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4. The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

Author

Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J.-M., Deleuze, M., Rull, F., Manrique, J.-A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J.-P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J.-C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q.-M., Legett, IV, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J.-F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H.-C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.

Published
2021
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6. SEIS: Insight’s Seismic Experiment for Internal Structure of Mars

Author

Lognonné, P., Banerdt, W. B., Giardini, D., Pike, W. T., Christensen, U., Laudet, P., de Raucourt, S., Zweifel, P., Calcutt, S., Bierwirth, M., Hurst, K. J., Ijpelaan, F., Umland, J. W., Llorca-Cejudo, R., Larson, S. A., Garcia, R. F., Kedar, S., Knapmeyer-Endrun, B., Mimoun, D., Mocquet, A., Panning, M. P., Weber, R. C., Sylvestre-Baron, A., Pont, G., Verdier, N., Kerjean, L., Facto, L. J., Gharakanian, V., Feldman, J. E., Hoffman, T. L., Klein, D. B., Klein, K., Onufer, N. P., Paredes-Garcia, J., Petkov, M. P., Willis, J. R., Smrekar, S. E., Drilleau, M., Gabsi, T., Nebut, T., Robert, O., Tillier, S., Moreau, C., Parise, M., Aveni, G., Ben Charef, S., Bennour, Y., Camus, T., Dandonneau, P. A., Desfoux, C., Lecomte, B., Pot, O., Revuz, P., Mance, D., tenPierick, J., Bowles, N. E., Charalambous, C., Delahunty, A. K., Hurley, J., Irshad, R., Liu, Huafeng, Mukherjee, A. G., Standley, I. M., Stott, A. E., Temple, J., Warren, T., Eberhardt, M., Kramer, A., Kühne, W., Miettinen, E.-P., Monecke, M., Aicardi, C., André, M., Baroukh, J., Borrien, A., Bouisset, A., Boutte, P., Brethomé, K., Brysbaert, C., Carlier, T., Deleuze, M., Desmarres, J. M., Dilhan, D., Doucet, C., Faye, D., Faye-Refalo, N., Gonzalez, R., Imbert, C., Larigauderie, C., Locatelli, E., Luno, L., Meyer, J.-R., Mialhe, F., Mouret, J. M., Nonon, M., Pahn, Y., Paillet, A., Pasquier, P., Perez, G., Perez, R., Perrin, L., Pouilloux, B., Rosak, A., Savin de Larclause, I., Sicre, J., Sodki, M., Toulemont, N., Vella, B., Yana, C., Alibay, F., Avalos, O. M., Balzer, M. A., Bhandari, P., Blanco, E., Bone, B. D., Bousman, J. C., Bruneau, P., Calef, F. J., Calvet, R. J., D’Agostino, S. A., de los Santos, G., Deen, R. G., Denise, R. W., Ervin, J., Ferraro, N. W., Gengl, H. E., Grinblat, F., Hernandez, D., Hetzel, M., Johnson, M. E., Khachikyan, L., Lin, J. Y., Madzunkov, S. M., Marshall, S. L., Mikellides, I. G., Miller, E. A., Raff, W., Singer, J. E., Sunday, C. M., Villalvazo, J. F., Wallace, M. C., Banfield, D., Rodriguez-Manfredi, J. A., Russell, C. T., Trebi-Ollennu, A., Maki, J. N., Beucler, E., Böse, M., Bonjour, C., Berenguer, J. L., Ceylan, S., Clinton, J., Conejero, V., Daubar, I., Dehant, V., Delage, P., Euchner, F., Estève, I., Fayon, L., Ferraioli, L., Johnson, C. L., Gagnepain-Beyneix, J., Golombek, M., Khan, A., Kawamura, T., Kenda, B., Labrot, P., Murdoch, N., Pardo, C., Perrin, C., Pou, L., Sauron, A., Savoie, D., Stähler, S., Stutzmann, E., Teanby, N. A., Tromp, J., van Driel, M., Wieczorek, M., Widmer-Schnidrig, R., and Wookey, J.

Published
2019
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7. Benefits of homemade chocolate consumption on human health.

Author

Córdova-Avalos, V., Mena-De los Santos, G., Cruz-Palacios, V., Pérez-Flores, Julián, Chávez-García, E., Córdova-Avalos, A., Córdova-Aquino, J., and Izquierdo-Reyes, F.

Subjects
CACAO beans, CHOCOLATE, HUNGER, SENTIMENT analysis, CHI-squared test, SOCIAL interaction, SOCIAL networks, MOTIVATIONAL interviewing, COVID-19 pandemic
Abstract

Objective: To describe the benefits of homemade chocolate consumption on human health in La Chontalpa, Tabasco, Mexico. Design/Methodology/Approach: We interviewed 49 persons in La Chontalpa, along with 30 contacts from social networks; additionally, a participatory workshop was held with 15 persons trained in making homemade chocolate. A traditional specialist doctor who uses cacao as a medicinal base was interviewed and we were observers during cacao ceremonies. The information was analyzed using opinion analysis and the Chi-square test. Results: Ninety-seven-point nine percent of the interviewees agreed that consuming homemade chocolate is beneficial for health, while 89.8% mentioned that consuming chocolate makes them feel good. Fifty-five percent of the consumers consider that chocolate provides them energy; 51.1% say that it helps them to control hunger and thirst; and 36.7% feel that consuming it takes away sadness and laziness. The benefits of chocolate consumption reported in the ceremonies, workshops, and interviews were that it controls depression, promotes concentration, and causes joy; it also cures diarrhea, anemia, headaches, and stomach ache. Study Limitations/Implications: The sanitary restrictions derived from the COVID-19 pandemic limited face-to-face interviews in 2021, which were instead carried out using social networks. It is forbidden to record and take photos and videos of cacao ceremonies; therefore, we were unable to document them. Findings/Conclusions: In La Chontalpa, Tabasco, the population consumes homemade chocolate because they believe that chocolate provides mental and physical health benefits. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Neutrophils contribute to ER stress in lung epithelial cells in the pristane-induced diffuse alveolar hemorrhage mouse model

Author

Moore Re, De Los Santos G, Akaveka L, Mariko L. Ishimori, Caroline A. Jefferies, Gantsetseg Tumurkhuu, Daniel J. Wallace, Yang Wang, Swamy Venuturupalli, Erica N. Montano, Contreras J, Ercan Laguna D, and Lindsy J. Forbess

Subjects
Lung, biology, business.industry, Endoplasmic reticulum, Inflammation, Diffuse alveolar hemorrhage, Lung injury, Peritoneal cavity, medicine.anatomical_structure, Integrin alpha M, Unfolded protein response, Cancer research, biology.protein, Medicine, medicine.symptom, business
Abstract

Diffuse alveolar hemorrhage (DAH), although rare, is a life-threatening complication of systemic lupus erythematosus (SLE). Little is known about the pathophysiology of DAH in humans, although increasingly neutrophils, NETosis and inflammatory monocytes have been shown to play an important role in the pristane-induced model of SLE which develops lung hemorrhage and recapitulates many of the pathologic features of human DAH. Using this experimental model, we asked whether endoplasmic reticulum (ER) stress played a role in driving the pathology of pulmonary hemorrhage and what role infiltrating neutrophils had in this process. Analysis of lung tissue from pristane-treated mice showed genes associated with ER stress and NETosis were increased in a time-dependent manner and reflected the timing of CD11b+Ly6G+ neutrophil accumulation in the lung. Using precision cut lung slices from untreated mice we observed that neutrophils isolated from the peritoneal cavity of pristane-treated mice could directly induce the expression of genes associated with ER stress, namely Chop and Bip. Mice which had myeloid-specific deletion of PAD4 were generated and treated with pristane to assess the involvement of PAD4 and PAD4-dependent NET formation in pristane-induced lung inflammation. Specific deletion of PAD4 in myeloid cells resulted in decreased expression of ER stress genes in the pristane model, with accompanying reduction in IFN-driven genes and pathology. Lastly, coculture experiments of human neutrophils and human lung epithelial cell line (BEAS-2b) showed neutrophils from SLE patients induced significantly more ER stress and interferon-stimulated genes in epithelial cells compared to healthy control neutrophils. These results support a pathogenic role of neutrophils and NETs in lung injury during pristane-induced DAH through the induction of ER stress response and suggest that overactivation of neutrophils in SLE and NETosis may underlie development of DAH.

Published
2021
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9. Convection-Enhanced Drug Delivery and Radiosensitization for Diffuse Midline Glioma.

Author

Gallitto, M., De los Santos, G., Zhang, X., Wei, H.J., Fernández, E. Calvo, Kinslow, C.J., Berg, X., Canoll, P., Bruce, J.N., Gartrell, R., Cheng, S.K., Wechsler-Reya, R., Zhang, Z., and Wu, C.C.

