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1. A global consensus on the definitions, diagnosis and management of fibrostenosing small bowel Crohn’s disease in clinical practice

Author

Bettenworth, Dominik, Baker, Mark E., Fletcher, Joel G., Jairath, Vipul, Lu, Cathy, Bemelman, Willem, d’Haens, Geert, d’Hoore, Andre, Dignass, Axel, Dotan, Iris, Feakins, Roger, Fleshner, Phillip, Ha, Christina, Henderson, Gaylyn, Lyu, Ruishen, Panes, Julian, Rogler, Gerhard, Mao, Ren, Rimola, Jordi, Sandborn, William J., Ng, Siew C., Siegmund, Britta, Silverberg, Mark, Taylor, Stuart A., Verstockt, Bram, Gordon, Ilyssa O., Bruining, David H., Feagan, Brian G., and Rieder, Florian

Published
2024
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2. The importance of including a mental health dimension in a multimorbidity indicator: an analysis of Belgian health survey data

Author

Pierre Laloux, Lydia Gisle, William D’hoore, Rana Charafeddine, and Johan Van der Heyden

Subjects
Multimorbidity, Mental health, Health interview survey, Quality of life, Activity limitation, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Multimorbidity is a rising public health concern. Indicators that address these complex health conditions are often exclusively devoted to physical diseases. Because of their high disease burden, mental health disorders ought to be considered as well. This paper aims to measure the added value of including a mental health dimension in a population-based multimorbidity indicator and identify which mental health measures are most appropriate. Methods Secondary analyses were conducted on data from the Belgian Health Interview Survey 2018. We compared the prevalence of different multimorbidity indicators (MIs) in relation to health impact measures, such as quality of life (EQ-5D score) and activity limitation (GALI). The MIs differed as to the health conditions involved: one was based on physical conditions only; the other three included mental health dimensions that were either self-reported or assessed by a scale (GAD-7, PHQ-9, and GHQ-12). We performed linear and logistic regressions to assess the association between the MIs and the health correlates and compared the goodness of fit of the different models. Results MI prevalence was higher when including a mental health dimension assessed with the GHQ-12 (42.0%) and with the GAD-7 or the PHQ-9 (39.4%) as compared to physical conditions only (35.0%). Associations between the MI and health correlates were consistently stronger if the MI included a mental health dimension. The regression models with MI including the GAD-7 and PHQ-9 showed the strongest association between MI and the health correlates and also had the best goodness-of-fit measures. Conclusions MIs that only take physical conditions into account underestimate their impact on individuals’ lives. Including mental ill-health in an MI is key to linking it to health correlates.

Published
2024
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5. Risks of Organ Preservation in Rectal Cancer: Data From Two International Registries on Rectal Cancer

Author

Fernandez, Laura M., São Julião, Guilherme P., Santacruz, Carlos Cerdan, Renehan, Andrew G., Cano-Valderrama, Oscar, Beets, Geerard L., Azevedo, Jose, Lorente, Blas F., Rancaño, Rocío S., Biondo, Sebastiano, Espin-Basany, Eloy, Vailati, Bruna B., Nilsson, Per J., Martling, Anna, Van De Velde, Cornelis J.H., Parvaiz, Amjad, Habr-Gama, Angelita, Perez, Rodrigo O., Antona, Francisco Blanco, Martín, Elena Yagüe, Tébar, Jesús Cifuentes, Calvo, Alberto Parajó, Quintana, Natalia Uribe, Alonso, Mauricio García, Cotoré, Jesús Paredes, Riesco, Ana Benítez, Cánovas, Noelia Ibañez, Sanchez, Camen Martinez, Ribe i Serrat, Didac, Ais, Guillermo, Jiménez Toscano, Marta, Climent, Antonio, Reig Pérez, Monica, Sierra Grañón, José Enrique, Mateo, Janire, Biondo, Sebastiano, Saldaña, Ana Gálvez, Laso, Carlos Álvarez, Allende, Ignacio Aguirre, Álvarez, Daniel Huerga, Coll, Ramón Farrés, Sánchez Bautista, Wilson M., Torres Sánchez, Maria Teresa, Dujovne, Paula, Camps, Ignasi, Cuadrado, Marta, Díaz, Olga Maseda, Sánchez, Nieves, de la Vega Olías, Maria del Coral, Basan, Eloy Espin, Carre, Miquel Kraft, Aghili, Mahdi, Arnold, Marion, Asoglu, Oktar, Bujko, Krzysztof, Caiado, André, Carvalho, Carlos, Chautems, Ronald, Coco, Claudio, Chiloiro, Giuditta, Cunningham, Chris, Custers, Petra, Haak, Hester, DʼHoore, André, Dimofte, Gabriel, Ding, Peirong, Duff, S., Felicio, Natalia, Figueiredo, Nuno, Gaertner, Wolfgang, Gérard, Jean-Pierre, Gama-Rodrigues, Joaquim, Geubels, Barbara, Gregory, Ellen, Salazar, Ivana P., Herrando, Ignacio, Hill, J., Huq, Z., Jacquinot, Frederique, Jakobsen, Anders, Jensen, Lars Henrik, Jones, D., Keshvari, Amir, Ketelaers, Stijn H.J., Khan, U., Kushwaha, R., Kordnejad, Shahrzad, Leitner, Kurt, Madoff, Robert, Malcomson, Lee, Martling, Anna, Fechner, Katja, Matzel, Klaus E., Mazzarisi, Claudia, Meershoek, Elma, Melenhorst, Jarno, Nouritaromlou, Mohammed, Paolo, Goffredo, Pennings, Alexander, Murad-Regadas, Sthela M., Pandini, Rafael, Peeters, Koen C.M.J., Rawat, S., Richards, D., Rosa, Isadora, Rossi, Gustavo, Rutten, Harm J.T., Sanchez Loria, Fernando, Santiago, Ines, Siddiqui, K.H., Solkar, M.H., Sun Myint, Arthur, Telford, K., Tang, J., Temmink, Sofieke, Tokmak, Handan, Vaccaro, Carlos A., Ward, S., Wolthuis, Albert M., Wytze, Lameris, Yu, Jiehai, and Zhang, Zhen

