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2. ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, Ug, Fontenot, T., Marshall, P., Shekerdemian, Ls, Coss-Bu, Ja, Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, Jc, Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, Am, Ieperen, Sn, Kinderen, Ep, Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Akcan-Arikan, A., Silva, Jc, Goldsworthy, M., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano, Sm, Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, Ir, El Adawy, As, Mohammed, Hm, Mohamed, An, Parry, Sm, Knight, Ld, Denehy, L., Morton, N., Baldwin, Ce, Sani, D., Kayambu, G., Da Silva, Vz, Phongpagdi, P., Puthucheary, Za, Granger, Cl, Rydingsward, Je, Horkan, Cm, Christopher, Kb, Mcwilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, Lm, Rattray, J., Kenardy, J., Hull, Am, Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, Jc, Rocha, Ll, Freitas, Ff, Cavalheiro, Am, Lucinio, Nm, Lobato, Ms, Ebeling, G., Kraegpoeth, A., Laerkner, E., Brito-Ashurst, I., White, C., Gregory, S., Forni, Lg, Flowers, E., Curtis, A., Wood, Ca, Siu, K., Venkatesan, K., Muhammad, Jb, Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., Molina, Fj, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, Rm, Palencia, E., Jareño, A., Granada, Rm, Ignacio, Ml, Getgag, Working Group, Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Mignot, T., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, Ma, Patel, C., Mohankumar, L., Akhtar, N., Noriega, Sk, Aldana, Nn, León, Jl, Baquero, Jd, Bernal, Ff, Ahmadnia, E., Hadley, Js, Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Jseptic, Clinical Trial Group, Rotzel, Hb, Lázaro, As, Prada, Da, Gimillo, MR, Barinas, Od, Cortes, Ml, Franco, Jf, Roca, Jm, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, Pj, Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, Le, Lesmes, Sp, Romero, Jc, Herrera, An, Pertuz, Ed, Sánchez, Mj, Sanz, Er, Hualde, Jb, Hernández, Aa, Irazabal, Jm, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, Eh, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, Jm, Arias-Verdu, Md, Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Ramírez, Jr, León, Jp, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, Jl, Pérez, H., Calpe, P., Alcala, Ma, Robaglia, D., Perez, C., Lan, Sk, Cunha, Mm, Moreira, T., Santos, F., Lafuente, E., Fernandes, Mj, Silva, Jg, Echeverría, Jg, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, Jc, Araujo, Nj, García-Olivares, P., Keough, E., Dalorzo, M., Tang, Lk, Sousa, I., Díaz, M., Marcos-Zambrano, Lj, Guerrero, Je, Gomez, Se, Lopez, Gd, Cuellar, Ai, Nieto, Or, Gonzalez, Ja, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, Mk, Sampley, S., Sekhri, K., Nandha, R., Aliaga, Fa, Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, Mp, Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, Jf, Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, Ia, Kashiya, S., Golovnya, E., Baikova, Vn, Ageeva, T., Haritydi, T., Kulaga, Ev, Rios-Toro, Jj, Lopez-Caler, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, Mg, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Yd, Jeong, Wy, Kim, Mh, Jeong, Iy, Ahn, My, Ahn, Jy, Han, Sh, Choi, Jy, Song, Yg, Kim, Jm, Ku, Ns, Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, Rm, Romeu, Jd, Antón, Dg, Quinart, A., Martí, At, Laura Navarro Guillamon, Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, Mf, Capcri, Study, Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, Pa, Taggu, A., Renuka, S., Sampath, S., Rood, Pj, Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., Hoeven, Jg, Den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, Mj, Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, Mp, Heiden, Es, Twisk, Jw, Girbes, Ar, Spijkstra, Jj, Bell, C., Peters, K., Feehan, A., Churchill, K., Hawkins, K., Brook, R., Paver, N., Maistry, N., Wijk, A., Rouw, N., Galen, T., Evelein-Brugman, S., Krishna, B., Putzu, A., Fang, M., Berto, Mb, Belletti, A., Cassina, T., Cabrini, L., Mistry, M., Alhamdi, Y., Welters, I., Abrams, St, Toh, Ch, Han, Hs, Gil, Em, Lee, Ds, Park, Cm, Winder-Rhodes, S., Lotay, R., Doyle, J., Ke, Mw, Huang, Wc, Chiang, Ch, Hung, Wt, Cheng, Cc, Lin, Kc, Lin, Sc, Chiou, Kr, Wann, Sr, Shu, Cw, Kang, Pl, Mar, Gy, Liu, Cp, Dubó, S., Aquevedo, A., Jibaja, M., Berrutti, D., Labra, C., Lagos, R., García, Mf, Ramirez, V., Tobar, M., Picoita, F., Peláez, C., Carpio, D., Alegría, L., Hidalgo, C., Godoy, K., Bakker, J., Hernández, G., Sadamoto, Y., Katabami, K., Wada, T., Ono, Y., Maekawa, K., Hayakawa, M., Sawamura, A., Gando, S., Marin-Mateos, H., Perez-Vela, Jl, Garcia-Gigorro, R., Peiretti, Ma, Lopez-Gude, Mj, Chacon-Alves, S., Renes-Carreño, E., Montejo-González, Jc, Parlevliet, Kl, Touw, Hr, Beerepoot, M., Boer, C., Elbers, Pw, Tuinman, Pr, Abdelmonem, Sa, Helmy, Ta, El