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The coronavirus disease-2019 (COVID-19) pandemic has impaired the quality of life (QoL) for many due to its extensive impacts. However, few studies have addressed the specific impact of COVID-19 on the mental health of adolescents, particularly post-traumatic stress disorder (PTSD). This study considered the impact of COVID-19-related PTSD on the QoL of adolescents in China, the mediating effects of insomnia, and the moderating effects of resilience. Participants included 50,666 adolescents aged 12–18 years selected using a comprehensive sampling method. We performed data collection from January 8th to January 18th, 2023, using the Children's Revised Impact of Event Scale, Pittsburgh Sleep Quality Index, Ten-item Connor-Davidson Resilience Scale, and Screening for and Promotion of Health-related QoL in Children and Adolescents Questionnaire for data collection. Male adolescents exhibited significantly lower levels of PTSD and insomnia compared to females and scored significantly higher in psychological resilience and overall QoL. Insomnia played a mediating role between PTSD and QoL. Psychological resilience moderated the impact of COVID-19-related stress on adolescents' QoL through its influence on insomnia. PTSD resulting from the COVID-19 pandemic affects the QoL of adolescents through the presence of insomnia. Psychological resilience plays a moderating role in this process. Cultivating psychological resilience in adolescents can effectively enhance their ability to cope with the impacts of sudden public events. [ABSTRACT FROM AUTHOR]

Purpose: Examine the alterations in antipsychotic concentrations following coronavirus disease-2019 (COVID-19) infection among hospitalized patients with mental disorders and conduct an analysis of the factors influencing these changes. Methods: Data were collected from inpatients at Beijing Huilongguan Hospital between December 12, 2022, and January 11, 2023, pre- and post-COVID-19. Based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, 329 inpatients with mental disorders were included (3 with incomplete data excluded). Primary outcomes assessed changes in antipsychotic concentrations pre- and post-COVID-19, while secondary outcomes examined factors linked to concentration increases and antipsychotic dose adjustments. Results: Clozapine (P < 0.001), aripiprazole (P < 0.001), quetiapine (P = 0.005), olanzapine (P < 0.001), risperidone (P < 0.001), and paliperidone (P < 0.001) concentrations increased post-COVID-19 in patients with mental disorders. Notably, clozapine concentration surpassing pre-infection levels was highest. Clozapine users were more likely to adjust their dose (50.4%) compared to olanzapine (17.5%) and other antipsychotics. Moreover, traditional Chinese patent medicines and antibiotics during COVID-19 infection were associated with antipsychotic reduction or withdrawal (OR = 2.06, P = 0.0247; OR = 7.53, P = 0.0024, respectively). Conclusion: Antipsychotic concentrations in hospitalized patients with mental disorders increased after COVID-19 infection, that may be related not only to COVID-19, but also to the use of Chinese patent medicines during infection. The pre-infection concentration and types of antipsychotics, patient's gender, and combination of traditional Chinese medicine or antibiotics, were factors found to correlate with increased drug concentrations and necessitate dose adjustments. [ABSTRACT FROM AUTHOR]

Background Aims Methods Results Conclusions Community‐acquired pneumonia (CAP) leads to considerable morbidity and mortality globally. However, data on CAP burden in Australia, especially during the coronavirus disease 2019 (COVID‐19) pandemic, are limited.We characterised and assessed clinical outcomes of non‐COVID‐19 CAP hospitalisations over a 6‐year period at two major hospitals in South Australia.All non‐COVID‐19 CAP hospitalisations were identified using the International Statistical Classification of Diseases and Related Health Problems, Tenth revision, Australian modification (ICD‐10‐AM) codes, between 1 January 2018 and 31 December 2023, at two tertiary hospitals in Adelaide. Clinical outcomes included in‐hospital and 30‐day mortality, length of stay (LOS) in, intensive care unit (ICU) admission and 30‐day readmissions. Multilevel regression models were utilised to identify predictors of clinical outcomes.Over the 6‐year period, there were 7853 non‐COVID‐19 CAP hospitalisations, with a temporal increase from 100 per 100 000 population in 2018 to 208 per 100 000 population in 2023 (P < 0.001). The mean (SD) age was 75.1 (17.6) years, and 54.6% were males. The mean age declined over time (P < 0.05), while other characteristics remained stable. Streptococcus pneumoniae was the most commonly identified bacterium (21.8% of cases). In‐hospital mortality occurred in 7.8% of patients, with 30‐day mortality and readmission rates of 14.3% and 16.9% respectively. LOS declined significantly during the pandemic years; however, mortality remained stable over time. Frailty status, malnutrition and number of comorbidities significantly predicted 30‐day mortality and LOS, in addition to pneumonia severity and ICU admission.There has been an increasing trend of hospitalisations for non‐COVID‐19 CAP during the COVID‐19 pandemic, with a concomitant trend towards shorter LOS and no significant shift in other clinical outcomes. [ABSTRACT FROM AUTHOR]

Introduction: Measles, a highly transmissible disease marked by fever and a maculopapular rash, posed a substantial threat to life in the 1960s. Nevertheless, the advent of the measles vaccine had a profound impact, significantly diminishing its toll on mortality. Similarly, through effective influenza surveillance and early epidemic warning systems, public health officials can timely identify influenza trends and provide crucial scientific support for prevention and control measures. This proactive approach holds great public health significance. Aim: To analyse the long-term trend of measles cases in Rajasthan, India, and the impact of Coronavirus Disease-2019 (COVID-19) on it, with future predictions using Auto-Regressive Integrated Moving Average (ARIMA) modelling. Materials and Methods: The present study was a retrospective, descriptive observational study in which monthly diagnosed measles cases were collected from the Measles Rubella Laboratory, Department of Microbiology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India, for the period of April 2010 to April 2023. An ARIMA model was developed using data from 2010 to 2020 to predict the monthly number of measles cases in 2021. The predicted values were then compared to the actual cases in 2021 to assess the model’s accuracy. Results: Out of the total positive cases, males were slightly more prone to acquire infection than females (1734 males, 54%; 1477 females, 46%). The monthly index for new measles cases ranged from 0.11 to 2.6. It reached its lowest point in July (0.106) and August (0.25) and peaked in March (2.594) and April (1.84). The overall trend was fluctuating; however, the incidence of measles cases clearly increased after the year 2021. The difference between observed cases and predicted cases for the period of April 2020 to December 2021 was not statistically significant (t-value=0.261 and p-value=0.797). Conclusion: The fluctuating trend of measles was observed during the last decade; however, the observed cases of measles showed an upward trajectory during and after the COVID-19 outbreak. This study also highlighted the monthly index of the measles cases, which peaked in March to April and was lowest in July to August. [ABSTRACT FROM AUTHOR]

Introduction: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in China, the epidemic has rapidly spread all over the world in just a few months. Different steroids have been proven effective in treating COVID-19 pneumonia. However, comparative efficacy data between different steroids have been evaluated in a few studies from various parts of the world. To date, no study with a large number of patients has been conducted in the eastern part of India. Aim: To compare the efficacy of dexamethasone and methylprednisolone in terms of outcomes and disease progression in COVID-19 pneumonia patients. Materials and Methods: This retrospective cohort study included 377 patients with moderate and severe COVID-19 pneumonia admitted to Medical College and Hospital from May 2020 to December 2020, Kolkata, West Bengal, India. Patient records were divided into two groups based on the type of steroids administered (dexamethasone and methylprednisolone). Clinical, laboratory, treatment, and outcome data were tabulated for analysis. Demographic patterns in the two groups were compared, and efficacy was analysed in terms of hospital course (hospital stay length, type of respiratory support received) and final outcome (cured or death) in both groups. The data collected were analysed using Statistical Package for Social Sciences (SPSS) software version 29.0. Qualitative variables were expressed as counts and percentages, while quantitative variables were presented as mean±Standard Deviation (SD). Results: There were no significant differences between the two treatment groups based on demographic features (age, sex), co-morbidities (diabetes, hypertension, etc.), disease severity (hypoxia, hypotension) on admission day, and smoking status. The study showed that methylprednisolone significantly reduced the requirement for high-flow oxygen (p-value=0.002), Non Invasive Ventilation (NIV) (p-value=0.001), and invasive ventilation (p-value=0.001) compared to dexamethasone. However, there was no significant difference (p-value=0.800) in the duration of hospital stay between the methylprednisolone and dexamethasone treatment groups. Kaplan-Meier survival analysis also showed a significant survival benefit among patients who received methylprednisolone compared to dexamethasone (log-rank p-value=0.039). Conclusion: The present study concludes that in COVID-19 pneumonia, the administration of methylprednisolone leads to a significant reduction in mortality and the need for high-flow oxygen, NIV, and invasive ventilation compared to dexamethasone. [ABSTRACT FROM AUTHOR]

Background: Having a weakened immune system can make patients easily get nosocomial infection (NI) with multi-drug resistant (MDR) bacteria and put them in a dangerous situation. It causes long hospital stays, disability, economic burden, and even death. The present study aimed to determine the prevalence of NI in patients suffering from COVID-19. Methods: In this retrospective study, the information on 250 patients suffering from COVID-19 in the intensive care unit (ICU) (2020 to 2021) was considered. For statistical analysis, analysis of variance (ANOVA), paired samples t-test, and chi-square using SPSS-23 software were used (p<0.05). Results: Two hundred and fifty hospitalized (107 females and 143 males, mean ± standard deviation (SD) of age; 56.50 ± 17.20) patients were considered. The most (97.60%) medicine prescribed was remdesivir. Candida spp. (two females), Escherichia coli (two females), Acinetobacter spp. (one female), Citrobacter spp. (one female), Pseudomonas spp. (one male), Sphingomonas spp. (one male), Stenotrophomonas spp. (one male) and Enterobacter spp. (one male) were isolated from the patient's specimens. Four of seven bacterial isolates were positive for MDR. NI was diagnosed in six patients. There was no significant relationship between the age with the isolated microbes (P=0.154) and MDR (P=0.987) and also between gender with common microbes (P=0.576) and MDR (P=0.143). Conclusion: The coexistence of bacteria and NI was observed in patients. Remdesivir was prescribed for most patients. Most bacteria were resistant to antibiotics, especially, β-lactams. [ABSTRACT FROM AUTHOR]

