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3. Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles

Author

Huffman, Jennifer E., Nicholas, Jayna, Hahn, Julie, Heath, Adam S., Raffield, Laura M., Yanek, Lisa R., Brody, Jennifer A., Thibord, Florian, Almasy, Laura, Bartz, Traci M., Bielak, Lawrence F., Bowler, Russell P., Carrasquilla, Germán D., Chasman, Daniel I., Chen, Ming-Huei, Emmert, David B., Ghanbari, Mohsen, Haessler, Jeffrey, Hottenga, Jouke-Jan, Kleber, Marcus E., Le, Ngoc-Quynh, Lee, Jiwon, Lewis, Joshua P., Li-Gao, Ruifang, Luan, Jian'an, Malmberg, Anni, Mangino, Massimo, Marioni, Riccardo E., Martinez-Perez, Angel, Pankratz, Nathan, Polasek, Ozren, Richmond, Anne, Rodriguez, Benjamin A. T., Rotter, Jerome I., Steri, Maristella, Suchon, Pierre, Trompet, Stella, Weiss, Stefan, Zare, Marjan, Auer, Paul, Cho, Michael H., Christofidou, Paraskevi, Davies, Gail, de Geus, Eco, Deleuze, Jean-François, Delgado, Graciela E., Ekunwe, Lynette, Faraday, Nauder, Gögele, Martin, Greinacher, Andreas, Gao, He, Howard, Tom, Joshi, Peter K., Kilpeläinen, Tuomas O., Lahti, Jari, Linneberg, Allan, Naitza, Silvia, Noordam, Raymond, Paüls-Vergés, Ferran, Rich, Stephen S., Rosendaal, Frits R., Rudan, Igor, Ryan, Kathleen A., Souto, Juan Carlos, van Rooij, Frank J. A., Wang, Heming, Zhao, Wei, Becker, Lewis C., Beswick, Andrew, Brown, Michael R., Cade, Brian E., Campbell, Harry, Cho, Kelly, Crapo, James D., Curran, Joanne E., de Maat, Moniek P. M., Doyle, Margaret, Elliott, Paul, Floyd, James S., Fuchsberger, Christian, Grarup, Niels, Guo, Xiuqing, Harris, Sarah E., Hou, Lifang, Kolcic, Ivana, Kooperberg, Charles, Menni, Cristina, Nauck, Matthias, O'Connell, Jeffrey R., Orrù, Valeria, Psaty, Bruce M., Räikkönen, Katri, Smith, Jennifer A., Soria, Jose Manuel, Stott, David J., van Hylckama Vlieg, Astrid, Watkins, Hugh, Willemsen, Gonneke, Wilson, Peter W. F., Ben-Shlomo, Yoav, Blangero, John, Boomsma, Dorret, Cox, Simon R., Dehghan, Abbas, Eriksson, Johan G., Fiorillo, Edoardo, Fornage, Myriam, Hansen, Torben, Hayward, Caroline, Ikram, M. Arfan, Jukema, J. Wouter, Kardia, Sharon L. R., Lange, Leslie A., März, Winfried, Mathias, Rasika A., Mitchell, Braxton D., Mook-Kanamori, Dennis O., Morange, Pierre-Emmanuel, Pedersen, Oluf, Pramstaller, Peter P., Redline, Susan, Reiner, Alexander, Ridker, Paul M., Silverman, Edwin K., Spector, Tim D., Völker, Uwe, Wareham, Nicholas J., Wilson, James F., Yao, Jie, Trégouët, David-Alexandre, Johnson, Andrew D., Wolberg, Alisa S., de Vries, Paul S., Sabater-Lleal, Maria, Morrison, Alanna C., and Smith, Nicholas L.

Published
2024
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5. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels

Author

Abe, Namiko, Abecasis, Gonçalo, Aguet, Francois, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Ardlie, Kristin, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Ayas, Najib, Balasubramanian, Adithya, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Becker, Lewis, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Blue, Nathan, Boerwinkle, Eric, Bowden, Donald W., Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Brown, Deborah, Bunting, Karen, Burchard, Esteban, Bustamante, Carlos, Buth, Erin, Cade, Brian, Cardwell, Jonathan, Carey, Vincent, Carrier, Julie, Carson, April P., Carty, Cara, Casaburi, Richard, Casas Romero, Juan P, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Conomos, Matthew, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, de las Fuentes, Lisa, de Vries, Paul, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Dinh, Huyen, Doddapaneni, Harsha, Duan, Qing, Dugan-Perez, Shannon, Duggirala, Ravi, Durda, Jon Peter, Dutcher, Susan K., Eaton, Charles, Ekunwe, Lynette, El Boueiz, Adel, Ellinor, Patrick, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Farek, Jesse, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Geiger, Heather, Gelb, Bruce, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Gray, Kathryn J., Grine, Daniel, Gross, Colin, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Han, Yi, Hanly, Patrick, Harris, Daniel, Hawley, Nicola L., He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Hu, Jianhong, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Khan, Ziad, Kim, Wonji, Kimoff, John, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Jiwon, Lee, Sandra, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Xihong, Liu, Simin, Liu, Yongmei, Liu, Yu, Loos, Ruth J. F., Lubitz, Steven, Lunetta, Kathryn, Luo, James, Magalang, Ulysses, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manning, Alisa, Manson, JoAnn, Martin, Lisa, Marton, Melissa, Mathai, Susan, Mathias, Rasika, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, McGoldrick, Daniel, McHugh, Caitlin, McNeil, Becky, Mei, Hao, Meigs, James, Menon, Vipin, Mestroni, Luisa, Metcalf, Ginger, Meyers, Deborah A, Mignot, Emmanuel, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton D., Moll, Matt, Momin, Zeineen, Montasser, May E., Montgomery, Courtney, Muzny, Donna, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Natarajan, Pradeep, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nessner, Caitlin, Nickerson, Deborah, Nkechinyere, Osuji, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Okwuonu, Geoffrey, Pack, Allan, Paik, David T., Palmer, Nicholette, Pankow, James, Papanicolaou, George, Parker, Cora, Peloso, Gina, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S, Pleiness, Jacob, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Rajendran, Mahitha, Ramachandran, Vasan S., Rao, D. C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Reeves, Catherine, Regan, Elizabeth, Reiner, Alex, Reupena, Muagututi‘a Sefuiva, Rice, Ken, Rich, Stephen, Robillard, Rebecca, Robine, Nicolas, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Runnels, Alexi, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sabino, Ester Cerdeira, Saleheen, Danish, Salimi, Shabnam, Salvi, Sejal, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay G., Santibanez, Jireh, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sériès, Frédéric, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Skomro, Robert, Smith, Albert Vernon, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent D., Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, Van Den Berg, David, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Fei Fei, Wang, Heming, Wang, Jiongming, Watson, Karol, Watt, Jennifer, Weeks, Daniel E., Weinstock, Joshua, Weir, Bruce, Weiss, Scott T, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Winterkorn, Lara, Wong, Quenna, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yu, Ketian, Zekavat, Seyedeh Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhu, Xiaofeng, Ziv, Elad, Zody, Michael, Zoellner, Sebastian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, AlexandreTrégouët, David, Smith, Nicholas L., de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc-Quynh, Bebo, Allison, Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Lewis, Joshua P., Rodriguez, Benjamin A. T., Polasek, Ozren, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David-Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Davies, Gail, Delgado, Graciela E., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., Osburn, William O., O'Connell, Jeffrey R., Beswick, Andrew, Kolcic, Ivana, Souto, Juan Carlos, Becker, Lewis C., Hansen, Torben, Doyle, Margaret F., Harris, Sarah E., Moissl, Angela P., Rich, Stephen S., Campbell, Harry, Stott, David J., Soria, Jose Manuel, de Maat, Moniek P. M., Brody, Lawrence C., Auer, Paul L., Ben-Shlomo, Yoav, Hayward, Caroline, Mathias, Rasika A., Kilpeläinen, Tuomas O., Lange, Leslie A., Cox, Simon R., März, Winfried, Rotter, Jerome I., Mook-Kanamori, Dennis O., Wilson, James F., van der Harst, Pim, Jukema, J. Wouter, Ikram, M. Arfan, Desch, Karl C., Sabater-Lleal, Maria, Lowenstein, Charles J., and Morrison, Alanna C.