Sayed, I., Ghazal, S., Akhlagh, Sh, Masjedi, M., Hozhabri, K., Kamali, E., Zýková, I., Paldusová, B., Sedlák, P., Morman, D., Youn, Am, Ohta, Y., Sakuma, M., Bates, D., Morimoto, T., Su, Pl, Chang, Wy, Lin, Wc, Chen, Cw, Facchin, F., Zarantonello, F., Panciera, G., Cassai, A., Venrdramin, A., Ballin, A., Tonetti, T., Persona, P., Ori, C., Del Sorbo, L., Rossi, S., Vergani, G., Cressoni, M., Chiumello, D., Chiurazzi, C., Brioni, M., Algieri, I., Guanziroli, M., Colombo, A., Tomic, I., Crimella, F., Carlesso, E., Gasparovic, V., Gattinoni, L., Neto, As, Schmidt, M., Pham, T., Combes, A., Abreu, Mg, Pelosi, P., Schultz, Mj, Prove, Reva Research Network And The Network Investigators, Katira, Bh, Engelberts, D., Giesinger, Re, Ackerley, C., Zabini, D., Otulakowski, G., Post, 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W., Geri, G., Dumas, F., Champigneulle, B., Legriel, S., Charpentier, J., Mira, Jp, Sandroni, C., Zimmerman, J., Sullivan, E., Noursadeghi, M., Fox, B., Sampson, D., Mchugh, L., Yager, T., Cermelli, S., Seldon, T., Bhide, S., Brandon, Ra, Brandon, Rb, Zwaag, J., Beunders, R., Kox, M., Gul, F., Arslantas, Mk, Genc, D., Zibandah, N., Topcu, L., Akkoc, T., Cinel, I., Greco, E., Lauretta, Mp, Garcia, Ip, Cordero, M., Martin, Ad, Pallás, Ta, Montero, Jg, Rey, Jr, Malo, Lr, Montoya, Aa, Martinez, Ad, Ayala, Ly, Zepeda, Em, Granillo, Jf, Sanchez, Ja, Alejo, Gc, Cabrera, Ar, Montenegro, Ap, Beduneau, G., Schortgen, F., Piquilloud, L., Zogheib, E., Jonas, M., Grelon, F., Runge, I., Terzi, N., Grangé, S., Barberet, G., Guitard, Pg, Frat, Jp, Constan, A., Chrétien, Jm, Mancebo, J., Mercat, A., Richard, Jc, Brochard, L., Wind, Study Group, Soilemezi, E., Koco, E., Savvidou, S., Nouris, C., Matamis, D., Plug Working Group, Di Mussi, R., Spadaro, S., Volta, Ca, Mariani, M., Colaprico, A., Antonio, C., Bruno, F., Grasso, S., Rodriguez, A., Martín-Loeches, I., Díaz, E., Masclans, Jr, Gordo, F., Solé-Violán, J., Bodí, M., Avilés-Jurado, Fx, Trefler, S., Magret, M., Reyes, Lf, Marín-Corral, J., Yebenes, Jc, Esteban, A., Anzueto, A., Aliberti, S., Restrepo, Mi, GETGAG/SEMICYUC, Larsson, Js, Redfors, B., Ricksten, Se, Haines, R., Powell-Tuck, J., Leonard, H., Ostermann, M., Berthelsen, Re, Itenov, Ts, Perner, A., Jensen, Ju, Ibsen, M., Jensen, Ae, Bestle, Mh, Bucknall, T., Dixon, J., Boa, F., Macphee, I., Philips, Bj, Aki, Research Group, St George’s University of London, Saadat, F., Samuels, T., Huddart, S., Mccormick, B., Debrunnar, R., Preece, J., Swart, M., Peden, C., Richardson, S., Forni, L., Kalfon, P., Baumstarck, K., Estagnasie, P., Geantot, Ma, Berric, A., Simon, G., Floccard, B., Signouret, T., Boucekine, M., Fromentin, M., Nyunga, M., Sossou, A., Venot, M., Robert, R., Follin, A., Renault, A., Garrouste, M., Collange, O., Levrat, Q., Villard, I., Thévenin, D., Pottecher, 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Quintana, S., Martínez, L., Algarte, R., Sánchez, B., Trenado, J., Brock, N., Viegas, E., Filipe, E., Cottle, D., Traynor, T., Martínez, Mv, Márquez, Mp, Gómez, Lc, Martínez, Na, Muñoz, Jm, Bellver, Bq, Varea, Mm, Llorente, Má, Calvo, Cp, Hillier, Sd, Faulds, Mc, Hendra, H., Lawrence, N., Kodate, A., Tominaga, N., Mizugaki, A., Murakami, H., Silva, S., Kerhuel, L., Malagurski, B., Chabanne, R., Laureys, S., Puybasset, L., Nobile, L., Pognuz, Er, Rossetti, Ao, Verginella, F., Gaspard, N., Ben-Hamouda, N., Oddo, M., Taccone, Fs, Iijima, H., Andersen, Lw, Raymond, T., Berg, R., Nadkarni, V., Grossestreuer, A., Kurth, T., Donnino, M., Krüger, A., Ostadal, P., Janotka, M., Vondrakova, D., Kongpolprom, N., Cholkraisuwat, J., Pekkarinen, Pt, Ristagno, G., Masson, S., Latini, R., Bendel, S., Ala-Kokko, T., Varpula, T., Vaahersalo, J., Tiainen, M., Mion, Mm, Plebani, M., Pettilä, V., Skrifvars, Mb, Finnresusci, Study Group, Son, Y., Kim, Ks, Suh, Gj, Kwon, Wy, Ko, Ji, Park, Mj, Cavicchi, Fz, Iesu, E., Tanaka, H., Otani, N., Ode, S., Ishimatsu, S., Romero, I., Martínez, F., Kruger, A., Malek, F., Neuzil, P., Yeh, Yc, Wang, Ch, Huang, Ch, Chao, A., Lee, Ct, Lai, Ch, Chan, Ws, Cheng, Yj, Sun, Wz, Kaese, S., Horstmann, C., Lebiedz, P., Mourad, M., Gaudard, P., Eliet, J., Zeroual, N., Colson, P., Mlcek, M., Hrachovina, M., Mates, M., Hala, P., Kittnar, O., Jacky, A., Rudiger, A., Spahn, Dr, Bettex, Da, Kara, A., Akin, S., Dos Reis