Search

Your search keyword '"da Luz, Thiarlen Marinho"' showing total 15 results
Start Over Author "da Luz, Thiarlen Marinho"
15 results on '"da Luz, Thiarlen Marinho"'

1. Toxicity of carbon nanofibers in earthworms (Lumbricus terrestris) naturally infected with Monocystis sp.

Author

Montalvão, Mateus Flores, Gomes, Alex Rodrigues, Guimarães, Abraão Tiago Batista, Rodrigues, Aline Sueli de Lima, Matos, Letícia Paiva de, Mendonça, Juliana dos Santos, da Luz, Thiarlen Marinho, Matos, Stênio Gonçalves da Silva, Rahman, M. Safiur, Ragavendran, Chinnasamy, Senthil-Nathan, Sengottayan, Guru, Ajay, Rakib, Md. Refat Jahan, Mubarak, Nabisab Mujawar, Rahman, Md. Mostafizur, Rocha, Thiago Lopes, Islam, Abu Reza Md. Towfiqul, and Malafaia, Guilherme

Published
2024
Full Text
View/download PDF

2. Environmental impacts of COVID-19 treatment: Toxicological evaluation of azithromycin and hydroxychloroquine in adult zebrafish

Author

Mendonça-Gomes, Juliana Moreira, da Costa Araújo, Amanda Pereira, da Luz, Thiarlen Marinho, Charlie-Silva, Ives, Braz, Helyson Lucas Bezerra, Jorge, Roberta Jeane Bezerra, Ahmed, Mohamed Ahmed Ibrahim, Nóbrega, Rafael Henrique, Vogel, Christoph FA, and Malafaia, Guilherme

Subjects
Biological Sciences, Environmental Sciences, Pollution and Contamination, Good Health and Well Being, Animals, Azithromycin, Ecosystem, Humans, Hydroxychloroquine, Molecular Docking Simulation, Pandemics, SARS-CoV-2, Zebrafish, COVID-19 Drug Treatment, Water pollution, SARs-Cov-2, Danio rerio, Ecotoxicity, Antibiotic, Antimalarial
Abstract

One of the most impact issues in recent years refers to the COVID-19 pandemic, the consequences of which thousands of deaths recorded worldwide, are still inferior understood. Its impacts on the environment and aquatic biota constitute a fertile field of investigation. Thus, to predict the impact of the indiscriminate use of azithromycin (AZT) and hydroxychloroquine (HCQ) in this pandemic context, we aim to assess their toxicological risks when isolated or in combination, using zebrafish (Danio rerio) as a model system. In summary, we observed that 72 h of exposure to AZT and HCQ (alone or in binary combination, both at 2.5 μg/L) induced the reduction of total protein levels, accompanied by increased levels of thiobarbituric acid reactive substances, hydrogen peroxide, reactive oxygen species and nitrite, suggesting a REDOX imbalance and possible oxidative stress. Molecular docking analysis further supported this data by demonstrating a strong affinity of AZT and HCQ with their potential antioxidant targets (catalase and superoxide dismutase). In the protein-protein interaction network analysis, AZT showed a putative interaction with different cytochrome P450 molecules, while HCQ demonstrated interaction with caspase-3. The functional enrichment analysis also demonstrated diverse biological processes and molecular mechanisms related to the maintenance of REDOX homeostasis. Moreover, we also demonstrated an increase in the AChE activity followed by a reduction in the neuromasts of the head when zebrafish were exposed to the mixture AZT + HCQ. These data suggest a neurotoxic effect of the drugs. Altogether, our study demonstrated that short exposure to AZT, HCQ or their mixture induced physiological alterations in adult zebrafish. These effects can compromise the health of these animals, suggesting that the increase of AZT and HCQ due to COVID-19 pandemic can negatively impact freshwater ecosystems.

