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1. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L.W., Jóźwiak, K., Ter Hoeve, N.D., van Diest, P.J., Opdam, M., Wang, Y., Schmidt, M.K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R.H.T., Kerver, E.D., van Dalen, T., Bins, A.D., Beeker, A., van den Heiligenberg, S.M., de Jong, P.C., Bakker, S.D., Rietbroek, R.C., Konings, I.R., Blankenburgh, R., Bijlsma, R.M., Imholz, A.L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E.H., Koop, E.A., Varga, Z., van Deurzen, C.H.M., Mooyaart, A.L., Córdoba, A., Groen, E., Bart, J., Willems, S.M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A.C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G.M.H.E., Hauptmann, M., Kok, M., and Linn, S.C.

Published
2024
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4. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, et al, de Boo, L W, Jóźwiak, K; https://orcid.org/0000-0002-9614-6586, Ter Hoeve, N D, van Diest, P J; https://orcid.org/0000-0003-0658-2745, Opdam, M; https://orcid.org/0000-0001-5832-6386, Wang, Y; https://orcid.org/0000-0002-1482-7039, Schmidt, M K; https://orcid.org/0000-0002-2228-429X, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D; https://orcid.org/0009-0004-6456-4857, van Dalen, T, Bins, A D, Beeker, A; https://orcid.org/0000-0003-4133-769X, van den Heiligenberg, S M, de Jong, P C, Bakker, S D; https://orcid.org/0000-0003-3936-4648, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M; https://orcid.org/0000-0003-0980-6652, Imholz, A L T, Stathonikos, N, Vreuls, W; https://orcid.org/0000-0001-6661-6017, Sanders, J, Rosenberg, E H; https://orcid.org/0000-0002-3859-6941, Koop, E A, Varga, Z; https://orcid.org/0000-0002-2855-983X, and et al

Published
2024

5. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, Linn, S C, Pathologie, Cancer, MMB opleiding Arts microbioloog, Neurogenetica, MS CGO, Public Health Practice, Affectieve & Psychotische Med., MS Medische Oncologie, Pathologie Support, Pathologie Pathologen staf, MS Reumatologie/Immunologie/Infectie, Speerpunt Cancer, KVO Docenten, de Boo, L W, Jóźwiak, K, Ter Hoeve, N D, van Diest, P J, Opdam, M, Wang, Y, Schmidt, M K, de Jong, V, Kleiterp, S, Cornelissen, S, Baars, D, Koornstra, R H T, Kerver, E D, van Dalen, T, Bins, A D, Beeker, A, van den Heiligenberg, S M, de Jong, P C, Bakker, S D, Rietbroek, R C, Konings, I R, Blankenburgh, R, Bijlsma, R M, Imholz, A L T, Stathonikos, N, Vreuls, W, Sanders, J, Rosenberg, E H, Koop, E A, Varga, Z, van Deurzen, C H M, Mooyaart, A L, Córdoba, A, Groen, E, Bart, J, Willems, S M, Zolota, V, Wesseling, J, Sapino, A, Chmielik, E, Ryska, A, Broeks, A, Voogd, A C, van der Wall, E, Siesling, S, Salgado, R, Dackus, G M H E, Hauptmann, M, Kok, M, and Linn, S C

Published
2024

6. Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

Author

de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., Linn, S. C., de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H.T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., Konings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L.T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H.M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M.H.E., Hauptmann, M., Kok, M., and Linn, S. C.

Abstract

Background: In the absence of prognostic biomarkers, most patients with early-stage triple-negative breast cancer (eTNBC) are treated with combination chemotherapy. The identification of biomarkers to select patients for whom treatment de-escalation or escalation could be considered remains an unmet need. We evaluated the prognostic value of histopathologic traits in a unique cohort of young, (neo)adjuvant chemotherapy-naïve patients with early-stage (stage I or II), node-negative TNBC and long-term follow-up, in relation to stromal tumor-infiltrating lymphocytes (sTILs) for which the prognostic value was recently reported. Materials and methods: We studied all 485 patients with node-negative eTNBC from the population-based PARADIGM cohort which selected women aged <40 years diagnosed between 1989 and 2000. None of the patients had received (neo)adjuvant chemotherapy according to standard practice at the time. Associations between histopathologic traits and breast cancer-specific survival (BCSS) were analyzed with Cox proportional hazard models. Results: With a median follow-up of 20.0 years, an independent prognostic value for BCSS was observed for lymphovascular invasion (LVI) [adjusted (adj.) hazard ratio (HR) 2.35, 95% confidence interval (CI) 1.49-3.69], fibrotic focus (adj. HR 1.61, 95% CI 1.09-2.37) and sTILs (per 10% increment adj. HR 0.75, 95% CI 0.69-0.82). In the sTILs <30% subgroup, the presence of LVI resulted in a higher cumulative incidence of breast cancer death (at 20 years, 58%; 95% CI 41% to 72%) compared with when LVI was absent (at 20 years, 32%; 95% CI 26% to 39%). In the ≥75% sTILs subgroup, the presence of LVI might be associated with poor survival (HR 11.45, 95% CI 0.71-182.36, two deaths). We confirm the lack of prognostic value of androgen receptor expression and human epidermal growth factor receptor 2 -low status. Conclusions: sTILs, LVI and fibrotic focus provide independent prognostic information in young women with node-negat

Published
2024

7. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study

Author

Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Yusuf, S, Dejesus, J, Agapay, D, Tongana, T, Solano, R, Kay, I, Trottier, S, Rimac, J, Elsheikh, W, Heldman, L, Ramezani, E, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Qing, Deng, Xiaoru, Cheng, Xinye, He, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Rózanska, D, Wolyniec, M, Alkamel, Ali, M, Kruger, M A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Boström, K Bengtsson, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Oguz, A, Imeryuz, N, Altuntas, Y, Gulec, S, Temizhan, A, Karsidag, K, Calik, KBT, Akalin, AAK, Caklili, OT, Keskinler, MV, Erbakan, AN, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Hussain, F, Al Shaibani, H, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Al Shuwaihi, SM, Al Omairi, MA, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, Mapanga, R, Miller, Victoria, Mente, Andrew, Dehghan, Mahshid, Rangarajan, Sumathy, Zhang, Xiaohe, Swaminathan, Sumathi, Dagenais, Gilles, Gupta, Rajeev, Mohan, Viswanathan, Lear, Scott, Bangdiwala, Shrikant I, Schutte, Aletta E, Wentzel-Viljoen, Edelweiss, Avezum, Alvaro, Altuntas, Yuksel, Yusoff, Khalid, Ismail, Noorhassim, Peer, Nasheeta, Chifamba, Jephat, Diaz, Rafael, Rahman, Omar, Mohammadifard, Noushin, Lana, Fernando, Zatonska, Katarzyna, Wielgosz, Andreas, Yusufali, Afzalhussein, Iqbal, Romaina, Lopez-Jaramillo, Patricio, Khatib, Rasha, Rosengren, Annika, Li, Wei, Liu, Jiankang, Liu, Xiaoyun, Yin, Lu, Teo, Koon, Anand, Sonia, and Yusuf, Salim

Published
2017
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8. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study

Author

Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Yusuf, S, Dejesus, J, Agapay, D, Tongana, T, Solano, R, Kay, I, Trottier, S, Rimac, J, Elsheikh, W, Heldman, L, Ramezani, E, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Qing, Deng, Xiaoru, Cheng, Xinye, He, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Rózanska, D, Wolyniec, M, Alkamel, Ali, M, Kruger, M A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Boström, K Bengtsson, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Oguz, A, Imeryuz, N, Altuntas, Y, Gulec, S, Temizhan, A, Karsidag, K, Calik, KBT, Akalin, AAK, Caklili, OT, Keskinler, MV, Erbakan, AN, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Hussain, F, Al Shaibani, H, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Al Shuwaihi, SM, Al Omairi, MA, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, Mapanga, R, Dehghan, Mahshid, Mente, Andrew, Zhang, Xiaohe, Swaminathan, Sumathi, Li, Wei, Mohan, Viswanathan, Iqbal, Romaina, Kumar, Rajesh, Wentzel-Viljoen, Edelweiss, Rosengren, Annika, Amma, Leela Itty, Avezum, Alvaro, Chifamba, Jephat, Diaz, Rafael, Khatib, Rasha, Lear, Scott, Lopez-Jaramillo, Patricio, Liu, Xiaoyun, Gupta, Rajeev, Mohammadifard, Noushin, Gao, Nan, Oguz, Aytekin, Ramli, Anis Safura, Seron, Pamela, Sun, Yi, Szuba, Andrzej, Tsolekile, Lungiswa, Wielgosz, Andreas, Yusuf, Rita, Hussein Yusufali, Afzal, Teo, Koon K, Rangarajan, Sumathy, Dagenais, Gilles, Bangdiwala, Shrikant I, Islam, Shofiqul, Anand, Sonia S, and Yusuf, Salim