Published
2024
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6. Belgium (Flanders)

Author

D’Hoore, Nathan, Léonard, Pierre, Zeimers, Géraldine, Scheerder, Jeroen, Coates, Dennis, Series Editor, Hallmann, Kirstin, editor, Heikkinen, Suvi, editor, and Vehmas, Hanna, editor

Published
2024
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10. Intercellular interaction between [FAP.sup.+] fibroblasts and [CD150.sup.+] inflammatory monocytes mediates fibrostenosis in Crohn's disease

Author

Ke, Bo-Jun, Abdurahiman, Saeed, Biscu, Francesca, Zanella, Gaia, Dragoni, Gabriele, Santhosh, Sneha, De Simone, Veronica, Zouzaf, Anissa, van Baarle, Lies, Stakenborg, Michelle, Bosakova, Veronika, Van Rymenant, Yenti, Verhulst, Emile, Verstockt, Sare, Klein, Elliott, Bislenghi, Gabriele, Wolthuis, Albert, Fric, Jan, Breynaert, Christine, D'Hoore, Andre, Van der Veken, Pieter, De Meester, Ingrid, Lovisa, Sara, Hawinkels, Lukas J.A.C., Verstockt, Bram, De Hertogh, Gert, Vermeire, Severine, and Matteoli, Gianluca

Subjects
Diagnosis, Care and treatment, Health aspects, Crohn's disease -- Diagnosis -- Care and treatment, Monocytes -- Health aspects, Extracellular matrix -- Health aspects, Transcription factors -- Health aspects, Fibrosis -- Diagnosis -- Care and treatment
Abstract

Introduction Crohn's disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, characterized by transmural inflammation that often leads to complications such as strictures, fistulas, and abscesses. The disease [...], Crohn's disease (CD) is marked by recurring intestinal inflammation and tissue injury, often resulting in fibrostenosis and bowel obstruction, necessitating surgical intervention with high recurrence rates. To elucidate the mechanisms underlying fibrostenosis in CD, we analyzed the transcriptome of cells isolated from the transmural ileum of patients with CD, including a trio of lesions from each patient: non-affected, inflamed, and stenotic ileum samples, and compared them with samples from patients without CD. Our computational analysis revealed that profibrotic signals from a subset of monocyte- derived cells expressing CD150 induced a disease-specific fibroblast population, resulting in chronic inflammation and tissue fibrosis. The transcription factor TWIST1 was identified as a key modulator of fibroblast activation and extracellular matrix (ECM) deposition. Genetic and pharmacological inhibition of TWIST1 prevents fibroblast activation, reducing ECM production and collagen deposition. Our findings suggest that the myeloid-stromal axis may offer a promising therapeutic target to prevent fibrostenosis in CD.

Published
2024
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13. Impact of microsatellite status in early-onset colonic cancer.

Author

Zaborowski, Alexandra M, Adamina, Ahmed Abdile Michel, Aigner, Felix, d'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D, Salido, Andrea Jiménez, Jiménez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Peter, Koh, Cherry, and Kok, Neils

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetic Testing, Digestive Diseases, Genetics, Clinical Research, Colo-Rectal Cancer, Aetiology, 2.1 Biological and endogenous factors, Colonic Neoplasms, Colorectal Neoplasms, Humans, Microsatellite Instability, Microsatellite Repeats, Mutation, Prognosis, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), REACCT Collaborative, Medical and Health Sciences, Surgery, Clinical sciences
Abstract

BackgroundThe molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status.MethodsAnonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated.ResultsA total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively).ConclusionPatients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

Published
2022

14. Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer

Author

Collaborative, REACCT, O’Connell, Lauren V, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d’Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliott, Brodie, Emile, Sameh, Espin-Basany, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D, Salido, Andrea Jiménez, Jiménez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Petr, and Koh, Cherry

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rehabilitation, Cancer, Clinical Research, Digestive Diseases, Good Health and Well Being, REACCT Collaborative, early onset rectal cancer, functional outcome, patient reported outcome, rectal cancer, young rectal cancer, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundImpairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (

Published
2022

15. Single cell dynamics of tumor specificity vs bystander activity in CD8+ T cells define the diverse immune landscapes in colorectal cancer

Author

Daniel Morales Borràs, Sara Verbandt, Markus Ausserhofer, Gregor Sturm, Jinyeong Lim, Gil Arasa Verge, Isaure Vanmeerbeek, Raquel S. Laureano, Jannes Govaerts, Jenny Sprooten, Yourae Hong, Rebecca Wall, Gert De Hertogh, Xavier Sagaert, Gabriele Bislenghi, André D’Hoore, Albert Wolthuis, Francesca Finotello, Woong-Yang Park, Stefan Naulaerts, Sabine Tejpar, and Abhishek D. Garg