Objective: In this retrospective and cross-sectional study, it was aimed to evaluate the efficacy of tocilizumab (TCZ) treatment in critical COVID-19 patients who were hospitalized in the intensive care unit (ICU) and developed cytokine storm. Materials and Methods: The study included 219 critically ill COVID-19 patients followed in the ICU and treated with TCZ. All patients received 2 doses of 400 mg/day TCZ treatment during their stay in the ICU. Clinical conditions, laboratory data, inotrope requirement and chest radiographs before and after TCZ treatment were compared. Mortality rates at the 7th day, 28th day and total mortality rates of the patients were recorded. Results: It was observed that there was a significant decrease in CRP values over time after TCZ treatment. There was a significant increase in leukocyte, lymphocyte, lactate, urea, creatinine, AST, D-dimer, LDH and PCT values. The 7-day mortality of the patients was 21%, the 28-day mortality was 64.8%, and the total mortality rate was 65.3%. Conclusion: It was determined that after TCZ treatment, only CRP levels, which are among the inflammatory parameters, decreased significantly in patients, and the mortality rates were still high with the increase in the values of kidney and liver function tests of the patients.

Abstract The coronavirus disease-2019 (COVID-19) pandemic has impaired the quality of life (QoL) for many due to its extensive impacts. However, few studies have addressed the specific impact of COVID-19 on the mental health of adolescents, particularly post-traumatic stress disorder (PTSD). This study considered the impact of COVID-19-related PTSD on the QoL of adolescents in China, the mediating effects of insomnia, and the moderating effects of resilience. Participants included 50,666 adolescents aged 12–18 years selected using a comprehensive sampling method. We performed data collection from January 8th to January 18th, 2023, using the Children’s Revised Impact of Event Scale, Pittsburgh Sleep Quality Index, Ten-item Connor-Davidson Resilience Scale, and Screening for and Promotion of Health-related QoL in Children and Adolescents Questionnaire for data collection. Male adolescents exhibited significantly lower levels of PTSD and insomnia compared to females and scored significantly higher in psychological resilience and overall QoL. Insomnia played a mediating role between PTSD and QoL. Psychological resilience moderated the impact of COVID-19-related stress on adolescents’ QoL through its influence on insomnia. PTSD resulting from the COVID-19 pandemic affects the QoL of adolescents through the presence of insomnia. Psychological resilience plays a moderating role in this process. Cultivating psychological resilience in adolescents can effectively enhance their ability to cope with the impacts of sudden public events.

Introduction: Coronavirus disease 2019 (COVID-19), a unique viral infection causing multiorgan failure, can lead to diverse dermatological manifestations, unlike other viral exanthems. There is a scarcity of Indian literature describing these manifestations. Aims and Objectives: To study the dermatological manifestations due to COVID-19 infection. Materials and Methods: It was a retrospective analysis (6 month) of patients with dermatological manifestations related to COVID-19 infection. Medical records were evaluated with respect to demography, detailed clinical presentations, real-time reverse transcription–polymerase chain reaction/rapid antigen test positivity, and related investigations. Statistical Analysis: It was done using proportion, mean, and percentages. Results: A total of 76 cases were recruited. Out of the 76 COVID-19-related cases, there were 67 diagnosed and 9 suspected cases (later came positive). The overall female predominance (n = 69) was observed. The most common age affected was 31-40 years. The most common presentation during prodromal, acute, and postacute phases was urticaria. Other manifestations were chilblain-like, varicella-like, pityriasis rosea-like, erythema multiforme-like, petechial rash, multisystemic inflammatory syndrome in children and confirmed cases of mucormycosis seen with cutaneous manifestation. Conclusion: Our study highlights the need for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing in patients presenting with rash in otherwise asymptomatic individuals having contact with confirmed case and when associated with systemic symptoms. Dermatological manifestations may play an important role in identifying cases early and serve as an important proxy in managing further spread of this disease in the midst of the global pandemic. Urticaria with fever has diagnostic significance since this combination can be a symptom of an otherwise not confirmed SARS-CoV-2 infection.

Introduction: Since the outbreak of Coronavirus Disease 2019 (COVID-19) in China, the epidemic has rapidly spread all over the world in just a few months. Different steroids have been proven effective in treating COVID-19 pneumonia. However, comparative efficacy data between different steroids have been evaluated in a few studies from various parts of the world. To date, no study with a large number of patients has been conducted in the eastern part of India. Aim: To compare the efficacy of dexamethasone and methylprednisolone in terms of outcomes and disease progression in COVID-19 pneumonia patients. Materials and Methods: This retrospective cohort study included 377 patients with moderate and severe COVID-19 pneumonia admitted to Medical College and Hospital from May 2020 to December 2020, Kolkata, West Bengal, India. Patient records were divided into two groups based on the type of steroids administered (dexamethasone and methylprednisolone). Clinical, laboratory, treatment, and outcome data were tabulated for analysis. Demographic patterns in the two groups were compared, and efficacy was analysed in terms of hospital course (hospital stay length, type of respiratory support received) and final outcome (cured or death) in both groups. The data collected were analysed using Statistical Package for Social Sciences (SPSS) software version 29.0. Qualitative variables were expressed as counts and percentages, while quantitative variables were presented as mean±Standard Deviation (SD). Results: There were no significant differences between the two treatment groups based on demographic features (age, sex), co-morbidities (diabetes, hypertension, etc.), disease severity (hypoxia, hypotension) on admission day, and smoking status. The study showed that methylprednisolone significantly reduced the requirement for high-flow oxygen (p-value=0.002), Non Invasive Ventilation (NIV) (p-value=0.001), and invasive ventilation (p-value=0.001) compared to dexamethasone. However, there was no significant difference (p-value=0.800) in the duration of hospital stay between the methylprednisolone and dexamethasone treatment groups. Kaplan-Meier survival analysis also showed a significant survival benefit among patients who received methylprednisolone compared to dexamethasone (log-rank p-value=0.039). Conclusion: The present study concludes that in COVID-19 pneumonia, the administration of methylprednisolone leads to a significant reduction in mortality and the need for high-flow oxygen, NIV, and invasive ventilation compared to dexamethasone.

Introduction: Measles, a highly transmissible disease marked by fever and a maculopapular rash, posed a substantial threat to life in the 1960s. Nevertheless, the advent of the measles vaccine had a profound impact, significantly diminishing its toll on mortality. Similarly, through effective influenza surveillance and early epidemic warning systems, public health officials can timely identify influenza trends and provide crucial scientific support for prevention and control measures. This proactive approach holds great public health significance. Aim: To analyse the long-term trend of measles cases in Rajasthan, India, and the impact of Coronavirus Disease-2019 (COVID-19) on it, with future predictions using Auto-Regressive Integrated Moving Average (ARIMA) modelling. Materials and Methods: The present study was a retrospective, descriptive observational study in which monthly diagnosed measles cases were collected from the Measles Rubella Laboratory, Department of Microbiology, Sawai Man Singh Medical College, Jaipur, Rajasthan, India, for the period of April 2010 to April 2023. An ARIMA model was developed using data from 2010 to 2020 to predict the monthly number of measles cases in 2021. The predicted values were then compared to the actual cases in 2021 to assess the model’s accuracy. Results: Out of the total positive cases, males were slightly more prone to acquire infection than females (1734 males, 54%; 1477 females, 46%). The monthly index for new measles cases ranged from 0.11 to 2.6. It reached its lowest point in July (0.106) and August (0.25) and peaked in March (2.594) and April (1.84). The overall trend was fluctuating; however, the incidence of measles cases clearly increased after the year 2021. The difference between observed cases and predicted cases for the period of April 2020 to December 2021 was not statistically significant (t-value=0.261 and p-value=0.797). Conclusion: The fluctuating trend of measles was observed during the last decade; however, the observed cases of measles showed an upward trajectory during and after the COVID-19 outbreak. This study also highlighted the monthly index of the measles cases, which peaked in March to April and was lowest in July to August.

Objectives: In coronavirus disease-2019 (COVID-19), autonomic dysfunction may ensue. The heart rate recovery index (HRRI) measures autonomic function and predicts cardiovascular disease (CVD). The research assessed HRRI in patients with COVID-19. Materials and Methods: The research group included 160 verified COVID-19 cases, and the control group had 160 healthy participants without a history of immunization. All patients underwent treadmill stress electrocardiogram according to the Bruce protocol. After the stress test, HRRIs were taken at 1, 2, 3, and 5 min. HRRI is computed by subtracting the subject’s maximum exercise heart rate (HR) at the end of the exercise from HR after 1, 2, 3, and 5 min of recovery. Results: Both groups had equal exercise duration, metabolic equivalents, maximum (max.) HR, systolic blood pressure (SBP) and diastolic blood pressure (DBP) at baseline, max. SBP and DBP, and changes in SBP and DBP (p>0.05). HRRIs were greater in COVID-19 patients than in controls at 1, 2, 3, and 5 min (p

Recent research has highlighted the link between childhood obesity, dental caries, and malocclusion, and how the Coronavirus Disease - 2019 (COVID-19) pandemic and social media have worsened these health issues. Increased screentime and decreased physical activity during the pandemic have significantly contributed to these conditions among children. Studies emphasise the need to address common risk factors such as unhealthy diets, limited healthcare access, and poor public health policies to reduce their negative effects. This review explores the complex relationship between childhood obesity, dental caries, and malocclusion, with a focus on their global importance. It examines the connections and shared risk factors between these conditions, particularly in the context of the pandemic and the growing influence of social media on children. The goal is to provide insights for developing effective interventions and management strategies to improve children's health worldwide. The present review stresses the urgent need for comprehensive strategies that target both individual and collective risk factors, while also considering broader socio-economic and digital influences on children's health behaviours. Promoting healthy lifestyles, access to nutritious foods, physical activity, and better dental care can help to alleviate these conditions. Understanding the interplay between these health issues and the digital environment is crucial to creating effective and adaptable public health interventions.