Miranda, D., Struijs, A., Caliskan, K., Thiel, Rj, Dubois, Ea, Wilde, W., Zijlstra, F., Gommers, D., Ince, C., Marca, L., Xini, A., Mongkolpun, W., Cordeiro, Cp, Leite, Rt, Lheureux, O., Bader, A., Rincon, L., Santacruz, C., Preiser, Jc, Chao, As, Kim, W., Ahn, C., Cho, Y., Lim, Th, Oh, J., Choi, Ks, Jang, Bh, Ha, Jk, Mecklenburg, A., Stamm, J., Soeffker, G., Kubik, M., Sydow, K., Reichenspurner, H., Kluge, S., Braune, S., Bergantino, B., Ruberto, F., Magnanimi, E., Privato, E., Zullino, V., Bruno, K., Pugliese, F., Sales, G., Girotto, V., Vittone, F., Brazzi, L., Fritz, C., Kimmoun, A., Vanhuyse, F., Trifan, B., Orlowski, S., Albuisson, E., Tran, N., Levy, B., Chhor, V., Joachim, J., Chatelon, J., Fave, G., Mantz, J., Diaz, Dd, Villanova, M., Aguirregabyria, M., Andrade, G., López, L., John, G., Cowan, R., Hart, R., Lake, K., Litchfield, K., Song, Jw, Lee, Yj, Cho, Yj, Choi, S., Vermeir, P., Vandijck, D., Mariman, A., Verhaeghe, R., Deveugele, M., Vogelaers, D., Chok, L., Bachli, Eb, Bettex, D., Cottini, Sr, Keller, E., Maggiorini, M., Schuepbach, R., Stiphout, C., Grevelink, M., Vaneker, I., Ruijter, A., Buise, M., Tena, Sa, Barrachina, Lg, Portillo, Jh, Aznar, Gp, Campos, Lm, Sellés, Md, Tomás, Ma, Muncharaz, Ab, Skinner, L., Monsalvo, S., Olavarria, E., Stümpfle, R., Na, Sj, Park, J., Chung, Cr, Suh, Gy, Yang, Jh, Witter, T., Brousseau, C., Butler, Mb, Erdogan, M., Dougall, Pc, Green, Rs, Abbott, Te, Torrance, Hd, Cron, N., Vaid, N., Emmanuel, J., Siddiqui, Ss, Prabu, N., Chaudhari, Hk, Patil, Vp, Divatia, Jv, Solanki, S., Kulkarni, Ap, Gutierrez, La, Brasseur, A., Hempel, D., Stauffert, N., Recker, F., Schröder, T., Reusch, S., Schleifer, J., Breitkreutz, R., Sjövall, F., Møller, Mh, Moraes, Rb, Borges, Fk, Guillen, Ja, Zabaletta, Wj, Pics- Hcpa, Programa Intrahospitalar Combate À Sepse Do Hospital Clínicas Porto Alegre, Ruiz-Ramos, J., Marqués-Miñana, MR, Sosa, M., Concha, P., Menendez, R., Ramírez, Cs, Santana, Mc, Balcázar, Lc, Escalada, Sh, Viera, Ma, Vázquez, Cf, Díaz, Jj, Campelo, Fa, Monroy, Ns, Santana, Ps, Santana, Sr, Gutiérrez-Pizarraya, A., Garnacho-Montero, J., Martin, C., Mainardi, Jl, Cholley, B., Hubbard, A., Frontera, Pr, Vega, Lm, Miguelena, Pr, Usón, Mc, López, Ar, Clemente, Ea, Ibañes, Pg, Aguilar, Al, Palomar, M., Olaechea, P., Uriona, S., Vallverdu, M., Catalan, M., Aragon, C., Lerma, Fa, Envin-Helics, Study Group, Bassi, Gl, Xiol, Ea, Senussi, T., Idone, Fa, Motos, A., Travierso, C., Fernández-Barat, L., Amaro, R., Hua, Y., Ranzani, Ot, Bobi, Q., Rigol, M., Torres, A., Fernández, If, Soler, Ea, Vera, Ap, Pastor, Ee, Hernandis, V., Ros Martínez, J., Rubio, Rj, Torner, Mm, Brugger, Sc, Eroles, Aa, Moles, Si, Cabello, Jt, Schoenenberger, Ja, Casals, Xn, Vidal, Mv, Garrido, Bb, Martinez, Mp, Mirabella, L., Cotoia, A., Tullo, L., Stella, A., Di Bello, F., Di Gregorio, A., Dambrosio, M., Cinnella, G., Ramirez, Jr, Takahashi, H., Kazutoshi, F., Okada, Y., Oobayashi, W., Naito, T., Baidya, Dk, Maitra, S., Anand, Rk, Ray, Br, Arora, Mk, Ruffini, C., Rota, L., Corona, A., Sesana, G., Ravasi, S., Catena, E., Naumann, Dn, Mellis, C., Husheer, Sl, Bishop, J., Midwinter, Mj, Hutchings, S., Manca, T., Ramelli, A., Nicolini, F., Gherli, T., Vezzani, A., Young, A., Carmona, Af, Santiago, Ai, Guillamon, Ln, Delgado, Mj, Delgado-Amaya, M., Curiel-Balsera, E., Rivera-Romero, L., Carrero-Gómez, F., Aguayo-Dehoyos, E., Ariam, Registry Of Adult Cardiac Surgery, Healey, Aj, Cameron, C., Jiao, Lr, Pérez, A., Martin, S., Del Moral, Ol, Toval, S., Rico, J., Aldecoa, C., Oguzhan, K., 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Kouatchet, A., Similowski, T., Demoule, A., Diaz, P., Nunes, J., Escórcio, S., Silva, G., Chaves, S., Jardim, M., Câmara, M., Fernandes, N., Duarte, R., Jardim, Jj, Pereira, Ca, Nóbrega, Jj, Chen, Cm, Lai, Cc, Cheng, Kc, Chou, W., Lee, Sj, Cha, Ys, Lee, Wy, Onodera, M., Nakataki, E., Oto, J., Imanaka, H., Nishimura, M., Khadjibaev, A., Sabirov, D., Rosstalnaya, A., Akalaev, R., Parpibaev, F., Antonucci, E., Rossini, P., Gandolfi, S., Montini, E., Orlando, S., Nes, M., Karachi, F., Hanekom, S., Pereira, Uv, Parkin, Ms, Moore, M., Carvalho, Kv, Min, Hj, Kim, Hj, Choi, Yy, Lee, Ey, Song, I., Kim, Dj, E, Yy, Kim, Jw, Park, Js, Lee, Jh, Suh, Jw, Jo, Yh, Ferrero-Calleja, J., Merino-Vega, D., González-Jiménez, Ai, Sigcha, Ms, Hernández-Tejedor, A., Martin-Vivas, A., Gabán-Díez, Á, Luna, Rr, La Calle-Pedrosa, N., Temprano-Gómez, I., Afonso-Rivero, D., Pellin-Ariño, Ji, Algora-Weber, A., Fumis, Rr, Ferraz, Ab, Junior, Jm, Kirca, H., Cakin, O., Unal, M., Mutlu, H., Ramazanoglu, A., Cengiz, M., 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3. Frequency, complications, and mortality of inhalation injury in burn patients: A systematic review and meta-analysis protocol.