Published
2024
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8. Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

Author

Boeddha, Navin P., Driessen, Gertjan J., Hagedoorn, Nienke N., Kohlfuerst, Daniela S., Hoggart, Clive J., van Rijswijk, Angelique L., Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J., Herberg, Jethro A., de Groot, Ronald, Anderson, Suzanne T., Fink, Colin G., Carrol, Enitan D., van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W., Zenz, Werner, de Maat, Moniek P. M., Hazelzet, Jan A., Emonts, Marieke, and Dik, Willem A.

Published
2021
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9. The association between human blood clot analogue computed tomography imaging, composition, contraction, and mechanical characteristics

Author

Cruts, Janneke M. H., primary, Giezen, Jo-Anne, additional, van Gaalen, Kim, additional, Beurskens, Robert, additional, Ridwan, Yanto, additional, Dijkshoorn, Marcel L., additional, van Beusekom, Heleen M. M., additional, Boodt, Nikki, additional, van der Lugt, Aad, additional, de Vries, Judith J., additional, de Maat, Moniek P. M., additional, Gijsen, Frank J. H., additional, and Cahalane, Rachel M. E., additional

Published
2023
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10. Transient Autoreactive PF4 and Antiphospholipid Antibodies in COVID-19 Vaccine Recipients.

Author

Raadsen, Matthijs P., Visser, Chantal, Lavell, A. H. Ayesha, van de Munckhof, Anita A. G. A., Coutinho, Jonathan M., de Maat, Moniek P. M., GeurtsvanKessel, Corine H., Bomers, Marije K., Haagmans, Bart L., van Gorp, Eric C. M., Porcelijn, Leendert, and Kruip, Marieke J. H. A.

Subjects
PHOSPHOLIPID antibodies, COVID-19 vaccines, MEDICAL personnel, IDIOPATHIC thrombocytopenic purpura, MESSENGER RNA
Abstract

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare autoimmune condition associated with recombinant adenovirus (rAV)-based COVID-19 vaccines. It is thought to arise from autoantibodies targeting platelet factor 4 (aPF4), triggered by vaccine-induced inflammation and the formation of neo-antigenic complexes between PF4 and the rAV vector. To investigate the specific induction of aPF4 by rAV-based vaccines, we examined sera from rAV vaccine recipients (AZD1222, AD26.COV2.S) and messenger RNA (mRNA) based (mRNA-1273, BNT162b2) COVID-19 vaccine recipients. We compared the antibody fold change (FC) for aPF4 and for antiphospholipid antibodies (aPL) of rAV to mRNA vaccine recipients. We combined two biobanks of Dutch healthcare workers and matched rAV-vaccinated individuals to mRNA-vaccinated controls, based on age, sex and prior history of COVID-19 (AZD1222: 37, Ad26.COV2.S: 35, mRNA-1273: 47, BNT162b2: 26). We found no significant differences in aPF4 FCs after the first (0.99 vs. 1.08, mean difference (MD) = −0.11 (95% CI −0.23 to 0.057)) and second doses of AZD1222 (0.99 vs. 1.10, MD = −0.11 (95% CI −0.31 to 0.10)) and after a single dose of Ad26.COV2.S compared to mRNA-based vaccines (1.01 vs. 0.99, MD = 0.026 (95% CI −0.13 to 0.18)). The mean FCs for the aPL in rAV-based vaccine recipients were similar to those in mRNA-based vaccines. No correlation was observed between post-vaccination aPF4 levels and vaccine type (mean aPF difference −0.070 (95% CI −0.14 to 0.002) mRNA vs. rAV). In summary, our study indicates that rAV and mRNA-based COVID-19 vaccines do not substantially elevate aPF4 levels in healthy individuals. [ABSTRACT FROM AUTHOR]

Published
2023
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11. The association of coagulation and atrial fibrillation:a systematic review and meta-analysis

Author

Tilly, Martijn J., Geurts, Sven, Pezzullo, Angelo M., Bramer, Wichor M., de Groot, Natasja M. S., Kavousi, Maryam, de Maat, Moniek P. M., Tilly, Martijn J., Geurts, Sven, Pezzullo, Angelo M., Bramer, Wichor M., de Groot, Natasja M. S., Kavousi, Maryam, and de Maat, Moniek P. M.