Subjects
Cytology, QH573-671
Abstract

Abstract CD8+ T cell activation via immune checkpoint blockade (ICB) is successful in microsatellite instable (MSI) colorectal cancer (CRC) patients. By comparison, the success of immunotherapy against microsatellite stable (MSS) CRC is limited. Little is known about the most critical features of CRC CD8+ T cells that together determine the diverse immune landscapes and contrasting ICB responses. Hence, we pursued a deep single cell mapping of CRC CD8+ T cells on transcriptomic and T cell receptor (TCR) repertoire levels in a diverse patient cohort, with additional surface proteome validation. This revealed that CRC CD8+ T cell dynamics are underscored by complex interactions between interferon-γ signaling, tumor reactivity, TCR repertoire, (predicted) TCR antigen-specificities, and environmental cues like gut microbiome or colon tissue-specific ‘self-like’ features. MSI CRC CD8+ T cells showed tumor-specific activation reminiscent of canonical ‘T cell hot’ tumors, whereas the MSS CRC CD8+ T cells exhibited tumor unspecific or bystander-like features. This was accompanied by inflammation reminiscent of ‘pseudo-T cell hot’ tumors. Consequently, MSI and MSS CRC CD8+ T cells showed overlapping phenotypic features that differed dramatically in their TCR antigen-specificities. Given their high discriminating potential for CD8+ T cell features/specificities, we used the single cell tumor-reactive signaling modules in CD8+ T cells to build a bulk tumor transcriptome classification for CRC patients. This “Immune Subtype Classification” (ISC) successfully distinguished various tumoral immune landscapes that showed prognostic value and predicted immunotherapy responses in CRC patients. Thus, we deliver a unique map of CRC CD8+ T cells that drives a novel tumor immune landscape classification, with relevance for immunotherapy decision-making.

Published
2023
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16. Perianal Fistulizing Crohn’s Disease: Utilizing the TOpClass Classification in Clinical Practice to Provide Targeted Individualized Care

Author

Hanna, Luke N., Anandabaskaran, Sulak, Iqbal, Nusrat, Geldof, Jeroen, LeBlanc, Jean-Frédéric, Dige, Anders, Lundby, Lilli, Vermeire, Séverine, D’Hoore, André, Verstockt, Bram, Bislenghi, Gabriele, De Looze, Danny, Lobaton, Triana, Van de Putte, Dirk, Spinelli, Antonino, Carvello, Michele, Danese, Silvio, Buskens, Christianne J., Gecse, Krisztina, Hompes, Roel, Becker, Marte, van der Bilt, Jarmila, Bemelman, Willem, Sebastian, Shaji, Moran, Gordan, Lightner, Amy L., Wong, Serre-Yu, Colombel, Jean-Frédéric, Cohen, Benjamin L., Holubar, Stefan D., Ding, Nik S., Behrenbruch, Corina, Sahnan, Kapil, Misra, Ravi, Lung, Phillip, Hart, Ailsa, and Tozer, Phil

Published
2024
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17. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer

Author

Collaborative, REACCT, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d’Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Figueiredo, Nuno, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Gong, Jianping, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hoffmeister, Michael, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah Dorna, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, and Kennelly, Rory

Subjects
Aging, Nutrition, Digestive Diseases, Cancer, Colo-Rectal Cancer, Genetics, Clinical Research, Prevention, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Adult, Age of Onset, Colorectal Neoplasms, Humans, Incidence, Middle Aged, Risk Factors, REACCT Collaborative
Abstract

ImportanceThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.ObservationsWithin the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.Conclusions and relevanceThe clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Published
2021

18. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.

Author

REACCT Collaborative, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D'Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Figueiredo, Nuno, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Gong, Jianping, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hoffmeister, Michael, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah Dorna, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, and Kennelly, Rory

Subjects
REACCT Collaborative
Abstract

ImportanceThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.ObservationsWithin the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.Conclusions and relevanceThe clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Published
2021

20. Unveiling the urban sports landscape: Profiling participants, motives, and policy implications.

Author

Jef Huyghe, Nathan D'Hoore, Erik Thibaut, and Jeroen Scheerder

Subjects
Medicine, Science
Abstract

BackgroundThe lack of knowledge regarding urban sports poses pressing challenges for governments and sports organisations to deal with in light of its increasing popularity. To develop targeted policy strategies, more insight is needed into the features of urban sports. Therefore, this research aims to establish a profile of urban sports participants in terms of characteristics, behaviours in sports participation, and motives for sports participation.MethodsData was gathered during a large-scale research project on sports participation in the Belgian city of Bruges. A total of 3,951 residents between 6 and 75 years old participated in an online survey. Descriptive statistics and binomial logistic regression analyses were used to examine the differences between urban and traditional sports participants.ResultsBased on a binomial regression model, the sports level and location significantly predict urban sports participation. The physical motives for sports participation are significantly less important for urban sports participants compared to the group of traditional sports participants. Urban sports participants value the fun and relaxation motives for sports participation significantly more than traditional sports participants.ConclusionsThis paper aimed to establish a comprehensive profile of urban sports participants and juxtaposed it to that of traditional sports participants. While existing literature often portrays urban sports participants as a relatively homogeneous group, our findings reveal a surprising heterogeneity. Consequently, given its increasing popularity, urban sports present a valuable avenue for governments and sports organisations to engage with a diverse range of sports participants.

Published
2024
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21. Sculpting vesicles with active particles: Less is more

Author

Vutukuri, Hanumantha Rao, Hoore, Masoud, Abaurrea-Velasco, Clara, van Buren, Lennard, Dutto, Alessandro, Auth, Thorsten, Fedosov, Dmitry A., Gompper, Gerhard, and Vermant, Jan

Subjects
Condensed Matter - Soft Condensed Matter, Condensed Matter - Materials Science, Physics - Biological Physics
Abstract

Biological cells are able to generate intricate structures and respond to external stimuli, sculpting their membrane from within. Simplified biomimetic systems can aid in understanding the principles which govern these shape changes and elucidate the response of the cell membrane under strong deformations. Here, a combined experimental and simulation approach is used to identify the conditions under which different non-equilibrium shapes and distinct active shape fluctuations can be obtained by enclosing self-propelled particles in giant vesicles. Interestingly, the most pronounced shape changes are observed at relatively low particle loadings, starting with the formation of tether-like protrusions to highly branched, dendritic structures. At high volume fractions, globally deformed vesicle shapes are observed. The obtained state diagram of vesicles sculpted by active particles predicts the conditions under which local internal forces can generate dramatic cell shape changes, such as branched structures in neurons., Comment: 18 pages, 3 figures, SI