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Herdy Guerra Avila JE, Aniceto Santana L, Rabelo Suzuki D, Maldaner da Silva VZ, Duarte ML, Mizusaki Imoto A, and Ferreira Amorim F
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- Humans, Respiration, Artificial adverse effects, Burns, Inhalation complications, Burns, Inhalation mortality, Burns, Inhalation therapy, Prognosis, Smoke Inhalation Injury complications, Smoke Inhalation Injury mortality, Systematic Reviews as Topic, Meta-Analysis as Topic, Burns mortality, Burns complications
- Abstract
Introduction: Burns are tissue traumas caused by energy transfer and occur with a variable inflammatory response. The consequences of burns represent a public health problem worldwide. Inhalation injury (II) is a severity factor when associated with burn, leading to a worse prognosis. Its treatment is complex and often involves invasive mechanical ventilation (IMV). The primary purpose of this study will be to assess the evidence regarding the frequency and mortality of II in burn patients. The secondary purposes will be to assess the evidence regarding the association between IIs and respiratory complications (pneumonia, airway obstruction, acute respiratory failure, acute respiratory distress syndrome), need for IMV and complications in other organ systems, and highlight factors associated with IIs in burn patients and prognostic factors associated with acute respiratory failure, need for IMV and mortality of II in burn patients., Methods: This is a systematic literature review and meta-analysis, according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA). PubMed/MEDLINE, Embase, LILACS/VHL, Scopus, Web of Science, and CINAHL databases will be consulted without language restrictions and publication date. Studies presenting incomplete data and patients under 19 years of age will be excluded. Data will be synthesized through continuous (mean and standard deviation) and dichotomous (relative risk) variables and the total number of participants. The means, sample sizes, standard deviations from the mean, and relative risks will be entered into the Review Manager web analysis software (The Cochrane Collaboration)., Discussion: Despite the extensive experience managing IIs in burn patients, they still represent an important cause of morbidity and mortality. Diagnosis and accurate measurement of its damage are complex, and therapies are essentially based on supportive measures. Considering the challenge, their impact, and their potential severity, IIs represent a promising area for research, needing further studies to understand and contribute to its better evolution. The protocol of this review is registered on the International prospective register of systematic reviews platform of the Center for Revisions and Disclosure of the University of York, United Kingdom (https://www.crd.york.ac.uk/prospero), under number RD42022343944., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Herdy Guerra Avila et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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4. Lucio's phenomenon: A systematic literature review of definition, clinical features, histopathogenesis and management.
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Frade MAC, Coltro PS, Filho FB, Horácio GS, Neto AA, da Silva VZ, Westin AT, Guimarães FR, Innocentini LMAR, Motta ACF, and Farina JA Junior
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- Drug Therapy, Combination, Humans, Leprostatic Agents therapeutic use, Erythema Nodosum diagnosis, Erythema Nodosum therapy, Leprosy diagnosis, Leprosy drug therapy, Leprosy, Lepromatous diagnosis, Leprosy, Lepromatous drug therapy, Leprosy, Lepromatous pathology, Leprosy, Multibacillary drug therapy
- Abstract
Leprosy is a chronic disease with clinical presentations according to the immunologic spectrum. Lepromatous form is the most advanced, with the highest transmissibility and risk of causing disabilities. Lucio's phenomenon is a rare manifestation among lepromatous patients with a rapid and severe evolution and high mortality. It is difficult to differentiate from ulcerative/necrotic erythema nodosum leprosum and has no consensus on how it should be treated. This article is a qualitative review of the literature after the introduction of multidrug therapy, aiming to bring consensus related to the clinical, laboratory and histopathological diagnostic criteria of the disease and its management.