Abstract

AIMS: While atrial fibrillation (AF) is suggested to induce a prothrombotic state, increasing thrombotic risk, it is also hypothesized that coagulation underlies AF onset. However, conclusive evidence is lacking. With this systematic review and meta-analysis, we aimed to summarize and combine the evidence on the associations between coagulation factors with AF in both longitudinal and cross-sectional studies. METHODS AND RESULTS: We systematically searched for longitudinal cohort and cross-sectional studies investigating AF and thrombosis. For longitudinal studies, pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. For cross-sectional studies, we determined pooled standardized mean differences (SMDs) and 95% CIs. A total of 17 longitudinal and 44 cross-sectional studies were included. In longitudinal studies, we found significant associations between fibrinogen (HR 1.05, 95% CI 1.00-1.10), plasminogen activator inhibitor 1 (PAI-1) (HR 1.06, 95% CI 1.00-1.12), and D-dimer (HR 1.10, 95% CI 1.02-1.19) and AF incidence. In cross-sectional studies, we found significantly increased levels of fibrinogen (SMD 0.47, 95% CI 0.20-0,74), von Willebrand factor (SMD 0.96, 95% CI 0.28-1.66), P-selectin (SMD 0.31, 95% CI 0.08-0.54), ß-thromboglobulin (SMD 0.82, 95% CI 0.61-1.04), Platelet Factor 4 (SMD 0.42, 95% CI 0.12-0.7), PAI-1 (1.73, 95% CI 0.26-3.19), and D-dimer (SMD 1.74, 95% CI 0.36-3.11) in AF patients, as opposed to controls. CONCLUSION: These findings suggest that higher levels of coagulation factors are associated with prevalent and incident AF. These associations are most pronounced with prevalent AF in cross-sectional studies. Limited evidence from longitudinal studies suggests a prothrombotic state underlying AF development.

Published
2023

12. Atrial fibrillation patterns and their cardiovascular risk profiles in the general population:the Rotterdam study

Author

Tilly, Martijn J., Lu, Zuolin, Geurts, Sven, Ikram, M. Arfan, Stricker, Bruno H., Kors, Jan A., de Maat, Moniek P. M., de Groot, Natasja M. S., Kavousi, Maryam, Tilly, Martijn J., Lu, Zuolin, Geurts, Sven, Ikram, M. Arfan, Stricker, Bruno H., Kors, Jan A., de Maat, Moniek P. M., de Groot, Natasja M. S., and Kavousi, Maryam

Abstract

Background: Clinical guidelines categorize atrial fibrillation (AF) based on the temporality of AF events. Due to its dependence on event duration, this classification is not applicable to population-based cohort settings. We aimed to develop a simple and standardized method to classify AF patterns at population level. Additionally, we compared the longitudinal trajectories of cardiovascular risk factors preceding the AF patterns, and between men and women. Methods: Between 1990 and 2014, participants from the population-based Rotterdam study were followed for AF status, and categorized into ‘single-documented AF episode’, ‘multiple-documented AF episodes’, or ‘long-standing persistent AF’. Using repeated measurements we created linear mixed-effects models to assess the longitudinal evolution of risk factors prior to AF diagnosis. Results: We included 14,061 participants (59.1% women, mean age 65.4 ± 10.2 years). After a median follow-up of 9.4 years (interquartile range 8.27), 1,137 (8.1%) participants were categorized as ‘single-documented AF episode’, 208 (1.5%) as ‘multiple-documented AF episodes’, and 57 (0.4%) as ‘long-standing persistent AF’. In men, we found poorer trajectories of weight and waist circumference preceding ‘long-standing persistent AF’ as compared to the other patterns. In women, we found worse trajectories of all risk factors between ‘long-standing persistent AF’ and the other patterns. Conclusion: We developed a standardized method to classify AF patterns in the general population. Participants categorized as ‘long-standing persistent AF’ showed poorer trajectories of cardiovascular risk factors prior to AF diagnosis, as compared to the other patterns. Our findings highlight sex differences in AF pathophysiology and provide insight into possible risk factors of AF patterns. Graphical abstract: [Figure not available: see fulltext.].

Published
2023

15. Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial.

Author

van der Ende, Nadinda A. M., Roozenbeek, Bob, Smagge, Lucas E. M., Luijten, Sven P. R., Aerden, Leo A. M., Kraayeveld, Petra, van den Wijngaard, Ido R., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Flach, H. Zwenneke, Postma, Alida A., Roosendaal, Stefan D., Krietemeijer, G. Menno, Yo, Lonneke S. F., de Maat, Moniek P. M., Nieboer, Daan, Del Zoppo, Gregory J., Meurer, William J., Lingsma, Hester F., and van der Lugt, Aad

Published
2023
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16. Atrial fibrillation patterns and their cardiovascular risk profiles in the general population: the Rotterdam study.

