5 results on '"de Lima, Elisangela Martins"'
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2. Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study
- Author
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Gomes, Marisa Zenaide Ribeiro, primary, Braga, Douglas Quintanilha, additional, Pinheiro, Debora Otero Britto Passos, additional, Verduc, Renata Cristina Amorim Silveira, additional, dos Reis, Letícia Vellozo, additional, de Lima, Elisangela Martins, additional, Lourenço, Newton Dias, additional, Cid, Patrícia Aquen, additional, Beck, Debora Souza, additional, Pinheiro, Luiz Henrique Zanata, additional, Tonhá, João Pedro Silva, additional, de Sousa, Luiza Silva, additional, Dias, Mayra Lopes Secundo, additional, da Silva Machado, Amanda Aparecida, additional, Castro, Murillo Marçal, additional, Dutra, Vitoria Pinson Ruggi, additional, de Mello, Luciana Sênos, additional, da Silva, Maxuel Cassiano, additional, Tozo, Thaisa Medeiros, additional, Mathuiy, Yann Rodrigues, additional, de Abreu Rosas, Lucas Lameirão Pinto, additional, Barros, Paulo Cesar Mendes, additional, da Silva, Jeane Oliveira, additional, da Silva, Priscila Pinho, additional, Bandeira, Carolina Souza, additional, de Sant′Anna Reis Di Chiara Salgado, Scyla Maria, additional, de Oliveira Alves, Marcio Zenaide, additional, Santos, Roberto Queiroz, additional, Marques, José Aurélio, additional, Rodrigues, Caio Augusto Santos, additional, and dos Santos Gomes Junior, Saint Clair, additional
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- 2022
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3. Predictive Score for Carbapenem-Resistant Gram-Negative Bacilli Sepsis: Single-Center Prospective Cohort Study.
- Author
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Gomes, Marisa Zenaide Ribeiro, Braga, Douglas Quintanilha, Pinheiro, Debora Otero Britto Passos, Verduc, Renata Cristina Amorim Silveira, dos Reis, Letícia Vellozo, de Lima, Elisangela Martins, Lourenço, Newton Dias, Cid, Patrícia Aquen, Beck, Debora Souza, Pinheiro, Luiz Henrique Zanata, Tonhá, João Pedro Silva, de Sousa, Luiza Silva, Dias, Mayra Lopes Secundo, da Silva Machado, Amanda Aparecida, Castro, Murillo Marçal, Dutra, Vitoria Pinson Ruggi, de Mello, Luciana Sênos, da Silva, Maxuel Cassiano, Tozo, Thaisa Medeiros, and Mathuiy, Yann Rodrigues
- Subjects
SEPSIS ,GRAM-negative bacteria ,LONGITUDINAL method ,COHORT analysis ,LENGTH of stay in hospitals - Abstract
A clinical–epidemiological score to predict CR-GNB sepsis to guide empirical antimicrobial therapy (EAT), using local data, persists as an unmet need. On the basis of a case–case–control design in a prospective cohort study, the predictive factors for CR-GNB sepsis were previously determined as prior infection, use of mechanical ventilation and carbapenem, and length of hospital stay. In this study, each factor was scored according to the logistic regression coefficients, and the ROC curve analysis determined its accuracy in predicting CR-GNB sepsis in the entire cohort. Among the total of 629 admissions followed by 7797 patient-days, 329 single or recurrent episodes of SIRS/sepsis were enrolled, from August 2015 to March 2017. At least one species of CR-GNB was identified as the etiology in 108 (33%) episodes, and 221 were classified as the control group. The cutoff point of ≥3 (maximum of 4) had the best sensitivity/specificity, while ≤1 showed excellent sensitivity to exclude CR-GNB sepsis. The area under the curve was 0.80 (95% CI: 0.76–0.85) and the number needed to treat was 2.0. The score may improve CR-GNB coverage and spare polymyxins with 22% (95% CI: 17–28%) adequacy rate change. The score has a good ability to predict CR-GNB sepsis and to guide EAT in the future. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Additional file 1 of Geographical information system and spatial–temporal statistics for monitoring infectious agents in hospital: a model using Klebsiella pneumoniae complex
- Author
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da Silva, Priscila Pinho, da Silva, Fabiola A., Rodrigues, Caio Augusto Santos, Souza, Leonardo Passos, de Lima, Elisangela Martins, Pereira, Maria Helena B., Candella, Claudio Neder, de Oliveira Alves, Marcio Zenaide, Lourenço, Newton D., Tassinari, Wagner S., Barcellos, Christovam, and Gomes, Marisa Zenaide Ribeiro
- Abstract
