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The research goal is the comparative analysis of Russian and foreign studies concerned the possibility of radiological methods of diagnostics of cancer of urinary bladder. The problem of early diagnostics of initial tumor and tumor recurrence, determination of stages of bladder cancer, its prognosis and outcome remains an actual one

Introduction. Toxic epidermal necrolysis (TEN) or Lyell syndrome is a lifethreatening adverse drug reaction, characterized bywidespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes. The estimatedmortality associated with this illness varies widely in different reports, from 30-40%. In 90% of cases is associated with the exposure to the drug. Radiotherapy rarely triggers the illness. Objective. Presentation of the TEN provoked by radiotherapy. Case report.We present a case of 82-year-old patient with TEN provoked by radiotherapywhichwas used to treat a cancer of bladder.On admission the lesions covered about 60%of the total body surface area, involving oral mucosa and conjunctiva. Fever and oliguriawere observed.Diagnostic investigation revealed leukocytosis, increased level of creatinine, glycosuria and proteinuria. After treatment with cyclosporine, 4 mg/kg, and metylprednisolon 48mg, the skin, oralmucosa and conjunctiva lesionswere curedwithin 3 weeks and there was the normalization of laboratory abnormalities. Conclusions. In some cases reported in literature, patients with primary and metastatic brain tumors develop TEN after treatment with phenytoin and its derivatives combinedwith radiation therapy. Such a reaction is called EMPACT (erythemamultiforme associatedwith phenytoin and cranial radiation therapy). The development of TEN after radiation therapy is seldom reported. [ABSTRACT FROM AUTHOR]