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182 results on '"de Bont, Eveline S.J.M."'

13. Data from VEGFC Antibody Therapy Drives Differentiation of AML

Author

Kampen, Kim R., primary, Scherpen, Frank J.G., primary, Mahmud, Hasan, primary, ter Elst, Arja, primary, Mulder, André B., primary, Guryev, Victor, primary, Verhagen, Han J.M.P., primary, De Keersmaecker, Kim, primary, Smit, Linda, primary, Kornblau, Steven M., primary, and De Bont, Eveline S.J.M., primary

Published
2023
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16. Supplementary Table 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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19. Supplementary Table 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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20. Supplementary Figure 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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22. Supplementary Figure 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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23. Supplementary Figure 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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24. Supplementary Table 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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25. Supplementary Table 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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26. Supplementary Figure 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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31. Clinical relevance of proteomic profiling in de novo pediatric acute myeloid leukemia: a Children’s Oncology Group study

Author

Hoff, Fieke W., van Dijk, Anneke D., Qiu, Yihua, Hu, Chenyue W., Ries, Rhonda E., Ligeralde, Andrew, Jenkins, Gaye N., Gerbing, Robert B., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Alonzo, Todd A., Meshinchi, Soheil, Qutub, Amina A., de Bont, Eveline S.J.M., Horton, Terzah M., and Kornblau, Steven M.

Abstract

Pediatric acute myeloid leukemia (AML) remains a fatal disease for at least 30% of patients, stressing the need for improved therapies and better risk stratification. As proteins are the unifying feature of (epi)genetic and environmental alterations, and are often targeted by novel chemotherapeutic agents, we studied the proteomic landscape of pediatric AML. Protein expression and activation levels were measured in 500 bulk leukemic patients’ samples and 30 control CD34+ cell samples, using reverse phase protein arrays with 296 strictly validated antibodies. The multistep MetaGalaxy analysis methodology was applied and identified nine protein expression signatures (PrSIG), based on strong recurrent protein expression patterns. PrSIG were associated with cytogenetics and mutational state, and with favorable or unfavorable prognosis. Analysis based on treatment (i.e., ADE vs. ADE plus bortezomib) identified three PrSIG that did better with ADE plus bortezomib than with ADE alone. When PrSIG were studied in the context of cytogenetic risk groups, PrSIG were independently prognostic after multivariate analysis, suggesting a potential value for proteomics in combination with current classification systems. Proteins with universally increased (n=7) or decreased (n=17) expression were observed across PrSIG. Certain proteins significantly differentially expressed from normal could be identified, forming a hypothetical platform for personalized medicine.

Published
2022

36. High-frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine

Author

Bachas, Costa, Schuurhuis, Gerrit Jan, Hollink, Iris H.I.M., Kwidama, Zinia J., Goemans, Bianca F., Zwaan, C. Michel, van den Heuvel-Eibrink, Marry M., de Bont, Eveline S.J.M., Reinhardt, Dirk, Creutzig, Ursula, de Haas, Valerie, Assaraf, Yehuda G., Kaspers, Gertjan J.L., and Cloos, Jacqueline

Published
2010
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39. Chemotherapy treatment in pediatric patients with acute myeloid leukemia receiving antimicrobial prophylaxis leads to a relative increase of colonization with potentially pathogenic bacteria in the gut

Author

van Vliet, Michel J., Tissing, Wim J.E., Dun, Catharina A.J., Meessen, Nico E.L., Kamps, Willem A., de Bont, Eveline S.J.M., and Harmsen, Hermie J.M.

Subjects
Chemotherapy -- Complications and side effects, Chemotherapy -- Demographic aspects, Chemotherapy -- Research, Antibiotics -- Physiological aspects, Antibiotics -- Demographic aspects, Antibiotics -- Research, Microbiota (Symbiotic organisms) -- Research, Cancer -- Chemotherapy, Cancer -- Complications and side effects, Cancer -- Demographic aspects, Cancer -- Research, Health, Health care industry
Published
2009

44. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3

Author

Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M., Duffourd, Yannis, Duijkers, Floor, Avila, Magali, Geneviève, David, Houcinat, Nada, Jouan, Thibaud, Kuentz, Paul, Lichtenbelt, Klaske D., Thauvin-Robinet, Christel, St-Onge, Judith, Thevenon, Julien, van Gassen, Koen L.I., van Haelst, Mieke, van Koningsbruggen, Silvana, Hess, Daniel, Smallwood, Sebastien A., Rivière, Jean Baptiste, Faivre, Laurence, Betschinger, Joerg, Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M., Duffourd, Yannis, Duijkers, Floor, Avila, Magali, Geneviève, David, Houcinat, Nada, Jouan, Thibaud, Kuentz, Paul, Lichtenbelt, Klaske D., Thauvin-Robinet, Christel, St-Onge, Judith, Thevenon, Julien, van Gassen, Koen L.I., van Haelst, Mieke, van Koningsbruggen, Silvana, Hess, Daniel, Smallwood, Sebastien A., Rivière, Jean Baptiste, Faivre, Laurence, and Betschinger, Joerg