Published
2019
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23. High-Dose Vitamin D Does Not Prevent Postoperative Recurrence of Crohn’s Disease in a Randomized Placebo-Controlled Trial

Author

Bemelman, W., Buskens, C., Clasquin, E., De Bruyn, J., D’Haens, G., Duijvestein, M., Van der Bilt, J., Ferreira, B., Mulder, S., West, R., Dijkstra, G., Engelsman, A., Lange, J., Homans, L., Witteman, B., Eroglu-Berger, A., Russel, M., Jansen, J., Schakel–van den Berge, T., Cuppen, S., Hoentjen, F., Van Esch, A., De Jong, D.J., Mahmmod, N., Hove.P. De Lange, W. Ten, Mallant, R., Houben, P., Ferrante, M., Vermeire, S., Outtier, A., Hermans, T., Lefrère, J., D’Hoore, A., Asnong, K., Bossuyt, P., Van de Schoot, I., Claerbout, B., Lambrecht, G., Boutaffala, L., Guebelle, C., Louis, E., Franchimont, D., Wambacq, V., Colard, A., Deflandre, A., de Bruyn, Jessica R., Bossuyt, Peter, Ferrante, Marc, West, Rachel L., Dijkstra, Gerard, Witteman, Ben J., Wildenberg, Manon, Hoentjen, Frank, Franchimont, Denis, Clasquin, Esmé, van der Bilt, Jarmila D., Tollens, Tim, Bemelman, Willem A., D’Hoore, Andre, Duijvestein, Marjolijn, and D’Haens, Geert R.

Published
2021
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24. Healthcare bias and health inequalities towards displaced Syrians in Lebanon: a qualitative study

Author

Riwa Khalifeh, William D’Hoore, Christiane Saliba, Pascale Salameh, and Marie Dauvrin

Subjects
health inequalities, healthcare bias, displaced Syrians, Lebanon, discrimination, access to health services, Public aspects of medicine, RA1-1270
Abstract

IntroductionAccording to Lebanese official data, Lebanon hosts over 1.5 million displaced Syrians (DS). Research shows that migrants encounter barriers when accessing healthcare. The social determinants of health (SDOH) related to migration are an additional challenge for DS in Lebanon, though bias plays a significant factor in exacerbating health inequalities. This study aims to identify DS perception of healthcare biases in the Lebanese healthcare system, and its consequences on DS’ accessing and receiving quality healthcare in Lebanon.MethodsA qualitative analysis using in-depth, semi-structured interviews was utilized. 28 semi-structured interviews were conducted with doctors (n = 12) and nurses (n = 16) in 2021. Six group interviews were conducted with DS (n = 22) in Lebanese healthcare facilities. The recruitment of participants relied on reasoned and targeted sampling. Thematic analysis was performed to identify common themes in participants’ experiences with DS accessing Lebanese healthcare.ResultsThe findings indicated that there were barriers to accessing healthcare related to the SDOH, such as transportation and financial resources. The results also suggested that DS perceived health biases, including discriminatory behavior from Lebanese healthcare providers, stereotypes and racism leading to health inequalities.ConclusionBased on the perceptions and experiences reported by participants, the underlying causes of biases are due to the fragility of the Lebanese healthcare system when facing a humanitarian crisis as well as a collapsing infrastructure torn by past wars and the current socio-political and financial crises in the country. Global initiatives are required to provide the necessary resources needed for offering equitable health services. Such initiatives involve addressing biases, health inequities, discrimination, and the lack of a Lebanese infrastructure system for the provision of healthcare. Addressing health inequalities remains a major health objective in achieving health equity on the micro level (cultural awareness and competencies) and macro level (equitable distribution of resources, implementation of a universal health coverage) in order to guarantee quality healthcare services to DS.

Published
2023
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26. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort

Author

Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francois, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adreas, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nicholas, Mishra, Amitabh, Manatakis, Dimitrios, Agalianos, Christos, Tasis, Nikolaos, Antonopoulou, Maria-Ioanna, Karavokyros, Ioannis, Charalabopoulos, Alexandros, Schizas, Dimitrios, Baili, Efstratia, Syllaios, Athanasios, Karydakis, Lysandros, Vailas, Michail, Balalis, Dimitrios, Korkolis, Dimitrios, Plastiras, Aris, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelos, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorios, Perivoliotis, Konstantinos, Tzovaras, George, Baloyiannis, Ioannis, Ho, Man-Fung, Ng, Simon Siu-man, Mak, Tony Wing-chung, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, osić, Jurica, Zukanović, Goran, Kelly, Michael E., Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton

Published
2023
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27. Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma

Author

Viktor Proesmans, Tom Vandaele, Jan Van Slambrouck, Albert Wolthuis, André D´Hoore, Jeroen Dekervel, Eric Van Cutsem, Raphaëla Dresen, Gert De Hertogh, Karlien Degezelle, Dirk Van Raemdonck, Philippe Nafteux, and Laurens J. Ceulemans

Subjects
HITHOC, pleural decortication, pseudomyxoma peritonei, Medical technology, R855-855.5
Abstract

Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available.Methods: We describe the successful treatment of a 67-year-old male diagnosed with left-sided intrapleural dissemination of PMP (low-grade appendiceal mucinous neoplasm), 2 years after treatment of abdominal PMP with cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy. Treatment consisted of extended pleural decortication (ePD) and oxaliplatin-based hyperthermic intrathoracic chemotherapy (HITHOC). The patient is doing well without complications or signs of recurrence, 26 months after thoracic surgery.Conclusion: ePD in combination with HITHOC is a valuable treatment for thoracic PMP.