Published
2017
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9. Association of dietary nutrients with blood lipids and blood pressure in 18 countries: a cross-sectional analysis from the PURE study

Author

Yusuf, S, Rangarajan, S, Teo, K K, Chow, C K, O'Donnell, M, Mente, A, Leong, D, Smyth, A, Joseph, P, Merchant, A, Islam, S, Zhang, M, Hu, W, Ramasundarahettige, C, Wong, G, Bangdiwala, S, Dyal, L, Casanova, A, Dehghan, M, Lewis, G, Aliberti, A, Arshad, A, Reyes, A, Zaki, A, Lewis, B, Zhang, B, Agapay, D, Hari, D, Milazzo, E, Ramezani, E, Hussain, F, Shifaly, F, McAlpine, G, Kay, I, Lindeman, J, Rimac, J, Swallow, J, Heldman, L, Mushtaha, M(a), Mushtaha, M(o), Trottier, M, Riggi, M, Aoucheva, N, Kandy, N, Mackie, P, Solano, R, Chin, S, Ramacham, S, Shahrook, S, Trottier, S, Tongana, T, ElSheikh, W, Iyengar, Y, McQueen, M, Hall, K, Keys, J, Wang, X, Keneth, J, Devanath, A, Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Dejesus, J, Elsheikh, W, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Qing, Deng, Xiaoru, Cheng, Xinye, He, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Dans, A, Co, HU, Sanchez, JT, Pudol, L, Zamora-Pudol, C, Palileo-Villanueva, LAM, Aquino, MR, Abaquin, C, Pudol, SL, Cabral, ML, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Rózanska, D, Wolyniec, M, AlHabib, KF, Hersi, A, Kashour, T, Alfaleh, H, Alshamiri, M, Altaradi, HB, Alnobani, O, Bafart, A, Alkamel, N, Ali, M, Abdulrahman, M, Nouri, R, Kruger, A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Bengtsson Boström, K, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Yeates, K, Sleeth, J, Kilonzo, K, Oguz, A, Imeryuz, N, Altuntas, Y, Gulec, S, Temizhan, A, Karsidag, K, Calik, KBT, Akalin, AAK, Caklili, OT, Keskinler, MV, Erbakan, AN, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Al Shaibani, H, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Al Shuwaihi, SM, Al Omairi, MA, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, Mapanga, R, Mente, Andrew, Dehghan, Mahshid, Rangarajan, Sumathy, McQueen, Matthew, Dagenais, Gilles, Wielgosz, Andreas, Lear, Scott, Li, Wei, Chen, Hui, Wang, Yang, Diaz, Rafael, Avezum, Alvaro, Lopez-Jaramillo, Patricio, Seron, Pamela, Kumar, Rajesh, Gupta, Rajeev, Mohan, Viswanathan, Swaminathan, Sumathi, Kutty, Raman, Zatonska, Katarzyna, Iqbal, Romaina, Yusuf, Rita, Mohammadifard, Noushin, Khatib, Rasha, Nasir, Nafiza Mat, Ismail, Noorhassim, Oguz, Aytekin, Rosengren, Annika, Yusufali, Afzalhussein, Wentzel-Viljoen, Edelweiss, Puoane, Thandi, Chifamba, Jephat, Teo, Koon, Anand, Sonia S, and Yusuf, Salim

Published
2017
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10. Availability and affordability of blood pressure-lowering medicines and the effect on blood pressure control in high-income, middle-income, and low-income countries: an analysis of the PURE study data

Author

Yusuf, S, Rangarajan, S, Teo, K K, Chow, C K, O'Donnell, M, Mente, A, Leong, D, Smyth, A, Joseph, P, Islam, S, Zhang, M, Hu, W, Ramasundarahettige, C, Wong, G, Dayal, L, Casanova, A, Dehghan, M, Lewis, G, Aliberti, A, Reyes, A, Zaki, A, Lewis, B, Zhang, B, Agapay, D, Hari, D, Milazzo, E, Ramezani, E, Hussain, F, Shifaly, F, Kay, I, Rimac, J, Swallow, J, Heldman, L, Mushtaha, M(a), Mushtaha, M(o), Trottier, M, Aoucheva, N, Kandy, N, Mackie, P, Solano, R, Chin, S, Ramacham, S, Shahrook, S, Trottier, S, Tongana, T, ElSheikh, W, Lindeman, J, McQueen, M, Hall, K, Keys, J, Wang, X, Keneth, J, Devanath, A, Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Maini Cuneo, JM, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Dejesus, J, Elsheikh, W, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, JiaXuan, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Qing, Deng, Xiaoru, Cheng, Xinye, He, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, BianRongwen, TianXiuzhen, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Shankar, K, Kurpad, AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Dans, A, Co, HU, Sanchez, JT, Pudol, L, Zamora-Pudol, C, Palileo-Villanueva, LAM, Aquino, MR, Abaquin, C, Pudol, SL, Cabral, ML, Zatonski, W, Szuba, A, Zatonska, K, Ilow#, R, Ferus, M, Regulska-Ilow, B, Różańska, D, Wolyniec, M, AlHabib, KF, Hersi, A, Kashour, T, Alfaleh, H, Alshamiri, M, Altaradi, HB, Alnobani, O, Bafart, A, Alkamel, N, Ali, M, Abdulrahman, M, Nouri, R, Kruger, A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Boström, K Bengtsson, Lindblad, U, Langkilde, P, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Pettersson, K, Moberg, E, Yeates, K, Sleeth, J, Kilonzo, K, Oguz, A, Akalin, AAK, Calik, KBT, Imeryuz, N, Temizhan, A, Alphan, E, Gunes, E, Sur, H, Karsidag, K, Gulec, S, Altuntas, Y, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Shaibani, H Al, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Shuwaihi, SM Al, Omairi, MA Al, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, Mapanga, R, Attaei, Marjan W, Khatib, Rasha, McKee, Martin, Lear, Scott, Dagenais, Gilles, Igumbor, Ehimario U, AlHabib, Khalid F, Kaur, Manmeet, Kruger, Lanthe, Teo, Koon, Lanas, Fernando, Yusoff, Khalid, Oguz, Aytekin, Gupta, Rajeev, Yusufali, Afzalhussein M, Bahonar, Ahmad, Kutty, Raman, Rosengren, Annika, Mohan, Viswanathan, Avezum, Alvaro, Yusuf, Rita, Szuba, Andrzej, Rangarajan, Sumathy, Chow, Clara, and Yusuf, Salim

Published
2017
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11. Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules

Author

van Loo, B., ten Den, S.A., Araújo-Gomes, N., de Jong, V., Snabel, R.R., Schot, M., Rivera-Arbeláez, J.M., Veenstra, G.J.C., Passier, R., Kamperman, T., Leijten, J., van Loo, B., ten Den, S.A., Araújo-Gomes, N., de Jong, V., Snabel, R.R., Schot, M., Rivera-Arbeláez, J.M., Veenstra, G.J.C., Passier, R., Kamperman, T., and Leijten, J.