Published
2021

3. Cellulose microcrystalline: A promising ecofriendly approach to control Culex quinquefasciatus larvae

Author

Souza, Sindoval Silva de, Gomes, Alex Rodrigues, Guimarães, Abraão Tiago Batista, Rodrigues, Aline Sueli de Lima, de Matos, Letícia Paiva, dos Santos Mendonça, Juliana, da Luz, Thiarlen Marinho, Matos, Stênio Gonçalves da Silva, Rahman, M. Safiur, Ragavendran, Chinnasamy, Senthil-Nathan, Sengottayan, Guru, Ajay, Rakib, Md. Refat Jahan, Mubarak, Nabisab Mujawar, Rahman, Md. Mostafizur, Rocha, Thiago Lopes, Islam, Abu Reza Md. Towfiqul, and Malafaia, Guilherme

Published
2023
Full Text
View/download PDF

5. Corrigendum to “Green toxicology approach involving polylactic acid biomicroplastics and neotropical tadpoles: (Eco)toxicological safety or environmental hazard?” [Science of The Total Environment, 783 (2021), 146,994]

Author

Malafaia, Guilherme, primary, Nascimento, Ítalo Freitas, additional, Estrela, Fernanda Neves, additional, Guimarães, Abraão Tiago Batista, additional, Ribeiro, Fabianne, additional, da Luz, Thiarlen Marinho, additional, and de Lima Rodrigues, Aline Sueli, additional

Published
2023
Full Text
View/download PDF

6. Toxicity of carbon nanofibers in earthworms (Lumbricus terrestris) naturally infected with Monocystis sp.

Author

Montalvão, Mateus Flores, primary, Gomes, Alex Rodrigues, additional, Guimarães, Abraão Tiago Batista, additional, de Lima Rodrigues, Aline Sueli, additional, de Matos, Letícia Paiva, additional, dos Santos Mendonça, Juliana, additional, da Luz, Thiarlen Marinho, additional, da Silva Matos, Stênio Gonçalves, additional, Rahman, M. Safiur, additional, Ragavendran, Chinnasamy, additional, Senthil-Nathan, Sengottayan, additional, Guru, Ajay, additional, Rakib, Md. Refat Jahan, additional, Mubarak, Nabisab Mujawar, additional, Rahman, Md. Mostafizur, additional, Rocha, Thiago Lopes, additional, Islam, Abu Reza Md. Towfiqul, additional, and Malafaia, Guilherme, additional

Published
2023
Full Text
View/download PDF

8. First report on the toxicity of Sars-Cov-2, alone and in combination with polyethylene microplastics in neotropical fish

Author

de Oliveira Ferreira, Raíssa, primary, Guimarães, Abraão Tiago Batista, additional, da Luz, Thiarlen Marinho, additional, de Lima Rodrigues, Aline Sueli, additional, Towfiqul Islam, Abu Reza Md., additional, Rahman, Md. Mostafizur, additional, Ragavendran, Chinnasamy, additional, Kamaraj, Chinnaperumal, additional, Charlie-Silva, Ives, additional, Durigon, Edison Luiz, additional, Braz, Helyson Lucas Bezerra, additional, Arias, Andrés Hugo, additional, Santiago, Omar Cruz, additional, Barceló, Damià, additional, and Malafaia, Guilherme, additional

Published
2023
Full Text
View/download PDF

9. Plant-ZnO Nanoparticles Interaction: An Approach To Improve Guinea Grass (Panicum maximum) Productivity And Evaluation Of The Impacts Of Its Ingestion By Freshwater Teleost Fish

Author

Gomes, Alex Rodrigues, primary, de Matos, Letícia Paiva, additional, Guimarães, Abraão Tiago Batista, additional, Freitas, Ítalo Nascimento, additional, da Luz, Thiarlen Marinho, additional, Silva, Abner Marcelino, additional, Silva Matos, Stênio Gonçalves da, additional, Lima Rodrigues, Aline Sueli de, additional, Ferreira, Raíssa de Oliveira, additional, Islam, Abu Reza Md. Towfiqul, additional, Rahman, Md. Mostafizur, additional, Ragavendran, Chinnasamy, additional, Kamaraj, Chinnaperumal, additional, Mubarak, Nabisab Mujawar, additional, Arias, Andrés Hugo, additional, Gomes, Paula Cristine Silva, additional, Silva, Fabiano Guimarães, additional, and Malafaia, Guilherme, additional