Subjects
*TARGETED drug delivery, *TUMORS in children, *ULTRASONIC imaging, *BLOOD-brain barrier, *LABORATORY mice, *INTRAPERITONEAL injections, *XENOGRAFTS
Abstract

Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. The only approved standard of care is radiation therapy (RT). Studies examining the role of other systemic agents have failed to demonstrate a survival benefit, partially due to tumor extension into areas of the brain where the blood-brain barrier (BBB) remains intact. As our laboratory has recently determined active NAD(P)H Quinone Dehydrogenase 1 (NQO1) expression in patient-derived DMG tumor samples, and RT has been shown to induce NQO1 expression, we sought to investigate the NQO1 bioactivatable ROS inducing agent, Napabucasin, as a potential radiosensitizer in DMG. Furthermore, we explore the safety and feasibility of convection-enhanced drug delivery (CED) to overcome limitations of the BBB. Using two DMG cell lines, we performed clonogenic survival assays with increasing doses of RT with and without Napabucasin. We then created subcutaneous xenograft mouse models, treating with (1) vehicle control, (2) Napabucasin 10mg/kg via intraperitoneal injection, (3) 2 Gy of RT daily, or (4) combination treatment with RT and Napabucasin. Flank tumor measurements were obtained weekly using ultrasound imaging. For our syngeneic orthotopic DMG mouse model, we implanted 7-day osmotic infusion pumps containing either vehicle or 80uM Napabucasin. Mice then underwent a second randomization with or without daily RT for 5 days. Weekly MRIs and daily weights were obtained to measure local control and overall survival (OS), respectively. We identified a robust radiosensitizing effect with Napabucasin using in vitro clonogenic survival assays (Bliss synergy score 16.6). In subcutaneous flank models, combination treatment led to a statistically significant decrease in tumor volume post-treatment completion when compared to any monotherapy (P < 0.05). In our syngeneic orthotopic DMG mouse model, RT after osmotic pump implantation in the brainstem did not lead to significant morbidity or mortality. Combination RT and CED of Napabucasin led to a significant OS benefit when compared to monotherapy (median OS 46 days with combination treatment, 33 days with RT monotherapy, and 26 days with Napabucasin monotherapy, P < 0.001). In this study, we identify Napabucasin as a promising radiosensitizer in DMG. Furthermore, this is the first preclinical study showing safety/efficacy of CED with concurrent RT in DMG. As RT is the cornerstone of DMG care, identifying novel radiosensitizing techniques in this devastating disease is paramount to clinical success. [ABSTRACT FROM AUTHOR]

Published
2024
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10. The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

Author

Química analítica, Kimika analitikoa, Maurice, Sylvestre, Wiens, Roger C., Bernardi, Pernelle, Cais, Philippe, Robinson, Scott H., Nelson, T., Gasnault, Olivier, Reess, Jean-Michel, Deleuze, Muriel, Rull, Fernando, Manrique, José Antonio, Abbaki, S., Anderson, Ryan B., Andre, Yves, Angel, S. M., Arana Momoitio, Gorka, Battault, T., Beck, Pierre, Benzerara, Karim, Bernard, Sylvain, Berthias, J. P., Beyssac, Olivier, Bonafous, M., Bousquet, Bruno, Boutillier, M., Cadu, A., Castro Ortiz de Pinedo, Kepa, Chapron, F., Chide, Baptiste, Clark, Kevin, Clavé, E., Clegg, Sam, Cloutis, Edward, Collin, C., Cordoba, Elizabeth C., Cousin, Agnes, Dameury, J. C., D'Anna, W., Daydou, Y., Debus, A., Deflores, Lauren, Dehouck, E., Delapp, Dorothea, De Los Santos, G., Donny, Christophe, Doressoundiram, A., Dromart, Gilles, Dubois, Bruno, Dufour, A., Dupieux, M., Egan, Miles, Ervin, Joan, Fabre, Cecile, Fau, Amaury, Fischer, Woodward, Forni, Olivie, Fouchet, Thierry, Frydenvang, Jens, Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, Ivair, González, R., Granena, D., Grotzinger, John, Hassen Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, Xavier, Jacquinod, Sophie, Johnson, Jeffrey R., Kouach, D., Lacombe, G., Lanza, Nina, Lapauw, L., Laserna, Javier, Lasue, Jeremie, Le Deit, L., Le Comte, E., Lee, Q. M., Legett, Carey, Leveille, Richard, Lewin, Eric, Leyrat, C., López Reyes, Guillermo, Lorenz, Ralph, Lucero, Briana, Madariaga, J. M., Madsen, Soren, Madsen, Morten, Mangold, Nicolas, Manni, F., Mariscal, J. F., Martínez Frías, Jesús, Mathieu, K., Mathon, R., McCabe, Kevin P., McConnochie, Timothy H., McLennan, Scott M., Mekki, J., Melikechi, Noureddine, Meslin, Pierre-Yves, Micheau, Y., Michel, Y., Michel, John M., Mimoun, David, Misra, Anupam, Montagnac, Gilles, Montaron, C., Montmessin, Franck, Moros, J., Mousset, Valerie, Morizet, Y., Murdoch, Naomi, Newell, Raymond T., Newsom, Horton, Tuong, N. N., Ollila, Ann M., Orttner, G., Oudda, L., Pares, Laurent, Parisot, J., Parot, Yann, Pérez, R., Pheav, D., Picot, L., Pilleri, Paolo, Pilorget, C., Pinet, Patrick, Pont, Gabriel, Poulet, Francois, Quantin-Nataf, C., Quertier, Benjamin, Rambaud, D., Rapin, William, Romano, Philip J., Roucayrol, L., Royer, Clement, Ruellan, M., Sandoval, Benigno, Sautter, Violaine, Schoppers, Marcel J., Schroder, S., Seran, H. C., Sharma, Shiv K., Sobrón, Pablo, Sodki, M., Sournac, A., Sridhar, Vishnu, Standarovsky, D., Storms, Steven, Striebig, N., Tatat, M., Toplis, Michael J., Torre Fernández, Imanol, Toulemont, N., Velasco, C., Veneranda, Marco, Venhaus, Dawn, Virmontois, C., Viso, M., Willis, Peter, Wong, K. W., Química analítica, Kimika analitikoa, Maurice, Sylvestre, Wiens, Roger C., Bernardi, Pernelle, Cais, Philippe, Robinson, Scott H., Nelson, T., Gasnault, Olivier, Reess, Jean-Michel, Deleuze, Muriel, Rull, Fernando, Manrique, José Antonio, Abbaki, S., Anderson, Ryan B., Andre, Yves, Angel, S. M., Arana Momoitio, Gorka, Battault, T., Beck, Pierre, Benzerara, Karim, Bernard, Sylvain, Berthias, J. P., Beyssac, Olivier, Bonafous, M., Bousquet, Bruno, Boutillier, M., Cadu, A., Castro Ortiz de Pinedo, Kepa, Chapron, F., Chide, Baptiste, Clark, Kevin, Clavé, E., Clegg, Sam, Cloutis, Edward, Collin, C., Cordoba, Elizabeth C., Cousin, Agnes, Dameury, J. C., D'Anna, W., Daydou, Y., Debus, A., Deflores, Lauren, Dehouck, E., Delapp, Dorothea, De Los Santos, G., Donny, Christophe, Doressoundiram, A., Dromart, Gilles, Dubois, Bruno, Dufour, A., Dupieux, M., Egan, Miles, Ervin, Joan, Fabre, Cecile, Fau, Amaury, Fischer, Woodward, Forni, Olivie, Fouchet, Thierry, Frydenvang, Jens, Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, Ivair, González, R., Granena, D., Grotzinger, John, Hassen Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, Xavier, Jacquinod, Sophie, Johnson, Jeffrey R., Kouach, D., Lacombe, G., Lanza, Nina, Lapauw, L., Laserna, Javier, Lasue, Jeremie, Le Deit, L., Le Comte, E., Lee, Q. M., Legett, Carey, Leveille, Richard, Lewin, Eric, Leyrat, C., López Reyes, Guillermo, Lorenz, Ralph, Lucero, Briana, Madariaga, J. M., Madsen, Soren, Madsen, Morten, Mangold, Nicolas, Manni, F., Mariscal, J. F., Martínez Frías, Jesús, Mathieu, K., Mathon, R., McCabe, Kevin P., McConnochie, Timothy H., McLennan, Scott M., Mekki, J., Melikechi, Noureddine, Meslin, Pierre-Yves, Micheau, Y., Michel, Y., Michel, John M., Mimoun, David, Misra, Anupam, Montagnac, Gilles, Montaron, C., Montmessin, Franck, Moros, J., Mousset, Valerie, Morizet, Y., Murdoch, Naomi, Newell, Raymond T., Newsom, Horton, Tuong, N. N., Ollila, Ann M., Orttner, G., Oudda, L., Pares, Laurent, Parisot, J., Parot, Yann, Pérez, R., Pheav, D., Picot, L., Pilleri, Paolo, Pilorget, C., Pinet, Patrick, Pont, Gabriel, Poulet, Francois, Quantin-Nataf, C., Quertier, Benjamin, Rambaud, D., Rapin, William, Romano, Philip J., Roucayrol, L., Royer, Clement, Ruellan, M., Sandoval, Benigno, Sautter, Violaine, Schoppers, Marcel J., Schroder, S., Seran, H. C., Sharma, Shiv K., Sobrón, Pablo, Sodki, M., Sournac, A., Sridhar, Vishnu, Standarovsky, D., Storms, Steven, Striebig, N., Tatat, M., Toplis, Michael J., Torre Fernández, Imanol, Toulemont, N., Velasco, C., Veneranda, Marco, Venhaus, Dawn, Virmontois, C., Viso, M., Willis, Peter, and Wong, K. W.

Abstract

On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2-7 m, while providing data at sub-mm to mm scales. We report on SuperCam's science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.