Abstract

Item does not contain fulltext

Published
2023

12. High rates of clinically relevant incidental findings by total-body CT scanning in trauma patients; results of the REACT-2 trial

Author

Treskes, K., Bos, S. A., Beenen, L. F. M., Sierink, J. C., Edwards, M. J. R., Beuker, B. J. A., Muradin, G. S. R., Hohmann, J., Luitse, J. S. K., Hollmann, M. W., Dijkgraaf, M. G. W., Goslings, J. C., Saltzherr, T. P., Schepers, T., de Jong, V. M., van Vugt, R., Brink, M., Peters, J., El Moumni, M., Harbers, J. S., Wendt, K. W., van Lieshout, E. M. M., Elzinga, M. J., Jansen, E. H., Zähringer, C., Bless, N., Bingisser, R., and on behalf of the REACT-2 study group

Published
2017
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15. LBA14 Intensified alkylating chemotherapy with autologous stem cell rescue (IACT) or conventional chemotherapy followed by olaparib (CCT-O) in stage III, HER2-negative, homologous recombination deficient (HRD) breast cancer (BC): Survival results of the randomized-controlled SUBITO trial

Author

Linn, S., Seefat, R.L., De Jong, V., Vliek, S.B., Balduzzi, S., Bijlsma, R.M., Jongen-Lavrencic, M., Mandjes, I., Delfos, M., Schot, M., van Rosmalen, M.M., Retel, V., Eekhout, I., Kuip, E., Gonçalves, A., Nuver, J., Wymenga, M., Konings, I.R., Tjan-Heijnen, V., and Jager, A.

Published
2024
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16. Additional file 1 of Indwelling time of peripherally inserted central catheters and incidence of bloodstream infections in haematology patients: a cohort study

Author

Caris, M. G., de Jonge, N. A., Punt, H. J., Salet, D. M., de Jong, V. M. T., Lissenberg-Witte, B. I., Zweegman, S., Vandenbroucke-Grauls, C. M. J. E., van Agtmael, M. A., and Janssen, J. J. W. M.

Abstract

Additional file 1: Table S1. Annual figures of PICCs, diagnoses and SCT from 2013 to 2020.

Published
2022
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17. Assessing global risk factors for non-fatal injuries from road traffic accidents and falls in adults aged 35–70 years in 17 countries: a cross-sectional analysis of the Prospective Urban Rural Epidemiological (PURE) study

Author

Raina, Parminder, Sohel, Nazmul, Oremus, Mark, Shannon, Harry, Mony, Prem, Kumar, Rajesh, Li, Wei, Wang, Yang, Wang, Xingyu, Yusoff, Khalid, Yusuf, Rita, Iqbal, Romaina, Szuba, Andrzej, Oguz, Aytekin, Rosengren, Annika, Kruger, Annamarie, Chifamba, Jephat, Mohammadifard, Noushin, Darwish, Ebtihal Ahmad, Dagenais, Gilles, Diaz, Rafael, Avezum, Alvaro, Lopez-Jaramillo, Patricio, Seron, Pamela, Rangarajan, Sumathy, Teo, Koon, Yusuf, Salim, Yusuf, S, Rangarajan, S, Teo, KK, Chow, C K, OʼDonnell, M, Mente, A, Leong, D, Smyth, A, Joseph, P, Islam, S, Zhang, M, Hu, W, Wong, G, Manandhar, N, Dehghan, M, Royerr, M, DeJesus, J, Lewis, G, Mackie, P, Farago, L, Kay, I, Agapay, D, Solano, R, Ramacham, S, Kandy, N, Rimac, J, Trottier, S, ElSheikh, W, Mustaha, M, Tongana, T, Aoucheva, N, Swallow, J, Ramezani, E, Lindeman, J, McQueen, M, Hall, K, Keys, J, Wang, X, Keneth, J, Devanath, A, Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Yusuf, S, Dejesus, J, Agapay, D, Tongana, T, Solano, R, Kay, I, Trottier, S, Rimac, J, Elsheikh, W, Heldman, L, Ramezani, E, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Qing, Deng, Xiaoru, Cheng, Xinye, He, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PACamacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, S Thakur, J, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Różańska, D, Wolyniec, M, Kruger, A, Voster, HH, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Bengtsson Boström, K, Lindblad, U, Langkilde, P, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Pettersson, K, Moberg, E, Oguz, A, Akalin, AAK, Calik, KBT, Imeryuz, N, Temizhan, A, Alphan, E, Gunes, E, Sur, H, Karsidag, K, Gulec, S, Altuntas, Y, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Omer Awed, SA, Movahedi, GA, Hussain, F, Shaibani, H Al, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Shuwaihi, SM Al, Omairi, MA Al, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Mrambiwa, P, Machiweni, T, and Mapanga, R

Published
2016
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18. Refining the criteria for immediate total-body CT after severe trauma

Author

Treskes, Kaij, Saltzherr, Teun P., Edwards, Michael J. R., Beuker, Benn J. A., van Lieshout, Esther M. M., Hohmann, Joachim, Luitse, Jan S. K., Beenen, Ludo F. M., Hollmann, Markus W., Dijkgraaf, Marcel G. W., Goslings, J. Carel, Sierink, J. C., van Dieren, S., de Jong, V. M., den Hartog, D., Hagenaars, T., Muradin, G. S. R., Bingisser, R., Zähringer, C., Bless, N., van Vugt, R., Tromp, T. N., Brink, M., ten Duis, K., Harbers, J. S., Wendt, K. W., Surgery, Faculteit Medische Wetenschappen/UMCG, Graduate School, AMS - Restoration & Development, APH - Methodology, Radiology and Nuclear Medicine, ACS - Microcirculation, ACS - Pulmonary hypertension & thrombosis, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, ANS - Neurovascular Disorders, ARD - Amsterdam Reproduction and Development, Anesthesiology, ACS - Heart failure & arrhythmias, Epidemiology and Data Science, and AMS - Musculoskeletal Health

Subjects
Adult, Male, PROTOCOLS, medicine.medical_specialty, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Whole body imaging, Logistic regression, RADIATION-EXPOSURE, 030218 nuclear medicine & medical imaging, Multidetector computed tomography, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Injury Severity Score, Trauma Centers, Medicine, Humans, REACT-2, Radiology, Nuclear Medicine and imaging, Whole Body Imaging, BLUNT TRAUMA, Neuroradiology, Whole-body imaging, Emergency Radiology, Receiver operating characteristic, medicine.diagnostic_test, business.industry, Patient Selection, Wounds and injuries, RADIOLOGY, 030208 emergency & critical care medicine, Total body, Interventional radiology, Multiple trauma, General Medicine, Middle Aged, Radiation Exposure, Trauma care, Prognosis, POLYTRAUMA, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Logistic Models, MULTISLICE COMPUTED-TOMOGRAPHY, Severe trauma, WHOLE, Diagnostic imaging, Female, Radiology, business
Abstract

Objectives Initial trauma care could potentially be improved when conventional imaging and selective CT scanning is omitted and replaced by immediate total-body CT (iTBCT) scanning. Because of the potentially increased radiation exposure by this diagnostic approach, proper selection of the severely injured patients is mandatory. Methods In the REACT-2 trial, severe trauma patients were randomized to iTBCT or conventional imaging and selective CT based on predefined criteria regarding compromised vital parameters, clinical suspicion of severe injuries, or high-risk trauma mechanisms in five trauma centers. By logistic regression analysis with backward selection on the 15 study inclusion criteria, a revised set of criteria was derived and subsequently tested for prediction of severe injury and shifts in radiation exposure. Results In total, 1083 patients were enrolled with median ISS of 20 (IQR 9–29) and median GCS of 13 (IQR 3–15). Backward logistic regression resulted in a revised set consisting of nine original and one adjusted criteria. Positive predictive value improved from 76% (95% CI 74–79%) to 82% (95% CI 80–85%). Sensitivity decreased by 9% (95% CI 7–11%). The area under the receiver operating characteristics curve remained equal and was 0.80 (95% CI 0.77–0.83), original set 0.80 (95% CI 0.77–0.83). The revised set retains 8.78 mSv (95% CI 6.01–11.56) for 36% of the non-severely injured patients. Conclusions Selection criteria for iTBCT can be reduced from 15 to 10 clinically criteria. This improves the positive predictive value for severe injury and reduces radiation exposure for less severely injured patients. Key Points • Selection criteria for iTBCT can be reduced to 10 clinically useful criteria. • This reduces radiation exposure in 36% of less severely injured patients. • Overall discriminative capacity for selection of severely injured patients remained equal.