Author

Tilly, Martijn J., Lu, Zuolin, Geurts, Sven, Ikram, M. Arfan, Stricker, Bruno H., Kors, Jan A., de Maat, Moniek P. M., de Groot, Natasja M. S., and Kavousi, Maryam

Abstract

Background: Clinical guidelines categorize atrial fibrillation (AF) based on the temporality of AF events. Due to its dependence on event duration, this classification is not applicable to population-based cohort settings. We aimed to develop a simple and standardized method to classify AF patterns at population level. Additionally, we compared the longitudinal trajectories of cardiovascular risk factors preceding the AF patterns, and between men and women. Methods: Between 1990 and 2014, participants from the population-based Rotterdam study were followed for AF status, and categorized into 'single-documented AF episode', 'multiple-documented AF episodes', or 'long-standing persistent AF'. Using repeated measurements we created linear mixed-effects models to assess the longitudinal evolution of risk factors prior to AF diagnosis. Results: We included 14,061 participants (59.1% women, mean age 65.4 ± 10.2 years). After a median follow-up of 9.4 years (interquartile range 8.27), 1,137 (8.1%) participants were categorized as 'single-documented AF episode', 208 (1.5%) as 'multiple-documented AF episodes', and 57 (0.4%) as 'long-standing persistent AF'. In men, we found poorer trajectories of weight and waist circumference preceding 'long-standing persistent AF' as compared to the other patterns. In women, we found worse trajectories of all risk factors between 'long-standing persistent AF' and the other patterns. Conclusion: We developed a standardized method to classify AF patterns in the general population. Participants categorized as 'long-standing persistent AF' showed poorer trajectories of cardiovascular risk factors prior to AF diagnosis, as compared to the other patterns. Our findings highlight sex differences in AF pathophysiology and provide insight into possible risk factors of AF patterns. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units

Author

Noordermeer, Tessa, Schutgens, Roger E. G., Visser, Chantal, Rademaker, Emma, de Maat, Moniek P. M., Jansen, A. J. Gerard, Limper, Maarten, Cremer, Olaf L., Kruip, Marieke J. H. A., Endeman, Henrik, Maas, Coen, de Laat, Bas, Urbanus, Rolf T., van de Beek, D., Brouwer, M. C., de Bruin, S., Coppens, M., van Es, N., van Haaps, T. F., Juffermans, N. P., Muller, M. C. A., Vlaar, A. P. J., Hertogh, C. M. P. M., Heunks, L. M. A., Hugtenburg, J. G., van Kooten, J., Nossent, E. J., Smulders, Y., Tuinman, P. R., Noordegraaf, A. Vonk, Grootenboers, M. J. J. H., van Guldener, C., Kant, M., Lansbergen, A., Faber, J., Hajer, G., Stemerdink, A., van den Akker, J., Bierings, R., Endeman, H., Goeijenbier, M., Hunfeld, N. G. M., van Gorp, E. C. M., Gommers, D. A. M. P. J., Koopmans, M. P. G., Kruip, M. J. H. A., Kuiken, T., Langerak, T., Leebeek, Lauw, M. N., de Maat, M. P. M., Noack, D., Paats, M. S., Raadsen, M. P., Rockx, B., Rokx, C., Schurink, C. A. M., Tong-Minh, K., van den Toorn, L., den Uil, C. A., Visser, C., Boutkourt, F., Roest, T., Douma, R. A., de Haan, L. R., ten Wolde, M., Bemelmans, R. H. H., Festen, B., Stads, S., de Jager, C. P. C., Simons, K. S., Antoni, M. L., Bos, M. H., Burggraaf, J. L. I., Cannegieter, S. C., Eikenboom, H. C. J., den Exter, P. L., Geelhoed, J. J. M., Huisman, M. V., de Jonge, E., Kaptein, F. H. J., Klok, F. A., Kroft, L. J. M., Lijfering, W. M., Nab, L., Ninaber, M. K., Putter, H., Ramai, S. R. S., da Rocha Rondon, A. M., Roukens, A. H. E., Stals, M. A. M., Versteeg, H. H., Vliegen, H. W., van Vlijmen, B. J. M., van de Berg, T., Bruggemann, R., van Bussel, B. C. T., ten Cate, H., ten Cate-Hoek, A., Hackeng, T. M., Henskens, ir. Y., Hulshof, A., Mulder, M., Olie, R. H., Schurgers, L., Spaetgens, B., Spronk, H., Spruit, M. A., Winckers, K., Nieuwenhuizen, L., Franken, B., Schrover, I. M., de Waal, E. G. M., Beishuizen, A., Cornet, A., Krabbe, J., Kramers, K., Leentjens, J., de Mast, Q., Middeldorp, S., Brouwer, R. E., Ellerbroek, J. L. J., Tijmensen, J., Hovens, M. M. C., Oostdijk, E. A. N., Westerhof, B. D., Faber, L. M., van den Biggelaar, M., Meijers, J. C. M., Voorberg, J., Kevenaar, M. E., Soei, Y. L., Wils, E. J., Croles, F. N., de Laat, B., Kamphuisen, P. W., Vink, R., Lisman, T., Meijer, K., van Tichelaar, Y. I. G., Cremer, O. L., Geersing, G., Kaasjager, H. A. H., Kusadasi, N., Huisman, A., Maas, C., Nijkeuter, M., Schutgens, R. E. G., Creveldkliniek, Van, Urbanus, R. T., Westerink, J., Faber, H. J., Koster, S. C. E., van Montfort, P., van Twist, D. J. L., RS: Carim - B01 Blood proteins & engineering, Biochemie, Hematology, Intensive Care, Neurology, ANS - Neuroinfection & -inflammation, Intensive Care Medicine, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Graduate School, ACS - Microcirculation, Medical Microbiology and Infection Prevention, ARD - Amsterdam Reproduction and Development, Experimental Vascular Medicine, Landsteiner Laboratory, ACS - Atherosclerosis & ischemic syndromes, Elderly care medicine, APH - Aging & Later Life, Clinical pharmacology and pharmacy, APH - Health Behaviors & Chronic Diseases, Pulmonary medicine, Internal medicine, ACS - Diabetes & metabolism, Intensive care medicine, General practice, and Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], lupus anticoagulant, risk factor, critically ill, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], COVID-19, Hematology, thrombosis, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract

Contains fulltext : 286889.pdf (Publisher’s version ) (Open Access) BACKGROUND: Thrombosis is a frequent and severe complication in patients with coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Lupus anticoagulant (LA) is a strong acquired risk factor for thrombosis in various diseases and is frequently observed in patients with COVID-19. Whether LA is associated with thrombosis in patients with severe COVID-19 is currently unclear. OBJECTIVE: To investigate if LA is associated with thrombosis in critically ill patients with COVID-19. PATIENTS/METHODS: The presence of LA and other antiphospholipid antibodies was assessed in patients with COVID-19 admitted to the ICU. LA was determined with dilute Russell's viper venom time (dRVVT) and LA-sensitive activated partial thromboplastin time (aPTT) reagents. RESULTS: Of 169 patients with COVID-19, 116 (69%) tested positive for at least one antiphospholipid antibody upon admission to the ICU. Forty (24%) patients tested positive for LA; of whom 29 (17%) tested positive with a dRVVT, 19 (11%) tested positive with an LA-sensitive aPTT, and 8 (5%) tested positive on both tests. Fifty-eight (34%) patients developed thrombosis after ICU admission. The odds ratio (OR) for thrombosis in patients with LA based on a dRVVT was 2.5 (95% confidence interval [CI], 1.1-5.7), which increased to 4.5 (95% CI, 1.4-14.3) in patients at or below the median age in this study (64 years). LA positivity based on a dRVVT or LA-sensitive aPTT was only associated with thrombosis in patients aged less than 65 years (OR, 3.8; 95% CI, 1.3-11.4) and disappeared after adjustment for C-reactive protein. CONCLUSION: Lupus anticoagulant on admission is strongly associated with thrombosis in critically ill patients with COVID-19, especially in patients aged less than 65 years.

Published
2022

20. Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study

Author

de Vries, Judith J., primary, Autar, Anouchska S. A., additional, van Dam-Nolen, Dianne H. K., additional, Donkel, Samantha J., additional, Kassem, Mohamed, additional, van der Kolk, Anja G., additional, van Velzen, Twan J., additional, Kooi, M. Eline, additional, Hendrikse, Jeroen, additional, Nederkoorn, Paul J., additional, Bos, Daniel, additional, van der Lugt, Aad, additional, de Maat, Moniek P. M., additional, and van Beusekom, Heleen M. M., additional

Published
2022
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21. Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis

Author

de Vries, Judith J, Visser, Chantal, Geers, Lotte, Slotman, Johan A, van Kleef, Nadine D, Maas, Coen, Bax, Hannelore I, Miedema, Jelle R, van Gorp, Eric C M, Goeijenbier, Marco, van den Akker, Johannes P C, Endeman, Henrik, Rijken, Dingeman C, Kruip, Marieke J H A, de Maat, Moniek P M, de Vries, Judith J, Visser, Chantal, Geers, Lotte, Slotman, Johan A, van Kleef, Nadine D, Maas, Coen, Bax, Hannelore I, Miedema, Jelle R, van Gorp, Eric C M, Goeijenbier, Marco, van den Akker, Johannes P C, Endeman, Henrik, Rijken, Dingeman C, Kruip, Marieke J H A, and de Maat, Moniek P M

Abstract

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of thrombosis.OBJECTIVES: By studying the fibrin network structure of coronavirus disease 2019 (COVID-19) patients, we aimed to unravel pathophysiological mechanisms that contribute to this increased risk of thrombosis. This may contribute to optimal prevention and treatment of COVID-19 related thrombosis.PATIENTS/METHODS: In this case-control study, we collected plasma samples from intensive care unit (ICU) patients with COVID-19, with and without confirmed thrombosis, between April and December 2020. Additionally, we collected plasma from COVID-19 patients admitted to general wards without thrombosis, from ICU patients with pneumococcal infection, and from healthy controls. Fibrin fiber diameters and fibrin network density were quantified in plasma clots imaged with stimulated emission depletion microscopy and confocal microscopy. Finally, we determined the sensitivity to fibrinolysis.RESULTS: COVID-19 ICU patients (n = 37) and ICU patients with pneumococcal disease (n = 7) showed significantly higher fibrin densities and longer plasma clot lysis times than healthy controls (n = 7). No differences were observed between COVID-19 ICU patients with and without thrombosis, or ICU patients with pneumococcal infection. At a second time point, after diagnosis of thrombosis or at a similar time point in patients without thrombosis, we observed thicker fibers and longer lysis times in COVID-19 ICU patients with thrombosis (n = 19) than in COVID-19 ICU patients without thrombosis (n = 18).CONCLUSIONS: Our results suggest that severe COVID-19 is associated with a changed fibrin network structure and decreased susceptibility to fibrinolysis. Because these changes were not exclusive to COVID-19 patients, they may not explain the increased thrombosis risk.

Published
2022

22. Immunothrombosis and new-onset atrial fibrillation in the general population::the Rotterdam Study

Author

Tilly, Martijn J., Geurts, Sven, Donkel, Samantha J., Ikram, M. Arfan, de Groot, Natasja M. S., de Maat, Moniek P. M., Kavousi, Maryam, Tilly, Martijn J., Geurts, Sven, Donkel, Samantha J., Ikram, M. Arfan, de Groot, Natasja M. S., de Maat, Moniek P. M., and Kavousi, Maryam

Abstract

Background: Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia. The etiology underlying AF is still largely unknown. At the intersection of the innate immune system and hemostasis, immunothrombosis may be a possible cause of atrial remodeling, and therefore be an underlying cause of AF. Methods: From 1990 to 2014, we followed participants aged 55 and over, free from AF at inclusion. Immunothrombosis factors fibrinogen, von Willebrand factor, ADAMTS13, and neutrophil extracellular traps (NETs) levels were measured at baseline. Participants were followed until either onset of AF, loss-to-follow-up, or reaching the end-date of 01-01-2014. Cox proportional hazard modelling was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for cardiovascular risk factors. Results: We followed 6174 participants (mean age 69.1 years, 57% women) for a median follow-up time of 12.8 years. 364 men (13.7%, incidence rate 13.0/1000 person-years) and 365 women (10.4%, incidence rate 8.9/1000 person-years) developed AF. We found no significant association between markers of immunothrombosis and new-onset AF after adjusting for cardiovascular risk factors [HR 1.00 (95% CI 0.93–1.08) for fibrinogen, 1.04 (0.97–1.12) for von Willebrand factor, 1.00 (1.00–1.01) for ADAMTS13, and 1.01 (0.94–1.09) for NETs]. In addition, we found no differences in associations between men and women. Conclusion: We found no associations between markers of immunothrombosis and new-onset AF in the general population. Inflammation and immunothrombosis may be associated with AF through other cardiovascular risk factors or predisposing conditions of AF. Our findings challenge the added value of biomarkers in AF risk prediction. Graphic abstract: [Figure not available: see fulltext.].