Published
2021

11. The SuperCam Instrument Suite on the Mars 2020 Rover:Science Objectives and Mast-Unit Description

Author

Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., Wong, K. W., Maurice, S., Wiens, R. C., Bernardi, P., Caïs, P., Robinson, S., Nelson, T., Gasnault, O., Reess, J. M., Deleuze, M., Rull, F., Manrique, J. A., Abbaki, S., Anderson, R. B., André, Y., Angel, S. M., Arana, G., Battault, T., Beck, P., Benzerara, K., Bernard, S., Berthias, J. P., Beyssac, O., Bonafous, M., Bousquet, B., Boutillier, M., Cadu, A., Castro, K., Chapron, F., Chide, B., Clark, K., Clavé, E., Clegg, S., Cloutis, E., Collin, C., Cordoba, E. C., Cousin, A., Dameury, J. C., D’Anna, W., Daydou, Y., Debus, A., Deflores, L., Dehouck, E., Delapp, D., De Los Santos, G., Donny, C., Doressoundiram, A., Dromart, G., Dubois, B., Dufour, A., Dupieux, M., Egan, M., Ervin, J., Fabre, C., Fau, A., Fischer, W., Forni, O., Fouchet, T., Frydenvang, J., Gauffre, S., Gauthier, M., Gharakanian, V., Gilard, O., Gontijo, I., Gonzalez, R., Granena, D., Grotzinger, J., Hassen-Khodja, R., Heim, M., Hello, Y., Hervet, G., Humeau, O., Jacob, X., Jacquinod, S., Johnson, J. R., Kouach, D., Lacombe, G., Lanza, N., Lapauw, L., Laserna, J., Lasue, J., Le Deit, L., Le Mouélic, S., Le Comte, E., Lee, Q. M., Legett, C., Leveille, R., Lewin, E., Leyrat, C., Lopez-Reyes, G., Lorenz, R., Lucero, B., Madariaga, J. M., Madsen, S., Madsen, M., Mangold, N., Manni, F., Mariscal, J. F., Martinez-Frias, J., Mathieu, K., Mathon, R., McCabe, K. P., McConnochie, T., McLennan, S. M., Mekki, J., Melikechi, N., Meslin, P.-Y., Micheau, Y., Michel, Y., Michel, J. M., Mimoun, D., Misra, A., Montagnac, G., Montaron, C., Montmessin, F., Moros, J., Mousset, V., Morizet, Y., Murdoch, N., Newell, R. T., Newsom, H., Nguyen Tuong, N., Ollila, A. M., Orttner, G., Oudda, L., Pares, L., Parisot, J., Parot, Y., Pérez, R., Pheav, D., Picot, L., Pilleri, P., Pilorget, C., Pinet, P., Pont, G., Poulet, F., Quantin-Nataf, C., Quertier, B., Rambaud, D., Rapin, W., Romano, P., Roucayrol, L., Royer, C., Ruellan, M., Sandoval, B. F., Sautter, V., Schoppers, M. J., Schröder, S., Seran, H. C., Sharma, S. K., Sobron, P., Sodki, M., Sournac, A., Sridhar, V., Standarovsky, D., Storms, S., Striebig, N., Tatat, M., Toplis, M., Torre-Fdez, I., Toulemont, N., Velasco, C., Veneranda, M., Venhaus, D., Virmontois, C., Viso, M., Willis, P., and Wong, K. W.

Abstract

On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2–7 m, while providing data at sub-mm to mm scales. We report on SuperCam’s science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.

Published
2021

12. Pediatric Barcelona Olfactory Test ̶ 6 (pBOT-6): Validation of a Combined Odor Identification and Threshold Screening Test in Healthy Spanish Children and Adolescents

Author

Mariño-Sánchez, F, primary, Valls-Mateus, M, additional, Fragola, C, additional, de los Santos, G, additional, Aguirre, A, additional, Alonso, J, additional, Valero, J, additional, Santamaría, A, additional, Rojas Lechuga, MJ, additional, Cobeta, I, additional, Alobid, I, additional, and Mullol, J, additional

Published
2020
Full Text
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15. Multimorbidities of Pediatric Allergic Rhinitis

Author

Mariño-Sánchez F, Valls-Mateus M, de Los Santos G, Plaza-Martín AM, Cobeta I, and Mullol J

Subjects
Septal deformity, Adenoids, Turbinate enlargement, Asthma, Atopic dermatitis, Pediatric allergic rhinitis
Abstract

PURPOSE OF REVIEW: Most children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities. RECENT FINDINGS: The presence of AR and one or more accompanying multimorbidities is associated to a higher severity and duration of the disease, a negative impact on quality of life, with worse control and lack of improvement with medical treatment. Therefore, AR needs to be managed with a multidisciplinary collaborative approach. Pediatric AR needs to be considered in the context of a systemic disease, which requires a coordinated therapeutic strategy.

Published
2019

23. Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial

Author

Wanner, Christoph, Heerspink, Hiddo J. L., Zinman, Bernard, Inzucchi, Silvio E., Koitka-Weber, Audrey, Mattheus, Michaela, Hantel, Stefan, Woerle, Hans-Juergen, Broedl, Uli C., von Eynatten, Maximilian, Groop, Per-Henrik, Aizenberg, D., Ulla, M., Waitman, J., De Loredo, L., Farias, J., Fideleff, H., Lagrutta, M., Maldonado, N., Colombo, H., Ferre Pacora, F., Wasserman, A., Maffei, L., Lehman, R., Selvanayagam, J., d'Emden, M., Fasching, P., Paulweber, B., Toplak, H., Luger, A., Drexel, H., Prager, R., Schnack, C., Schernthaner, G., Fliesser-Goerzer, E., Kaser, S., Scheen, A., Van Gaal, Luc, Hollanders, G., Kockaerts, Y., Capiau, L., Chachati, A., Persu, A., Hermans, M., Vantroyen, D., Vercammen, C., Van de Borne, P., Mathieu, C., Benhalima, Katrien, Lienart, F., Mortelmans, J., Strivay, M., Vereecken, G., Keymeulen, B., Lamkanfi, F., Chacra, A., Eliaschewitz, F., Zanella, M., Faludi, A., Bertolami, M., Hayashida, C., Nunes Salles, J., Monte, O., Dinato, M., Manenti, E., Rassi, N., Halpern, A., Lima Filho, M., Ayoub, J., Felicio, J., Borges, J., Gross, J., Sgarbi, J., Betti, R., Tiburcio, A., Purisch, S., Schmid, H., Takahashi, M., Castro, M., Rea, R., Hissa, M., Geloneze Neto, B., Saraiva, J., Henein, S., Lochnan, H., Imran, S. A., Clayton, D., Bayly, K., Berlingieri, J., Boucher, P., Chan, Y., Gupta, M., Chehayeb, R., Ouellett, A., Ur, E., Woo, V., Zinman, B., St Amour, E., Terront Lozano, M., Yupanqui Lozno, H., Urina, M., Lopez Jaramillo, P., Jaramillo, N., Sanchez, G., Perez, G., Tusek, S., Mirosevic, G., Goldoni, V., Jurisic-Erzen, D., Balasko, A., Balic, S., Drvodelic-Sunic, E., Varzic, S. Canecki, Machkova, M., Weiner, P., Lastuvka, J., Olsovsky, J., Krarup, T., Ridderstrale, M., Tarnow, L., Boesgaard, T. Wellov, Lihn, A. Saetre, Christensen, P., Juhl, H., Urhammer, S., Lund, P., Adojaan, B., Jakovlev, U., Lanno, R., Lubi, M., Marandi, T., Gouet, D., Courreges, J., Zaoui, P., Choukroun, G., Petit, C., Formagne, L., Estour, B., Mabire, P., Daugenet, C., Lemarie, B., Clavel, S., Aure, P., Remaud, P., Halimi, J., Hadjadj, S., Couffinhal, T., Glonti, S., Metreveli, D., Lominadze, Z., Giorgadze, E., Burtchuladze, T., Javashvili, L., Kurashvili, G., Kurashvili, R., Virsaladze, D., Nadareishvili, L., Khomasuridze, A., Cahill, T., Green, F., MacRury, S., Waldron, M., Middleton, A., McKnight, J., Pearson, E., Butler, M., Choksi, M., Caldwell, I., Farmer, I., Wyatt, N., Patrick, J., O'Brien, I., Devers, M., Bousboulas, S., Pappas, S., Piaditis, G., Vryonidou, A., Tentolouris, N., Karamitsos, K., Manes, C., Benroubi, M., Avramidis, I., Ozaki, R., Tan, K., Siu, S., Tsang, C., Dudas, M., Nagy, K., Salamon, C., Ip, T., Geroo, L., Patkay, J., Tabak, A., Juhasz, F., Szentpeteri, I., Tamas, G., Ghaisas, N., Bantwal, G., Mohan, V., Gupta, J., Sadhu, N., Kulkarni, A., Garg, N., Reddy, S., Deshpande, N., Gutlapalli, K., Pillai, M., Premchand, R., Badgandi, M., Jain, S., Aravind, S., Shamanna, P., Pandey, A., Gupta, S., Pramono, B., Saksono, H. Dante, Agung, P., Wahono, S. Djoko, Suastika, K., Tanggo, Y., Juwana, Y., Siswanto, B., Adawi, F., Efrati, S., Mazen, E., Bashkin, A., Herskovits, T., Jaffe, A., Schiff, E., Wainstein, J., Taddei, S., Aiello, A., Arca, M., Calabro, P., Cignarelli, M., Fioretto, P., Reggiani, G. Marchesini, Gnasso, A., Marchionni, N., Marsilii, A., Bucci, M., Mezzetti, A., Pozzilli, P., Colivicchi, F., Santini, M., Moro, E., Toscano, V., Fucili, A., Semplicini, A., Monno, S., Furui, K., Higashiue, S., Hiramatsu, N., Kawamitsu, K., Takenaka, T., Takahashi, H., Hojo, F., Onishi, Y., Izumino, K., Okubo, M., Wakida, Y., Kondo, Y., Hieshima, K., Jinnouchi, H., Suzuki, A., Ito, M., Park, S., Kim, Y., Hong, T., Park, H., Gwon, H., Kim, H., Kang, K., Jeong, M., Seung, K., Lim, D., Rha, S., Tahk, S., Yang, J., Yoon, J., Shin, M., Kim, D., Jeong, J., Ahmad, N. Nik, Mustafa, N., Mohamed, W. Wan, Fung, Y., Ghani, R. Abdul, Chandramouli, A., Chee, K., Kadir, K. Abdul, Ling, K., Abu Hassan, M., Foo, S., Lee, S., Garcia Hernandez, P., Aguilar-Salinas, C., Vidrio Velazquez, M., Flores, F., Alpizar Salazar, M., Micher Escalante, D., Garcia Soria, M., Cardona Munoz, E., Storms, G., Schaper, N., Kooy, A., Krekels, M., van Bemmel, T., Verhoeven, R., Mulder, H., Oldenburg-Ligtenberg, P., Gonkel, F., de Jong, A., van Soest, J., Viergever, P., Mevissen, H., Lochorn, G., Zwiers, G., Hoogslag, P., Ronner, E., Nierop, P., Al-Windy, N., Kragten, J., Dekelver, P., Benatar, J., Krebs, J., Scott, R., Heggen, E., Berz, A., Fossum, C., Hurtig, U., Langslet, G., Baranowski, M., Sparby, J., Karlsson, T., Karlsson, Thomas, Delgado Torres, C., Rodriguez Escudero, A., Lisson, R., Allemant Maldonado, A., Gallardo Rojas, W., Gonzales Bravo, L., Lema Osores, J., Farfan, J., Zapata, L., Godoy Junchaya, J., Roldan Concha, Y., Urquiaga Calderon, J., Sy, R., Tan, G., Aquitania, G., De Los Santos, G., Panelo, A., Roderos, O., Rosales, R., Toledo, R., Liwag, A., Ramoncito, H., Skokowska, E., Krzyzagorska, E., Ogorek, M., Wojnowski, L., Spyra, J., Konieczny, M., Piesiewicz, W., Kus, W., Ocicka-Kozakiewicz, A., Orlowska-Kunikowska, E., Zmuda, W., Duarte, S., Leitao, A., Monteiro, P., Rita, H., Salgado, V., Pinto, L., Queiros, J., Teixeira, J., Rogado, C., Duarte, R., Sobral do Rosario, F., Silva, A., Andrade, L., Velez, M., Brazao, M., Istratoaie, O., Lichiardopol, R., Catrinoiu, D., Militaru, C., Zetu, C., Barbonta, D., Cosma, D., Crisan, C., Pop, L., Esip, V., Khetagurova, F., Petrov, A., Arutyunov, G., Boyarkin, M., Agafyina, A., Vorokhobina, N., Petunina, N., Libov, I., Zalevskaya, A., Nikolaev, K., Barbarash, O., Potemkin, V., Bystrova, A., Krasilnikova, E., Barbarich, V., Chumakova, G., Tarasov, N., Meleshkevich, T., Zateyshchikov, D., Lantseva, O., Belenkiy, D., Obrezan, A., Rossolko, L., Fillipova, E., Yakhontova, P., Khokhlov, A., Tan, R., Sum, C., Chang, H., Distiller, L., Pretorius, M., Nortje, H., Mitha, E., Burgess, L., Blignaut, S., Venter, T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., Magee, M., Hippert, R., Sofley, C., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Kidney Center (GKC), Methods in Medicines evaluation & Outcomes research (M2O), and EMPA-REG OUTCOME Investigators