Published
2020
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21. BRCA1 promoter methylation confers a more favorable prognosis to systemically untreated young triple-negative breast cancer patients than tumour BRCA1 mutation

Author

Neurogenetica, Pathologie Opleiding, Cancer, Pathologie, MMB opleiding Arts microbioloog, Pathologie Support, Wang, Y., Rosenberg, E. H., Dackus, G. M. H. E., Broeks, A., Cornelissen, S., van Diest, P. J., Hauptmann, M., Ter Hoeve, N., De Jong, V., Jozwiak, K., Koop, E., Nederlof, P. M., Opdam, M., Siesling, S., Stathonikos, N., Voogd, A., Vreuls, W., Kok, M., Linn, S. C., Schmidt, M. K., Neurogenetica, Pathologie Opleiding, Cancer, Pathologie, MMB opleiding Arts microbioloog, Pathologie Support, Wang, Y., Rosenberg, E. H., Dackus, G. M. H. E., Broeks, A., Cornelissen, S., van Diest, P. J., Hauptmann, M., Ter Hoeve, N., De Jong, V., Jozwiak, K., Koop, E., Nederlof, P. M., Opdam, M., Siesling, S., Stathonikos, N., Voogd, A., Vreuls, W., Kok, M., Linn, S. C., and Schmidt, M. K.

Published
2021

22. Erratum to: High rates of clinically relevant incidental findings by total-body CT scanning in trauma patients: Results of the REACT-2 trial

Author

Treskes, K., Bos, S. A., Beenen, L. F. M., Sierink, J. C., Edwards, M. J. R., Beuker, B. J. A., Muradin, G. S. R., Hohmann, J., Luitse, J. S. K., Hollmann, M. W., Dijkgraaf, M. G. W., Goslings, J. C., Saltzherr, T. P., Schepers, T., de Jong, V. M., van Vugt, R., Brink, M., Peters, J., El Moumni, M., Harbers, J. S., Wendt, K. W., van Lieshout, E. M. M., Elzinga, M. J., Jansen, E. H., Zähringer, C., Bless, N., Bingisser, R., and on behalf of the REACT-2 study group

Published
2017
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23. 9P BRCA1 promoter methylation confers a more favorable prognosis to systemically untreated young triple-negative breast cancer patients than tumour BRCA1 mutation

Author

Wang, Y., primary, Rosenberg, E.H., additional, Dackus, G.M.H.E., additional, Broeks, A., additional, Cornelissen, S., additional, van Diest, P.J., additional, Hauptmann, M., additional, Ter Hoeve, N., additional, De Jong, V., additional, Jozwiak, K., additional, Koop, E., additional, Nederlof, P.M., additional, Opdam, M., additional, Siesling, S., additional, Stathonikos, N., additional, Voogd, A., additional, Vreuls, W., additional, Kok, M., additional, Linn, S.C., additional, and Schmidt, M.K., additional

Published
2021
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26. Diagnostiek en behandeling van fractuur-gerelateerde infecties

Author

Govaert, Geertje A M, Termaat, M Frank, Glaudemans, A W J M, Geurts, J A P, de Jong, T, de Jong, V M, Joosse, P, Kooijmans, H, Overbosch, J, Scheper, H, Spijkerman, I J B, Orthopedie, MUMC+: MA Orthopedie (9), and RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Abstract

Fracture-related infection (FRI) is a serious complication after fracture care and can lead to severe morbidity with loss of quality of life, a significant increase in medical expenses and loss of participation in work and social life. Early recognition, adequate surgical debridement, deep uncontaminated tissue cultures with (if indicated) soft tissue reconstruction and fracture stabilization followed by antibiotic therapy are the cornerstones of the successful management of FRI. Recently, in 2018, the AO/EBJIS consensus definition for FRI was published and both national and international working groups are being assembled and provide guidelines and tools for the care of patients with FRI. This paper is a synopsis of the Dutch guideline on FRI (2018), illustrated by a clinical case, and is aiming to provide an overview of the current knowledge on diagnosis and treatment of this disease.

Published
2019

27. Early detection of severe injuries after major trauma by immediate total-body CT scouts

Author

Zorgeenheid Traumatologie, Treskes, K., Russchen, M. J. A. M., Beenen, L. F. M., de Jong, V. M., Kolkman, S., de Bruin, I. G. J. M., Dijkgraaf, M. G. W., Van Lieshout, E. M. M., Saltzherr, T. P., Goslings, J. C., Zorgeenheid Traumatologie, Treskes, K., Russchen, M. J. A. M., Beenen, L. F. M., de Jong, V. M., Kolkman, S., de Bruin, I. G. J. M., Dijkgraaf, M. G. W., Van Lieshout, E. M. M., Saltzherr, T. P., and Goslings, J. C.

Published
2020

28. Tumor size and overall survival in a cohort of young (≤40 years), nodenegative, systemically untreated breast cancer patients; by the PARADIGM study group

Author

De Jong, V., primary, ter Hoeve, N.D., additional, Opdam, M., additional, Vreuls, W., additional, Koop, E., additional, Varga, Z., additional, Willems, S.M., additional, van Deurzen, C.H.M., additional, Cordoba, A., additional, Broeks, A., additional, Stathonikos, N., additional, Voogd, A., additional, Jozwiak, K., additional, Hauptmann, M., additional, Sonke, G.S., additional, van der Wall, E., additional, Siesling, S., additional, van Diest, P.J., additional, Linn, S.C., additional, and Dackus, G M H E, additional

Published
2019
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31. Multidisciplinaire aanpak bij aangezichtsletsel

Author

Dubois, L., Schreurs, R., Lapid, O., Saeed, P., Adriaensen, G. F., Hoefnagels, F. M., de Jong, V. M., Oral and Maxillofacial Surgery, Plastic, Reconstructive and Hand Surgery, AMS - Restoration & Development, Ophthalmology, Surgery, and ACS - Diabetes & metabolism

Subjects
stomatognathic diseases
Abstract

Approximately one quarter of polytrauma patients has facial injuries, which usually lead to loss of form and function. Several specialties are involved in the acute and reconstructive phases of facial injuries, such as oral and maxillofacial surgery, otorhinolaryngology, plastic surgery, ophthalmology and dentistry. A 25-year-old man with severe facial injuries was brought to the shock room after sustaining high-energy trauma. He had a panfacial fracture that required reconstruction. This was done with two surgeries, with an interval of 4 days. The patient recovered successfully after this. Because of the complexity of facial trauma, many factors are involved in acute care and treatment. It is therefore important to designate one coordinating specialty to guide this process. The oral and maxillofacial surgeon plays a vital role in this

Published
2017

32. De valkuilen bij necrotiserende wekedeleninfecties

Author

de Jong, V. M., Goslings, J. C., Surgery, and Amsterdam Movement Sciences

Subjects
integumentary system
Abstract

Necrotising soft tissue infections require early consultation of an experienced surgeon, regardless of what time of day they occur. Delays in diagnosis and treatment should not occur. Necrotectomy should be skin-sparing when possible. A low threshold for consultation with a tertiary referral center is recommended

Published
2016

33. Association of dietary nutrients with blood lipids and blood pressure in 18 countries: a cross-sectional analysis from the PURE study