Background: Having a weakened immune system can make patients easily get nosocomial infection (NI) with multi-drug resistant (MDR) bacteria and put them in a dangerous situation. It causes long hospital stays, disability, economic burden, and even death. The present study aimed to determine the prevalence of NI in patients suffering from COVID-19. Methods: In this retrospective study, the information on 250 patients suffering from COVID-19 in the intensive care unit (ICU) (2020 to 2021) was considered. For statistical analysis, analysis of variance (ANOVA), paired samples t-test, and chi-square using SPSS-23 software were used (p

Introduction: In the relentless global battle against the Coronavirus Disease-2019 (COVID-19) pandemic, accurate prediction of disease severity remains a critical challenge, with profound implications for patient outcomes and healthcare resource allocation. As the virus continues to evolve and pose new threats, the need for reliable prognostic indicators becomes increasingly urgent. Effective identification of patients at high-risk of developing severe illness not only facilitates timely intervention and personalised treatment strategies but also optimises healthcare resource utilisation. In this context, the exploration of novel biomarkers and predictive models holds immense promise for enhancing ones understanding of disease progression and improving clinical decision-making. Aim: To study the association between haematological parameters, including Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR), with Computed Tomography Scan Severity Score (CTSS) in COVID-19 patients. Materials and Methods: A prospective cohort study was conducted from March 2021 to July 2022 at Government General Hospital (GGH) Nizamabad, Telangana, India. The study encompassed all three COVID-19 waves, included a sample size of 159 Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) positive patients, excluding pregnant women and children under 10 years. Upon admission, CTSS and ratios of NLR, LMR, and PLR were recorded in an MS Excel sheet before any medical intervention and then analysed using Statistical Package for Social Sciences (SPSS) software 22.0. Results: The study comprised 159 patients with a mean age of 50.86±13.89 years (ranging from 16 to 85), predominantly male 90 (56.61%). The highest infection rate 85 (53.45%) was in the 41-60 years age group. The NLR was significantly elevated from a mean value of 4.58 to 11.24 (r value=0.78, p-value=

The coronavirus disease-2019 (COVID-19) has been declared a global pandemic by the World Health Organization due to its spread to more than 90% of nations of the world with significant consequences on their health, social structure, and economy. The causative agent, severe acute respiratory syndrome coronavirus 2, is a highly contagious virus of the coronaviridae family that is known to survive on many surfaces for days at various temperatures. It is acid stable at a high titer (1.2 × 103 PFU) for up to an hour and inactivated when exposed to temperatures 33°C and above for up to 30 min. Chemical agents such as ethanol, diethyl ether, chlorine, per-acetic acid, and chloroform likewise inactivate it as well as exposure to ultraviolet (UV) rays at 254 nm. Emerging evidence indicate that while modes of transmission of the disease are the same across the globe, incidence rates, clinical manifestation, severity, and outcome of COVID-19 in tropical Africa differ from other continent. Patients in Africa have presented with less severe symptoms, higher rates of recovery, and lower case-fatality rates. There are suggestions that higher environmental temperature and humidity in African countries, immune status, dietary pattern, and sociocultural practices of the people may have contributed to this. This review of literature sought to investigate the probable influence of these factors on the impact of COVID-19 in Africa with recommendations to mitigate its spread and impact on morbidity and mortality.

Introduction: Survivors of severe Coronavirus Disease-2019 (COVID-19) pneumonia may experience Exercise-Induced Desaturation (EID), which can remain undiagnosed at discharge, as most exhibit normal resting Arterial Blood Gases (ABGs). This undiagnosed condition may lead to unexpected hospital readmissions, causing additional burden to the health system. However, the prevalence of EID among this population, especially in developing countries, is not well documented. Aim: To estimate the prevalence of EID among survivors of severe COVID-19 pneumonia and to explore the predictive role of Lung Ultrasound Scan (LUS) in detecting EID. Materials and Methods: This hospital-based, observational, cross-sectional study was conducted at the Institute of Chest Diseases in Kozhikode, Kerala, India from October 2021 to September 2022. It involved 153 COVID-19 patients aged 18 years and above who had recovered from severe pneumonia, were otherwise fit for hospital discharge, and had normal resting ABGs. The study examined the prevalence of EID using the 6-Minute Walk Test (6MWT). Additionally, it investigated the predictive ability of a LUS for EID. A LUS was performed on all patients and scoring was conducted according to the established protocol. Results: The mean age of the study subjects was 53.50±14.13 years, with 119 (77.8%) being male. During the 6MWT, 96 patients (62.7%) showed significant desaturation. A total of 83 (95.4%) subjects in the desaturated group required Non-Invasive Ventilation (NIV) compared to 4 (4.6%) in the non-desaturated group (p

Recent research has highlighted the link between childhood obesity, dental caries, and malocclusion, and how the Coronavirus Disease - 2019 (COVID-19) pandemic and social media have worsened these health issues. Increased screentime and decreased physical activity during the pandemic have significantly contributed to these conditions among children. Studies emphasise the need to address common risk factors such as unhealthy diets, limited healthcare access, and poor public health policies to reduce their negative effects. This review explores the complex relationship between childhood obesity, dental caries, and malocclusion, with a focus on their global importance. It examines the connections and shared risk factors between these conditions, particularly in the context of the pandemic and the growing influence of social media on children. The goal is to provide insights for developing effective interventions and management strategies to improve children's health worldwide. The present review stresses the urgent need for comprehensive strategies that target both individual and collective risk factors, while also considering broader socioeconomic and digital influences on children's health behaviours. Promoting healthy lifestyles, access to nutritious foods, physical activity, and better dental care can help to alleviate these conditions. Understanding the interplay between these health issues and the digital environment is crucial to creating effective and adaptable public health interventions. [ABSTRACT FROM AUTHOR]

Aim: Coronavirus disease 2019 emerged in December 2019 and spread worldwide. This study aimed to clarify the impact of the coronavirus disease 2019 pandemic on the diagnosis and treatment of hepatocellular carcinoma (HCC) in Japan. Methods: First, we collected the monthly numbers of HCC‐related general medical practices from January 2019 to December 2021 at liver disease‐specific medical institutions in Japan. Next, we collected individual clinical information from patients with newly diagnosed HCC during this period. Results: There was a decrease in the number of HCC‐related medical practices, including referrals, enhanced abdominal ultrasonography and radiofrequency ablation, in Japan's first state of emergency (SOE; April–May 2020) compared with 2019. Fewer patients were diagnosed with new HCC during the first SOE than before or after it. There was no difference in tumor diameter, number of tumors or Barcelona Clinic Liver Cancer stage between patients diagnosed before the first SOE and those diagnosed during or after the first SOE. The median waiting times for treatment of patients diagnosed during and after the first SOE were 31 and 37 days, which were significantly shorter and not longer than that of patients diagnosed before the first SOE (36 days), respectively. Conclusion: The number of HCC‐related general medical practices decreased during the first SOE. However, the coronavirus disease 2019 pandemic did not lead to HCC progression by diagnostic delays or cause HCC treatment delays in Japan. [ABSTRACT FROM AUTHOR]

Introduction: In the relentless global battle against the Coronavirus Disease-2019 (COVID-19) pandemic, accurate prediction of disease severity remains a critical challenge, with profound implications for patient outcomes and healthcare resource allocation. As the virus continues to evolve and pose new threats, the need for reliable prognostic indicators becomes increasingly urgent. Effective identification of patients at highrisk of developing severe illness not only facilitates timely intervention and personalised treatment strategies but also optimises healthcare resource utilisation. In this context, the exploration of novel biomarkers and predictive models holds immense promise for enhancing ones understanding of disease progression and improving clinical decision-making. Aim: To study the association between haematological parameters, including Neutrophil-to-Lymphocyte Ratio (NLR), Lymphocyte-to-Monocyte Ratio (LMR), and Platelet-to-Lymphocyte Ratio (PLR), with Computed Tomography Scan Severity Score (CTSS) in COVID-19 patients. Materials and Methods: A prospective cohort study was conducted from March 2021 to July 2022 at Government General Hospital (GGH) Nizamabad, Telangana, India. The study encompassed all three COVID-19 waves, included a sample size of 159 Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) positive patients, excluding pregnant women and children under 10 years. Upon admission, CTSS and ratios of NLR, LMR, and PLR were recorded in an MS Excel sheet before any medical intervention and then analysed using Statistical Package for Social Sciences (SPSS) software 22.0. Results: The study comprised 159 patients with a mean age of 50.86±13.89 years (ranging from 16 to 85), predominantly male 90 (56.61%). The highest infection rate 85 (53.45%) was in the 41-60 years age group. The NLR was significantly elevated from a mean value of 4.58 to 11.24 (r value=0.78, p-value=<0.001), and LMR notably reduced from 8.27 to 3.80 (r value=0.67, p-value=0.003) in correlation with the severity as indicated by CTSS. Although PLR values were higher in severe cases, increasing from 173.07 in mild cases to 272.29 in severe cases, there was no significant correlation with CTSS (r-value=-0.78, p-value=0.177). Conclusion: CTSS emerges as a valuable radiological biomarker for predicting COVID-19 severity. However, due to its cost and limited availability in grassroots-level hospitals, there is a need for alternative severity prediction models. Present study proposes a predictive model using NLR and LMR biomarkers as alternatives to CTSS for assessing COVID-19 severity. [ABSTRACT FROM AUTHOR]