Published
2022

23. Altered fibrin network structure and fibrinolysis in intensive care unit patients with COVID-19, not entirely explaining the increased risk of thrombosis

Author

CDL Contact activatie, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Pathologie Opleiding, de Vries, Judith J, Visser, Chantal, Geers, Lotte, Slotman, Johan A, van Kleef, Nadine D, Maas, Coen, Bax, Hannelore I, Miedema, Jelle R, van Gorp, Eric C M, Goeijenbier, Marco, van den Akker, Johannes P C, Endeman, Henrik, Rijken, Dingeman C, Kruip, Marieke J H A, de Maat, Moniek P M, CDL Contact activatie, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Pathologie Opleiding, de Vries, Judith J, Visser, Chantal, Geers, Lotte, Slotman, Johan A, van Kleef, Nadine D, Maas, Coen, Bax, Hannelore I, Miedema, Jelle R, van Gorp, Eric C M, Goeijenbier, Marco, van den Akker, Johannes P C, Endeman, Henrik, Rijken, Dingeman C, Kruip, Marieke J H A, and de Maat, Moniek P M

Published
2022

24. Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study

Author

Computational Imaging, Cancer, Divisie Beeld, Brain, Researchgr. Neuroradiologie, de Vries, Judith J, Autar, Anouchska S A, van Dam-Nolen, Dianne H K, Donkel, Samantha J, Kassem, Mohamed, van der Kolk, Anja G, van Velzen, Twan J, Kooi, M Eline, Hendrikse, Jeroen, Nederkoorn, Paul J, Bos, Daniel, van der Lugt, Aad, de Maat, Moniek P M, van Beusekom, Heleen M M, Computational Imaging, Cancer, Divisie Beeld, Brain, Researchgr. Neuroradiologie, de Vries, Judith J, Autar, Anouchska S A, van Dam-Nolen, Dianne H K, Donkel, Samantha J, Kassem, Mohamed, van der Kolk, Anja G, van Velzen, Twan J, Kooi, M Eline, Hendrikse, Jeroen, Nederkoorn, Paul J, Bos, Daniel, van der Lugt, Aad, de Maat, Moniek P M, and van Beusekom, Heleen M M

Published
2022

25. Whole-exome sequencing of 14 389 individuals from the ESP and CHARGE consortia identifies novel rare variation associated with hemostatic factors

Author

Pankratz, Nathan, primary, Wei, Peng, additional, Brody, Jennifer A, additional, Chen, Ming-Huei, additional, de Vries, Paul S, additional, Huffman, Jennifer E, additional, Stimson, Mary Rachel, additional, Auer, Paul L, additional, Boerwinkle, Eric, additional, Cushman, Mary, additional, de Maat, Moniek P M, additional, Folsom, Aaron R, additional, Franco, Oscar H, additional, Gibbs, Richard A, additional, Haagenson, Kelly K, additional, Hofman, Albert, additional, Johnsen, Jill M, additional, Kovar, Christie L, additional, Kraaij, Robert, additional, McKnight, Barbara, additional, Metcalf, Ginger A, additional, Muzny, Donna, additional, Psaty, Bruce M, additional, Tang, Weihong, additional, Uitterlinden, André G, additional, van Rooij, Jeroen G J, additional, Dehghan, Abbas, additional, O'Donnell, Christopher J, additional, Reiner, Alex P, additional, Morrison, Alanna C, additional, and Smith, Nicholas L, additional

Published
2022
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28. Levels of Fibrinogen Variants Are Altered in Severe COVID-19

Author

de Vries, Judith J., Visser, Chantal, van Ommen, Maureen, Rokx, Casper, van Nood, Els, van Gorp, Eric C. M., Goeijenbier, Marco, van den Akker, Johannes P. C., Endeman, Henrik, Rijken, Dingeman C., Kruip, Marieke J. H. A., Weggeman, Miranda, Koopman, Jaap, and de Maat, Moniek P. M.

Published
2023
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30. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

Author

de Vries, Paul S., Chasman, Daniel I., Sabater-Lleal, Maria, Chen, Ming-Huei, Huffman, Jennifer E., Steri, Maristella, Tang, Weihong, Teumer, Alexander, Marioni, Riccardo E., Grossmann, Vera, Hottenga, Jouke J., Trompet, Stella, Müller-Nurasyid, Martina, Zhao, Jing Hua, Brody, Jennifer A., Kleber, Marcus E., Guo, Xiuqing, Wang, Jie Jin, Auer, Paul L., Attia, John R., Yanek, Lisa R., Ahluwalia, Tarunveer S., Lahti, Jari, Venturini, Cristina, Tanaka, Toshiko, Bielak, Lawrence F., Joshi, Peter K., Rocanin-Arjo, Ares, Kolcic, Ivana, Navarro, Pau, Rose, Lynda M., Oldmeadow, Christopher, Riess, Helene, Mazur, Johanna, Basu, Saonli, Goel, Anuj, Yang, Qiong, Ghanbari, Mohsen, Willemsen, Gonneke, Rumley, Ann, Fiorillo, Edoardo, de Craen, Anton J. M., Grotevendt, Anne, Scott, Robert, Taylor, Kent D., Delgado, Graciela E., Yao, Jie, Kifley, Annette, Kooperberg, Charles, Qayyum, Rehan, Lopez, Lorna M., Berentzen, Tina L., Räikkönen, Katri, Mangino, Massimo, Bandinelli, Stefania, Peyser, Patricia A., Wild, Sarah, Trégouët, David-Alexandre, Wright, Alan F., Marten, Jonathan, Zemunik, Tatijana, Morrison, Alanna C., Sennblad, Bengt, Tofler, Geoffrey, de Maat, Moniek P. M., de Geus, Eco J. C., Lowe, Gordon D., Zoledziewska, Magdalena, Sattar, Naveed, Binder, Harald, Völker, Uwe, Waldenberger, Melanie, Khaw, Kay-Tee, Mcknight, Barbara, Huang, Jie, Jenny, Nancy S., Holliday, Elizabeth G., Qi, Lihong, Mcevoy, Mark G., Becker, Diane M., Starr, John M., Sarin, Antti-Pekka, Hysi, Pirro G., Hernandez, Dena G., Jhun, Min A., Campbell, Harry, Hamsten, Anders, Rivadeneira, Fernando, Mcardle, Wendy L., Slagboom, P. Eline, Zeller, Tanja, Koenig, Wolfgang, Psaty, Bruce M., Haritunians, Talin, Liu, Jingmin, Palotie, Aarno, Uitterlinden, André G., Stott, David J., Hofman, Albert, Franco, Oscar H., Polasek, Ozren, Rudan, Igor, Morange, Pierre-Emmanuel, Wilson, James F., Kardia, Sharon L. R., Ferrucci, Luigi, Spector, Tim D., Eriksson, Johan G., Hansen, Torben, Deary, Ian J., Becker, Lewis C., Scott, Rodney J., Mitchell, Paul, März, Winfried, Wareham, Nick J., Peters, Annette, Greinacher, Andreas, Wild, Philipp S., Jukema, J. Wouter, Boomsma, Dorret I., Hayward, Caroline, Cucca, Francesco, Tracy, Russell, Watkins, Hugh, Reiner, Alex P., Folsom, Aaron R., Ridker, Paul M., OʼDonnell, Christopher J., Smith, Nicholas L., Strachan, David P., and Dehghan, Abbas