Author

Mente, Andrew, primary, Dehghan, Mahshid, additional, Rangarajan, Sumathy, additional, McQueen, Matthew, additional, Dagenais, Gilles, additional, Wielgosz, Andreas, additional, Lear, Scott, additional, Li, Wei, additional, Chen, Hui, additional, Yi, Sun, additional, Wang, Yang, additional, Diaz, Rafael, additional, Avezum, Alvaro, additional, Lopez-Jaramillo, Patricio, additional, Seron, Pamela, additional, Kumar, Rajesh, additional, Gupta, Rajeev, additional, Mohan, Viswanathan, additional, Swaminathan, Sumathi, additional, Kutty, Raman, additional, Zatonska, Katarzyna, additional, Iqbal, Romaina, additional, Yusuf, Rita, additional, Mohammadifard, Noushin, additional, Khatib, Rasha, additional, Nasir, Nafiza Mat, additional, Ismail, Noorhassim, additional, Oguz, Aytekin, additional, Rosengren, Annika, additional, Yusufali, Afzalhussein, additional, Wentzel-Viljoen, Edelweiss, additional, Puoane, Thandi, additional, Chifamba, Jephat, additional, Teo, Koon, additional, Anand, Sonia S, additional, Yusuf, Salim, additional, Yusuf, S, additional, Rangarajan, S, additional, Teo, K K, additional, Chow, C K, additional, O'Donnell, M, additional, Mente, A, additional, Leong, D, additional, Smyth, A, additional, Joseph, P, additional, Merchant, A, additional, Islam, S, additional, Zhang, M, additional, Hu, W, additional, Ramasundarahettige, C, additional, Wong, G, additional, Bangdiwala, S, additional, Dyal, L, additional, Casanova, A, additional, Dehghan, M, additional, Lewis, G, additional, Aliberti, A, additional, Arshad, A, additional, Reyes, A, additional, Zaki, A, additional, Lewis, B, additional, Zhang, B, additional, Agapay, D, additional, Hari, D, additional, Milazzo, E, additional, Ramezani, E, additional, Hussain, F, additional, Shifaly, F, additional, McAlpine, G, additional, Kay, I, additional, Lindeman, J, additional, Rimac, J, additional, Swallow, J, additional, Heldman, L, additional, Mushtaha, M(a), additional, Mushtaha, M(o), additional, Trottier, M, additional, Riggi, M, additional, Aoucheva, N, additional, Kandy, N, additional, Mackie, P, additional, Solano, R, additional, Chin, S, additional, Ramacham, S, additional, Shahrook, S, additional, Trottier, S, additional, Tongana, T, additional, ElSheikh, W, additional, Iyengar, Y, additional, McQueen, M, additional, Hall, K, additional, Keys, J, additional, Wang, X, additional, Keneth, J, additional, Devanath, A, additional, Diaz, R, additional, Orlandini, A, additional, Linetsky, B, additional, Toscanelli, S, additional, Casaccia, G, additional, Cuneo, JM Maini, additional, Rahman, O, additional, Yusuf, R, additional, Azad, AK, additional, Rabbani, KA, additional, Cherry, HM, additional, Mannan, A, additional, Hassan, I, additional, Talukdar, AT, additional, Tooheen, RB, additional, Khan, MU, additional, Sintaha, M, additional, Choudhury, T, additional, Haque, R, additional, Parvin, S, additional, Avezum, A, additional, Oliveira, GB, additional, Marcilio, CS, additional, Mattos, AC, additional, Teo, K, additional, Dejesus, J, additional, Elsheikh, W, additional, Dagenais, G, additional, Poirier, P, additional, Turbide, G, additional, Auger, D, additional, De Bluts, A LeBlanc, additional, Proulx, MC, additional, Cayer, M, additional, Bonneville, N, additional, Lear, S, additional, Gasevic, D, additional, Corber, E, additional, de Jong, V, additional, Vukmirovich, I, additional, Wielgosz, A, additional, Fodor, G, additional, Pipe, A, additional, Shane, A, additional, Lanas, F, additional, Seron, P, additional, Martinez, S, additional, Valdebenito, A, additional, Oliveros, M, additional, Wei, Li, additional, Lisheng, Liu, additional, Chunming, Chen, additional, Xingyu, Wang, additional, Wenhua, Zhao, additional, Hongye, Zhang, additional, Xuan, Jia, additional, Bo, Hu, additional, Jian, Bo, additional, Xiuwen, Zhao, additional, Xiaohong, Chang, additional, Tao, Chen, additional, Hui, Chen, additional, Qing, Deng, additional, Xiaoru, Cheng, additional, Xinye, He, additional, Jian, Li, additional, Juan, Li, additional, Xu, Liu, additional, Bing, Ren, additional, Wei, Wang, additional, Yang, Wang, additional, Jun, Yang, additional, Yi, Zhai, additional, Manlu, Zhu, additional, Fanghong, Lu, additional, Jianfang, Wu, additional, Yindong, Li, additional, Yan, Hou, additional, Liangqing, Zhang, additional, Baoxia, Guo, additional, Xiaoyang, Liao, additional, Shiying, Zhang, additional, Rongwen, Bian, additional, Xiuzhen, Tian, additional, Dong, Li, additional, Di, Chen, additional, Jianguo, Wu, additional, Yize, Xiao, additional, Tianlu, Liu, additional, Peng, Zhang, additional, Changlin, Dong, additional, Ning, Li, additional, Xiaolan, Ma, additional, Yuqing, Yang, additional, Rensheng, Lei, additional, Minfan, Fu, additional, Jing, He, additional, Yu, Liu, additional, Xiaojie, Xing, additional, Qiang, Zhou, additional, Lopez-Jaramillo, P, additional, Lopez, PA Camacho, additional, Garcia, R, additional, Jurado, LJA, additional, Gómez-Arbeláez, D, additional, Arguello, JF, additional, Dueñas, R, additional, Silva, S, additional, Pradilla, LP, additional, Ramirez, F, additional, Molina, DI, additional, Cure-Cure, C, additional, Perez, M, additional, Hernandez, E, additional, Arcos, E, additional, Fernandez, S, additional, Narvaez, C, additional, Paez, J, additional, Sotomayor, A, additional, Garcia, H, additional, Sanchez, G, additional, David, T, additional, Rico, A, additional, Mony, P, additional, Vaz, M, additional, Bharathi, A V, additional, Swaminathan, S, additional, Kurpad, K Shankar AV, additional, Jayachitra, KG, additional, Kumar, N, additional, Hospital, HAL, additional, Mohan, V, additional, Deepa, M, additional, Parthiban, K, additional, Anitha, M, additional, Hemavathy, S, additional, Rahulashankiruthiyayan, T, additional, Anitha, D, additional, Sridevi, K, additional, Gupta, R, additional, Panwar, RB, additional, Mohan, I, additional, Rastogi, P, additional, Rastogi, S, additional, Bhargava, R, additional, Kumar, R, additional, Thakur, J S, additional, Patro, B, additional, Lakshmi, PVM, additional, Mahajan, R, additional, Chaudary, P, additional, Kutty, V Raman, additional, Vijayakumar, K, additional, Ajayan, K, additional, Rajasree, G, additional, Renjini, AR, additional, Deepu, A, additional, Sandhya, B, additional, Asha, S, additional, Soumya, HS, additional, Kelishadi, R, additional, Bahonar, A, additional, Mohammadifard, N, additional, Heidari, H, additional, Yusoff, K, additional, Ismail, TST, additional, Ng, KK, additional, Devi, A, additional, Nasir, NM, additional, Yasin, MM, additional, Miskan, M, additional, Rahman, EA, additional, Arsad, MKM, additional, Ariffin, F, additional, Razak, SA, additional, Majid, FA, additional, Bakar, NA, additional, Yacob, MY, additional, Zainon, N, additional, Salleh, R, additional, Ramli, MKA, additional, Halim, NA, additional, Norlizan, SR, additional, Ghazali, NM, additional, Arshad, MN, additional, Razali, R, additional, Ali, S, additional, Othman, HR, additional, Hafar, CWJCW, additional, Pit, A, additional, Danuri, N, additional, Basir, F, additional, Zahari, SNA, additional, Abdullah, H, additional, Arippin, MA, additional, Zakaria, NA, additional, Noorhassim, I, additional, Hasni, MJ, additional, Azmi, MT, additional, Zaleha, MI, additional, Hazdi, KY, additional, Rizam, AR, additional, Sazman, W, additional, Azman, A, additional, Khatib, R, additional, Khammash, U, additional, Khatib, A, additional, Giacaman, R, additional, Iqbal, R, additional, Afridi, A, additional, Khawaja, R, additional, Raza, A, additional, Kazmi, K, additional, Dans, A, additional, Co, HU, additional, Sanchez, JT, additional, Pudol, L, additional, Zamora-Pudol, C, additional, Palileo-Villanueva, LAM, additional, Aquino, MR, additional, Abaquin, C, additional, Pudol, SL, additional, Cabral, ML, additional, Zatonski, W, additional, Szuba, A, additional, Zatonska, K, additional, Ilow, R, additional, Ferus, M, additional, Regulska-Ilow, B, additional, Rózanska, D, additional, Wolyniec, M, additional, AlHabib, KF, additional, Hersi, A, additional, Kashour, T, additional, Alfaleh, H, additional, Alshamiri, M, additional, Altaradi, HB, additional, Alnobani, O, additional, Bafart, A, additional, Alkamel, N, additional, Ali, M, additional, Abdulrahman, M, additional, Nouri, R, additional, Kruger, A, additional, Voster, H H, additional, Schutte, A E, additional, Wentzel-Viljoen, E, additional, Eloff, FC, additional, de Ridder, H, additional, Moss, H, additional, Potgieter, J, additional, Roux, AA, additional, Watson, M, additional, de Wet, G, additional, Olckers, A, additional, Jerling, JC, additional, Pieters, M, additional, Hoekstra, T, additional, Puoane, T, additional, Igumbor, E, additional, Tsolekile, L, additional, Sanders, D, additional, Naidoo, P, additional, Steyn, N, additional, Peer, N, additional, Mayosi, B, additional, Rayner, B, additional, Lambert, V, additional, Levitt, N, additional, Kolbe-Alexander, T, additional, Ntyintyane, L, additional, Hughes, G, additional, Swart, R, additional, Fourie, J, additional, Muzigaba, M, additional, Xapa, S, additional, Gobile, N, additional, Ndayi, K, additional, Jwili, B, additional, Ndibaza, K, additional, Egbujie, B, additional, Rosengren, A, additional, Bengtsson Boström, K, additional, Gustavsson, A, additional, Andreasson, M, additional, Snällman, M, additional, Wirdemann, L, additional, Yeates, K, additional, Sleeth, J, additional, Kilonzo, K, additional, Oguz, A, additional, Imeryuz, N, additional, Altuntas, Y, additional, Gulec, S, additional, Temizhan, A, additional, Karsidag, K, additional, Calik, KBT, additional, Akalin, AAK, additional, Caklili, OT, additional, Keskinler, MV, additional, Erbakan, AN, additional, Yusufali, AM, additional, Almahmeed, W, additional, Swidan, H, additional, Darwish, EA, additional, Hashemi, ARA, additional, Al-Khaja, N, additional, Muscat-Baron, JM, additional, Ahmed, SH, additional, Mamdouh, TM, additional, Darwish, WM, additional, Abdelmotagali, MHS, additional, Awed, SA Omer, additional, Movahedi, GA, additional, Al Shaibani, H, additional, Gharabou, RIM, additional, Youssef, DF, additional, Nawati, AZS, additional, Salah, ZAR Abu, additional, Abdalla, RFE, additional, Al Shuwaihi, SM, additional, Al Omairi, MA, additional, Cadigal, OD, additional, Alejandrino, R.S., additional, Chifamba, J, additional, Gwaunza, L, additional, Terera, G, additional, Mahachi, C, additional, Murambiwa, P, additional, Machiweni, T, additional, and Mapanga, R, additional