Background & objective: Cytokine storms play a significant role in conditions leading to multi-organ failure in patients with severe corona virus disease-2019 (COVID-19). The eradication of pro-inflammatory cytokines through hemoperfusion has been suggested to be a possible strategy to improve outcomes in these patients. We evaluated the impact of adjunctive HA330 hemoperfusion on outcomes in severe COVID-19 patients. Methodology: A single-center retrospective cohort study was conducted from December 2021 to December 2022. We included severe COVID-19 patients with elevated pro-inflammatory markers, who received three consecutive sessions of HA330 hemoperfusion in addition to the standard treatment protocol. Clinical data, including demographic information, baseline characteristics, and treatment outcomes, were analyzed. Results: We evaluated 24 severe COVID-19 patients. We observed a significant reduction in levels of CRP (P < 0.001) and IL-6 (P = 0.042), as well as a significant increase in arterial partial pressure of oxygen (P = 0.041). Importantly, no patient experienced cytotoxicity after the HA330 hemoperfusion sessions, confirming the biocompatibility of the treatment. Conclusion: Three consecutive sessions of HA330 hemoperfusion, used as an adjunctive therapy to standard care in severe COVID-19 patients, effectively reduced pro-inflammatory cytokine levels and improved oxygenation. However, large multicenter trials are required to validate these clinical outcomes. [ABSTRACT FROM AUTHOR]

Introduction: Survivors of severe Coronavirus Disease-2019 (COVID-19) pneumonia may experience Exercise-Induced Desaturation (EID), which can remain undiagnosed at discharge, as most exhibit normal resting Arterial Blood Gases (ABGs). This undiagnosed condition may lead to unexpected hospital readmissions, causing additional burden to the health system. However, the prevalence of EID among this population, especially in developing countries, is not well documented. Aim: To estimate the prevalence of EID among survivors of severe COVID-19 pneumonia and to explore the predictive role of Lung Ultrasound Scan (LUS) in detecting EID. Materials and Methods: This hospital-based, observational, cross-sectional study was conducted at the Institute of Chest Diseases in Kozhikode, Kerala, India from October 2021 to September 2022. It involved 153 COVID-19 patients aged 18 years and above who had recovered from severe pneumonia, were otherwise fit for hospital discharge, and had normal resting ABGs. The study examined the prevalence of EID using the 6-Minute Walk Test (6MWT). Additionally, it investigated the predictive ability of a LUS for EID. A LUS was performed on all patients and scoring was conducted according to the established protocol. Results: The mean age of the study subjects was 53.50±14.13 years, with 119 (77.8%) being male. During the 6MWT, 96 patients (62.7%) showed significant desaturation. A total of 83 (95.4%) subjects in the desaturated group required Non-Invasive Ventilation (NIV) compared to 4 (4.6%) in the non-desaturated group (p<0.001). All 24 (100%) subjects in the desaturated group required Invasive Mechanical Ventilation (IMV), while none in the non-desaturated group did. The mean Length Of Stay (LOS) in the hospital was 35.50±13.35 days for the desaturated group, compared to 23.32±16.25 days for the non-desaturated group (p<0.001). The LUS score was significantly higher in the desaturated group (16.61±5.92) than in the non-desaturated group (5.54±4.62). The Receiver Operating Characteristic (ROC) curve for the LUS score indicated a cut-off value of 8.5 for identifying significant EID. Conclusion: Survivors of COVID-19 who recovered from Acute Respiratory Failure (ARF) and have normal resting ABGs may still have significant EID. A protocol-based LUS score can potentially identify individuals at risk for EID. [ABSTRACT FROM AUTHOR]

Introduction: Years after SARS coronavirus disease 2019 (COVID-19) recovery, residual pulmonary abnormalities may still exist. This brings on the question of whether or not COVID-19 could have comparable late consequences. Structural changes in the lungs after recovery can be better visualized using computed tomography (CT) thorax. Computed Tomography Lung Parenchymal changes during hospitalization by COVID-19 and after 4 months of follow-up to correlate with the volumetric high-resolution computed tomography thorax indices, Pulmonary function tests (PFTs) indices, SpO2, and 6 min Walking Test (6MWT). Materials and Methods: This is a Hospital based cross-sectional study, with a follow-up among 100 Patients from 2020 to 2022. Each patient's different CT parameters and HRCT volumetric indices Normal Lung (NL), Normal Lung Percentage (NL%), Whole Lung (WL) were correlated with the PFT indices (Forced expiratory volume in 1s [FEV1], forced vital capacity [FVC], FEV1/FVC), Oxygen Saturation (SpO2) and 6-Minute Walking Test (6MWT). Results: The mean NL (L) and NL% during COVID were significantly lower than the mean values 4 months post-COVID. Architectural distortion, bronchiolar dilatation, interstitial thickening, and parenchymal bands were reduced considerably after 4 months post-COVID, compared to during COVID. PFTs results, such as PFT indices, were not significantly different after 4 months post-COVID, compared to during COVID. SpO2 (%) and 6 MWT (m) were significantly increased. During COVID and post-COVID, the values of NL (L) and NL (%) had a significant positive correlation with PFT indices, SpO2, and 6MWT (m). Conclusion: Hence, the different CT indices (NL and NL%) can be used as a surrogate for functional recovery of COVID patients since it correlates with the PFT indices (FEV1 and FEV1/FVC), SpO2, and 6MWT post-COVID. [ABSTRACT FROM AUTHOR]

Objectives: In coronavirus disease-2019 (COVID-19), autonomic dysfunction may ensue. The heart rate recovery index (HRRI) measures autonomic function and predicts cardiovascular disease (CVD). The research assessed HRRI in patients with COVID-19. Materials and Methods: The research group included 160 verified COVID-19 cases, and the control group had 160 healthy participants without a history of immunization. All patients underwent treadmill stress electrocardiogram according to the Bruce protocol. After the stress test, HRRIs were taken at 1, 2, 3, and 5 min. HRRI is computed by subtracting the subject’s maximum exercise heart rate (HR) at the end of the exercise from HR after 1, 2, 3, and 5 min of recovery. Results: Both groups had equal exercise duration, metabolic equivalents, maximum (max.) HR, systolic blood pressure (SBP) and diastolic blood pressure (DBP) at baseline, max. SBP and DBP, and changes in SBP and DBP (p>0.05). HRRIs were greater in COVID-19 patients than in controls at 1, 2, 3, and 5 min (p<0.001). Conclusion: COVID-19 impacts HRRI. COVID-19 may affect neural-cardiovascular systems. [ABSTRACT FROM AUTHOR]

Objective: To describe the characteristics of COVID-19 patients with pneumothorax and pneumomediastinum (PTX/PM) and their association with patient outcomes. Patients and methods: Adults admitted to five Mayo Clinic hospitals with COVID-19 between 03/2020–01/2022 were evaluated. PTX/PM was defined by imaging. Descriptive analyses and a matched (age, sex, admission month, COVID-19 severity) cohort comparison was performed. Hospital mortality, length of stay (LOS), and predisposing factors were assessed. Results: Among 6663 patients, 197 had PTX/PM (3 %) (75 PM, 40 PTX, 82 both). The median age was 59, with 71 % males. Exposure to invasive and non-invasive mechanical ventilation and high-flow nasal cannula before PTX/PM were 42 %, 17 %, and 20 %, respectively. Among isolated PTX and PM/PTX patients 70 % and 53.7 % underwent an intervention, respectively, while 96 % of the PM-only group was followed conservatively.A total of 171 patients with PTX/PM were compared to 171 matched controls. PTX/PM patients had more underlying lung disease (40.9 vs. 23.4 %, p

Aims:This study aimed to evaluate the mental health of mothers of children with attention deficit hyperactivity disorder (ADHD) after distance learning measures during the Coronavirus disease-2019 (COVID-19) pandemic, considering factors that may influence their well-being.Methods:In a cross-sectional design, the levels of burnout, depression, anxiety, stress, coping strategies, social support, and perceived changes in mental health among the mothers were assessed using the Maslach Burnout Inventory (MBI), Depression Anxiety Stress Scale-21 (DASS-21), Brief Coping Orientation to Problems Experienced Inventory, Multidimensional Scale of Perceived Social Support Scale, and Global Rating of Change (GRC) scale. Furthermore, the mothers completed the Atilla Turgay Scale (T-DSM-IV-S) to evaluate their perceptions of their children’s ADHD and behavioral problems.Results:Of the 72 mothers (mean age: 42.46±6.73 years, mean children age: 11.39±3.12 years), 50%, 44.4%, and 43.1% had depression symptoms, anxiety, and stress, respectively. According to the GRC, most mothers (67%) reported deterioration in mental well-being compared with the pre-pandemic period. The strongest correlations were between the subscales of T-DSM-IV-S and the total MBI score (r=0.51, p