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- 2022
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5. Inflammatory, synaptic, motor, and behavioral alterations induced by gestational sepsis on the offspring at different stages of life.
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Granja MG, Alves LP, Leardini-Tristão M, Saul ME, Bortoni LC, de Moraes FM, Ferreira EC, de Moraes BPT, da Silva VZ, Dos Santos AFR, Silva AR, Gonçalves-de-Albuquerque CF, Bambini-Junior V, Weyrich AS, Rondina MT, Zimmerman GA, and de Castro-Faria-Neto HC
- Subjects
- Animals, Behavior, Animal, Brain metabolism, Cognitive Dysfunction etiology, Female, Inflammation, Mice, Motor Activity physiology, Pregnancy, Prenatal Exposure Delayed Effects metabolism, Sepsis complications, Synapses metabolism, Brain immunology, Prenatal Exposure Delayed Effects immunology, Sepsis immunology
- Abstract
Background: The term sepsis is used to designate a systemic condition of infection and inflammation associated with hemodynamic changes that result in organic dysfunction. Gestational sepsis can impair the development of the central nervous system and may promote permanent behavior alterations in the offspring. The aim of our work was to evaluate the effects of maternal sepsis on inflammatory cytokine levels and synaptic proteins in the hippocampus, neocortex, frontal cortex, and cerebellum of neonatal, young, and adult mice. Additionally, we analyzed the motor development, behavioral features, and cognitive impairments in neonatal, young and adult offspring., Methods: Pregnant mice at the 14
th embryonic day (E14) were intratracheally instilled with saline 0.9% solution (control group) or Klebsiella spp. (3 × 108 CFU) (sepsis group) and started on meropenem after 5 h. The offspring was sacrificed at postnatal day (P) 2, P8, P30, and P60 and samples of liver, lung, and brain were collected for TNF-α, IL-1β, and IL-6 measurements by ELISA. Synaptophysin, PSD95, and β-tubulin levels were analyzed by Western blot. Motor tests were performed at all analyzed ages and behavioral assessments were performed in offspring at P30 and P60., Results: Gestational sepsis induces a systemic pro-inflammatory response in neonates at P2 and P8 characterized by an increase in cytokine levels. Maternal sepsis induced systemic downregulation of pro-inflammatory cytokines, while in the hippocampus, neocortex, frontal cortex, and cerebellum an inflammatory response was detected. These changes in the brain immunity were accompanied by a reduction of synaptophysin and PSD95 levels in the hippocampus, neocortex, frontal cortex, and cerebellum, in all ages. Behavioral tests demonstrated motor impairment in neonates, and depressive-like behavior, fear-conditioned memory, and learning impairments in animals at P30 and P60, while spatial memory abilities were affected only at P60, indicating that gestational sepsis not only induces an inflammatory response in neonatal mouse brains, but also affects neurodevelopment, and leads to a plethora of behavioral alterations and cognitive impairments in the offspring., Conclusion: These data suggest that maternal sepsis may be causatively related to the development of depression, learning, and memory impairments in the litter.- Published
- 2021
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6. Construction of Recombinant Klebsiella pneumoniae to Increase Ethanol Production on Residual Glycerol Fed-Batch Cultivations.
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da Silva VZ, Ourique LJ, de David C, and Ayub MAZ
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- Biotechnology, Biotransformation, Kinetics, Klebsiella pneumoniae growth & development, Batch Cell Culture Techniques, DNA, Recombinant genetics, Ethanol metabolism, Glycerol metabolism, Klebsiella pneumoniae genetics, Klebsiella pneumoniae metabolism
- Abstract
K. pneumoniae BLh-1 strain was genetically modified aiming at obtaining high ethanol productivity in cultivations using residual glycerol from biodiesel synthesis as substrate. The recombinant strain K. pneumoniae Kp17 was obtained by inserting the multicopy plasmid pTOPOBL17 containing the AdhE gene, and its own promoter, from K. pneumoniae BLh-1. Influence of Fe
2+ supplementation and initial glycerol concentration on culture conditions were analyzed, both in rotatory shaker and in batch bioreactors. In the bioreactor cultures, K. pneumoniae Kp17 strain produced 4.5 g L-1 of ethanol (productivity of 0.50 g L-1 h-1 and yields of 0.15 g g-1 ) after 24-h cultivation, corresponding to an increase of approximately 40% in ethanol concentration compared to wild strain, K. pneumoniae BLh-1. Best conditions were then applied in exponential fed-batch bioreactors, with final ethanol concentration of 17.30 g L-1 (productivity of 0.59 g L-1 h-1 and yields of 0.16 g g-1 ) after 30 h of feeding, representing 11.5% of increment in titer of ethanol compared to the wild strain. Mutant cells kept 92.5% of the plasmids under batch in 24 h, and 71.9% under fed-batch after 27 h of exponential feeding. The findings in this work show the possibility of using a simple approach to genetically modify K. pneumoniae to be employed this versatile bacterium for the bioconversion of residual glycerol into ethanol.- Published
- 2020
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7. Early mobilization: Why, what for and how?