Published
2022
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28. Sniffing out safety: canine detection and identification of SARS-CoV-2 infection from armpit sweat

Author

Chris Callewaert, Maria Pezavant, Rony Vandaele, Bart Meeus, Ellen Vankrunkelsven, Phaedra Van Goethem, Alain Plumacker, Benoit Misset, Gilles Darcis, Sonia Piret, Lander De Vleeschouwer, Frank Staelens, Kristel Van Varenbergh, Sofie Tombeur, Anouck Ottevaere, Ilke Montag, Patricia Vandecandelaere, Stijn Jonckheere, Linos Vandekerckhove, Els Tobback, Gregoire Wieers, Jean-Christophe Marot, Kurt Anseeuw, Leen D’Hoore, Sebastiaan Tuyls, Brecht De Tavernier, Julie Catteeuw, Ali Lotfi, Alexey Melnik, Alexander Aksenov, Dominique Grandjean, Miguel Stevens, Frank Gasthuys, and Hugues Guyot

Subjects
COVID-19, detection dogs, GC/MS (gas chromatograph/mass spectrometry), acceptability analysis, odor, axilla, Medicine (General), R5-920
Abstract

Detection dogs were trained to detect SARS-CoV-2 infection based on armpit sweat odor. Sweat samples were collected using cotton pads under the armpits of negative and positive human patients, confirmed by qPCR, for periods of 15–30 min. Multiple hospitals and organizations throughout Belgium participated in this study. The sweat samples were stored at −20°C prior to being used for training purposes. Six dogs were trained under controlled atmosphere conditions for 2–3 months. After training, a 7-day validation period was conducted to assess the dogs’ performances. The detection dogs exhibited an overall sensitivity of 81%, specificity of 98%, and an accuracy of 95%. After validation, training continued for 3 months, during which the dogs’ performances remained the same. Gas chromatography/mass spectrometry (GC/MS) analysis revealed a unique sweat scent associated with SARS-CoV-2 positive sweat samples. This scent consisted of a wide variety of volatiles, including breakdown compounds of antiviral fatty acids, skin proteins and neurotransmitters/hormones. An acceptability survey conducted in Belgium demonstrated an overall high acceptability and enthusiasm toward the use of detection dogs for SARS-CoV-2 detection. Compared to qPCR and previous canine studies, the detection dogs have good performances in detecting SARS-CoV-2 infection in humans, using frozen sweat samples from the armpits. As a result, they can be used as an accurate pre-screening tool in various field settings alongside the PCR test.

Published
2023
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29. Nonoperative versus operative approach according to the response to neoadjuvant chemoradiotherapy for rectal cancer: A prospective cohort study

Author

Philippe P. Bulens, Lien Smets, Annelies Debucquoy, Ines Joye, André D'Hoore, Albert Wolthuis, Lynn Debrun, Jeroen Dekervel, Eric Van Cutsem, Raphaëla Dresen, Vincent Vandecaveye, Christophe M. Deroose, Xavier Sagaert, and Karin Haustermans

Subjects
Rectal cancer, Organ preservation, Watch-and-Wait, Chemoradiotherapy, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: To report on organ preservation following chemoradiotherapy (CRT) in a prospective cohort of locally advanced rectal cancer patients. Methods and materials: Fifty-two patients received CRT. MRI and 18F-FDG-PET/CT were performed prior to CRT. Response assessment was done 6 and 12 weeks after CRT using digital rectal examination, MRI, 18F-FDG-PET/CT and endoscopy. For clinical complete response or minimal residual disease, a watch-and-wait (W&W) protocol was started.Regrowth-free survival (ReFS), Total Mesorectal Excision-free disease-free survival, distant metastasis-free survival (DMFS) and overall survival (OS) were evaluated using Kaplan-Meier method. Functional outcome was compared with the Wilcoxon signed-rank test using EORTC QLQ-C30, MSKCC BFI, LARS and IIEF-5/FSFI-5 questionnaires. A previously developed prediction model performance was tested using receiver operating characteristic analysis. Results: 29/52 patients entered a W&W protocol. There was no difference in two-year DMFS (81.1 % vs 78.8 %, p = 0.82), two-year OS (96.4 % vs 100 %, p = 0.38) and two-year DFS (77.5 % vs 78.8 %, p = 0.87) between W&W patients and those who underwent surgery at 12 weeks after CRT. Two-year DMFS differed between W&W with local regrowth, W&W with sustained response and patients who had surgery (66.7 % vs 88.0 % vs 78.8 %; p = 0.04). At 6 and 12 months, W&W patients reported good QoL and bowel function. The model validation reached an AUC of 0.627. Conclusion: Good functional outcome in patients with rectal cancer allocated to surveillance after CRT needs to be balanced against potentially worse DMFS in a subset of patients without sustained clinical complete response. Reliable prediction of patients eligible for surveillance programs needs further investigation.

Published
2022
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30. Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium

Author

Kiran, Ravi P, Kochhar, Gursimran S, Kariv, Revital, Rex, Douglas K, Sugita, Akira, Rubin, David T, Navaneethan, Udayakumar, Hull, Tracy L, Ko, Huaibin Mabel, Liu, Xiuli, Kachnic, Lisa A, Strong, Scott, Iacucci, Marietta, Bemelman, Willem, Fleshner, Philip, Safyan, Rachael A, Kotze, Paulo G, D'Hoore, André, Faiz, Omar, Lo, Simon, Ashburn, Jean H, Spinelli, Antonino, Bernstein, Charles N, Kane, Sunanda V, Cross, Raymond K, Schairer, Jason, McCormick, James T, Farraye, Francis A, Chang, Shannon, Scherl, Ellen J, Schwartz, David A, Bruining, David H, Philpott, Jessica, Bentley-Hibbert, Stuart, Tarabar, Dino, El-Hachem, Sandra, Sandborn, William J, Silverberg, Mark S, Pardi, Darrell S, Church, James M, and Shen, Bo

Published
2022
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31. Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus

Author

Abreu, M, Ahuja, V, Allez, M, Ananthakrishnan, A, Bemelman, W, Bernstein, C, Braun, J, Chowers, Y, Colombel, J-F, Danese, S, D'Haens, G, D'Hoore, A, Dignass, A, Dotan, I, Dubinsky, M, Ekbom, A, Fleshner, P, Gasche, C, Gassull, MA, Gearry, R, Ghosh, S, Gibson, P, Griffiths, A, Halfvarson, J, Hanauer, S, Harpaz, N, Hart, A, Hibi, T, Kamm, M, Kaplan, G, Kaser, A, Korelitz, B, Kotze, P, Koutroubakis, I, Kruis, W, Lakatos, P, Lewis, J, Lindsay, J, Loftus, E, Louis, E, Lukas, M, Magro, F, Mahadevan, U, Mantzaris, G, Mary, J-Y, McGovern, D, Moum, B, Munkholm, P, Neurath, M, Ng, S, O'Morain, C, Oresland, T, Panaccione, R, Panes, J, Panis, Y, Pemberton, J, Peyrin-Biroulet, L, Prantera, C, Rachmilewitz, D, Ran, Z, Reinisch, W, Remzi, F, Rhodes, J, Riddell, R, Rogler, G, Rubin, D, Sachar, D, Sandborn, W, Sands, B, Sartor, B, Schoelmerich, J, Schreiber, S, Siegel, C, Siegmund, B, Silverberg, M, Söderholm, J, Sood, A, Spinelli, A, Stange, E, Steinwurz, F, Targan, S, Travis, S, Turner, D, Tysk, C, Vatn, M, Vermeire, S, Watanabe, M, Yamamoto, T, Yamamoto-Furusho, J, Ananthakrishnan, Ashwin N, Kaplan, Gilaad G, Bernstein, Charles N, Burke, Kristin E, Lochhead, Paul J, Sasson, Alexa N, Agrawal, Manasi, Tiong, Jimmy Ho Tuan, Steinberg, Joshua, Kruis, Wolfgang, Steinwurz, Flavio, Ahuja, Vineet, Ng, Siew C, Rubin, David T, Colombel, Jean-Frederic, and Gearry, Richard

Published
2022
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33. The Impact of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation on the Early Development of Intestinal Fibrosis in Crohn's Disease.

Author

Dragoni, Gabriele, Ke, Bo-Jun, Picariello, Lucia, Abdurahiman, Saeed, Ceni, Elisabetta, Biscu, Francesca, Mello, Tommaso, Polvani, Simone, Innocenti, Tommaso, Spalart, Valérie, Milani, Stefano, D'Hoore, André, Bislenghi, Gabriele, Scaringi, Stefano, Verstockt, Bram, Hertogh, Gert De, Martinod, Kimberly, Galli, Andrea, Matteoli, Gianluca, and Vermeire, Séverine

Abstract

Background and Aims During early phases of inflammation, activated neutrophils extrude neutrophil extracellular traps (NETs) in a peptidyl arginine deiminase 4 (PAD4)-dependent manner, aggravating tissue injury and remodeling. In this study, we investigated the potential pro-fibrotic properties and signaling of NETs in Crohn's disease (CD). Methods NETs and activated fibroblasts were labeled on resected ileum from CD patients by multiplex immunofluorescence staining. NETs-treated human primary intestinal fibroblasts were analyzed by bulk RNA sequencing to uncover cell signaling pathways, and by high-throughput imaging to assess collagen production and migratory activity. Consequentially, TLR2/NF-κB pathway was evaluated by transfection of CCD-18Co fibroblasts with an NF-κB-luciferase reporter plasmid, incorporating C29 to block TLR2 signaling. A chronic dextran sulfate sodium (DSS) mouse model was used to define the specific role of PAD4 deletion in neutrophils (MRP8 -Cre, Pad4 fl/fl). Results Immunofluorescence showed spatial colocalization of NETs and activated fibroblasts in ileal ulcerations of CD patients. Transcriptomic analysis revealed upregulation of pro-fibrotic genes and activation of Toll-like receptor signaling pathways in NETs-treated fibroblasts. NETs treatment induced fibroblast proliferation, diminished migratory capability, and increased collagen release. Transfection experiments indicated a substantial increase in an NF-κB expression with NETs, whereas C29 led to decreased expression and release of collagen. In line, a significant reduction in collagen content was observed in the colon of MRP8 -Cre, Pad4 fl/fl mice subjected to chronic DSS colitis. Conclusions NETs potentially serve as an initial stimulus for pathological activation of fibroblasts within the intestine via the TLR2/NF-κB pathway. Given their early involvement in inflammation, inhibition of PAD4 might offer a strategy to modulate both inflammation and fibrogenesis in CD. [ABSTRACT FROM AUTHOR]

Published
2025
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35. Classifying perianal fistulising Crohn's disease: an expert consensus to guide decision-making in daily practice and clinical trials

Author

Geldof, Jeroen, Iqbal, Nusrat, LeBlanc, Jean-Frédéric, Anandabaskaran, Sulak, Sawyer, Rachel, Buskens, Christianne, Bemelman, Willem, Gecse, Krisztina, Lundby, Lilli, Lightner, Amy L, Danese, Silvio, Spinelli, Antonino, Carvello, Michele, Faiz, Omar, Warusavitarne, Janindra, Lung, Phillip, De Looze, Danny, D'Hoore, André, Vermeire, Séverine, Hart, Ailsa, and Tozer, Phil

Published
2022
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38. Treatment of pouchitis, Crohn's disease, cuffitis, and other inflammatory disorders of the pouch: consensus guidelines from the International Ileal Pouch Consortium