Introduction: Acute respiratory failure is the most common clinical feature in patients with severe Coronavirus Disease -2019 (COVID-19) who are admitted to an Intensive Care Unit (ICU) and may require invasive mechanical ventilation, which is generally linked with a high fatality rate. Patients with established co-morbidities, such as diabetes, invariably fall into the category of patients with severe disease presentation and rapid disease progression. Aim: To study the clinical outcomes of COVID-19 diabetic patients after sequential oxygen therapy using a reservoir bag mask, High Frequency Nasal Oxygen (HFNO), and Non-invasive Ventilation (NIV). Materials and Methods: In this retrospective cohort study, adhering to the STROBE statement criteria, the authors included 150 patients suffering from COVID-19 acute respiratory failure, who were known diabetics, divided into three groups based on admission oxygen saturation and Respiratory Rate (RR) for Non-Rebreather Bag-Mask (NRBM) therapy, HFNO, and NIV. For two weeks, all patients were monitored, and measures such as Saturation of peripheral Oxygen (SpO2), Respiratory Rate (RR) escalation of oxygen requirement, glycaemic management, compliance and problems with continued oxygen therapy, the need for invasive mechanical ventilation, and mortality were recorded. The recorded parameters among the three groups were compared using Analysis of Variance (ANOVA) test. Results: Among the demographic parameters recorded, the authors noted that individuals older than 50-55 years of either sex were admitted for HFNO (56.02±11.71 years) and NIV (54.28±14.67 years) therapy, whereas no such preponderance was noted among the two genders. Significant results were noted in all three groups in terms of the escalation of oxygen fraction (FiO2) requirements on the 10th day of observation (NRBM 12.63±2.48%, HFNO 37.74±13.56%, NIV 82.44±11.11%). The need for tracheal intubation was higher in patients in the NIV group (10) compared to the HFNO (9) and NRBM (1) groups. Patients whose blood sugar levels remained uncontrolled throughout the course of observation in the study were disparagingly seen to have been a part of the HFNO and NIV groups, and hence the subsequent mortality. Conclusion: There was a steady escalation of mean oxygen requirements in all three groups of oxygen therapy over the course of two weeks, coinciding with the ensuing ‘cytokine storm’ associated with Severe Acute Respiratory Syndrome- Coronavirus- 2 (SARS-CoV-2) infection. This trend of escalation of oxygen requirement also in turn coincided with the raised glycaemic charting trends of the patients over the same course of two weeks, delineating those individuals with diabetes mellitus, in view of their compromised immunity and innate pro -inflammatory state, are more prone to develop severe form of the disease with more serious complications, which may even lead to mortality. With regards to the compliance, NRBM & HFNO provided best results in comparison to NIV. The rates of complications were also noted to be higher with the use of NIV in this instance.

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, which began in Wuhan, China, in December 2019, has quickly spread worldwide, causing numerous challenges for people, such as lockdowns, isolation, and subsequent mental stress. Developing mental resilience is crucial for handling stress effectively. Understanding the impact of the COVID-19 pandemic on stress and the resilience of the Indian population enables insight and facilitates thoughtful reformation in aiding the community. Aim: To assess the stress and resilience among the general population during the COVID-19 pandemic and to find the association between demographic variables and stress and resilience. Additionally, the study aimed to evaluate the correlation between stress and resilience among these subjects. Materials and Methods: A cross-sectional study was conducted Department of Psychiatry, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India, from February 2021 to April 2021. A total of 740 willing respondents affected by the COVID-19 pandemic participated in the study. A snowball sampling method was used in which participants were approached via a Google form circulated through their known contacts. The study encompassed those who had experienced either direct or indirect effects of the COVID-19 pandemic. The user-friendly Google form collected essential demographic information such as gender, marital status, and employment type. The stress and resilience levels were measured using the Perceived Stress Scale (PSS) and Resilience Scale. The statistical analysis of sample characteristics with frequency distributions and categorical variables was done with the application of Chi-square tests. Correlation analysis was done using the Spearman's test. A p-value of

Introduction: Coronavirus Disease-2019 (COVID-19) impacts multiple organs like the kidneys, heart, and liver, but primarily affects the respiratory system, leading to symptoms such as cough with sputum production, fever, and in severe cases, respiratory failure. Research on Severe Acute Respiratory Syndrome (SARS)-Coronavirus-2 (CoV-2) has revealed impairments in lung function during the early recovery phase following COVID-19 infection. The aim is to understand the virus’s impact and identify any obstructive, restrictive, or mixed pulmonary alterations in medical professionals six weeks after recovery. Aim: To assess Pulmonary Function Tests (PFTs) six weeks after COVID-19 recovery in health science students at a medical college in North Karnataka. Materials and Methods: A descriptive cross-sectional study was conducted in the Department of Physiology at Jawaharlal Nehru Medical College in North Karnataka, India, from January 2021 to December 2021. A total of 155 COVID-19-recovered health science students were included, and their anthropometry, physiological parameters, and pulmonary parameters were recorded. The “Spirometer Helios 401” was used to estimate an individual’s PFT. Data were analysed using independent sample t-tests, with a p-value

ABSTRACT Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has had a significant psychological impact on people's lives, including healthcare providers. This impact has manifested in the form of anxiety and fear. Since COVID-19 is a respiratory disease spread through the mouth and nose, dental practitioners have experienced anxiety due to their close proximity to the oro-nasal tissues. Aim: To assess the mental health condition, specifically fear and anxiety, of a group of dental students in Saudi Arabia during the COVID-19 pandemic and to explore students' perceptions about dentistry as a career choice following the pandemic. Materials and Methods: A cross-sectional questionnaire-based study was conducted, which included demographic data, the Coronavirus Anxiety Scale (CAS), the Fear of COVID-19 Scale (FCV-19S), as well as a few questions to assess why students chose dentistry as a career and their perceptions about dentistry as a career following the pandemic. A digital link to the questionnaires was distributed through social media outlets such as Twitter, WhatsApp, etc., with the aim of reaching dental students across all dental schools in Saudi Arabia. Dental students and those undergoing internships from both public and private Dental Colleges across Saudi Arabia were approached. The study included a total of 633 students from 21 dental schools across Saudi Arabia. Data were analysed using the Statistical Package for Social Sciences, including Analysis of Variance(ANOVA), independent t-tests, and Chi-square tests. Results: Fear and anxiety levels were found to be the highest among interns and fourth-year dental students, respectively. A total of 346 (54.66%) of the respondents reported that they chose dentistry as a career due to personal desire. Approximately, 239 (37.8%) of the respondents reported being either 'Not Sure' or would not choose dentistry as a career if they had the choice, considering the uncertainty created by the COVID-19 pandemic. Conclusion: Fear and anxiety were reported to be higher among dental students exposed to clinical practice. The majority of dental students reported that they would still choose dentistry as a career option despite the uncertainty caused by the COVID-19 pandemic.

Introduction: The Coronavirus Disease-2019 pandemic is considered the most catastrophic disease of the last decades, with evolving knowledge and improved management over time. Pregnant women are known to be particularly vulnerable, and COVID-19 has been shown to damage the endothelium due to its proinflammatory nature. Aim: To determine the occurrence of oligohydramnios in pregnant women who tested positive for COVID-19. Materials and Methods: A retrospective observational study was conducted at the Department of Obstetrics and Gynaecology, Koru Health Groups, Ankara, Çankaya, Turkey from January 2023 to June 2023. The study included a total of 459 women who were followed during pregnancy and delivered in the same hospital between April 2020 and October 2022. The patients were divided into two groups: COVID-19 positive group (n=101) and negative group (n=358). Various parameters such as age, parity, gestational week at birth, Body Mass Index (BMI), 1st and 5th-minute Appearance, Pulse, Grimace, Activity and Respiration (APGAR) scores, weight of the newborn, Amniotic Fluid Index (AFI), and the risk of developing oligohydramnios were assessed between the positive and negative groups. Parametric variables were analysed using independent t-tests and non parametric ones using Mann-Whitney U tests. Chi-square test was used to compare categorical variables. A p-value of

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has had a significant impact on the elderly population, leading to both fatalities from the virus and delayed treatment of acute emergencies. Additionally, many elderly individuals have demonstrated poor health-seeking behaviour in managing chronic conditions. Reasons for this include fear, access barriers, and strain on healthcare resources and personnel. Aim: To evaluate the change in health-seeking behaviour among the elderly in rural areas of central Kerala during the pandemic and identify the associated factors. Materials and Methods: A community-based cross-sectional study was conducted in the rural field-practice areas of the Department of Community Medicine at a tertiary care Medical College in Kerala, India from May 2021 to August 2021. A total of 252 elderly individuals aged 60 years and above were interviewed using a structured pretested questionnaire. Socio-demographic details and responses on health-seeking behaviour during the pandemic were documented. Data were summarised using frequencies and percentages for categorical variables or mean and standard deviation for continuous variables. Associations were tested using the Chi-square test. Results: The study revealed that 83.73% (211 out of 252) of the elderly participants had Non Communicable Diseases (NCDs), with hypertension in 130 (51.59%) and diabetes in 90 (35.71%) being the most prevalent. A significant change in the preference for healthcare facilities was noted (p

Introduction: Blood donor deferral is vital for ensuring safe blood transfusion. However, with the unfolding Coronavirus Disease-2019 (COVID-19) pandemic, significant changes were made in donor screening and blood donation criteria, resulting in a shift in the pattern of donor deferrals. Aim: To estimate the blood donor deferral patterns during the COVID-19 pandemic. Materials and Methods: A retrospective cross-sectional study was conducted in the Department of Transfusion Medicine at SMHS Hospital/GMC Srinagar, Jammu and Kashmir, India. The study spanned two years, from March 2020 to February 2022. All blood donors were screened in accordance with the Ministry of Health and Family Welfare (MOHFW), National Acquired Immune Deficiency Syndrome (AIDS) control organisation (National blood transfusion services) 2017 guidelines. The data was analysed in Microsoft Excel, considering factors such as age, gender, type of deferral, and reasons for deferral. Results: Deferred blood donors were most common in the age group of 18-33 years. During the study period, a total of 19,895 blood donors (19493 males and 402 females) were registered for blood donation. Out of these, 3441 donors (17.30%) were deferred, with a male donor deferral rate of 3258/19493 (16.71%) and a female donor deferral rate of 183/402 (45.52%). Temporary blood donor deferrals accounted for 3272 (95.09%) cases, while permanent deferrals were 169 (4.91%). The most common cause of deferral was low haemoglobin, accounting for 991/3441 (28.80%) cases, followed by deferrals due to reasons attributable to the COVID-19 pandemic (786/3441, 22.84%) and hypertension (653/3441, 18.98%). Conclusion: The study observed a substantial increase in the total donor deferral rate, as well as a change in the donor deferral pattern during the COVID-19 pandemic.