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Miranda Rocha AR, Martinez BP, Maldaner da Silva VZ, and Forgiarini Junior LA
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- Clinical Protocols, Clinical Trials as Topic, Contraindications, Procedure, Humans, Intensive Care Units, Length of Stay statistics & numerical data, Meta-Analysis as Topic, Muscle Strength, Muscular Atrophy prevention & control, Neuromuscular Diseases prevention & control, Quality of Life, Recovery of Function, Treatment Outcome, Critical Care methods, Early Ambulation methods
- Abstract
Early mobilization strategies in the intensive care unit may result in the prevention and reduction of polyneuromyopathy in the critical patient, improved quality of life, shortened ICU and hospital stay, and lesser mortality during hospitalization. However, it is well known that factors such as the protocol used, the population included in the studies, the timing of the strategy, the severity of the patients and different barriers directly influence the outcomes. This study examines the main protocols described in the literature and their associated results. The main techniques used were kinesitherapy, transfer and locomotion training, as well as neuromuscular electrical stimulation and cycle ergometry. Although two trials and a meta-analysis found no positive results with mobilization, programs that focus on specific populations, such as patients with weakness due to immobility and with preserved neuromuscular excitability can derive more positive effects from such treatment., (Copyright © 2016 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)
- Published
- 2017
- Full Text
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8. Functional Status Score for the ICU: An International Clinimetric Analysis of Validity, Responsiveness, and Minimal Important Difference.
- Author
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Huang M, Chan KS, Zanni JM, Parry SM, Neto SG, Neto JA, da Silva VZ, Kho ME, and Needham DM
- Subjects
- Activities of Daily Living, Aged, Humans, Length of Stay, Middle Aged, Patient Discharge, Reproducibility of Results, Intensive Care Units, Severity of Illness Index
- Abstract
Objectives: To evaluate the internal consistency, validity, responsiveness, and minimal important difference of the Functional Status Score for the ICU, a physical function measure designed for the ICU., Design: Clinimetric analysis., Settings: Five international datasets from the United States, Australia, and Brazil., Patients: Eight hundred nineteen ICU patients., Intervention: None., Measurements and Main Results: Clinimetric analyses were initially conducted separately for each data source and time point to examine generalizability of findings, with pooled analyses performed thereafter to increase power of analyses. The Functional Status Score for the ICU demonstrated good to excellent internal consistency. There was good convergent and discriminant validity, with significant and positive correlations (r = 0.30-0.95) between Functional Status Score for the ICU and other physical function measures, and generally weaker correlations with nonphysical measures (|r| = 0.01-0.70). Known group validity was demonstrated by significantly higher Functional Status Score for the ICU scores among patients without ICU-acquired weakness (Medical Research Council sum score, ≥ 48 vs < 48) and with hospital discharge to home (vs healthcare facility). Functional Status Score for the ICU at ICU discharge predicted post-ICU hospital length of stay and discharge location. Responsiveness was supported via increased Functional Status Score for the ICU scores with improvements in muscle strength. Distribution-based methods indicated a minimal important difference of 2.0-5.0., Conclusions: The Functional Status Score for the ICU has good internal consistency and is a valid and responsive measure of physical function for ICU patients. The estimated minimal important difference can be used in sample size calculations and in interpreting studies comparing the physical function of groups of ICU patients., Competing Interests: The authors declare that they have no other relevant financial interests.
- Published
- 2016
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9. Hemodynamic Effects Induced by Transcutaneous Electrical Nerve Stimulation in Apparently Healthy Individuals: A Systematic Review With Meta-Analysis.
- Author
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Campos FV, Neves LM, Da Silva VZ, Cipriano GF, Chiappa GR, Cahalin L, Arena R, and Cipriano G
- Subjects
- Adult, Female, Healthy Volunteers, Humans, Male, Middle Aged, Randomized Controlled Trials as Topic, Rest, Transcutaneous Electric Nerve Stimulation methods, Treatment Outcome, Blood Pressure physiology, Heart Rate physiology, Transcutaneous Electric Nerve Stimulation adverse effects
- Abstract
Objective: To determine the immediate effects of transcutaneous electrical nerve stimulation (TENS) on heart rate, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in apparently healthy adults (age ≥18y)., Data Sources: The Cochrane Library (online version 2014), PubMed (1962-2014), EMBASE (1980-2014), and LILACS (1980-2014) electronic databases were searched., Study Selection: Randomized controlled trials were included when TENS was administered noninvasively with surface electrodes during rest, and the effect of TENS was compared with that of control or placebo TENS. A sensitive search strategy for identifying randomized controlled trials was used by 2 independent reviewers. The initial search led to the identification of 432 studies, of which 5 articles met the eligibility criteria., Data Extraction: Two independent reviewers extracted data from the selected studies. Quality was evaluated using the PEDro scale. Mean differences or standardized mean differences in outcomes were calculated., Data Synthesis: Five eligible articles involved a total of 142 apparently healthy individuals. Four studies used high-frequency TENS and 3 used low-frequency TENS and evaluated the effect on SBP. Three studies using high-frequency TENS and 2 using low-frequency TENS evaluated the effect on DBP. Three studies using high-frequency TENS and 1 study using low-frequency TENS evaluated the effect on heart rate. A statistically significant reduction in SBP (-3.00mmHg; 95% confidence interval [CI], -5.02 to -0.98; P=.004) was found using low-frequency TENS. A statistically significant reduction in DBP (-1.04mmHg; 95% CI, -2.77 to -0.03; I(2)=61%; P=.04) and in heart rate (-2.55beats/min; 95% CI, -4.31 to -0.78; I(2)=86%; P=.005]) was found using both frequencies. The median value on the PEDro scale was 7 (range, 4-8)., Conclusions: TENS seems to promote a discrete reduction in SBP, DBP, and heart rate in apparently healthy individuals., (Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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10. Current evidence demonstrates similar effects of kilohertz-frequency and low-frequency current on quadriceps evoked torque and discomfort in healthy individuals: a systematic review with meta-analysis.