Published
2016
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33. Automated Fiber Diameter and Porosity Measurements of Plasma Clots in Scanning Electron Microscopy Images

Author

Daraei, Ali, primary, Pieters, Marlien, additional, Baker, Stephen R., additional, de Lange-Loots, Zelda, additional, Siniarski, Aleksander, additional, Litvinov, Rustem I., additional, Veen, Caroline S. B., additional, de Maat, Moniek P. M., additional, Weisel, John W., additional, Ariëns, Robert A. S., additional, and Guthold, Martin, additional

Published
2021
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36. Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

Author

Boeddha, Navin P, Driessen, Gertjan J, Hagedoorn, Nienke N, Kohlfuerst, Daniela S, Hoggart, Clive J, van Rijswijk, Angelique L, Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J, Herberg, Jethro A, de Groot, Ronald, Anderson, Suzanne T, Fink, Colin G, Carrol, Enitan D, van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W, Zenz, Werner, de Maat, Moniek P M, Hazelzet, Jan A, Emonts, Marieke, Dik, Willem A, Boeddha, Navin P, Driessen, Gertjan J, Hagedoorn, Nienke N, Kohlfuerst, Daniela S, Hoggart, Clive J, van Rijswijk, Angelique L, Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J, Herberg, Jethro A, de Groot, Ronald, Anderson, Suzanne T, Fink, Colin G, Carrol, Enitan D, van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W, Zenz, Werner, de Maat, Moniek P M, Hazelzet, Jan A, Emonts, Marieke, and Dik, Willem A

Abstract

IMPORTANCE: A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking.OBJECTIVES: To study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome.DESIGN: Data from two prospective cohort studies.SETTING AND PARTICIPANTS: Cohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission).MAIN OUTCOMES AND MEASURES: Primary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay.RESULTS: In cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis.CONCLUSIONS AND RELEVANCE: In children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital a

Published
2021

37. Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII : A Randomized Controlled Trial in Swine

Author

Atiq, Ferdows, Van De Wouw, Jens, Sorop, Oana, Heinonen, Ilkka, De Maat, Moniek P. M., Merkus, Daphne, Duncker, Dirk J., Leebeek, Frank W. G., Atiq, Ferdows, Van De Wouw, Jens, Sorop, Oana, Heinonen, Ilkka, De Maat, Moniek P. M., Merkus, Daphne, Duncker, Dirk J., and Leebeek, Frank W. G.

Abstract

All rights reserved.It is well known that high von Willebrand factor (VWF) and factor VIII (FVIII) levels are associated with an increased risk of cardiovascular disease. It is still debated whether VWF and FVIII are biomarkers of endothelial dysfunction and atherosclerosis or whether they have a direct causative role. Therefore, we aimed to unravel the pathophysiological pathways of increased VWF and FVIII levels associated with cardiovascular risk factors. First, we performed a randomized controlled trial in 34 Göttingen miniswine. Diabetes mellitus (DM) was induced with streptozotocin and hypercholesterolemia (HC) via a high-fat diet in 18 swine (DM + HC), while 16 healthy swine served as controls. After 5 months of follow-up, FVIII activity (FVIII:C) was significantly higher in DM + HC swine (5.85 IU/mL [5.00-6.81]) compared with controls (4.57 [3.76-5.40], p = 0.010), whereas VWF antigen (VWF:Ag) was similar (respectively 0.34 IU/mL [0.28-0.39] vs. 0.34 [0.31-0.38], p = 0.644). DM + HC swine had no endothelial dysfunction or atherosclerosis during this short-term follow-up. Subsequently, we performed a long-term (15 months) longitudinal cohort study in 10 Landrace-Yorkshire swine, in five of which HC and in five combined DM + HC were induced. VWF:Ag was higher at 15 months compared with 9 months in HC (0.37 [0.32-0.42] vs. 0.27 [0.23-0.40], p = 0.042) and DM + HC (0.33 [0.32-0.37] vs. 0.25 [0.24-0.33], p = 0.042). Both long-term groups had endothelial dysfunction compared with controls and atherosclerosis after 15 months. In conclusion, short-term hyperglycemia and dyslipidemia increase FVIII, independent of VWF. Long-term DM and HC increase VWF via endothelial dysfunction and atherosclerosis. Therefore, VWF seems to be a biomarker for advanced cardiovascular disease. © 2021 Georg Thieme Verlag., Övriga finansiärer:Dutch Heart FoundationCVON2014-11, CVON2016-ARENA-Prime European Commission FP7-Health-2010: MEDIA-261409German Center for Cardiovascular Research Shire/Takeda CSL BehringDeutsches Zentrum für Herz-Kreislaufforschung: DZHK81Z0600207, DZHKSuomen Akatemia: 251272Novo NordiskSydäntutkimussäätiö

