1. The effect of an artificial tear combining hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome: a new treatment for dry eye
- Author
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Pasquale Aragona, Maurizio Rolando, Stefano Bonini, Marco Nardi, Stefano Barabino, and Carlo Enrico Traverso
- Subjects
Questionnaires ,Male ,medicine.medical_treatment ,02 engineering and technology ,Tamarind seed ,Carmellose sodium ,Dry eye disease ,Hyaluronic acid ,Tamarind seeds polysaccharide ,Tear substitutes ,law.invention ,Cornea ,chemistry.chemical_compound ,0302 clinical medicine ,law ,Surveys and Questionnaires ,Tamarindus ,Food science ,Hyaluronic Acid ,chemistry.chemical_classification ,Chemistry ,General Medicine ,Middle Aged ,021001 nanoscience & nanotechnology ,Artificial tears ,Combination ,Seeds ,Drug Therapy, Combination ,Dry Eye Syndromes ,Female ,0210 nano-technology ,Conjunctiva ,physiopathology, Cornea ,physiopathology, Double-Blind Method, Drug Therapy ,Combination, Dry Eye Syndromes ,drug therapy/physiopathology, Female, Humans, Hyaluronic Acid ,therapeutic use, Male, Middle Aged, Ophthalmic Solutions, Phytotherapy, Polysaccharides ,therapeutic use, Questionnaires, Seeds ,chemistry, Tamarindus ,chemistry, Tears ,physiology ,chemistry ,Polysaccharide ,03 medical and health sciences ,Drug Therapy ,Double-Blind Method ,Polysaccharides ,Carmellose Sodium ,Botany ,medicine ,Humans ,In patient ,drug therapy/physiopathology ,equipment and supplies ,Ophthalmology ,Multicenter study ,therapeutic use ,Tears ,030221 ophthalmology & optometry ,physiopathology ,Ophthalmic Solutions ,Phytotherapy ,human activities - Abstract
Synergistic interactions between hyaluronic acid (HA) and tamarind seed polysaccharide (TS-polysaccharide) have been demonstrated by means of nuclear magnetic resonance spectroscopy. This study was designed to investigate the potential clinical benefit of a combination of HA and TS-polysaccharide in managing dry eye disease (DED).A total of 49 subjects with moderate DED, confirmed by Ocular Surface Disease Index (OSDI) questionnaire score between 10 and 25, tear break-up time (BUT)10 seconds, or Schirmer I test5.5 mm after 5 minutes, and lissamine green staining of the ocular surface2 according to National Eye Institute score system, were enrolled into this multicenter, randomized, double-masked study to receive either combination of HA and TS-polysaccharide or carmellose sodium for 3 months, both instilled 4 times per day. The assessments included OSDI questionnaire, tear film stability (BUT), tear production (Schirmer I test), and corneal and conjunctival staining.Patients treated with HA and TS-polysaccharide showed a statistically significant improvement in the OSDI score at the end of the study compared to the baseline and control groups. The HA and TS-polysaccharide and carmellose sodium were equally effective in reducing BUT and the extent of injury assessed by corneal and conjunctival staining. Non-significant changes were recorded for Schirmer I test.Based on the results of this clinical trial, the combination of HA and TS-polysaccharide appears to be effective in improving the symptoms of dry eye, opening new scenarios in possible treatment of the disease by combining different molecules.
- Published
- 2013