- Author
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da Silva VZ, Durigan JL, Arena R, de Noronha M, Gurney B, and Cipriano G Jr
- Subjects
- Biomechanical Phenomena, Healthy Volunteers, Humans, Myalgia diagnosis, Myalgia physiopathology, Pain Threshold, Torque, Electric Stimulation Therapy adverse effects, Isometric Contraction, Muscle Strength, Myalgia etiology, Quadriceps Muscle innervation
- Abstract
Background: Neuromuscular electrical stimulation (NMES) is widely utilized to enhance muscle performance. However, the optimal NMES waveform with respect to treatment effect has not been established., Objective: To investigate the effects of kilohertz-frequency alternating current (KFAC) and low-frequency pulsed current (PC) on quadriceps evoked torque and self-reported discomfort., Data Sources: PubMed, The Cochrane Library, EMBASE, MEDLINE, Physiotherapy Evidence Database (PEDro), SinoMed, ISI Web of Knowledge, and CINAHL were searched for randomized controlled trials (RCTs) and quasi-randomized controlled trials (QRCTs)., Study Selection: Two reviewers independently selected potential studies according to the inclusion criteria, extracted data, and assessed methodological quality., Data Extraction and Synthesis: Studies were eligible if they compared KFAC versus PC interventions. Studies that included outcome measures for percentage of maximal isometric voluntary contraction (%MIVC) torque and self-reported discomfort level were eligible for evaluation. Seven studies involving 127 individuals were included. The methodological quality of eligible trials was moderate, with a mean of 5 on the 10-point PEDro scale. Overall, PC was no better than KFAC in terms of evoked torque and there was no difference in self-reported discomfort level., Conclusion: KFAC and PC have similar effects on quadriceps evoked torque and self-reported discomfort level in healthy individuals. The small number and overall methodological quality of currently available studies included in this meta-analysis indicate that new RCTs are needed to better determine optimal NMES treatment parameters.
- Published
- 2015
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11. Aerobic exercise effect on prognostic markers for systolic heart failure patients: a systematic review and meta-analysis.
- Author
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Cipriano G Jr, Cipriano VT, da Silva VZ, Cipriano GF, Chiappa GR, de Lima AC, Cahalin LP, and Arena R
- Subjects
- Biomarkers, Carbon Dioxide, Heart Failure, Systolic physiopathology, Humans, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Prognosis, Exercise physiology, Exercise Therapy methods, Heart Failure, Systolic therapy
- Abstract
From previous systematic reviews and meta-analyses, there is consensus about the positive effect of exercise training on exercise capacity for systolic heart failure (HF); however, the effect on actual prognostic markers such as NTproBNP and minute ventilation/carbon dioxide production (VE/VCO2) slope has not been evaluated. The primary aim of the proposed study is to determine the effect of aerobic exercise training (AEX) on the VE/VCO2 slope and NTproBNP. The following databases (up to February 30, 2013) were searched with no language limitations: CENTRAL (The Cochrane Library 2013, issue 2), MEDLINE (from January 1966), EMBASE (from January 1980), and Physiotherapy Evidence Database (PEDro) (from January 1929). We screened reference lists of articles and also conducted an extensive hand search of the literature. Randomized controlled trials of exercise-based interventions with 2-month follow-up or longer compared to usual medical care or placebo were included. The study population comprised adults aged between 18 and 65 years, with evidence of chronic systolic heart failure (LVEF < 45 % and baseline NTproBNP > 300 pg/ml). Two review authors independently extracted data on study design, participants, interventions, and outcomes. We assessed the risk of bias using PEDro scale. We calculated mean differences (MD) or standardized mean differences between intervention and control groups for outcomes with sufficient data; for other outcomes, we described findings from individual studies. Eight studies involving a total of 408 participants met the inclusion criteria across the NTproBNP (5 studies with 191 patients) and VE/VCO2 slope (4 studies with 217 patients). Aerobic exercise significantly improved NTproBNP by a MD of -817.75 [95 % confidence interval (CI) -929.31 to -706.19]. Mean differences across VE/VCO2 slope were -6.55 (95 % CI -7.24 to -5.87). Those patients' characteristics and exercise were similar (frequency = 3-5 times/week; duration = 20-50 min/day; intensity = 60-80 % of VO2 peak) on the included studies. Moreover, the risk of bias across all studies was homogeneous (PEDro scale = 7-8 points). However, based on the statistical analysis, the heterogeneity among the studies was still high, which is related to the variable characteristics of the studies. Aerobic exercise may be effective at improving NTproBNP and the VE/VCO2 slope in systolic HF patients, but these effects are limited to a specific HF population meeting specific inclusion criterion in a limited number of studies. Future randomized controlled studies including diastolic and HF overleap with pulmonary diseases are needed to better understand the exact influence of AEX.
- Published
- 2014
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12. Noninvasive ventilation improves the cardiovascular response and fatigability during resistance exercise in patients with heart failure.
