1. Selective drug trace detection with low-field NMR
- Author
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Johannes F. P. Colell, Rafael Müller, Stefan Glöggler, Bernhard Blümich, Meike Emondts, and Stephan Appelt
- Subjects
Drug ,Nicotine ,Magnetic Resonance Spectroscopy ,chemistry [Hydrogen] ,media_common.quotation_subject ,Analytical chemistry ,analysis [Drug Residues] ,Opium ,Biochemistry ,Analytical Chemistry ,chemistry.chemical_compound ,Harmine ,Tobacco ,Electrochemistry ,Environmental Chemistry ,analysis [Harmine] ,Spectroscopy ,media_common ,Morphine ,analysis [Morphine] ,chemistry [Tobacco] ,Combinatorial chemistry ,Drug Residues ,methods [Magnetic Resonance Spectroscopy] ,chemistry [Opium] ,chemistry ,ddc:540 ,Proton NMR ,analysis [Nicotine] ,Hydrogen - Abstract
Advances with para-hydrogen induced polarization open up new fields of applications for portable low-field NMR. Here we report the possibility of tracing drugs down to the micromolar regime. We could selectively polarize nicotine quantities similar to those found in one cigarette. Also less than 1 mg of harmine, a drug used for treatment of Parkinson's disease, and morphine extracted from an opium solution were detectable after polarization with para-hydrogen in single-scan (1)H-experiments. Moreover, we demonstrate the possibility to selectively enhance and detect the (1)H-signal of drug molecules with PHIP in proton rich standard solutions that would otherwise mask the (1)H NMR signal of the drug.
- Published
- 2011
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