Published
2017
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34. 179PD - Tumor size and overall survival in a cohort of young (≤40 years), nodenegative, systemically untreated breast cancer patients; by the PARADIGM study group

Author

De Jong, V., ter Hoeve, N.D., Opdam, M., Vreuls, W., Koop, E., Varga, Z., Willems, S.M., van Deurzen, C.H.M., Cordoba, A., Broeks, A., Stathonikos, N., Voogd, A., Jozwiak, K., Hauptmann, M., Sonke, G.S., van der Wall, E., Siesling, S., van Diest, P.J., Linn, S.C., and Dackus, G M H E

Published
2019
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39. Formation of dioxins from combustion micropollutants over MSWI fly ash.

Author

Cieplik, M.K., De Jong, V., Bozovic, J., Liljelind, Per, Marklund, Stellan, Louw, R., Cieplik, M.K., De Jong, V., Bozovic, J., Liljelind, Per, Marklund, Stellan, and Louw, R.

Abstract

Formation of polychlorinated dibenzofurans and dibenzo-p-dioxins (PCDD/Fs) from a model mixture of products of incomplete combustion (PICs) representative of municipal solid waste incineration (MSWI) flue gases, over a fixed bed of MSWI fly ash has been investigated. For comparison, a single model compound (chlorobenzene) was also briefly studied. A newly developed lab-scale system enabled the application of (very) low and stable concentrations of organic substances--of 10(-6) M or less-to approach realistic conditions. Samples taken at several time intervals allowed the observation of changes in rates and patterns due to depletion of the carbon in fly ash. The model flue gas continuously produced PCDDs and PCDFs after the de novo reaction had ceased to occur. Dioxin output levels are comparable to those of "old" MSW incinerators. Replacing the PIC trace constituent phenol by its fully 13C-labeled analogue led to, e.g., PCDD with one labeled ring as prominent product, meaning that the formation is about first order in phenol, contrary to earlier assumptions. The meaning of the results for the formation of dioxins in the MSWI boiler is discussed.

Published
2006

40. Cu/Zn superoxide dismutase gene mutations in amyotrophic lateral sclerosis: correlation between genotype and clinical features

Author

Radunovíc, A, Leigh, Pn, Andersen, Pm, Robberecht, W, Baas, F, De Belleroche, J, Hamida, B, Brooks, Dhj, Camu, W, Chio', Adriano, Collinge, J, Conradi, S, Couratier, P, Christensen, P, Delgler, R, Gredal, O, Hardiman, O, Hawkes, G, Hugon, J, Idrisoglu, H, Ince, P, Jensen, Ts, De Jong, V, Kueter, G, Malafosse, A, Meininger, V, Mitchell, Jd, Mora, J, Morrison, K, Orrell, L, Pall, Hs, Palmer, M, Ronnevi, Lo, Sales, Ml, Schiffer, Davide, Shaw, P, Sostarko, M, Swash, M, Swingler, Rj, Troost, D, Vassipoulos, D, Werdelin, L, Wiles, Cm, Willaims, A, and Young, Ca

Subjects
Pathology, medicine.medical_specialty, Genotype, SOD1, Gene mutation, Book Review, Superoxide dismutase, Degenerative disease, Correspondence, Medicine, Humans, Amyotrophic lateral sclerosis, Gene, Genetics, biology, business.industry, Superoxide Dismutase, Amyotrophic Lateral Sclerosis, medicine.disease, Psychiatry and Mental health, Mutation (genetic algorithm), Mutation, biology.protein, Surgery, Neurology (clinical), business, Research Article
Abstract

We refer to the article by Radunovic et al 1 and the kindred referred to in this article and in the article by Cleveland et al 2 as the Australian superoxide dismutase (SOD1) Gly37Arg familial amyotrophic lateral sclerosis (FALS) kindred. It did seem extraordinary that the same mutation should produce such different disease phenotypes in two separate continents. Investigations in Australia, subsequent to the publication of the paper by Cleveland et al ,2identified the mutation in this family as His43Arg, not Gly37Arg. The mutation was identified as H43R by …