Additional file 1: Table S1. Distribution of wards and beds, and the number of Klebsiella pneumoniae complex isolates per type of ward, unit and floor in the Main and Annex buildings. Fig. S1. Thematic hospital map in QGis format. Table S2. Rectal swab protocol for surveillance of antimicrobial resistant Enterobacteriaceae. Table S3. Categories and antimicrobial agents used for susceptibility testing on K. pneumoniae complex. Algorithm 1. K. pneumoniae complex isolates included and excluded according to the hospital sectors of detection and the reason for exclusion. Fig. S2. Mapped distribution of K. pneumoniae complex isolates. Fig. S3. Thematic hospital maps of annual detection of K. pneumoniae complex according to the antimicrobial susceptibility profiles and regardless of clinical or surveillance samples. Fig. S4. Monthly incidence density of patients infected/colonised by K. pneumoniae complex per 1000 patient-days according to respective phenotypes. Fig. S5. Minimal inhibitory concentration (MIC) of meropenem and imipenem among carbapenem-resistant K. pneumoniae (CRKp) complex recovered from inpatients. Fig. S6. Time series analysis of patients harbouring CRKp complex adjusted by number of microbiological exams performed monthly. Fig. S7. Seasonal Trend decomposition using LOESS (STL) - Time series analysis of patients harbouring CRKp complex. Fig. S8. Seasonal Trend decomposition for data anomaly taking into the account time series data of patients harbouring CRKp complex. Fig. S9. Pattern of annual distribution of patients harbouring CRKp complex. Fig. S10. Space and time circulation of all patients carrying CRKp complex by ward of admission; before, at the time and after the detection of CRKp complex colonisation or infection. Fig. S11. Number of patients infected or colonised by CRKp complex by clustered wards and month of hospitalization, during the first and the second pre-cluster, cluster and post-cluster period. Table S4. Epidemiological and microbiological characteristics and outcome of patients involved in the first and second cluster. Fig. S12. Epidemiological link between patients colonised or infected by CRKp complex during the first cluster and the second cluster.
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- 2021
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5. Geographical information system and spatial–temporal statistics for monitoring infectious agents in hospital: a model using Klebsiella pneumoniae complex.
- Author
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da Silva, Priscila Pinho, da Silva, Fabiola A., Rodrigues, Caio Augusto Santos, Souza, Leonardo Passos, de Lima, Elisangela Martins, Pereira, Maria Helena B., Candella, Claudio Neder, de Oliveira Alves, Marcio Zenaide, Lourenço, Newton D., Tassinari, Wagner S., Barcellos, Christovam, Gomes, Marisa Zenaide Ribeiro, on behalf of Nucleus of Hospital Research Study Collaborators, Dutra, Vitoria Pinson Ruggi, da Silva, Maxuel Cassiano, Tonhá, João Pedro Silva, de Mello, Luciana Sênos, Castro, Murillo Marçal, Mathuiy, Yann Rodrigues, and da Silva Machado, Amanda Aparecida
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KLEBSIELLA pneumoniae ,GEOGRAPHIC information systems ,HOSPITAL utilization ,CHILD patients ,NOSOCOMIAL infections ,DRUG resistance in microorganisms ,HOSPITAL statistics - Abstract
Background: The emergence and spread of antimicrobial resistance and infectious agents have challenged hospitals in recent decades. Our aim was to investigate the circulation of target infectious agents using Geographic Information System (GIS) and spatial–temporal statistics to improve surveillance and control of healthcare-associated infection and of antimicrobial resistance (AMR), using Klebsiella pneumoniae complex as a model. Methods: A retrospective study carried out in a 450-bed federal, tertiary hospital, located in Rio de Janeiro. All isolates of K. pneumoniae complex from clinical and surveillance cultures of hospitalized patients between 2014 and 2016, identified by the use of Vitek-2 system (BioMérieux), were extracted from the hospital's microbiology laboratory database. A basic scaled map of the hospital's physical structure was created in AutoCAD and converted to QGis software (version 2.18). Thereafter, bacteria according to resistance profiles and patients with carbapenem-resistant K. pneumoniae (CRKp) complex were georeferenced by intensive and nonintensive care wards. Space–time permutation probability scan tests were used for cluster signals detection. Results: Of the total 759 studied isolates, a significant increase in the resistance profile of K. pneumoniae complex was detected during the studied years. We also identified two space–time clusters affecting adult and paediatric patients harbouring CRKp complex on different floors, unnoticed by regular antimicrobial resistance surveillance. Conclusions: In-hospital GIS with space–time statistical analysis can be applied in hospitals. This spatial methodology has the potential to expand and facilitate early detection of hospital outbreaks and may become a new tool in combating AMR or hospital-acquired infection. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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