Introduction: Mucormycosis is an angioinvasive disease associated with high morbidity and mortality caused by fungi of the order Mucorales. The rise in the incidence of mucormycosis, along with the surge of Coronavirus Disease-2019 (COVID-19), justifies reassessment of associated risk factors and the susceptible population. The present study aims to highlight the specific clinicopathological features and risk factors of mucormycosis in COVID-19 patients. Aim: To investigate the histopathological features, key clinical findings in mucormycosis, and the predisposing factors associated with mucormycosis in post-COVID-19 patients. Materials and Methods: This descriptive cross-sectional study was conducted at the Department of Pathology, Government Medical College, Manjeri, Malappuram, Kerala, India, in the Department of Pathology. It included all histopathologically proven Mucormycosis specimens from confirmed COVID-19 positive and post-COVID-19 cases in this Medical College from January 1, 2021, to December 31, 2021, amounting to a total of 30 cases. The type of tissue reaction, fungal hyphae, angioinvasion, necrosis, and fungal co-infections were assessed. Histopathologic analysis was performed using routine Haematoxylin and Eosin (H&E) slides, followed by special stains such as Periodic Acid Schiff (PAS) and Grocott Methenamine Silver (GMS). Data was collected using a proforma, and the clinical details were obtained from the request form received along with the biopsy specimen and case sheets. Age, gender, site of involvement, and risk factors were assessed and subjected to descriptive tabulation and analysis. Results: The mean age was 49.5 years with a male-to-female ratio of 1.30:1. The major risk factors observed in the present study were Diabetes Mellitus (DM) and steroid therapy, 30 all cases (100%), along with others such as chronic kidney disease 2 cases (6.67%) immune disorders, and renal transplantation 1 case each (3.33%). The most commonly involved site was sinuses 27 cases (90.00%). Multiple sinuses were affected in 22 cases (73.33%), with the ethmoid sinus being the most common site 24 cases (80.00%), followed by the maxillary sinus 21 cases (70.00%). The most common reaction pattern observed was acute inflammation 15 cases (50.00%). Angioinvasion was noticed in 19 cases (63.33%) and necrosis was present in 28 cases (93.33%). Co-infection with fungal pathogens was observed in 8 cases (26.67%), with aspergillus being the most common co-infection in all except one of the eight cases. Fungal hyphae were visible on H&E slides in 28 cases (93.33%), while the remaining cases were identified only through special stains (PAS and GMS). Conclusion: Mucormycosis infection is strongly associated with DM and steroid therapy. A more even distribution between males and females was noted, deviating from the male predominance described in most studies. The histopathological appearance of angioinvasion was less frequent compared to most studies, consistent with previous studies on the Indian population. Higher rates of co-infection and the presence of granulomatous inflammation were observed. Further studies are needed to explore the relationship between host immunity, morphological patterns, and their influence on prognosis.

Context: Evidence shows that knowledge is important in tackling pandemics. By assessing awareness and knowledge about the coronavirus, more profound insights can be gained into existing public reception and practices, thereby helping to identify attributes that influence the adoption of healthy practices and responsive behavior. Assessing knowledge is important in identifying gaps and strengthening ongoing prevention efforts. Aims: The study aimed to investigate the geriatric population's knowledge, attitudes, and practices (KAP) toward coronavirus disease-2019 (COVID-19) during the pandemic spike. Settings and Design: The study was designed as a cross-sectional study; a questionnaire was developed regarding the World Health Organization training material for the detection, prevention, response, and control of COVID-19 and was validated by experts in geriatrics and public health. Materials and Methods: A prevalidated questionnaire consisting of four sections will be used. The first section consists of demographic data such as age and gender. The second, third, and fourth section will include prevalidated questions to gather information about the patient's KAP regarding general awareness of COVID-19 among geriatric patients in a tertiary care center in central Kerala. The inclusion criteria included patients of age 60 years and above, patients who are willing to participate in the study, and patients who are willing to give informed consent. The questionnaire was answered by over 199 participants anonymously from November 01, 2021, to February 08, 2022. Results: In our study, 199 participants were involved the mean knowledge score was 10.3 ± 1.224. The average attitude score regarding COVID-19 among the participants was 1.9 ± 1.1. The majority of the participants (67.8%) had a poor attitude toward COVID-19. There was a significant difference in average attitude scores according to socioeconomic status. According to the present study, the average correct answer score of the ten questions regarding COVID-19 practice was 6.3 ± 1.4. The majority of participants (75.4%) had moderate practice toward COVID-19. The average practice scores were significant difference among the socioeconomic status. Conclusions: The third wave of the pandemic demonstrated good knowledge, positive attitudes, and reasonable practice regarding COVID-19 during the outbreak. The results indicated the need for the health system to attempt to increase the public knowledge of the older people to improve their attitude and practice to deal with the crisis.

The coronavirus disease-2019 (COVID-19) has caused a worldwide pandemic. Approximately 5% of victims develop severe acute respiratory distress syndrome (ARDS), and some require extracorporeal membrane oxygenation (ECMO). However, weaning patients with COVID-19-related ARDS from ECMO are challenging. Here, we report a COVID-19 case with severe ARDS that received venovenous ECMO to maintain adequate gas exchange for more than 4 weeks. We performed prolonged prone position ventilation and airway pressure release ventilation, and the patient was successfully weaned off ECMO.

Introduction: The emergence of Coronavirus Disease-2019 (COVID-19) caught the world by surprise, leading to a widespread global pandemic that has had profound and distressing effects on various levels. Its impact has been far-reaching, causing severe consequences that continue to unfold. COVID-19 is a multisystem inflammatory disease involving all organs, including the female reproductive system. Aim: To determine the prevalence of COVID-19 among students and compare post-COVID-19 menstrual abnormalities in the home and hospital groups. Materials and Methods: A cross-sectional study was conducted to assess post-COVID-19 menstrual abnormalities among medical students at Department of Obstetrics and Gynaecology, NRI Institute of Medical Sciences, Visakhapatnam, Andhra Pradesh, in southern India from April to December 2022. A total of 600 medical students were approached, and 549 responded, among whom 258 students were reported as COVID-19 positive and 291 reported as COVID-19 negative. After excluding risk factors, 204 COVID-19 positive students were selected as the study population. Data were collected using a prevalidated questionnaire. The COVID-19 study population of 204 (100%) was further stratified into two groups based on the treatment taken at home 162 (79.4%) or in the hospital 42 (20.5%). Chi-square test and Fisher’s-exact tests were used to compare post-COVID-19 menstrual abnormalities, including cycle length abnormalities, Heavy Menstrual Bleeding (HMB), dysmenorrhoea, Premenstrual Syndrome (PMS), and hypomenorrhoea. Results: The prevalence of COVID-19 in the study population was 204, accounting for 37.15% of the total population 204/549. Out of the 204 students, 162 (79.4%) received home treatment, and 42 (20.5%) received hospital treatment. PostCOVID-19 menstrual cycle abnormalities were more prevalent in the hospital group 26/42 (61.9%) than in the home treatment group 76/162 (46.9%). The most common abnormality in both groups was PMS, with a prevalence of 21 (50%) in the hospital group and 38 (23.4%) in the home group. In the home group, 37 (22.8%) experienced longer cycles, 33 (20.3%) had dysmenorrhoea, and 19 (11.7%) had shorter cycles. In the hospital group, 14 (33.3%) had longer cycles, 13 (30.9%) experienced dysmenorrhoea, and 9 (21.4%) had shorter cycles. HMB was reported by 6 (14.2%) in the hospital group and 13 (8%) in the home group, while hypomenorrhoea occurred in 11 (6.7%) in the home group and 5 (11.9%) in the hospital group. A significant association (p=0.001) was found between the COVID-19 treatment groups and PMS. However, for other post-COVID-19 menstrual abnormalities, such as cycle length, dysmenorrhoea, HMB, and hypomenorrhoea, there was no significant association between these abnormalities and COVID-19 treatment groups. Conclusion: Post-COVID-19 menstrual abnormalities were more frequently observed in the hospital group compared to the home group. All post-COVID-19 menstrual irregularities resolved within six months, except for PMS.

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has wreaked havoc around the world, causing serious mental health implications, especially among schoolgoing children who are most vulnerable. The pandemic has had a devastating effect on the mental health and well-being of children, with long-lasting consequences. The present study aims to understand the mental health problems, psychological well-being, and demands of school-going children. Additionally, it seeks to identify any factors associated with poor mental health status and psychological well-being during the COVID19 pandemic and the post pandemic situation. The findings will contribute to early identification and appropriate management or referrals for mental health issues. Aim: To assess the mental health status of school-going children aged 11 to 17 years during the COVID-19 pandemic and identify factors associated with poor mental health status in this group. Materials and Methods: A school-based cross-sectional study was conducted in Secondary and Higher Secondary schools of Bankura Town, West Bengal, India, from June 2021 to September 2021. Four schools were included in the study using simple random sampling technique, with a total of 54 school-going children per school of class VI to XI (nine students per class) included via simple random sampling. Data were collected using an interview guide in the form of a structured questionnaire on Google Forms. The data of 217 children (one additional student responded) was collected using the Paediatric Symptoms Checklist-17 (PSC Y-17) and the Centre for Epidemiological Studies Depression Scale for Children (CES-DC). Categorical variables were expressed as percentages, and continuous variables were expressed as mean (±SD). The association between dependent and independent variables was examined using the Chi-square (c2 ) test, with a significance level of p