Author

Shen, Bo, Kochhar, Gursimran S, Rubin, David T, Kane, Sunanda V, Navaneethan, Udayakumar, Bernstein, Charles N, Cross, Raymond K, Sugita, Akira, Schairer, Jason, Kiran, Ravi P, Fleshner, Philip, McCormick, James T, D’Hoore, André, Shah, Samir A, Farraye, Francis A, Kariv, Revital, Liu, Xiuli, Rosh, Joel, Chang, Shannon, Scherl, Ellen, Schwartz, David A, Kotze, Paulo Gustavo, Bruining, David H, Philpott, Jessica, Abraham, Bincy, Segal, Jonathan, Sedano, Rocio, Kayal, Maia, Bentley-Hibbert, Stuart, Tarabar, Dino, El-Hachem, Sandra, Sehgal, Priya, Picoraro, Joseph A, Vermeire, Séverine, Sandborn, William J, Silverberg, Mark S, and Pardi, Darrell S

Published
2022
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41. Diagnosis and classification of ileal pouch disorders: consensus guidelines from the International Ileal Pouch Consortium

Author

Shen, Bo, Kochhar, Gursimran S, Kariv, Revital, Liu, Xiuli, Navaneethan, Udayakumar, Rubin, David T, Cross, Raymond K, Sugita, Akira, D'Hoore, André, Schairer, Jason, Farraye, Francis A, Kiran, Ravi P, Fleshner, Philip, Rosh, Joel, Shah, Samir A, Chang, Shannon, Scherl, Ellen, Pardi, Darrell S, Schwartz, David A, Kotze, Paulo G, Bruining, David H, Kane, Sunanda V, Philpott, Jessica, Abraham, Bincy, Segal, Jonathan, Sedano, Rocio, Kayal, Maia, Bentley-Hibbert, Stuart, Tarabar, Dino, El-Hachem, Sandra, Sehgal, Priya, McCormick, James T, Picoraro, Joseph A, Silverberg, Mark S, Bernstein, Charles N, Sandborn, William J, and Vermeire, Séverine

Published
2021
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43. Physical activity levels after low anterior resection for rectal cancer: one-year follow-up

Author

Anne Asnong, André D’Hoore, Albert Wolthuis, Yves Van Molhem, Bart Van Geluwe, Annouschka Laenen, Nele Devoogdt, An De Groef, Tessa De Vrieze, Charlotte Van Calster, and Inge Geraerts

Subjects
Physical activity, Activities of daily living, Rectal neoplasms, Low anterior resection, Bowel symptoms, Predictive factors, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Overall survival rates after rectal cancer have increased. Therefore, functional outcomes rightly deserve more interest. The aims of this study were to assess progression in total, sports, occupational and household physical activity levels of rectal cancer survivors, from preoperatively to 12 months after surgery/stoma closure and to explore predictive factors. Methods Multi-center prospective study with 125 patients who underwent low anterior resection for rectal cancer. The Flemish Physical Activity Computerized Questionnaire was completed concerning all physical activity levels at baseline (past preoperative year) and at 1, 4, 6 and 12 months after surgery/stoma closure. At these timepoints, questionnaires (LARS−/ COREFO-questionnaire) regarding bowel symptoms were also filled out. Results were analyzed using linear mixed models for repeated measures. Results Total physical activity levels up to 12 months remained significantly lower than preoperative. Occupational and sports physical activity levels remained significantly lower until 6 and 4 months postoperative, respectively. Predictive factors for decreased physical activity levels at a specific timepoint were: younger age and no stoma (total physical activity, 1 month), low/mid rectal tumor, no stoma, non-employed status (total, 4 months), higher COREFO-scores (occupational, 4 months) and non-employed status (total, 12 months). At all timepoints, lower COREFO-scores were associated with higher total physical activity levels; male gender and lower educational levels with higher occupational levels; younger age, normal BMI, employed status and adjuvant therapy with higher sports levels; and female gender, lower educational level and unemployed status with higher household levels. Conclusions One year after rectal cancer treatment, total physical activity levels were still not recovered. Rectal cancer patients, especially those at risk for decreased physical activity levels and with major bowel complaints, should be identified and guided to increase their activities. Trial registration This trial has been registered at Netherlands Trial Register ( NTR6383 , 23/01/2017).

Published
2021
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44. Challenges and Opportunities in IBD Clinical Trial Design

Author

Abreu, Maria T., Collins, Rory, Dubinsky, Marla C., Jairath, Vipul, Lewis, James D., Lindsay, James, Merad, Miriam, Ng, Siew, Panaccione, Remo, Panes, Julian, Sands, Bruce, Siegal, Corey A., Singh, Siddarth, Vermeire, Severine, Ahuja, Vineet, Allez, Matthieu, Ananthakrishnan, Ashwin, Bemelman, Willem, Braun, Jonathan, Colombel, Jean-Frederic, Danese, Silvio, D’Haens, Geert, D’Hoore, André, Dignass, Axel, Dotan, Iris, Gassul, Miguel Angel, Griffiths, Anne, Halfvarson, Jonas, Hanauer, Stephen, Kotze, Paulo, Koutroubakis, Ioannis, Loftus, Edward, Louis, Edouard, Magro, Fernando, Mantzaris, Gerassimos, Mary, Jean-Yves, McGovern, Dermot, Munkholm, Pia, O’Morain, Colm, Panis, Yves, Peyrin-Biroulet, Laurent, Prantera, Cosimo, Ran, Zhihua, Siegmund, Britta, Silverberg, Mark, Stange, Eduard, Targan, Stephan, Tysk, Curt, Travis, Simon, Vatn, Morton, Yamamoto-Furusho, Yesus, Aarts, Janske, Abhyankar, Brihad, Ahmad, Harris, Aranda, Richard, Arora, Vipin, Benjacoub, Jalil, Berg, Sofie, Besuyen, Robin, Bojic, Daniela, Carriero, Valerio, Cataldi, Fabio, D’Agay, Laurence, Delgado-Aros, Silvia, Giannasca, Paul, Goyal, Kavitha, Greinwald, Roland, Gropper, Savion, Kageyama, Shunsuke, Laoun, Raphaël, Levesque, Barrett, Lissoos, Trevor, Modesto, Irene, Mohrbacher, Ralf, Mueller, Ralph, Naegeli, April, Naik, Snehal, Nguyen, Deanne, Niezychowski, Wojciech, O’Brien, Caitriona, Odnoletkova, Irina, Oortwijn, Alessandra, Park, Kun K.T., Radziszewski, Waldemar, Salese, Leonardo, Spleiss, Johannes, Stancati, Andrea, Tatro, Amanda, Thompson, Jennifer, Hofmann, Robert, Zambrano, Javier, Zhou, Wen, and Zigmont, Ellen

