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A male 15-year-old captive Siberian tiger (Panthera tigris altaica) developed pelvic limb hypermetry over the past 10 years. Recently, an ulcerated black nodule located caudally to the right ear was observed. The animal was submitted to surgery for removing the tumor, but died during anesthetic recovery. At necropsy, another infiltrative nodule was observed caudally to the right ear. Histologically, both nodules corresponded to melanocytic neoplasia, varying from heavily pigmented to amelanotic, with metastasis to mediastinal lymph nodes, spleen and lung. Lipofuscinosis and corpora amylacea were histologically observed in the central nervous system. Macroscopic and histologic findings confirmed the diagnosis of skin metastatic melanoma in a captive adult Siberian tiger. RESUMO Um tigre-siberiano (Panthera tigris altaica) de cativeiro, macho, de 15 anos de idade, apresentou hipermetria dos membros pélvicos nos últimos 10 anos, e recentemente, foi observado um nódulo preto e ulcerado caudalmente à orelha direita. O animal foi submetido à cirurgia para remoção do nódulo e morreu durante a recuperação anestésica. À necropsia, outro nódulo infiltrativo, foi detectado caudalmente a orelha direita. Histologicamente, ambos os nódulos correspondiam à neoplasia melanocítica, com células variando de fortemente pigmentadas a amelanóticas, com metástase para linfonodos mediastinais, baço e pulmão. Havia lipofucsinose e corpora amilácea no sistema nervoso central. Os achados macroscópicos e histológicos confirmam o diagnóstico de melanoma cutâneo metastático em um tigre-siberiano adulto de cativeiro.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:52:36Z No. of bitstreams: 1 S0100-879X1997001100016.pdf: 141685 bytes, checksum: e883b75d825e75f9788177059c163132 (MD5) Made available in DSpace on 2013-08-22T18:52:36Z (GMT). No. of bitstreams: 1 S0100-879X1997001100016.pdf: 141685 bytes, checksum: e883b75d825e75f9788177059c163132 (MD5) Previous issue date: 1997-11-01 Made available in DSpace on 2013-09-30T19:43:56Z (GMT). No. of bitstreams: 2 S0100-879X1997001100016.pdf: 141685 bytes, checksum: e883b75d825e75f9788177059c163132 (MD5) S0100-879X1997001100016.pdf.txt: 9024 bytes, checksum: 90d20a807ed4046261aa8a35436f50bb (MD5) Previous issue date: 1997-11-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:11:30Z No. of bitstreams: 2 S0100-879X1997001100016.pdf: 141685 bytes, checksum: e883b75d825e75f9788177059c163132 (MD5) S0100-879X1997001100016.pdf.txt: 9024 bytes, checksum: 90d20a807ed4046261aa8a35436f50bb (MD5) Made available in DSpace on 2014-05-20T15:11:30Z (GMT). No. of bitstreams: 2 S0100-879X1997001100016.pdf: 141685 bytes, checksum: e883b75d825e75f9788177059c163132 (MD5) S0100-879X1997001100016.pdf.txt: 9024 bytes, checksum: 90d20a807ed4046261aa8a35436f50bb (MD5) Previous issue date: 1997-11-01 Eight Panthera onca (Po), 13 Felis concolor (Fc), 7 Felis yagouaroundi (Fy), 7 Felis tigrina (Ft) and 5 Felis pardalis (Fp) specimens from São Paulo State zoos were used. All animals were restrained with darts containing 10 mg/kg ketamine and 1 mg/kg xylazine. Venous blood samples were collected as soon as possible (within 15-20 min) and serum was frozen until the time for cortisol quantification. Cortisol was determined using a solid phase radioimmunoassay with an intra-assay coefficient of 8.51%. Data were analyzed statistically by the Kruskal-Wallis test, followed by Dunn's multiple comparisons test, and the one-sample t-test, with the level of significance set at P