Published
2019

45. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3

Author

Genetica, UMC Utrecht, Genetica Klinische Genetica, Child Health, Genetica Sectie Genoomdiagnostiek, Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M., Duffourd, Yannis, Duijkers, Floor, Avila, Magali, Geneviève, David, Houcinat, Nada, Jouan, Thibaud, Kuentz, Paul, Lichtenbelt, Klaske D., Thauvin-Robinet, Christel, St-Onge, Judith, Thevenon, Julien, van Gassen, Koen L.I., van Haelst, Mieke, van Koningsbruggen, Silvana, Hess, Daniel, Smallwood, Sebastien A., Rivière, Jean Baptiste, Faivre, Laurence, Betschinger, Joerg, Genetica, UMC Utrecht, Genetica Klinische Genetica, Child Health, Genetica Sectie Genoomdiagnostiek, Villegas, Florian, Lehalle, Daphné, Mayer, Daniela, Rittirsch, Melanie, Stadler, Michael B., Zinner, Marietta, Olivieri, Daniel, Vabres, Pierre, Duplomb-Jego, Laurence, De Bont, Eveline S.J.M., Duffourd, Yannis, Duijkers, Floor, Avila, Magali, Geneviève, David, Houcinat, Nada, Jouan, Thibaud, Kuentz, Paul, Lichtenbelt, Klaske D., Thauvin-Robinet, Christel, St-Onge, Judith, Thevenon, Julien, van Gassen, Koen L.I., van Haelst, Mieke, van Koningsbruggen, Silvana, Hess, Daniel, Smallwood, Sebastien A., Rivière, Jean Baptiste, Faivre, Laurence, and Betschinger, Joerg

Published
2019

48. RNA-based FLT3-ITD allelic ratio is associated with outcome and ex vivo response to FLT3 inhibitors in pediatric AML

Author

Cucchi, David G.J., Denys, Barbara, Kaspers, Gertjan J.L., Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., de Haas, Valérie, Zwaan, C. Michel, van den Heuvel-Eibrink, Marry M., Philippé, Jan, Csikós, Tamás, Kwidama, Zinia, de Moerloose, Barbara, de Bont, Eveline S.J.M., Lissenberg-Witte, Birgit I., Zweegman, Sonja, Verwer, Femke, Vandepoele, Karl, Schuurhuis, Gerrit Jan, Sonneveld, Edwin, and Cloos, Jacqueline

Published
2018
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49. Peptide microarray of pediatric acute myeloid leukemia is related to relapse and reveals involvement of DNA damage response and repair

Author

Mahmud, Hasan, primary, Elst, Arja ter, additional, Scherpen, Frank J.G., additional, Boer, Tiny Meeuwsen-de, additional, Kampen, Kim R., additional, Haas, Valérie de, additional, Guryev, Victor, additional, Peppelenbosch, Maikel M., additional, Kornblau, Steven M., additional, and de Bont, Eveline S.J.M., additional

Published
2019
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50. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3

Author

Villegas, Florian, primary, Lehalle, Daphné, additional, Mayer, Daniela, additional, Rittirsch, Melanie, additional, Stadler, Michael B., additional, Zinner, Marietta, additional, Olivieri, Daniel, additional, Vabres, Pierre, additional, Duplomb-Jego, Laurence, additional, De Bont, Eveline S.J.M., additional, Duffourd, Yannis, additional, Duijkers, Floor, additional, Avila, Magali, additional, Geneviève, David, additional, Houcinat, Nada, additional, Jouan, Thibaud, additional, Kuentz, Paul, additional, Lichtenbelt, Klaske D., additional, Thauvin-Robinet, Christel, additional, St-Onge, Judith, additional, Thevenon, Julien, additional, van Gassen, Koen L.I., additional, van Haelst, Mieke, additional, van Koningsbruggen, Silvana, additional, Hess, Daniel, additional, Smallwood, Sebastien A., additional, Rivière, Jean-Baptiste, additional, Faivre, Laurence, additional, and Betschinger, Joerg, additional

Published
2019
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