Subjects
Male, Placebo-controlled study, PROGRESSION, Type 2 diabetes, 030204 cardiovascular system & hematology, PLACEBO-CONTROLLED TRIAL, GLOMERULAR-FILTRATION-RATE, HYPERFILTRATION, law.invention, ESTABLISHED CARDIOVASCULAR-DISEASE, Cohort Studies, MELLITUS, 0302 clinical medicine, Randomized controlled trial, Glucosides, law, Medicine, Diabetic Nephropathies, GFR DECLINE, General Medicine, Middle Aged, Nephrology, diabetes mellitus, randomized controlled trials, Disease Progression, Female, Glomerular Filtration Rate, medicine.medical_specialty, Urology, Renal function, 030209 endocrinology & metabolism, Placebo, 03 medical and health sciences, Double-Blind Method, Clinical Research, Diabetes mellitus, BASE-LINE CHARACTERISTICS, END-POINTS, Empagliflozin, Humans, Benzhydryl Compounds, Sodium-Glucose Transporter 2 Inhibitors, Aged, COTRANSPORTER 2 INHIBITION, Models, Statistical, Dose-Response Relationship, Drug, business.industry, chronic kidney disease, medicine.disease, Confidence interval, Diabetes Mellitus, Type 2, Human medicine, business
Abstract

BACKGROUND: Empagliflozin slowed the progression of CKD in patients with type 2 diabetes and cardiovascular disease in the EMPA-REG OUTCOME Trial. In a prespecified statistical approach, we assessed treatment differences in kidney function by analyzing slopes of eGFR changes.METHODS: Participants (n=7020) were randomized (1:1:1) to empagliflozin 10 mg/d, empagliflozin 25 mg/d, or placebo added to standard of care. We calculated eGFR slopes using random-intercept/random-coefficient models for prespecified study periods: treatment initiation (baseline to week 4), chronic maintenance treatment (week 4 to last value on treatment), and post-treatment (last value on treatment to follow-up).RESULTS: Compared with placebo, empagliflozin was associated with uniform shifts in individual eGFR slopes across all periods. On treatment initiation, adjusted mean slope (eGFR change per week, ml/min per 1.73 m2) decreased with empagliflozin (-0.77; 95% confidence interval, -0.83 to -0.71; placebo: 0.01; 95% confidence interval, -0.08 to 0.10; PCONCLUSIONS: The hemodynamic effects of empagliflozin, associated with reduction in intraglomerular pressure, may contribute to long-term preservation of kidney function.

Published
2018

24. Position paper on nasal obstruction: evaluation and treatment

Author

Valero, A, Navarro, A M, Del Cuvillo, A, Alobid, I, Benito, J R, Colás, C, de Los Santos, G, Fernández Liesa, R, García-Lliberós, A, González-Pérez, R, Izquierdo-Domínguez, A, Jurado-Ramos, A, Lluch-Bernal, M M, Montserrat Gili, J R, Mullol, J, Puiggròs Casas, A, Sánchez-Hernández, M C, Vega, F, Villacampa, J M, Armengot-Carceller, M, Dordal, M T, and SEAIC Rhinoconjunctivitis Committee & SEORL Rhinology, Allergy, and Skull Base Committee

Subjects
Rhinometry, Acoustic, medicine.medical_specialty, Visual analogue scale, Immunology, Population, Physical examination, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Acoustic rhinometry, medicine, Immunology and Allergy, Animals, Humans, Medical history, 030223 otorhinolaryngology, education, Intensive care medicine, education.field_of_study, Objective and subjective evaluation, medicine.diagnostic_test, business.industry, Nasal obstruction/nasal blockage/nasal respiratory insufficiency, Medical and surgical treatment, Rhinomanometry, 030228 respiratory system, Etiology, Quality of Life, Position paper, Nasal Cavity, Nasal Obstruction, business
Abstract

Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in the passage of air through the nostrils. It is a common reason for consultation in primary and specialized care and may affect up to 30%-40% of the population. It affects quality of life (especially sleep) and lowers work efficiency. The aim of this document is to agree on how to treat NO, establish a methodology for evaluating and diagnosing it, and define an individualized approach to its treatment. NO can be unilateral or bilateral, intermittent or persistent and may be caused by local or systemic factors, which may be anatomical, inflammatory, neurological, hormonal, functional, environmental, or pharmacological in origin. Directed study of the medical history and physical examination are key for diagnosing the specific cause. NO may be evaluated using subjective assessment tools (visual analog scale, symptom score, standardized questionnaires) or by objective estimation (active anterior rhinomanometry, acoustic rhinometry, peak nasal inspiratory flow). Although there is little correlation between the results, they may be considered complementary and not exclusive. Assessing the impact on quality of life through questionnaires standardized according to the underlying disease is also advisable. NO is treated according to its cause. Treatment is fundamentally pharmacological (topical and/or systemic) when the etiology is inflammatory or functional. Surgery may be necessary when medical treatment fails to complement or improve medical treatment or when other therapeutic approaches are not possible. Combinations of surgical techniques and medical treatment may be necessary.