- Author
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da Silva VZ, Lima A, Cipriano GB, da Silva ML, Campos FV, Arena R, Martins WR, Chiappa G, Bottaro M, and Cipriano G
- Subjects
- Cross-Over Studies, Double-Blind Method, Exercise Test, Fatigue etiology, Fatigue physiopathology, Follow-Up Studies, Heart Failure complications, Heart Failure physiopathology, Humans, Male, Middle Aged, Oxygen Consumption, Treatment Outcome, Blood Pressure physiology, Exercise Therapy methods, Exercise Tolerance physiology, Fatigue rehabilitation, Heart Failure rehabilitation, Noninvasive Ventilation methods
- Abstract
Purpose: Noninvasive ventilation may improve cardiovascular function and exercise performance. We evaluated the physiologic impact of noninvasive ventilation during isokinetic knee extension resistance exercise in patients with heart failure., Methods: This clinical trial included 10 male compensated patients with ischemic heart failure (age, 57 ± 9.1 years; ejection fraction, 28.5 ± 5.8%). Subjects underwent 2 bouts of exercise on an isokinetic dynamometer, separated by 72 hours of rest. The resistance exercise was concentric knee extension, at a speed of 60°/s. Five sets of 10 repetitions were performed during the 2 exercise bouts, and each set was separated by 2 minutes of rest. Subjects were administered either bilevel positive airway pressure ventilation (BV) or sham ventilation 20 minutes before and during the 2 exercise sessions in a randomized fashion. Heart rate, systolic blood pressure, and diastolic blood pressure were measured at rest, during exercise, and into recovery. Changes in peak torque (ΔPT), total work (ΔTW), and power (ΔPw) between the fifth and first sets were also measured., Results: Compared with the sham intervention, BV significantly decreased heart rate, systolic blood pressure, and diastolic blood pressure at rest and during exercise (P < .01). There were no significant differences in these variables during recovery. Bi-level positive airway pressure ventilation also significantly reduced ΔPT, ΔTW, and ΔPw compared with the sham intervention (P < .01)., Conclusions: Bi-level positive airway pressure ventilation significantly improved the cardiovascular response and fatigability during resistance exercise in patients with heart failure. These results suggest that use of BV during exercise training may be beneficial in this population with chronic disease.
- Published
- 2013
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13. Association between physical activity measurements and key parameters of cardiopulmonary exercise testing in patients with heart failure.
- Author
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da Silva VZ, Lima AC, Vargas FT, Cahalin LP, Arena R, and Cipriano G Jr
- Subjects
- Aged, Cross-Sectional Studies, Databases, Factual, Humans, Male, Middle Aged, Oxygen Consumption physiology, Exercise Test methods, Heart Failure diagnosis, Heart Failure physiopathology, Motor Activity physiology
- Abstract
Background: A hallmark characteristic of heart failure (HF) is reduced physical activity (PA) patterns. The relationship between key cardiopulmonary exercise testing (CPX) variables and PA patterns has not been investigated. Therefore, we evaluated PA patterns in patients with ischemic HF and its relationship to peak oxygen consumption (VO2), the minute ventilation/carbon dioxide production (VE/VCO2) slope, and the oxygen uptake efficiency slope (OUES)., Methods and Results: Sixteen patients with HF wore an accelerometer for six days to measure total steps/day as well as percentage of time at light, moderate, and vigorous PA. Symptom-limited CPX was performed on a treadmill using a ramping protocol. Total steps correlated with VO2 (r = 0.64 P < .05), the VE/VCO2 slope (r = -0.72; P < .05), and the OUES (0.63; P < .05). The percentage of time at light-intensity PA correlated with the VE/VCO2 slope (r = 0.58; P < .05) and the OUES (r = -0.51; P < .05). The percentage of time at vigorous-intensity PA correlated with peak VO2 (r = 0.55; P < .05) and the VE/VCO2 slope (r = -0.52; P < .05)., Conclusions: PA assessed by accelerometer is significantly associated with key CPX variables in patients with HF., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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14. Elastic resistance training to increase muscle strength in elderly: a systematic review with meta-analysis.
- Author
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Martins WR, de Oliveira RJ, Carvalho RS, de Oliveira Damasceno V, da Silva VZ, and Silva MS
- Subjects
- Humans, Middle Aged, Aged physiology, Muscle Strength, Resistance Training instrumentation
- Abstract
Analyze the efficiency of training programs with progressive elastic resistance on muscle strength in elderly 'healthy' and 'not healthy'. It was performed a systematic review in relevant databases to identify controlled clinical trials with outcomes from parameters of muscle strength. Two independent reviewers decided about the inclusion criteria, data extraction and evaluation of methodological quality of the articles. Standardized mean difference (SMD) and 95% confidence intervals (CI) were calculated for relevant outcomes and pooled using a random effects model. Among the 11 studies whose effect sizes were used in the meta-analysis, there were 834 individuals between the ages of 60 and 79. The resistance training with elastic bands showed strong effects on muscle strength in healthy elderly (SMD=1.30; 95% CI: 0.90, 1.71) and with some functional incapacity (SMD=1.01; 95% CI: 0.82, 1.19), and a moderate effect on muscle strength in elderly patients with pathology (SMD=0.54; 95% CI: 0.12, 0.96). There was little information available about the training intensity. The training with elastic resistance proved to be effective for improving muscle strength in 'healthy' and 'not healthy' elderly. Our results suggest that training with elastic resistance is most effective in 'healthy' subjects and with functional limitations, and less effective in subjects with some kind of disorders. To establish dose-response relations from different intensities of training on muscle strength in the elderly, new studies are needed to identify reliable and objective methods of evaluation of muscle strength using elastic materials directly., (Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2013
- Full Text
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