-biological combination is referred to as biohybrid NPs, which comprise both i) engineerable, readily producible, and trackable synthetic NPs as well as ii) biological moieties with the capability to cross-talk with immunological barriers. Here, the latest understanding on the in vivo interactions of NPs, biological barriers they face, and emerging methods for quantitative measurements of NPs' biodistribution are reviewed. Some key biomolecules that have emerged as negotiators with the immune system in the context of cancer and autoimmunity, and their inspirations on biohybrid NPs are introduced. Critical design considerations for efficient cross-talk between NPs and innate and adaptive immunity followed by hybridization methods are also discussed. Finally, clinical translation challenges and future perspectives regarding biohybrid NPs are discussed.

Published
2019

3. Biohybrid Nanoparticles to Negotiate with Biological Barriers.

Author

Mohammadi MR, Corbo C, Molinaro R, and Lakey JRT

Subjects
Animals, Gene Transfer Techniques, Humans, Immunity drug effects, Nanoparticles toxicity, Phagocytes cytology, Phagocytes drug effects, Precision Medicine, Tissue Distribution drug effects, Nanoparticles chemistry
Abstract

Incapability of effective cross-talk with biological environments has partly impaired the in vivo functionality of nanoparticles (NPs). Homing, biodistribution, and function of NPs could be engineered through regulating their interactions with in vivo niches. Inspired by communications in biological systems, endowing a "biological identity" to synthetic NPs is one approach to control their biodistribution, and immunonegotiation profiles. This synthetic-biological combination is referred to as biohybrid NPs, which comprise both i) engineerable, readily producible, and trackable synthetic NPs as well as ii) biological moieties with the capability to cross-talk with immunological barriers. Here, the latest understanding on the in vivo interactions of NPs, biological barriers they face, and emerging methods for quantitative measurements of NPs' biodistribution are reviewed. Some key biomolecules that have emerged as negotiators with the immune system in the context of cancer and autoimmunity, and their inspirations on biohybrid NPs are introduced. Critical design considerations for efficient cross-talk between NPs and innate and adaptive immunity followed by hybridization methods are also discussed. Finally, clinical translation challenges and future perspectives regarding biohybrid NPs are discussed., (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2019
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