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429 results on '"de Grey, Aubrey D.N.J."'

1. The Divide-and-Conquer Approach to Delaying Age-Related Functional Decline: Where Are We Now?

Author

de Grey, Aubrey D.N.J.

Subjects
*BIOLOGY, *BULLETS
Abstract

Over 20 years ago, together with seven illustrious colleagues, the author proposed that efforts to postpone the decline and debilitation of aging might most promisingly be pursued by tackling the various lifelong processes of accumulation of damage through a panel of interventions, rather than seeking a magic bullet that would retard them all. A decade later, this approach was embraced in a paper that rapidly became, and is still, by far the most highly cited publication in the biology of aging this century. Here I survey the progress that the field has made in relation to this philosophy and the challenges that remain. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
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29. Latest advances in aging research and drug discovery

Author

Bakula, Daniela, Ablasser, Andrea, Aguzzi, Adriano, Antebi, Adam, Barzilai, Nir, Bittner, Martin Immanuel, Jensen, Martin Borch, Calkhoven, Cornelis F., Chen, Danica, de Grey, Aubrey D.N.J., Feige, Jerome N., Georgievskaya, Anastasia, Gladyshev, Vadim N., Golato, Tyler, Gudkov, Andrei V., Hoppe, Thorsten, Kaeberlein, Matt, Katajisto, Pekka, Kennedy, Brian K., Lal, Unmesh, Martin-Villalba, Ana, Moskalev, Alexey A., Ozerov, Ivan, Petr, Michael A., Reason, Rubinsztein, David C., Tyshkovskiy, Alexander, Vanhaelen, Quentin, Zhavoronkov, Alex, Scheibye-Knudsen, Morten, Bakula, Daniela, Ablasser, Andrea, Aguzzi, Adriano, Antebi, Adam, Barzilai, Nir, Bittner, Martin Immanuel, Jensen, Martin Borch, Calkhoven, Cornelis F., Chen, Danica, de Grey, Aubrey D.N.J., Feige, Jerome N., Georgievskaya, Anastasia, Gladyshev, Vadim N., Golato, Tyler, Gudkov, Andrei V., Hoppe, Thorsten, Kaeberlein, Matt, Katajisto, Pekka, Kennedy, Brian K., Lal, Unmesh, Martin-Villalba, Ana, Moskalev, Alexey A., Ozerov, Ivan, Petr, Michael A., Reason, Rubinsztein, David C., Tyshkovskiy, Alexander, Vanhaelen, Quentin, Zhavoronkov, Alex, and Scheibye-Knudsen, Morten

Abstract

An increasing aging population poses a significant challenge to societies worldwide. A better understanding of the molecular, cellular, organ, tissue, physiological, psychological, and even sociological changes that occur with aging is needed in order to treat age-associated diseases. The field of aging research is rapidly expanding with multiple advances transpiring in many previously disconnected areas. Several major pharmaceutical, biotechnology, and consumer companies made aging research a priority and are building internal expertise, integrating aging research into traditional business models and exploring new go-to-market strategies. Many of these efforts are spearheaded by the latest advances in artificial intelligence, namely deep learning, including generative and reinforcement learning. To facilitate these trends, the Center for Healthy Aging at the University of Copenhagen and Insilico Medicine are building a community of Key Opinion Leaders (KOLs) in these areas and launched the annual conference series titled "Aging Research and Drug Discovery (ARDD)" held in the capital of the pharmaceutical industry, Basel, Switzerland (www.agingpharma.org). This ARDD collection contains summaries from the 6th annual meeting that explored aging mechanisms and new interventions in age-associated diseases. The 7th annual ARDD exhibition will transpire 2nd-4th of September, 2020, in Basel.

Published
2019

31. Preface

Author

DE GREY, AUBREY D.N.J.

Published
2004

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