Aim: The aim was to examine the outcomes of pregnant women admitted to intensive care unit with coronavirus disease-2019 (COVID-19) infection during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in India. The primary outcome of the study was maternal mortality at day 30. The secondary outcomes were the intensive care unit (ICU) and hospital length of stay, fetal mortality and preterm delivery. Materials and methods: This was a retrospective multicentric cohort study. Ethical clearance was obtained. All pregnant women of the 15--45- year age admitted to ICUs with SARS-CoV-2 infection during 1st March 2020 to 31st October, 2021 were included. Results: Data were collected from nine centers and for 211 obstetric patients admitted to the ICU with a confirmed diagnosis of COVID-19. They were divided in to two groups as per their SpO2 (saturation of peripheral oxygen) level at admission on room air, that is, normal SpO2 group (SpO2 > 90%) and low SpO2 group (SpO2 < 90%). The mean age was (30.06 ± 4.25) years and the gestational age was 36 ± 8 weeks. The maternal mortality rate was10.53%. The rate of fetal death and preterm delivery was 7.17 and 28.22%, respectively. The average ICU and hospital length of stay (LOS) were 6.35 ± 8.56 and 6.78 ± 6.04 days, respectively. The maternal mortality (6.21 vs 43.48%, p < 0.001), preterm delivery (26.55 vs 52.17%, p = 0.011) and fetal death (5.08 vs 26.09%, p = 0.003) were significantly higher in the low SpO2 group. Conclusion: The overall maternal mortality among critically ill pregnant women affected with COVID-19 infection was 10.53%. The rate of preterm birth and fetal death were 28.22 and 7.17%, respectively. These adverse maternal and fetal outcomes were significantly higher in those admitted with low SpO2 (<90%) at admission compared with those with normal SpO2. [ABSTRACT FROM AUTHOR]

The word library comes from the Latin word liber which translates to “book.” This study has taken library synonymous with books-textbooks, journals, reference books—all conventional methods of gaining knowledge. There has been a rapid decline in the use of traditional methods, including bedside teaching, owing to the new, digital sources of learningwhich has been precipitated by the deadly pandemic of coronavirus disease-2019 (COVID-19) among various other reasons. This research is focused on drawing conclusions regarding learning from actual, physical books, traditional classroom teaching, and the newonset era of digital learning. Digital learning has grown tremendously through the unfortunate COVID-19. [ABSTRACT FROM AUTHOR]

Introduction: Acute respiratory failure is the most common clinical feature in patients with severe Coronavirus Disease -2019 (COVID-19) who are admitted to an Intensive Care Unit (ICU) and may require invasive mechanical ventilation, which is generally linked with a high fatality rate. Patients with established co-morbidities, such as diabetes, invariably fall into the category of patients with severe disease presentation and rapid disease progression. Aim: To study the clinical outcomes of COVID-19 diabetic patients after sequential oxygen therapy using a reservoir bag mask, High Frequency Nasal Oxygen (HFNO), and Non-invasive Ventilation (NIV). Materials and Methods: In this retrospective cohort study, adhering to the STROBE statement criteria, the authors included 150 patients suffering from COVID-19 acute respiratory failure, who were known diabetics, divided into three groups based on admission oxygen saturation and Respiratory Rate (RR) for Non-Rebreather Bag-Mask (NRBM) therapy, HFNO, and NIV. For two weeks, all patients were monitored, and measures such as Saturation of peripheral Oxygen (SpO2), Respiratory Rate (RR) escalation of oxygen requirement, glycaemic management, compliance and problems with continued oxygen therapy, the need for invasive mechanical ventilation, and mortality were recorded. The recorded parameters among the three groups were compared using Analysis of Variance (ANOVA) test. Results: Among the demographic parameters recorded, the authors noted that individuals older than 50-55 years of either sex were admitted for HFNO (56.02±11.71 years) and NIV (54.28±14.67 years) therapy, whereas no such preponderance was noted among the two genders. Significant results were noted in all three groups in terms of the escalation of oxygen fraction (FiO2) requirements on the 10th day of observation (NRBM 12.63±2.48%, HFNO 37.74±13.56%, NIV 82.44±11.11%). The need for tracheal intubation was higher in patients in the NIV group (10) compared to the HFNO (9) and NRBM (1) groups. Patients whose blood sugar levels remained uncontrolled throughout the course of observation in the study were disparagingly seen to have been a part of the HFNO and NIV groups, and hence the subsequent mortality. Conclusion: There was a steady escalation of mean oxygen requirements in all three groups of oxygen therapy over the course of two weeks, coinciding with the ensuing 'cytokine storm' associated with Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection. This trend of escalation of oxygen requirement also in turn coincided with the raised glycaemic charting trends of the patients over the same course of two weeks, delineating those individuals with diabetes mellitus, in view of their compromised immunity and innate pro -inflammatory state, are more prone to develop severe form of the disease with more serious complications, which may even lead to mortality. With regards to the compliance, NRBM & HFNO provided best results in comparison to NIV. The rates of complications were also noted to be higher with the use of NIV in this instance. [ABSTRACT FROM AUTHOR]

Aims: This study aimed to evaluate the mental health of mothers of children with attention deficit hyperactivity disorder (ADHD) after distance learning measures during the Coronavirus disease-2019 (COVID-19) pandemic, considering factors that may influence their well-being. Methods: In a cross-sectional design, the levels of burnout, depression, anxiety, stress, coping strategies, social support, and perceived changes in mental health among the mothers were assessed using the Maslach Burnout Inventory (MBI), Depression Anxiety Stress Scale-21 (DASS-21), Brief Coping Orientation to Problems Experienced Inventory, Multidimensional Scale of Perceived Social Support Scale, and Global Rating of Change (GRC) scale. Furthermore, the mothers completed the Atilla Turgay Scale (T-DSM-IV-S) to evaluate their perceptions of their children's ADHD and behavioral problems. Results: Of the 72 mothers (mean age: 42.46±6.73 years, mean children age: 11.39±3.12 years), 50%, 44.4%, and 43.1% had depression symptoms, anxiety, and stress, respectively. According to the GRC, most mothers (67%) reported deterioration in mental well-being compared with the pre-pandemic period. The strongest correlations were between the subscales of T-DSM-IV-S and the total MBI score (r=0.51, p<0.001), DASS-21 score (r=0.35, p=0.003), and GRC score (r=-0.40, p=0.004), particularly with the inattention subscale. Child's attention deficit score, maternal education level, maladaptive coping level, and frequency of outdoor activities were identified as predictors of GRC. Conclusions: This study showed that the distance learning during the COVID-19 pandemic was associated with deteriorated mental health among mothers of children with ADHD. The mother's maladaptive coping strategies, frequency of outdoor activities, education level, and attention deficit level were identified as independent predictors of deteriorated mental health in mothers. [ABSTRACT FROM AUTHOR]

Introduction: The Coronavirus Disease-2019 pandemic is considered the most catastrophic disease of the last decades, with evolving knowledge and improved management over time. Pregnant women are known to be particularly vulnerable, and COVID-19 has been shown to damage the endothelium due to its proinflammatory nature. Aim: To determine the occurrence of oligohydramnios in pregnant women who tested positive for COVID-19. Materials and Methods: A retrospective observational study was conducted at the Department of Obstetrics and Gynaecology, Koru Health Groups, Ankara, Çankaya, Turkey from January 2023 to June 2023. The study included a total of 459 women who were followed during pregnancy and delivered in the same hospital between April 2020 and October 2022. The patients were divided into two groups: COVID-19 positive group (n=101) and negative group (n=358). Various parameters such as age, parity, gestational week at birth, Body Mass Index (BMI), 1st and 5th-minute Appearance, Pulse, Grimace, Activity and Respiration (APGAR) scores, weight of the newborn, Amniotic Fluid Index (AFI), and the risk of developing oligohydramnios were assessed between the positive and negative groups. Parametric variables were analysed using independent t-tests and non parametric ones using Mann-Whitney U tests. Chi-square test was used to compare categorical variables. A p-value of <0.05 was considered statistically significant. Results: The mean age of the pregnant women was 29.2±4.4 years, ranging from 20 to 43 years. Oligohydramnios was detected in 95 women, with 64 of them testing positive for COVID-19. There were no statistically significant differences in terms of age, parity, gestational week of birth, weight at birth, and 1st and 5th-minute APGAR scores between the two groups. However, BMI was significantly higher in COVID-19 positive patients compared to negative ones (p=0.003). Oligohydramnios was found to be significantly higher in COVID-19-positive pregnant women (n=64) compared to negative ones (n=31) (p<0.0001). Conclusion: The COVID-19 pandemic has caused an unprecedented level of global health problems. The virus's prothrombotic tendency leads to placental insufficiency, predisposing to oligohydramnios and intrauterine growth retardation. [ABSTRACT FROM AUTHOR]

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic, which began in Wuhan, China, in December 2019, has quickly spread worldwide, causing numerous challenges for people, such as lockdowns, isolation, and subsequent mental stress. Developing mental resilience is crucial for handling stress effectively. Understanding the impact of the COVID-19 pandemic on stress and the resilience of the Indian population enables insight and facilitates thoughtful reformation in aiding the community. Aim: To assess the stress and resilience among the general population during the COVID-19 pandemic and to find the association between demographic variables and stress and resilience. Additionally, the study aimed to evaluate the correlation between stress and resilience among these subjects. Materials and Methods: A cross-sectional study was conducted Department of Psychiatry, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India, from February 2021 to April 2021. A total of 740 willing respondents affected by the COVID-19 pandemic participated in the study. A snowball sampling method was used in which participants were approached via a Google form circulated through their known contacts. The study encompassed those who had experienced either direct or indirect effects of the COVID-19 pandemic. The user-friendly Google form collected essential demographic information such as gender, marital status, and employment type. The stress and resilience levels were measured using the Perceived Stress Scale (PSS) and Resilience Scale. The statistical analysis of sample characteristics with frequency distributions and categorical variables was done with the application of Chi-square tests. Correlation analysis was done using the Spearman's test. A p-value of <0.05 was considered statistically significant. Results: The research demonstrated remarkably low resilience levels and heightened stress levels among female participants (p<0.001, p<0.001) as well as single individuals (p=0.001, p<0.001). Conversely, a significant number of married men exhibited greater resilience (p=0.013) and reduced stress levels (p<0.001) compared to the rest of the population. Individuals in formal employment experienced less stress compared to those in informal employment (p=0.008). Notably, there was a moderate negative correlation between perceived stress and resilience which was significant (r=-0.562, p<0.001). Conclusion: The COVID-19 pandemic has greatly affected mental health and coping mechanisms; factors such as gender, social connections, and financial stability play significant roles. The study found that women, single individuals, and those working in informal sectors faced increased stress during these challenging times. Hence, psychological interventions targeting the pandemic crisis need to be planned considering the highlighted biological, socio-economic, and occupational factors. [ABSTRACT FROM AUTHOR]