Published
1996

42. Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study

Author

Miller, Victoria, Mente, Andrew, Dehghan, Mahshid, Rangarajan, Sumathy, Zhang, Xiaohe, Swaminathan, Sumathi, Dagenais, Gilles, Gupta, Rajeev, Mohan, Viswanathan, Lear, Scott, Bangdiwala, Shrikant I, Schutte, Aletta E, Wentzel-Viljoen, Edelweiss, Avezum, Alvaro, Altuntas, Yuksel, Yusoff, Khalid, Ismail, Noorhassim, Peer, Nasheeta, Chifamba, Jephat, Diaz, Rafael, Rahman, Omar, Mohammadifard, Noushin, Lana, Fernando, Zatonska, Katarzyna, Wielgosz, Andreas, Yusufali, Afzalhussein, Iqbal, Romaina, Lopez-Jaramillo, Patricio, Khatib, Rasha, Rosengren, Annika, Kutty, V Raman, Li, Wei, Liu, Jiankang, Liu, Xiaoyun, Yin, Lu, Teo, Koon, Anand, Sonia, Yusuf, Salim, Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Yusuf, S, Dejesus, J, Agapay, D, Tongana, T, Solano, R, Kay, I, Trottier, S, Rimac, J, Elsheikh, W, Heldman, L, Ramezani, E, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Xiaohong, Chang, Qing, Deng, Xiaoru, Cheng, Qing, Deng, Xinye, He, Bo, Hu, Xuan, Jia, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Yi, Sun, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Hongye, Zhang, Xiuwen, Zhao, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Rózanska, D, Wolyniec, M, Alkamel, Ali, M, Kruger, M A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Boström, K Bengtsson, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Oguz, A, Imeryuz, N, Altuntas, Y, Gulec, S, Temizhan, A, Karsidag, K, Calik, KBT, Akalin, AAK, Caklili, OT, Keskinler, MV, Erbakan, AN, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Hussain, F, Al Shaibani, H, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Al Shuwaihi, SM, Al Omairi, MA, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, and Mapanga, R

Abstract

The association between intake of fruits, vegetables, and legumes with cardiovascular disease and deaths has been investigated extensively in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, South America, Africa, or south Asia.

Published
2017
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43. Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study

Author

Dehghan, Mahshid, Mente, Andrew, Zhang, Xiaohe, Swaminathan, Sumathi, Li, Wei, Mohan, Viswanathan, Iqbal, Romaina, Kumar, Rajesh, Wentzel-Viljoen, Edelweiss, Rosengren, Annika, Amma, Leela Itty, Avezum, Alvaro, Chifamba, Jephat, Diaz, Rafael, Khatib, Rasha, Lear, Scott, Lopez-Jaramillo, Patricio, Liu, Xiaoyun, Gupta, Rajeev, Mohammadifard, Noushin, Gao, Nan, Oguz, Aytekin, Ramli, Anis Safura, Seron, Pamela, Sun, Yi, Szuba, Andrzej, Tsolekile, Lungiswa, Wielgosz, Andreas, Yusuf, Rita, Hussein Yusufali, Afzal, Teo, Koon K, Rangarajan, Sumathy, Dagenais, Gilles, Bangdiwala, Shrikant I, Islam, Shofiqul, Anand, Sonia S, Yusuf, Salim, Diaz, R, Orlandini, A, Linetsky, B, Toscanelli, S, Casaccia, G, Cuneo, JM Maini, Rahman, O, Yusuf, R, Azad, AK, Rabbani, KA, Cherry, HM, Mannan, A, Hassan, I, Talukdar, AT, Tooheen, RB, Khan, MU, Sintaha, M, Choudhury, T, Haque, R, Parvin, S, Avezum, A, Oliveira, GB, Marcilio, CS, Mattos, AC, Teo, K, Yusuf, S, Dejesus, J, Agapay, D, Tongana, T, Solano, R, Kay, I, Trottier, S, Rimac, J, Elsheikh, W, Heldman, L, Ramezani, E, Dagenais, G, Poirier, P, Turbide, G, Auger, D, De Bluts, A LeBlanc, Proulx, MC, Cayer, M, Bonneville, N, Lear, S, Gasevic, D, Corber, E, de Jong, V, Vukmirovich, I, Wielgosz, A, Fodor, G, Pipe, A, Shane, A, Lanas, F, Seron, P, Martinez, S, Valdebenito, A, Oliveros, M, Wei, Li, Lisheng, Liu, Chunming, Chen, Xingyu, Wang, Wenhua, Zhao, Hongye, Zhang, Xuan, Jia, Bo, Hu, Yi, Sun, Jian, Bo, Xiuwen, Zhao, Xiaohong, Chang, Tao, Chen, Hui, Chen, Xiaohong, Chang, Qing, Deng, Xiaoru, Cheng, Qing, Deng, Xinye, He, Bo, Hu, Xuan, Jia, Jian, Li, Juan, Li, Xu, Liu, Bing, Ren, Yi, Sun, Wei, Wang, Yang, Wang, Jun, Yang, Yi, Zhai, Hongye, Zhang, Xiuwen, Zhao, Manlu, Zhu, Fanghong, Lu, Jianfang, Wu, Yindong, Li, Yan, Hou, Liangqing, Zhang, Baoxia, Guo, Xiaoyang, Liao, Shiying, Zhang, Rongwen, Bian, Xiuzhen, Tian, Dong, Li, Di, Chen, Jianguo, Wu, Yize, Xiao, Tianlu, Liu, Peng, Zhang, Changlin, Dong, Ning, Li, Xiaolan, Ma, Yuqing, Yang, Rensheng, Lei, Minfan, Fu, Jing, He, Yu, Liu, Xiaojie, Xing, Qiang, Zhou, Lopez-Jaramillo, P, Lopez, PA Camacho, Garcia, R, Jurado, LJA, Gómez-Arbeláez, D, Arguello, JF, Dueñas, R, Silva, S, Pradilla, LP, Ramirez, F, Molina, DI, Cure-Cure, C, Perez, M, Hernandez, E, Arcos, E, Fernandez, S, Narvaez, C, Paez, J, Sotomayor, A, Garcia, H, Sanchez, G, David, T, Rico, A, Mony, P, Vaz, M, Bharathi, A V, Swaminathan, S, Kurpad, K Shankar AV, Jayachitra, KG, Kumar, N, Hospital, HAL, Mohan, V, Deepa, M, Parthiban, K, Anitha, M, Hemavathy, S, Rahulashankiruthiyayan, T, Anitha, D, Sridevi, K, Gupta, R, Panwar, RB, Mohan, I, Rastogi, P, Rastogi, S, Bhargava, R, Kumar, R, Thakur, J S, Patro, B, Lakshmi, PVM, Mahajan, R, Chaudary, P, Kutty, V Raman, Vijayakumar, K, Ajayan, K, Rajasree, G, Renjini, AR, Deepu, A, Sandhya, B, Asha, S, Soumya, HS, Kelishadi, R, Bahonar, A, Mohammadifard, N, Heidari, H, Yusoff, K, Ismail, TST, Ng, KK, Devi, A, Nasir, NM, Yasin, MM, Miskan, M, Rahman, EA, Arsad, MKM, Ariffin, F, Razak, SA, Majid, FA, Bakar, NA, Yacob, MY, Zainon, N, Salleh, R, Ramli, MKA, Halim, NA, Norlizan, SR, Ghazali, NM, Arshad, MN, Razali, R, Ali, S, Othman, HR, Hafar, CWJCW, Pit, A, Danuri, N, Basir, F, Zahari, SNA, Abdullah, H, Arippin, MA, Zakaria, NA, Noorhassim, I, Hasni, MJ, Azmi, MT, Zaleha, MI, Hazdi, KY, Rizam, AR, Sazman, W, Azman, A, Khatib, R, Khammash, U, Khatib, A, Giacaman, R, Iqbal, R, Afridi, A, Khawaja, R, Raza, A, Kazmi, K, Zatonski, W, Szuba, A, Zatonska, K, Ilow, R, Ferus, M, Regulska-Ilow, B, Rózanska, D, Wolyniec, M, Alkamel, Ali, M, Kruger, M A, Voster, H H, Schutte, A E, Wentzel-Viljoen, E, Eloff, FC, de Ridder, H, Moss, H, Potgieter, J, Roux, AA, Watson, M, de Wet, G, Olckers, A, Jerling, JC, Pieters, M, Hoekstra, T, Puoane, T, Igumbor, E, Tsolekile, L, Sanders, D, Naidoo, P, Steyn, N, Peer, N, Mayosi, B, Rayner, B, Lambert, V, Levitt, N, Kolbe-Alexander, T, Ntyintyane, L, Hughes, G, Swart, R, Fourie, J, Muzigaba, M, Xapa, S, Gobile, N, Ndayi, K, Jwili, B, Ndibaza, K, Egbujie, B, Rosengren, A, Boström, K Bengtsson, Gustavsson, A, Andreasson, M, Snällman, M, Wirdemann, L, Oguz, A, Imeryuz, N, Altuntas, Y, Gulec, S, Temizhan, A, Karsidag, K, Calik, KBT, Akalin, AAK, Caklili, OT, Keskinler, MV, Erbakan, AN, Yusufali, AM, Almahmeed, W, Swidan, H, Darwish, EA, Hashemi, ARA, Al-Khaja, N, Muscat-Baron, JM, Ahmed, SH, Mamdouh, TM, Darwish, WM, Abdelmotagali, MHS, Awed, SA Omer, Movahedi, GA, Hussain, F, Al Shaibani, H, Gharabou, RIM, Youssef, DF, Nawati, AZS, Salah, ZAR Abu, Abdalla, RFE, Al Shuwaihi, SM, Al Omairi, MA, Cadigal, OD, Alejandrino, R.S., Chifamba, J, Gwaunza, L, Terera, G, Mahachi, C, Murambiwa, P, Machiweni, T, and Mapanga, R