Published
2023
Full Text
View/download PDF

10. Short-term exposure of the mayfly larvae (Cloeon dipterum, Ephemeroptera: Baetidae) to SARS-CoV-2-derived peptides and other emerging pollutants: A new threat for the aquatic environments

Author

Freitas, Ítalo Nascimento, primary, Dourado, Amanda Vieira, additional, da Silva Matos, Stênio Gonçalves, additional, de Souza, Sindoval Silva, additional, da Luz, Thiarlen Marinho, additional, Rodrigues, Aline Sueli de Lima, additional, Guimarães, Abraão Tiago Batista, additional, Mubarak, Nabisab Mujawar, additional, Rahman, Md. Mostafizur, additional, Arias, Andrés Hugo, additional, and Malafaia, Guilherme, additional

Published
2022
Full Text
View/download PDF

11. Toxicological impact of SARS-CoV-2 on the health of the neotropical fish, Poecilia reticulata

Author

Malafaia, Guilherme, primary, Ahmed, Mohamed Ahmed Ibrahim, additional, Souza, Sindoval Silva de, additional, Rezende, Fernanda Neves Estrela, additional, Freitas, Ítalo Nascimento, additional, da Luz, Thiarlen Marinho, additional, da Silva, Abner Marcelino, additional, Charlie-Silva, Ives, additional, Braz, Helyson Lucas Bezerra, additional, Jorge, Roberta Jeane Bezerra, additional, Sanches, Paulo R.S., additional, Mendonça-Gomes, Juliana Moreira, additional, Cilli, Eduardo M., additional, and Araújo, Amanda Pereira da Costa, additional

Published
2022
Full Text
View/download PDF

12. Steel wools microfibers causes iron overload and induces biochemical changes in Gallus gallus domesticus chicks (Galliformes: Phasianidae)

Author

Nascimento, Ítalo Freitas, primary, Souza, Sindoval Silva de, additional, da Luz, Thiarlen Marinho, additional, Gomes, Lux Attiê Santos, additional, Gonçalves, Sandy de Oliveira, additional, Ahmed, Mohamed Ahmed Ibrahim, additional, Guimarães, Abraão Tiago Batista, additional, Rodrigues, Aline Sueli de Lima, additional, and Malafaia, Guilherme, additional

Published
2022
Full Text
View/download PDF

13. Environmental impacts of COVID-19 treatment: Toxicological evaluation of azithromycin and hydroxychloroquine in adult zebrafish

Author

Mendonça-Gomes, Juliana Moreira, primary, da Costa Araújo, Amanda Pereira, additional, da Luz, Thiarlen Marinho, additional, Charlie-Silva, Ives, additional, Braz, Helyson Lucas Bezerra, additional, Jorge, Roberta Jeane Bezerra, additional, Ahmed, Mohamed Ahmed Ibrahim, additional, Nóbrega, Rafael Henrique, additional, Vogel, Christoph F.A., additional, and Malafaia, Guilherme, additional

Published
2021
Full Text
View/download PDF

15. Do predictive environmentally relevant concentrations of ZnO nanoparticles induce antipredator behavioral response deficit in Swiss mice?

Author

da Luz, Thiarlen Marinho, primary, Freitas, Ítalo Nascimento, additional, Silva, Fabiano Guimarães, additional, da Costa Araújo, Amanda Pereira, additional, Fernandes, Thiago, additional, Rodrigues, Fernando Postalli, additional, de Oliveira Junior, Admilton Gonçalves, additional, and Malafaia, Guilherme, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results