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has had a significant psychological impact on people's lives, including healthcare providers. This impact has manifested in the form of anxiety and fear. Since COVID-19 is a respiratory disease spread through the mouth and nose, dental practitioners have experienced anxiety due to their close proximity to the oro-nasal tissues. Aim: To assess the mental health condition, specifically fear and anxiety, of a group of dental students in Saudi Arabia during the COVID-19 pandemic and to explore students' perceptions about dentistry as a career choice following the pandemic. Materials and Methods: A cross-sectional questionnairebased study was conducted, which included demographic data, the Coronavirus Anxiety Scale (CAS), the Fear of COVID-19 Scale (FCV-19S), as well as a few questions to assess why students chose dentistry as a career and their perceptions about dentistry as a career following the pandemic. A digital link to the questionnaires was distributed through social media outlets such as Twitter, WhatsApp, etc., with the aim of reaching dental students across all dental schools in Saudi Arabia. Dental students and those undergoing internships from both public and private Dental Colleges across Saudi Arabia were approached. The study included a total of 633 students from 21 dental schools across Saudi Arabia. Data were analysed using the Statistical Package for Social Sciences, including Analysis of Variance(ANOVA), independent t-tests, and Chi-square tests. Results: Fear and anxiety levels were found to be the highest among interns and fourth-year dental students, respectively. A total of 346 (54.66%) of the respondents reported that they chose dentistry as a career due to personal desire. Approximately, 239 (37.8%) of the respondents reported being either 'Not Sure' or would not choose dentistry as a career if they had the choice, considering the uncertainty created by the COVID-19 pandemic. Conclusion: Fear and anxiety were reported to be higher among dental students exposed to clinical practice. The majority of dental students reported that they would still choose dentistry as a career option despite the uncertainty caused by the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]

Introduction: Coronavirus Disease-2019 (COVID-19) impacts multiple organs like the kidneys, heart, and liver, but primarily affects the respiratory system, leading to symptoms such as cough with sputum production, fever, and in severe cases, respiratory failure. Research on Severe Acute Respiratory Syndrome (SARS)-Coronavirus-2 (CoV-2) has revealed impairments in lung function during the early recovery phase following COVID-19 infection. The aim is to understand the virus's impact and identify any obstructive, restrictive, or mixed pulmonary alterations in medical professionals six weeks after recovery. Aim: To assess Pulmonary Function Tests (PFTs) six weeks after COVID-19 recovery in health science students at a medical college in North Karnataka. Materials and Methods: A descriptive cross-sectional study was conducted in the Department of Physiology at Jawaharlal Nehru Medical College in North Karnataka, India, from January 2021 to December 2021. A total of 155 COVID-19-recovered health science students were included, and their anthropometry, physiological parameters, and pulmonary parameters were recorded. The "Spirometer Helios 401" was used to estimate an individual's PFT. Data were analysed using independent sample t-tests, with a p-value <0.05 considered statistically significant. Results: The mean age of the participants was 21.73±3.04 years. The Mean±Standard Devaiation (SD) of Forced Vital Capacity (FVC) (L), Forced Expiratory Volume (FEV) at the end of one second (L), Peak Expiratory Flow Rate (L), forced mid expiratory flow 25-75 (L/s), forced mid expiratory flow 25% (L/s), forced mid expiratory flow 50% (L/s), forced mid expiratory flow 75% (L/s), Inspiratory Reserve Volume (IRV) (L), Expiratory Reserve Volume (ERV) (L), Inspiratory Capacity (IC) (L), and Maximum Voluntary Ventilation (MVV) (L) ± SD of post-COVID-19 subjects were less compared to their corresponding predicted values. The Mean±SD of FEV1/FVC (%) and tidal volume (L) of COVID-19 recovered subjects were higher than their corresponding expected value. The FEV, Forced Expiratory Flow (FEF), and FEV1 values were significantly less in females compared to males. Conclusion: Coronavirus Disease-19-recovered subjects showed altered respiratory functions even after six weeks, with the majority having restrictive disease, followed by a mixed pattern and obstructive diseases, while the remaining showed no changes in lung function. Altered pulmonary functions in COVID-19 patients may be due to alveolar destruction or pulmonary interstitial fibrosis. [ABSTRACT FROM AUTHOR]

The coronavirus disease-2019 (COVID-19) spread out at the end of 2019 has sadly caused millions of human losses and hundreds of millions of cases and stressful health situations. As a result, governments forced the worldwide population to stay confined and change their social activities and working behaviors. Under such conditions all economic sectors have been impacted, therefore global electricity consumption pattern has changed consequently. The object of this study is to calculate energy drop for such circumstances to make strategies to face such events in the future. The study we conducted during the period of confinement aims to identify the effects of the Corona epidemic on electricity consumption in Algeria by emphasizing four months (March, April, May, and June) for four years (2018, 2019, 2020, and 2021) by comparing monthly load curves and calculating load deviation for each month. [ABSTRACT FROM AUTHOR]

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has had a significant impact on the elderly population, leading to both fatalities from the virus and delayed treatment of acute emergencies. Additionally, many elderly individuals have demonstrated poor health-seeking behaviour in managing chronic conditions. Reasons for this include fear, access barriers, and strain on healthcare resources and personnel. Aim: To evaluate the change in health-seeking behaviour among the elderly in rural areas of central Kerala during the pandemic and identify the associated factors. Materials and Methods: A community-based cross-sectional study was conducted in the rural field-practice areas of the Department of Community Medicine at a tertiary care Medical College in Kerala, India from May 2021 to August 2021. A total of 252 elderly individuals aged 60 years and above were interviewed using a structured pretested questionnaire. Socio-demographic details and responses on health-seeking behaviour during the pandemic were documented. Data were summarised using frequencies and percentages for categorical variables or mean and standard deviation for continuous variables. Associations were tested using the Chi-square test. results: The study revealed that 83.73% (211 out of 252) of the elderly participants had Non Communicable Diseases (NCDs), with hypertension in 130 (51.59%) and diabetes in 90 (35.71%) being the most prevalent. A significant change in the preference for healthcare facilities was noted (p<0.001), with a decline in appropriate health-seeking behaviour by 16.16%. Moreover, 9.13% (23 participants) resorted to self-treatment at home, and 49.21% (124 participants) opted for traditional remedies to boost their immunity. The type of family was significantly associated with the decline in health-seeking behaviour (p<0.05). Of the 16 participants who indicated a lapse in their regular follow-up since the onset of the pandemic, the primary reasons for missing appointments were fear of contracting COVID-19 in 14 cases (87.50%), lockdown restrictions in six cases (37.50%), and transportation challenges in three cases (18.75%). conclusion: The study revealed a high prevalence of chronic diseases like hypertension, diabetes, osteoarthritis, and Coronary Artery Disease (CAD) among the elderly. There was a decline in health-seeking behaviour by 16.16% among the elderly with chronic diseases due to various challenges posed by the pandemic. Implementing strategies such as utilising social media, promoting telemedicine, and adopting a comprehensive technological approach is crucial to enhance healthcare accessibility for elderly populations in rural areas. [ABSTRACT FROM AUTHOR]

Introduction: The Coronavirus Disease-2019 (COVID-19) pandemic has wreaked havoc around the world, causing serious mental health implications, especially among schoolgoing children who are most vulnerable. The pandemic has had a devastating effect on the mental health and well-being of children, with long-lasting consequences. The present study aims to understand the mental health problems, psychological well-being, and demands of school-going children. Additionally, it seeks to identify any factors associated with poor mental health status and psychological well-being during the COVID- 19 pandemic and the post pandemic situation. The findings will contribute to early identification and appropriate management or referrals for mental health issues. Aim: To assess the mental health status of school-going children aged 11 to 17 years during the COVID-19 pandemic and identify factors associated with poor mental health status in this group. Materials and Methods: A school-based cross-sectional study was conducted in Secondary and Higher Secondary schools of Bankura Town, West Bengal, India, from June 2021 to September 2021. Four schools were included in the study using simple random sampling technique, with a total of 54 school-going children per school of class VI to XI (nine students per class) included via simple random sampling. Data were collected using an interview guide in the form of a structured questionnaire on Google Forms. The data of 217 children (one additional student responded) was collected using the Paediatric Symptoms Checklist-17 (PSC Y-17) and the Centre for Epidemiological Studies Depression Scale for Children (CES-DC). Categorical variables were expressed as percentages, and continuous variables were expressed as mean (±SD). The association between dependent and independent variables was examined using the Chi-square (c2) test, with a significance level of p<0.05. Results: The mean age of the study participants was 13.67±1.76 years, with 169 (77.88%) male students and 48 (22.12%) female students. The prevalence of depressive symptoms according to CES-DC was 121 (55.76%), while the prevalence of psychological impairment according to PSC Y-17 was 39 (17.97%). Significant associations were found between death due to COVID-19 {5 (2.3%), p<0.0001}, hospital admission due to COVID-19 was {25 (11.52%), p<0.0001}, job loss due to COVID-19 was {31 (14.28%), p=0.025} and having a health worker in the family with poor mental health status {18 (8.29%), p<0.0001}. These factors were found to be associated with the participants' poor mental health status. Conclusion: The present study revealed a substantial proportion of participants experiencing psychological impairment and depressive symptoms. It emphasises the need for proactive efforts to support the mental health and well-being of schoolgoing children through educational campaigns and psychological support programmes. [ABSTRACT FROM AUTHOR]