Published
2018

31. Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk

Author

Zinman, Bernard, Inzucchi, Silvio E., Lachin, John M., Wanner, Christoph, Fitchett, David, Kohler, Sven, Mattheus, Michaela, Biomath, Dipl, Woerle, Hans J., Broedl, Uli C., Johansen, Odd Erik, Albers, Gregory W., Diener, Hans Christoph, Aizenberg, D., Ulla, M., Waitman, J., De Loredo, L., Farias, J., Fideleff, H., Lagrutta, M., Maldonado, N., Colombo, H., Ferre Pacora, F., Wasserman, A., Maffei, L., Lehman, R., Selvanayagam, J., d'Emden, M., Fasching, P., Paulweber, B., Toplak, H., Luger, A., Drexel, H., Prager, R., Schnack, C., Schernthaner, G., Fliesser-Goerzer, E., Kaser, S., Scheen, A., Van Gaal, L., Hollanders, G., Kockaerts, Y., Capiau, L., Chachati, A., Persu, A., Hermans, M., Vantroyen, D., Vercammen, C., Van de Borne, P., Mathieu, C., Benhalima, K., Lienart, F., Mortelmans, J., Strivay, M., Vereecken, G., Keymeulen, B., Lamkanfi, F., Chacra, A., Eliaschewitz, F., Zanella, M., Faludi, A., Bertolami, M., Hayashida, C., Nunes Salles, J., Monte, O., Dinato, M., Manenti, E., Rassi, N., Halpern, A., Lima Filho, M., Ayoub, J., Felicio, J., Borges, J., Gross, J., Sgarbi, J., Betti, R., Tiburcio, A., Purisch, S., Schmid, H., Takahashi, M., Castro, M., Rea, R., Hissa, M., Geloneze Neto, B., Saraiva, J., Henein, S., Lochnan, H., Imran, S. A., Clayton, D., Bayly, K., Berlingieri, J., Boucher, P., Chan, Y., Gupta, M., Chehayeb, R., Ouellett, A., Ur, E., Woo, V., Zinman, B., St Amour, E., Terront Lozano, M., Yupanqui Lozno, H., Urina, M., Lopez Jaramillo, P., Jaramillo, N., Sanchez, G., Perez, G., Tusek, S., Mirosevic, G., Goldoni, V., Jurisic-Erzen, D., Balasko, A., Balic, S., Drvodelic-Sunic, E., Varzic, S. Canecki, Machkova, M., Weiner, P., Lastuvka, J., Olsovsky, J., Krarup, T., Ridderstrale, M., Tarnow, L., Boesgaard, T. Wellov, Lihn, A. Saetre, Christensen, P., Juhl, H., Urhammer, S., Lund, P., Adojaan, B., Jakovlev, U., Lanno, R., Lubi, M., Marandi, T., Gouet, D., Courreges, J., Zaoui, P., Choukroun, G., Petit, C., Formagne, L., Estour, B., Mabire, P., Daugenet, C., Lemarie, B., Clavel, S., Aure, P., Remaud, P., Halimi, J., Hadjadj, S., Couffinhal, T., Glonti, S., Metreveli, D., Lominadze, Z., Giorgadze, E., Burtchuladze, T., Javashvili, L., Kurashvili, G., Kurashvili, R., Virsaladze, D., Nadareishvili, L., Khomasuridze, A., Cahill, T., Green, F., MacRury, S., Waldron, M., Middleton, A., McKnight, J., Pearson, E., Butler, M., Choksi, M., Caldwell, I., Farmer, I., Wyatt, N., Patrick, J., O'Brien, I., Devers, M., Bousboulas, S., Pappas, S., Piaditis, G., Vryonidou, A., Tentolouris, N., Karamitsos, K., Manes, C., Benroubi, M., Avramidis, I., Ozaki, R., Tan, K., Siu, S., Tsang, C., Dudas, M., Nagy, K., Salamon, C., Ip, T., Geroo, L., Patkay, J., Tabak, A., Juhasz, F., Szentpeteri, I., Tamas, G., Ghaisas, N., Bantwal, G., Mohan, V., Gupta, J., Sadhu, N., Kulkarni, A., Garg, N., Reddy, S., Deshpande, N., Gutlapalli, K., Pillai, M., Premchand, R., Badgandi, M., Jain, S., Aravind, S., Shamanna, P., Pandey, A., Gupta, S., Pramono, B., Saksono, H. Dante, Agung, P., Wahono, S. Djoko, Suastika, K., Tanggo, Y., Juwana, Y., Siswanto, B., Adawi, F., Efrati, S., Mazen, E., Bashkin, A., Herskovits, T., Jaffe, A., Schiff, E., Wainstein, J., Taddei, S., Aiello, A., Arca, M., Calabro, P., Cignarelli, M., Fioretto, P., Reggiani, G. Marchesini, Gnasso, A., Marchionni, N., Marsilii, A., Bucci, M., Mezzetti, A., Pozzilli, P., Colivicchi, F., Santini, M., Moro, E., Toscano, V., Fucili, A., Semplicini, A., Monno, S., Furui, K., Higashiue, S., Hiramatsu, N., Kawamitsu, K., Takenaka, T., Takahashi, H., Hojo, F., Onishi, Y., Izumino, K., Okubo, M., Wakida, Y., Kondo, Y., Hieshima, K., Jinnouchi, H., Suzuki, A., Ito, M., Park, S., Kim, Y., Hong, T., Park, H., Gwon, H., Kim, H., Kang, K., Jeong, M., Seung, K., Lim, D., Rha, S., Tahk, S., Yang, J., Yoon, J., Shin, M., Kim, D., Jeong, J., Ahmad, N. Nik, Mustafa, N., Mohamed, W. Wan, Fung, Y., Ghani, R. Abdul, Chandramouli, A., Chee, K., Kadir, K. Abdul, Ling, K., Abu Hassan, M., Foo, S., Lee, S., Garcia Hernandez, P., Aguilar-Salinas, C., Vidrio Velazquez, M., Flores, F., Alpizar Salazar, M., Micher Escalante, D., Garcia Soria, M., Cardona Munoz, E., Storms, G., Schaper, N., Kooy, A., Krekels, M., van Bemmel, T., Verhoeven, R., Mulder, H., Oldenburg-Ligtenberg, P., Gonkel, F., de Jong, A., van Soest, J., Viergever, P., Mevissen, H., Lochorn, G., Zwiers, G., Hoogslag, P., Ronner, E., Nierop, P., Al-Windy, N., Kragten, J., Dekelver, P., Benatar, J., Krebs, J., Scott, R., Heggen, E., Berz, A., Fossum, C., Hurtig, U., Langslet, G., Baranowski, M., Sparby, J., Karlsson, T., Karlsson, Thomas, Delgado Torres, C., Rodriguez Escudero, A., Lisson, R., Allemant Maldonado, A., Gallardo Rojas, W., Gonzales Bravo, L., Lema Osores, J., Farfan, J., Zapata, L., Godoy Junchaya, J., Roldan Concha, Y., Urquiaga Calderon, J., Sy, R., Tan, G., Aquitania, G., De Los Santos, G., Panelo, A., Roderos, O., Rosales, R., Toledo, R., Liwag, A., Ramoncito, H., Skokowska, E., Krzyzagorska, E., Ogorek, M., Wojnowski, L., Spyra, J., Konieczny, M., Piesiewicz, W., Kus, W., Ocicka-Kozakiewicz, A., Orlowska-Kunikowska, E., Zmuda, W., Duarte, S., Leitao, A., Monteiro, P., Rita, H., Salgado, V., Pinto, L., Queiros, J., Teixeira, J., Rogado, C., Duarte, R., Sobral do Rosario, F., Silva, A., Andrade, L., Velez, M., Brazao, M., Istratoaie, O., Lichiardopol, R., Catrinoiu, D., Militaru, C., Zetu, C., Barbonta, D., Cosma, D., Crisan, C., Pop, L., Esip, V., Khetagurova, F., Petrov, A., Arutyunov, G., Boyarkin, M., Agafyina, A., Vorokhobina, N., Petunina, N., Libov, I., Zalevskaya, A., Nikolaev, K., Barbarash, O., Potemkin, V., Bystrova, A., Krasilnikova, E., Barbarich, V., Chumakova, G., Tarasov, N., Meleshkevich, T., Zateyshchikov, D., Lantseva, O., Belenkiy, D., Obrezan, A., Rossolko, L., Fillipova, E., Yakhontova, P., Khokhlov, A., Tan, R., Sum, C., Chang, H., Distiller, L., Pretorius, M., Nortje, H., Mitha, E., Burgess, L., Blignaut, S., Venter, T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., III, Magee, M., Hippert, R., Sofley, C., Jr., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Jr., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., III, Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., and EMPA REG OUTCOME Investigators

Subjects
riesgo, compuestos de bencidrilo, type 2 diabetes mellitus, Original Contributions, humanos, Medizin, 030204 cardiovascular system & hematology, blood pressure, cardiovascular diseases, hematocrit, stroke, 0302 clinical medicine, Glucosides, glucósidos, 030212 general & internal medicine, Myocardial infarction, Stroke, mediana edad, anciano, OUTCOMES, Hazard ratio, Middle Aged, ISCHEMIC-STROKE, Anesthesia, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Cardiology, TRIAL, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, Risk, medicine.medical_specialty, Clinical Sciences, enfermedades cardiovasculares, Clinical Neurology, Placebo, 03 medical and health sciences, Outcome Assessment (Health Care), Internal medicine, medicine, Empagliflozin, Diabetes Mellitus, Humans, Hypoglycemic Agents, accidente cerebrovascular, Benzhydryl Compounds, METAANALYSIS, Aged, Advanced and Specialized Nursing, Science & Technology, business.industry, MORTALITY, Type 2 Diabetes Mellitus, medicine.disease, Confidence interval, Blood pressure, hipoglicemiantes, Peripheral Vascular Disease, evaluación de resultados (asistencia sanitaria), Cardiovascular System & Cardiology, Neurology (clinical), Neurosciences & Neurology, business, FOLLOW-UP
Abstract

Supplemental Digital Content is available in the text., Background and Purpose— In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients), empagliflozin added to standard of care in patients with type 2 diabetes mellitus and high cardiovascular risk reduced the risk of 3-point major adverse cardiovascular events, driven by a reduction in cardiovascular mortality, with no significant difference between empagliflozin and placebo in risk of myocardial infarction or stroke. In a modified intent-to-treat analysis, the hazard ratio for stroke was 1.18 (95% confidence interval, 0.89–1.56; P=0.26). We further investigated cerebrovascular events. Methods— Patients were randomized to empagliflozin 10 mg, empagliflozin 25 mg, or placebo; 7020 patients were treated. Median observation time was 3.1 years. Results— The numeric difference in stroke between empagliflozin and placebo in the modified intent-to-treat analysis was primarily because of 18 patients in the empagliflozin group with a first event >90 days after last intake of study drug (versus 3 on placebo). In a sensitivity analysis based on events during treatment or ≤90 days after last dose of drug, the hazard ratio for stroke with empagliflozin versus placebo was 1.08 (95% confidence interval, 0.81–1.45; P=0.60). There were no differences in risk of recurrent, fatal, or disabling strokes, or transient ischemic attack, with empagliflozin versus placebo. Patients with the largest increases in hematocrit or largest decreases in systolic blood pressure did not have an increased risk of stroke. Conclusions— In patients with type 2 diabetes mellitus and high cardiovascular risk, there was no significant difference in the risk of cerebrovascular events with empagliflozin versus placebo. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01131676.