Published
2021
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46. Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision (taTME) during the learning phase

Author

Caycedo-Marulanda, Antonio, Nadeau, Kara, Verschoor, Chris P., Sands, Dana, Spinelli, Antonino, Ashamalla, Shady, Patel, Sunil V., Di Candido, Francesca, Mujukian, Angela, Zaghiyan, Karen, Stevenson, Grant, Wolthuis, Albert, Clark, David A., D’Hoore, Andre, Stevenson, Andrew, and Wexner, Steven D.

Published
2021
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47. Factors to improve quality for older patients in the emergency department: a qualitative study of patient trajectory

Author

Isabelle De Brauwer, Pascale Cornette, William D’Hoore, Vincent Lorant, Franck Verschuren, Frédéric Thys, and Isabelle Aujoulat

Subjects
Emergency department, Elderly, Process of care, Qualitative observations, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Managing older people in the emergency department remains a challenge. We aimed to identify the factors influencing the care quality of older patients in the emergency department, to fine-tune future interventions for older people, considering the naturalistic context of the ED. Methods This is a qualitative study of some 450 h of observations performed in three emergency departments selected for their diverse contexts. We performed seventy observations of older patient trajectories admitted to the emergency department. Themes were extracted from the material using an inductive reasoning approach, to highlight factors positively or negatively influencing management of patient’s trajectories, in particular those presenting with typically geriatric syndromes. Results Four themes were developed: no geriatric flow routine; risk of discontinuity of care; unmet basic needs and patient-centered care; complex older patients are unwelcome in EDs. Conclusions The overall process of care was based on an organ- and flow-centered paradigm, which ignored older people’s specific needs and exposed them to discontinuity of care. Their basic needs were neglected and, when their management slowed the emergency department flow, older people were perceived as unwelcome. Findings of our study can inform the development of interventions about the influence of context and organizational factors.

Published
2021
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48. The importance of including a mental health dimension in a multimorbidity indicator: an analysis of Belgian health survey data.

Author

Laloux, Pierre, Gisle, Lydia, D'hoore, William, Charafeddine, Rana, and Van der Heyden, Johan

Subjects
MENTAL health services, MENTAL illness, PUBLIC health, QUALITY of life, GOODNESS-of-fit tests
Abstract

Background: Multimorbidity is a rising public health concern. Indicators that address these complex health conditions are often exclusively devoted to physical diseases. Because of their high disease burden, mental health disorders ought to be considered as well. This paper aims to measure the added value of including a mental health dimension in a population-based multimorbidity indicator and identify which mental health measures are most appropriate. Methods: Secondary analyses were conducted on data from the Belgian Health Interview Survey 2018. We compared the prevalence of different multimorbidity indicators (MIs) in relation to health impact measures, such as quality of life (EQ-5D score) and activity limitation (GALI). The MIs differed as to the health conditions involved: one was based on physical conditions only; the other three included mental health dimensions that were either self-reported or assessed by a scale (GAD-7, PHQ-9, and GHQ-12). We performed linear and logistic regressions to assess the association between the MIs and the health correlates and compared the goodness of fit of the different models. Results: MI prevalence was higher when including a mental health dimension assessed with the GHQ-12 (42.0%) and with the GAD-7 or the PHQ-9 (39.4%) as compared to physical conditions only (35.0%). Associations between the MI and health correlates were consistently stronger if the MI included a mental health dimension. The regression models with MI including the GAD-7 and PHQ-9 showed the strongest association between MI and the health correlates and also had the best goodness-of-fit measures. Conclusions: MIs that only take physical conditions into account underestimate their impact on individuals' lives. Including mental ill-health in an MI is key to linking it to health correlates. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Impact of rural versus urban setting on kidney markers: a cross-sectional study in South-Kivu, DRCongo

Author

Mannix Imani Masimango, Michel P. Hermans, Espoir Bwenge Malembaka, Pierre Wallemacq, Ernest Kiswaya Sumaili, Catherine Fillée, William D’Hoore, Cheryl A. Winkler, Sophie Limou, and Michel Jadoul

Subjects
CKD screening tests, Proteinuria dipstick, Albumin-to-creatinine ratio, Rural-urban location, Prevalence, Performance, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Most studies of chronic kidney disease (CKD) in Sub-Saharan Africa (SSA) have been conducted in urban settings. They relied on GFR estimated from serum creatinine alone and on the inexpensive, convenient urinary dipstick to assess proteinuria. The dipstick for proteinuria has not been directly compared with the gold standard albumin-to-creatinine ratio (ACR) in a large-sized study in SSA. We hereby assessed the influence of rural versus urban location on the level, interpretation, and diagnostic performance of proteinuria dipstick versus ACR. Methods In a cross-sectional population-based study of CKD in both urban (n = 587) and rural (n = 730) settings in South-Kivu, Democratic Republic of Congo (DRC), we assessed the prevalence, performance (sensitivity, specificity, positive predictive value and negative predictive value) and determinants of a positive dipstick proteinuria as compared with albuminuria (ACR). Albuminuria was subdivided into: A1 (

Published
2021
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