Abstract

The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear.

Published
2017
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44. Cocoa powder increases postprandial insulinemia in lean young adults.

Author

Brand-Miller, J, Holt, SHA, de Jong, V, Petocz, P, Brand-Miller, J, Holt, SHA, de Jong, V, and Petocz, P

Abstract

We hypothesized that chocolate products elicit higher insulin responses than matched products with alternate flavoring. To test this, we used a within-subject, repeated-measures comparison of six pairs of foods, one flavored with chocolate (cocoa powder) and the other not. Healthy subjects (n = 10, 4 men, 6 women) tested each pair of foods. Postprandial glucose and insulin levels were determined at intervals over 2 h using standardized glycemic index (GI) methodology. The product categories were chocolate bars, cakes, breakfast cereals, ice creams, flavored milks and puddings. Although the GI did not differ within each pair, the insulin index (II) of the chocolate product was always higher, by a mean of 28%, than the alternate flavored product (P < 0.001). The greatest difference occurred within the flavored milk category in which the chocolate version elicited 45% greater insulinemia than the strawberry flavored milk (P = 0.021). Macronutrient composition (fat, protein, sugar, fiber or energy density) accounted for nearly all of the variation in GI among the foods, but did not explain differences in insulinemia. The presence of cocoa powder in foods leads to greater postprandial insulin secretion than alternate flavorings. Specific insulinogenic amino acids or greater cephalic phase insulin release may explain the findings.

Published
2003

46. Complete medial column dislocation at the cuneonavicular joint: An unusual Lisfranc-like injury.

Author

Schepers, T., de Jong, V. M., and Luitse, J. S. K.

Abstract

Lisfranc injuries represent a wide spectrum of different injuries at the tarsometatarsal joint. Not all types fit the currently available classifications. This case illustrates a rare subtype of a Lisfranc injury, with a dislocation of the entire first ray. It is presented to create more awareness for midfoot injuries. This article reviews the literature and provides recommendations for the treatment of similar cases in the future. [ABSTRACT FROM AUTHOR]

Published
2014
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47. Variation in the CTLA43'UTR has phenotypic consequences for autoreactive T cells and associates with genetic risk for type 1 diabetes

Author

de Jong, V M, Zaldumbide, A, van der Slik, A R, Laban, S, Koeleman, B P C, and Roep, B O

Abstract

Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a protein receptor that downregulates the immune system. CTLA4gene variants associate with various autoimmune diseases, including type 1 diabetes. Fine mapping of the genetic risk has shown that the genomic region near CTLA4marked by the single-nucleotide polymorphism (SNP) CT60A/G (rs3087243) acts as a susceptibility factor. Yet, the functional basis for the increased susceptibility conferred by rs3087243 remains unclear. We demonstrate that the length of the dinucleotide (AT)nrepeat within the CTLA43’ untranslated region (3'UTR) strongly associates with the risk of SNP CT60A/G (P<6.5 × 10-72). Genomic (AT)nrepeat length inversely correlated with CTLA4 messenger RNA (mRNA) and protein levels in islet autoreactive T-cell lines. Transfer of a long (AT)nelement into T cells lead to a reduction of mRNA compared to a short (AT)nelement. Thus, this study provides evidence for a role of the CTLA43'UTR (AT)nrepeat in the increased genetic risk for islet autoimmunity associated with the CTLA4locus.

Published
2016
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49. ‘ Global Change ’ Impact of Inter-Annual Variation in Water Discharge as a Driving Factor to Dredging and Spoil Disposal in the River Rhine System and of Turbidity in the Wadden Sea

Author

de Jong, V. N. and de Jong, D. J.

Subjects
*GLOBAL environmental change, *BENTHOS
Abstract

Between 1970 to 2000, the annual mean suspended matter (SPM) concentrations in the Vlie and Marsdiep tidal inlets of the Wadden Sea varied over five times. The present paper examines the possible relationship between SPM in the Wadden Sea and changing river Rhine discharges and dredging operations. The major short-term variations in annual mean SPM in part of the Wadden Sea appears to be a non-linear, exponential, function of river Rhine discharge and dredge spoil disposal (110 km to over 200 km from the area in front of the Dutch coast near the river Rhine outlet). Correlation coefficients (with SPM as the fixed and dredge disposal as the independent variable) ranged from r=0·8 (deep tidal inlet of Marsdiep) to r=0·2 (shallow inner area of Vlie) and weakened mainly as a function of distance to the disposal site. The best correlation with river discharge was for Marsdiep tidal inlet (r=0·45), indicating the superior effect of dredge disposal over river discharge-related processes. Taking the estimated regression equation as an explorative model, indicates that, without any disposal of dredge spoil, the expected SPM concentration levels in the tidal inlets of the Wadden Sea will be <15 g m−3 (comparable to the 1950s). The overall mean (and the highest mean) annual concentrations for the investigation period reached 42 (90) g m−3 at Marsdiep and 35 (75) g m−3 at Vlie. Assuming a 10% (220 m−3 s−1) increase in river Rhine discharge over the next 50 years, and unchanged dredging policy and other circumstances, SPM concentrations would increase 5–15% for Marsdiep and Vlie. Compared with the calculated (12·4 g m−3 SPM in Marsdiep and 14·8 g m−3 SPM in Vlie) and measured (15 g m−3 SPM in Marsdiep) background SPM concentrations, the expected overall mean increase since 1950 is at least 250% of background. The natural variation in river Rhine discharge will cause further inter-annual variation. Changes in SPM concentrations, due to expected changes in wind climate, combined with river discharge are estimated to increase SPM concentrations 20% above the present situation. The possible implications of changes in land use in combination with further increasing river discharge, changed wind fields and increased temperature are discussed. An important management conclusion is that increasing mean river discharge will significantly increase the need for dredging and spoil disposal, and result in further elevated SPM concentrations in the Dutch coastal zone and the Wadden Sea. The presented relationships offer possibilities for developing new management strategies in relation to dredging and its effects. [Copyright &y& Elsevier]

Published
2002
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50. A bioflavonoid in sugar cane can reduce the postprandial glycaemic response to a high-GI starchy food.

Author

Holt, S., De Jong, V., Faramus, E., Lang, T., and Miller, J. Brand

Subjects
*BIOFLAVONOIDS, *SUGARCANE, *GLYCEMIC index, *CEREAL products, *NUTRITIONAL assessment
Abstract

The article focuses on a study investigating the ability of bioflavonoid in sugar cane to reduce the postprandial glycaemic response to starchy foods with high-glycaemic index (GI) in Sydney, New South Wales. It is noted that refined cereal products often have high GI values. The study involved 10 health young adults with normal glucose tolerance, who were requested to consume test meals. It has been found that bioflavonoid extract reduced the GI value of a high-GI starchy meal.

Published
2003

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