Published
2017

32. Spatial attributes of diffraction free fields

Author

J. Munoz-Lopez, G. Martinez-Niconoff, P. Martinez-Vara, S. I. De los Santos G., and M. A. Torres-Rodrìguez

Subjects
Diffraction, Physics, Field (physics), business.industry, Physics::Optics, Fraunhofer diffraction, Diffraction efficiency, 01 natural sciences, Computational physics, 010309 optics, symbols.namesake, Optics, Airy function, 0103 physical sciences, Airy disk, symbols, 010306 general physics, business, Optical vortex, Fresnel diffraction
Abstract

Optical diffraction fields have a not easy spatial structure, some times optical diffraction fields can generate a focusing region or caustic region, in this contribution, we describe the focusing region associated with highly symmetric transmittances, we analyze its associated phase function and show that generic features can be studied from a differential equation for a focusing geometry, which is obtained through angular representation for diffraction fields, the diffraction field presents focusing region whose geometry and spatial evolution can be described with the analysis of the phase singularities avoiding the integral representation. We show that in general the diffracted field has a decomposition in optical fields propagating along three optical axis mutually perpendicular. The decomposition is in terms of the Pearcey and Airy functions and generalized Airy function. Experimental results are shown.

Published
2016
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33. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME (R) trial

Author

Fitchett, David, Zinman, Bernard, Wanner, Christoph, Lachin, John M., Hantel, Stefan, Salsali, Afshin, Johansen, Odd Erik, Woerle, Hans J., Broedl, Uli C., Inzucchi, Silvio E., Aizenberg, D., Ulla, M., Waitman, J., De Loredo, L., Farias, J., Fideleff, H., Lagrutta, M., Maldonado, N., Colombo, H., Ferre Pacora, F., Wasserman, A., Maffei, L., Lehman, R., Selvanayagam, J., d'Emden, M., Fasching, P., Paulweber, B., Toplak, H., Luger, A., Drexel, H., Prager, R., Schnack, C., Schernthaner, G., Fliesser-Goerzer, E., Kaser, S., Scheen, A., Van Gaal, L., Hollanders, G., Kockaerts, Y., Capiau, L., Chachati, A., Persu, A., Hermans, M., Vantroyen, D., Vercammen, C., Van de Borne, P., Mathieu, C., Benhalima, K., Lienart, F., Mortelmans, J., Strivay, M., Vereecken, G., Keymeulen, B., Lamkanfi, F., Chacra, A., Eliaschewitz, F., Zanella, M., Faludi, A., Bertolami, M., Hayashida, C., Nunes Salles, J., Monte, O., Dinato, M., Manenti, E., Rassi, N., Halpern, A., Lima Filho, M., Ayoub, J., Felicio, J., Borges, J., Gross, J., Sgarbi, J., Betti, R., Tiburcio, A., Purisch, S., Schmid, H., Takahashi, M., Castro, M., Rea, R., Hissa, M., Geloneze Neto, B., Saraiva, J., Henein, S., Lochnan, H., Imran, S. A., Clayton, D., Bayly, K., Berlingieri, J., Boucher, P., Chan, Y., Gupta, M., Chehayeb, R., Ouellett, A., Ur, E., Woo, V., Zinman, B., St Amour, E., Terront Lozano, M., Yupanqui Lozno, H., Urina, M., Lopez Jaramillo, P., Jaramillo, N., Sanchez, G., Perez, G., Tusek, S., Mirosevic, G., Goldoni, V., Jurisic-Erzen, D., Balasko, A., Balic, S., Drvodelic-Sunic, E., Varzic, S. Canecki, Machkova, M., Weiner, P., Lastuvka, J., Olsovsky, J., Krarup, T., Ridderstrale, M., Tarnow, L., Boesgaard, T. Wellov, Lihn, A. Saetre, Christensen, P., Juhl, H., Urhammer, S., Lund, P., Adojaan, B., Jakovlev, U., Lanno, R., Lubi, M., Marandi, T., Gouet, D., Courreges, J., Zaoui, P., Choukroun, G., Petit, C., Formagne, L., Estour, B., Mabire, P., Daugenet, C., Lemarie, B., Clavel, S., Aure, P., Remaud, P., Halimi, J., Hadjadj, S., Couffinhal, T., Glonti, S., Metreveli, D., Lominadze, Z., Giorgadze, E., Burtchuladze, T., Javashvili, L., Kurashvili, G., Kurashvili, R., Virsaladze, D., Nadareishvili, L., Khomasuridze, A., Cahill, T., Green, F., MacRury, S., Waldron, M., Middleton, A., McKnight, J., Pearson, E., Butler, M., Choksi, M., Caldwell, I., Farmer, I., Wyatt, N., Patrick, J., O'Brien, I., Devers, M., Bousboulas, S., Pappas, S., Piaditis, G., Vryonidou, A., Tentolouris, N., Karamitsos, K., Manes, C., Benroubi, M., Avramidis, I., Ozaki, R., Tan, K., Siu, S., Tsang, C., Dudas, M., Nagy, K., Salamon, C., Ip, T., Geroo, L., Patkay, J., Tabak, A., Juhasz, F., Szentpeteri, I., Tamas, G., Ghaisas, N., Bantwal, G., Mohan, V., Gupta, J., Sadhu, N., Kulkarni, A., Garg, N., Reddy, S., Deshpande, N., Gutlapalli, K., Pillai, M., Premchand, R., Badgandi, M., Jain, S., Aravind, S., Shamanna, P., Pandey, A., Gupta, S., Pramono, B., Saksono, H. Dante, Agung, P., Wahono, S. Djoko, Suastika, K., Tanggo, Y., Juwana, Y., Siswanto, B., Adawi, F., Efrati, S., Mazen, E., Bashkin, A., Herskovits, T., Jaffe, A., Schiff, E., Wainstein, J., Taddei, S., Aiello, A., Arca, M., Calabro, P., Cignarelli, M., Fioretto, P., Reggiani, G. Marchesini, Gnasso, A., Marchionni, N., Marsilii, A., Bucci, M., Mezzetti, A., Pozzilli, P., Colivicchi, F., Santini, M., Moro, E., Toscano, V., Fucili, A., Semplicini, A., Monno, S., Furui, K., Higashiue, S., Hiramatsu, N., Kawamitsu, K., Takenaka, T., Takahashi, H., Hojo, F., Onishi, Y., Izumino, K., Okubo, M., Wakida, Y., Kondo, Y., Hieshima, K., Jinnouchi, H., Suzuki, A., Ito, M., Park, S., Kim, Y., Hong, T., Park, H., Gwon, H., Kim, H., Kang, K., Jeong, M., Seung, K., Lim, D., Rha, S., Tahk, S., Yang, J., Yoon, J., Shin, M., Kim, D., Jeong, J., Ahmad, N. Nik, Mustafa, N., Mohamed, W. Wan, Fung, Y., Ghani, R. Abdul, Chandramouli, A., Chee, K., Kadir, K. Abdul, Ling, K., Abu Hassan, M., Foo, S., Lee, S., Garcia Hernandez, P., Aguilar-Salinas, C., Vidrio Velazquez, M., Flores, F., Alpizar Salazar, M., Micher Escalante, D., Garcia Soria, M., Cardona Munoz, E., Storms, G., Schaper, N., Kooy, A., Krekels, M., van Bemmel, T., Verhoeven, R., Mulder, H., Oldenburg-Ligtenberg, P., Gonkel, F., de Jong, A., van Soest, J., Viergever, P., Mevissen, H., Lochorn, G., Zwiers, G., Hoogslag, P., Ronner, E., Nierop, P., Al-Windy, N., Kragten, J., Dekelver, P., Benatar, J., Krebs, J., Scott, R., Heggen, E., Berz, A., Fossum, C., Hurtig, U., Langslet, G., Baranowski, M., Sparby, J., Karlsson, T., Karlsson, Thomas, Delgado Torres, C., Rodriguez Escudero, A., Lisson, R., Allemant Maldonado, A., Gallardo Rojas, W., Gonzales Bravo, L., Lema Osores, J., Farfan, J., Zapata, L., Godoy Junchaya, J., Roldan Concha, Y., Urquiaga Calderon, J., Sy, R., Tan, G., Aquitania, G., De Los Santos, G., Panelo, A., Roderos, O., Rosales, R., Toledo, R., Liwag, A., Ramoncito, H., Skokowska, E., Krzyzagorska, E., Ogorek, M., Wojnowski, L., Spyra, J., Konieczny, M., Piesiewicz, W., Kus, W., Ocicka-Kozakiewicz, A., Orlowska-Kunikowska, E., Zmuda, W., Duarte, S., Leitao, A., Monteiro, P., Rita, H., Salgado, V., Pinto, L., Queiros, J., Teixeira, J., Rogado, C., Duarte, R., Sobral do Rosario, F., Silva, A., Andrade, L., Velez, M., Brazao, M., Istratoaie, O., Lichiardopol, R., Catrinoiu, D., Militaru, C., Zetu, C., Barbonta, D., Cosma, D., Crisan, C., Pop, L., Esip, V., Khetagurova, F., Petrov, A., Arutyunov, G., Boyarkin, M., Agafyina, A., Vorokhobina, N., Petunina, N., Libov, I., Zalevskaya, A., Nikolaev, K., Barbarash, O., Potemkin, V., Bystrova, A., Krasilnikova, E., Barbarich, V., Chumakova, G., Tarasov, N., Meleshkevich, T., Zateyshchikov, D., Lantseva, O., Belenkiy, D., Obrezan, A., Rossolko, L., Fillipova, E., Yakhontova, P., Khokhlov, A., Tan, R., Sum, C., Chang, H., Distiller, L., Pretorius, M., Nortje, H., Mitha, E., Burgess, L., Blignaut, S., Venter, T., Moodley, R., Lombaard, J., Govind, U., Naidoo, V., Mookadam, M., Engelbrecht, J., Omar, M., Jurgens, J., Podgorski, G., Vawda, H., Naidoo, D., Emanuel, S., Roodt, A., Amod, A., Van Zyl, L., Segura, J., Brito, M., Fernandez-Cruz, A., Artola, S., Iglesias, R., Toural, E., Garcia-Ortiz, L., Saban, J., Mesa, J., Vidal, J., Linares, J., del Canizo, F., Rigla, M., Suarez, C., Llorente, I., Moreno, B., Antoli, A., Gomez Peralta, F., Iglesias, M., Pereg, V., de Teresa, L., Camafort, M., Trescoli, C., Satarasinghe, R., Somasundaram, N., Siyambalapitiya, S., Antonypillai, C., Bulugahapitiya, D., Medagama, U., Huang, C., Lu, Y., Hwang, J., Chiang, C., Wen, M., Chen, J., Lai, W., Chang, K., Wang, J., Yeh, H., Kriangsak, P., Deerochanawong, C., Suwanwalaikorn, S., Mangklabruks, A., Kaewsuwanna, P., Piyayotai, D., Iabluchanskyi, M., Samoylov, O., Godlevska, O., Kovalyova, O., Voloshyna, O., Tseluyko, V., Zotov, S., Vykhovanyuk, I., Dulgeroff, A., Mayfield, R., Zaniewski-Singh, M., Ullal, J., Aloi, J., De La Rosa, R., Mosely, J., Wittmer, B., Aronoff, S., Rosenfeld, J., Seidner, M., Warren, M., Fishman, N., Weiss, R., Arif, A., Sandberg, M., Lewis, D., Ball, E., Graf, R., Breton, C., Tamayo, R., Richards, R., Cefalu, W., Uwaifo, G., Zayour, D., Hoffman, J., Fitz-Patrick, D., Khan, B., Blaze, K., Bressler, P., Halpern, S., Chappell, D., Bergenstal, R., Cuddihy, R., Matfin, G., Freedman, Z., Gonzalez-Campoy, J., Lerman, S., Rendell, M., Sitar, S., Reeves, M., Howard, T., Soufer, J., Miranda-Palma, B., Laliotis, A., Shomali, M., Teltser, M., Hurley, D., Morawski, E., Cherlin, R., Houchin, V., Welch, M., Goytia-Leos, D., Syed, M., Kowaloff, E., Weinrauch, L., Peniston, J., Brockmyre, A., First, B., Feld, L., Huffman, D., Nassim, O., Gottschlich, G., Patel, A., Knopke, C., Hernandez, M., Diaz, J., Giugliano, G., Nicasio, J., Eagerton, D., Huntley, R., Reed, J., III, Magee, M., Hippert, R., Sofley, C., Jr., Alzohaili, O., Levins, P., Anspach, R., Shah, S., Brusco, O., Naidu, J., Lindenbaum, J., Jacks, R., Hammond, G., Arena, C., Saxman, K., Mach, M., Kerstein, H., Kereiakes, D., Wahlen, J., Wehmeier, K., Chaykin, L., Rothman, J., Fogelfeld, L., Stroger, John H., Jr., Bittar, N., Rosenstock, J., Kayne, D., Navarro, J., Colfer, H., Mokshagundam, S., Shandilya, L., Connery, L., Wysham, C., Dela Llana, A., Jardula, M., MacAdams, M., Flippo, G., Heurich, E., Curtis, C., Sanders, D., Rawls, R., Velazquez, F., Osea, E., Mahood, K., Feldman, G., Eder, F., Riley, E., Fowler, W., Jain, M., Shepard, M., Schear, M., Barker, B., Strout, C., Obiekwe, O., Shanik, M., Green, C., Blakney, E., Roberson, K., Bretton, E., Pish, R., Kaveh, K., Maynard, B., Barager, W., Soldyshev, R., Austin, B., Parmar, P., Simpson, R., Chauhan, A., Kasper, J., Burr, R., Patel, N., Mariano, H., Pluto, T., Bratcher, C., Juarez, M., Levinson, L., Awad, A., Longshaw, K., Hoffman, K., Richwine, R., Molter, D., Boscia, J., III, Kowalyk, S., Lemis, P., Liss, J., Orr, R., Riser, J., Wood, J., Ubani, A., Paine, W., Hassani, F., Miranda, F., Hansen, V., Hansen, Val R., Farris, N., Bowden, R., Ajani, D., Maw, K., Andersen, J., Bergman, B., Dunmyer, S., Brandon, D., Anderson, M., Bononi, P., Prawer, J., Seidman, B., Cruz, H., Wilks, K., DiSanto, L., Buynak, R., Christensen, T., Denker, P., Koppel, W., Stedman, M., Lewy-Alterbaum, L., Karim, S., Shapiro, J., Gardner, T., Oskin, T., Gabra, N., Malano, J., EMPA-REG OUTCOME Trial, and EMPA-REG OUTCOME(R) trial investigators

Subjects
medicine.medical_specialty, Cardiac & Cardiovascular Systems, Aha Fasttrack, BLOOD-PRESSURE, 030209 endocrinology & metabolism, Cardiovascular disease, Hospitalization, Mortality, Type 2 diabetes, 030204 cardiovascular system & hematology, COLLABORATION, GUIDELINES, DOUBLE-BLIND, MELLITUS, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Empagliflozin, Medicine, ddc:610, Adverse effect, Science & Technology, COTRANSPORTER 2 INHIBITION, business.industry, MORTALITY, Hazard ratio, Heart Failure/Cardiomyopathy, medicine.disease, INSULIN, Editor's Choice, Endocrinology, Blood pressure, DISEASES, SAFETY, Heart failure, Cardiovascular System & Cardiology, Number needed to treat, Cardiology, Fast Track, Cardiology and Cardiovascular Medicine, business, Life Sciences & Biomedicine
Abstract

Aims We previously reported that in the EMPA-REG OUTCOME(R) trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular events, cardiovascular and all-cause death, and hospitalization for heart failure in patients with type 2 diabetes and high cardiovascular risk. We have now further investigated heart failure outcomes in all patients and in subgroups, including patients with or without baseline heart failure. Methods and results Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo. Seven thousand and twenty patients were treated; 706 (10.1%) had heart failure at baseline. Heart failure hospitalization or cardiovascular death occurred in a significantly lower percentage of patients treated with empagliflozin [265/4687 patients (5.7%)] than with placebo [198/2333 patients (8.5%)] [hazard ratio, HR: 0.66 (95% confidence interval: 0.55-0.79); P < 0.001], corresponding to a number needed to treat to prevent one heart failure hospitalization or cardiovascular death of 35 over 3 years. Consistent effects of empagliflozin were observed across subgroups defined by baseline characteristics, including patients with vs. without heart failure, and across categories of medications to treat diabetes and/or heart failure. Empagliflozin improved other heart failure outcomes, including hospitalization for or death from heart failure [2.8 vs. 4.5%; HR: 0.61 (0.47-0.79); P < 0.001] and was associated with a reduction in all-cause hospitalization [36.8 vs. 39.6%; HR: 0.89 (0.82-0.96); P = 0.003]. Serious adverse events and adverse events leading to discontinuation were reported by a higher proportion of patients with vs. without heart failure at baseline in both treatment groups, but were no more common with empagliflozin than with placebo. Conclusion In patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced heart failure hospitalization and cardiovascular death, with a consistent benefit in patients with and without baseline heart failure., This work was supported by Boehringer Ingelheim and Eli Lilly and Company. Boehringer Ingelheim was involved in the design and conduct of the study; collection, analysis, and interpretation of data; and preparation of this manuscript. Eli Lilly's involvement was limited to co-funding of the study. Funding to pay the Open Access publication charges for this article was provided by Boehringer Ingelheim.

Published
2016

35. Diffraction by three-dimensional slit-shape curves: decomposition in terms of Airy and Pearcey functions

Author

P. Martinez-Vara, J. Silva Barranco, S. I. De Los Santos G., J. Munoz-Lopez, M. A. Torres-Rodriguez, R. Suarez Xique, and G. Martinez-Niconoff

Subjects
Physics, Diffraction, business.industry, Physics::Optics, Torsion (mechanics), Optical field, Polarization (waves), Curvature, Atomic and Molecular Physics, and Optics, Optics, Airy function, Transmittance, business, Osculating circle
Abstract

We analyze the diffraction field generated by coherent illumination of a three-dimensional transmittance characterized by a slit-shape curve. Generic features are obtained using the Frenet-Serret equations, which allow a decomposition of the optical field. The analysis is performed by describing the influence of the curvature and torsion on osculating, normal, and rectifying planes. We show that the diffracted field has a decomposition in three optical fields propagating along three optical axes that are mutually perpendicular. The decomposition is in terms of the Pearcey and Airy functions, and the generalized Airy function. Experimental results are shown.

Published
2015

36. MOISTURE AND RUPTURE MODELS FOR CORN (ZEA MAYS) SEEDS OF DIFFERENT ENDOSPERM TYPES.

Author

Mancera-Rico, A., García-de-los-Santos, G., Zavaleta-Mancera, H. A., Carrillo-Salazar, J. A., González-Estrada, E., and Villaseñor-Perea, C. A.

Subjects
*CORN, *ENDOSPERM, *DEAD loads (Mechanics), *CORN seeds, *CORN quality, *SEEDS, *CORN industry, *POSTHARVEST losses of crops
Abstract

Mechanization of postharvest handling and conditioning inflicts damage on the physical, physiological, and sanitary qualities of corn (Zea mays) seeds, resulting in significant economic loss. The mechanical damage is related to the compression strength and strain, and therefore to the moisture content (MC) and endosperm type. This study was conducted from 2012 to 2014 at the Montecillo and Chapingo agricultural institutes in Mexico, where physical properties such as volumetric weight; apparent density; rupture compression strength, strain, and energy; and endosperm type were evaluated for five corn seed cultivars (floury, semi-floury, floury-flint, semi-flint, and flint) at seven MC levels (8%, 12%, 16%, 20%, 24%, 28%, and 32% w.b.). The aim of this study was to develop moisture-strength, moisture-strain, and moisture-energy regression models for postharvest handling of corn to prevent quality loss due to mechanization. For three model groups, the relationship (1) between MC and rupture strain was linear and directly proportional for the five studied cultivars; (2) between MC and rupture strength was linear and directly proportional for the floury cultivar, inverse for the semi-flint and flint cultivars, and quadratic for the semi-floury and floury-flint cultivars; and (3) between MC and rupture energy was linear and directly proportional for the floury cultivar and quadratic for the semi-floury, floury-flint, semi-flint, and flint cultivars. The models obtained in this study might be used as a reference for better handling of corn seeds, as none of the five studied varieties had a uniformly superior rupture strength, strain, or energy at the studied MC levels. Floury endosperm types might be handled at high MC and flint endosperm types might be handled at low MC to avoid mechanical damage produced by static loads; both types of endosperm support greater energy loads, e.g., impact, at higher MC. [ABSTRACT FROM AUTHOR]

Published
2019
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37. Resistencia a ruptura y calidad fisiológica en semillas de maíz bajo compresión axial

Author

Mancera Rico, Arturo, García de los Santos, G., Zavaleta Mancera, Hilda A., Carballo Carballo, Aquiles, Carrillo Salazar, José Alfredo, González Estrada, Elizabeth, Villaseñor Perea, Carlos Alberto, Mancera Rico, Arturo, García de los Santos, G., Zavaleta Mancera, Hilda A., Carballo Carballo, Aquiles, Carrillo Salazar, José Alfredo, González Estrada, Elizabeth, and Villaseñor Perea, Carlos Alberto

Abstract

The physical, physiological and sanitary qualities of corn seeds are reduced due to the mechanical damage caused by the mechanization of the production process. Knowing the strength and displacement critical values according to the type of endosperm will help decrease the damage during the cleaning, drying, storing and handling processes. This study assessed the strength and displacement from compression, the visible damage and the physiological quality of corn seeds from the following varieties: Cacahuacintle (floury), HS-2 (semi-floury) and Popcorn (hard) considering a humidity of 12 and 20%. The percentage of soft endosperm in Cacahuacintle, HS-2 and Popcorn was 76.20, 33.43 and 15.27%, respectively, while the percentage of hard endosperm was 5.25, 48.93 and 65.21%, respectively. The displacement and the strength for the Cacahuacintle variety was 0.8264 mm and 274.71 N, for the HS-2 variety was 0.5499 mm and 309.07 N and for the Popcorn variety was 0.5066 mm and 356.29 N, while for 12 and 20% humidity it was 0.3279 mm and 312.52 N and 0.9520 mm and 313.81 N, respectively. The damage indexes in compressed seeds were 276.67, 327.78 and 220.01 for Cacahuacintle, HS-2 and Popcorn, respectively, while for uncompressed seeds (control group) the damage indexes were 0.00. Germination was 85.20% for uncompressed seeds and 55% for those seeds subjected to fracture. The damage index was affected by the variety and the compression, but not by the humidity. Germination was not affected by the damage index, but it was affected by humidity and compression., La calidad física, fisiológica y sanitaria de la semilla se reduce debido al daño mecánico ocasionado por la mecanización del proceso de beneficio. Conocer los valores críticos de la fuerza y el desplazamiento a la compresión en función del tipo de endospermo, permitirá ayudar a disminuir el daño durante dicho proceso de limpieza, secado, almacenaje y manejo. En el presente estudio se evaluaron: la fuerza y el desplazamiento a compresión de ruptura, el daño visible y la calidad fisiológica de semillas de maíz de las variedades: Cacahuacintle (harinoso), HS-2 (semi-harinoso) y Palomero (duro) con humedad de 12 y 20%. El porcentaje de endospermo suave en Cacahuacintle, HS-2 y Palomero fue de 76.20, 33.43 y 15.27%, mientras que el de endospermo duro fue 5.25, 48.93 y 65.21%. El desplazamiento y la fuerza para Cacahuacintle, HS-2 y Palomero fue de 0.8264 mm y 274.71 N, 0.5499 mm y 309.07 N, y 0.5066 mm y 356.29 N; mientras que para 12 y 20% de humedad fue de 0.3279 mm y 312.52 N y 0.9520 mm y 313.81 N. Los índices de daño en semillas comprimidas fueron 276.67, 327.78 y 220.01 para Cacahuacintle, HS-2 y Palomero; mientras que para semillas sin comprimir (testigos) fue de 0.00. La germinación fue de 85.20 y 55% para semillas sin comprimir y para las sometidas a ruptura. El índice de daño estuvo afectado por la variedad y la compresión, pero no por la humedad. La germinación no estuvo afectada por el índice de daño, peri sí por la variedad, la humedad y la compresión.

Published
2016

38. Adaptive Ecology of Lotus corniculatus L. Genotypes: I. Plant Morphology and RAPD Marker Characterizations

Author

Steiner, J. J. and de los Santos, G. Garcia

Subjects
Botany -- Morphology -- Genetic aspects, Lotus (Legumes) -- Genetic aspects, Agricultural industry, Business, Genetic aspects
Abstract

Birdsfoot trefoil (Lotus corniculatus L.) is a highly variable and widely distributed Old-World perennial forage legume found in wild and naturalized populations throughout temperate regions of Europe, Asia Minor, North Africa, North and South America, Australia, and New Zealand. Understanding the relationships among birdsfoot trefoil morphologic, ecogeographic, and genetic characteristics may provide insights for better utilizing exotic germplasm. The objectives of this research were to (i) compare morphologic and random amplified polymorphic DNA (RAPD) classifications of 28 exotic and ecologically diverse genotypes from the USDA National Plant Germplasm System (NPGS) birdsfoot trefoil collection, and (ii) determine the relationships between genotype classifications and collecting-site ecogeographic features. Eighteen morphologic characteristics, 130 RAPD bands, and eight collecting-site ecogeographic characteristics were used to classify the genotypes. The relatedness of genetic, morphologic, ecologic, and geographic distances among the genotypes was measured using the product moment correlation. Genotype morphology was related to collecting-site distances from one another and ecologic similarity. Genetic relatedness was also associated with collecting-site ecology, and specific morphologic characteristics were associated with different ecogeographic features. The similarity between the genetic and ecologic classifications suggested that genotypes adapted to similar habitats, even if geographically distant, have acquired similar phenotypes. Since RAPD descriptors were associated with the ecologic similarity of genotype collecting sites but not with their geographic closeness, classifications of birdsfoot trefoil should rely on both ecogeographic and morphologic characteristics of accessions., THE GENUS Lotus is a large polymorphic and widely distributed group that comprises approximately 200 annual and perennial species (Grant, 1965). Birdsfoot trefoil is generally reported to have 2n = [...]

Published
2001

39. Adaptive Ecology of Lotus corniculatus L. Genotypes: II. Crossing Ability

Author

de los Santos, G. Garcia, Steiner, J.J., and Beuselinck, P.R.

Subjects
Crops and climate -- Research -- Analysis, Botany -- Morphology -- Research -- Analysis -- Genetic aspects, Genotype -- Analysis -- Research -- Genetic aspects, Agricultural industry, Business, Analysis, Research, Genetic aspects
Abstract

Birdsfoot trefoil (Lotus corniculatus L.) is a widely distributed polymorphic Old-World perennial forage legume found in wild and naturalized populations throughout temperate regions of Europe, Asia Minor, North Africa, and North and South America. Exotic birdsfoot trefoil germplasm has rarely been used for birdsfoot trefoil genetic enhancement, and information about its crossing ability with other exotics and commercial quality germplasm is not available. The objectives of this research were to (i) characterize the crossing ability of 27 exotic birdsfoot trefoil genotypes with two genetically diverse hybridization testers, and (ii) determine if crossing ability among genotypes was related to their genetic background measured by random amplified polymorphic DNA (RAPD) markers and their ecogeographic origins. Crossing ability was determined using reciprocal crosses with one commercial-quality germplasm and one exotic genotype tester. All possible crossing combinations for an eight-genotype subset were also determined. Crossing ability was measured as the percentage of pollinated flowers that set pods, [F.sub.1] progeny pollen viability, pod length, and seeds per pod. Self-genotype pod set and pollen viability were not correlated. Intermediate bridge crosses were identified that could potentially overcome specific cross incompatibilities and be used to obtain progeny for any combination of genotypes. Genotype-crossing ability was associated with ecogeographic features of the collecting site, but not with morphologic characteristics. This differs from findings that other genotype morphologic characteristics are associated with ecogeographic origins and genetic similarities based on RAPD markers. Exotic birdsfoot trefoil genotypes can be utilized with commercial-quality germplasm using conventional crossing methods., BIRDSFOOT TREFOIL a perennial, non-bloating, forage legume that has valuable attributes making it a good alternative to other legumes in temperate regions. It is adapted to slightly acidic, droughty, infertile, [...]

Published
2001

43. Kinematic of focusing regions

Author

Martínez-Niconoff, G, primary, De los Santos G, S I, additional, Silva-Barranco, J, additional, Martínez-Martínez, J A, additional, Martínez-Vara, P, additional, and Ramírez-San-Juan, J C, additional

Published
2014
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44. Kinematic of focusing regions

Author

G Martínez-Niconoff, S I De los Santos G, J Silva-Barranco, J A Martínez-Martínez, P Martínez-Vara, and J C Ramírez-San-Juan

Subjects
Physics, business.industry, Irradiance, Inelastic collision, Kinematics, Collision, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Distribution (mathematics), Optics, Diffusion process, Convection–diffusion equation, business, Refractive index
Abstract

We describe the interaction between focusing regions and analyze the resulting physical features. The study is supported by the fact that focusing regions exhibit particle-like behavior and the interaction among these presents features similar to inelastic collision. When focusing regions are generated in a medium with random refractive index, the irradiance distribution along the focusing regions changes according to the diffusion process and the collision between them generates vortex-like effects. This study was implemented by solving the irradiance transport equation. Experimental results are in good agreement with the theoretical model performed.

Published
2014
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