Published
2021
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38. Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis

Author

NVIC bedrijfsvoering, Other research (not in main researchprogram), Infectieziekten patientenzorg, Child Health, Boeddha, Navin P, Driessen, Gertjan J, Hagedoorn, Nienke N, Kohlfuerst, Daniela S, Hoggart, Clive J, van Rijswijk, Angelique L, Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J, Herberg, Jethro A, de Groot, Ronald, Anderson, Suzanne T, Fink, Colin G, Carrol, Enitan D, van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W, Zenz, Werner, de Maat, Moniek P M, Hazelzet, Jan A, Emonts, Marieke, Dik, Willem A, NVIC bedrijfsvoering, Other research (not in main researchprogram), Infectieziekten patientenzorg, Child Health, Boeddha, Navin P, Driessen, Gertjan J, Hagedoorn, Nienke N, Kohlfuerst, Daniela S, Hoggart, Clive J, van Rijswijk, Angelique L, Ekinci, Ebru, Priem, Debby, Schlapbach, Luregn J, Herberg, Jethro A, de Groot, Ronald, Anderson, Suzanne T, Fink, Colin G, Carrol, Enitan D, van der Flier, Michiel, Martinón-Torres, Federico, Levin, Michael, Leebeek, Frank W, Zenz, Werner, de Maat, Moniek P M, Hazelzet, Jan A, Emonts, Marieke, and Dik, Willem A

Published
2021

40. von Willebrand Factor and Factor VIII Clearance in Perioperative Hemophilia A Patients

Author

Poli Van Creveldkliniek Medisch, Circulatory Health, Infection & Immunity, van Moort, Iris, Bukkems, Laura H, Heijdra, Jessica M, Schutgens, Roger E G, Laros-van Gorkom, Britta A P, Nieuwenhuizen, Laurens, van der Meer, Felix J M, Fijnvandraat, Karin, Ypma, Paula, de Maat, Moniek P M, Leebeek, Frank W G, Meijer, Karina, Eikenboom, Jeroen, Mathôt, Ron A A, Cnossen, Marjon H, “OPTI-CLOT” study group, Poli Van Creveldkliniek Medisch, Circulatory Health, Infection & Immunity, van Moort, Iris, Bukkems, Laura H, Heijdra, Jessica M, Schutgens, Roger E G, Laros-van Gorkom, Britta A P, Nieuwenhuizen, Laurens, van der Meer, Felix J M, Fijnvandraat, Karin, Ypma, Paula, de Maat, Moniek P M, Leebeek, Frank W G, Meijer, Karina, Eikenboom, Jeroen, Mathôt, Ron A A, Cnossen, Marjon H, and “OPTI-CLOT” study group

Published
2020

42. Von Willebrand Factor Multimer Densitometric Analysis: Validation of the Clinical Accuracy and Clinical Implications in Von Willebrand Disease

Author

Boender, Johan, primary, Atiq, Ferdows, additional, Cnossen, Marjon H., additional, van der Bom, Johanna G., additional, Fijnvandraat, Karin, additional, de Meris, Joke, additional, de Maat, Moniek P. M., additional, van Galen, Karin P. M., additional, Laros-van Gorkom, Britta A. P., additional, Meijer, Karina, additional, Eikenboom, Jeroen, additional, and Leebeek, Frank W. G., additional

Published
2021
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44. Impact of COVID‐19 pandemic on the quality of test output in haemostasis laboratories.

Author

Arisz, Ryanne A., Meijer, Piet, Péquériaux, Nathalie C.V., van de Leur, Sjef J., Lukens, Michaël V., de Maat, Moniek P. M., and Hollestelle, Martine J.

Subjects
PATHOLOGICAL laboratories, HEMOSTASIS, SURVEYS, COMPARATIVE studies, QUALITY assurance, QUALITY control, QUESTIONNAIRES, DESCRIPTIVE statistics, COVID-19 pandemic, FIBRIN fibrinogen degradation products
Abstract

Introduction: The high incidence of thrombotic events in patients with COVID‐19 affects health care worldwide and results in an increased workload in haemostasis laboratories due to more frequent testing of D‐dimer, haemostatic parameters and anti‐Xa tests. However, the impact of this increase in assay requests on the quality of performance in haemostasis laboratories remains unclear. In this study, the impact of the COVID‐19 pandemic on the quality of performance and management of haemostasis laboratories was evaluated. Methods: The impact on the quality of performance was studied using external quality assessment data from 2019 to 2020 derived from ECAT surveys. A questionnaire was sent to Dutch haemostasis laboratories to identify challenges and management strategies. Furthermore, the number of assays performed in 2019 and 2020 was supplied by four Dutch hospitals, located in regions with different disease incidence. Results: No differences in response rate nor the quality of the measurements were observed between the EQA surveys in 2019 and 2020. The questionnaire results showed a large increase of >25% in the number of test requests for anti‐Xa, D‐dimer and fibrinogen assays in 2020 compared to 2019. Extreme peaks in test requests were also observed in the four evaluated hospitals. Additionally, 84% of the respondents indicated that they had experienced increased work pressure, and increased sick leave was observed in 71% of the participating laboratories. Conclusions: The enormous increase in test requests, especially for D‐dimer assays and anti‐Xa activity, did not affect the quality of performance within haemostatic laboratories during the COVID‐19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

Author

Pons, Douwe, Trompet, Stella, de Craen, Anton J M, Thijssen, Peter E, Quax, Paul H A, de Vries, Margreet R, Wierda, Rutger J, van den Elsen, Peter J, Monraats, Pascalle S, Ewing, Mark M, Heijmans, Bastiaan T, Slagboom, P Eline, Zwinderman, Aeilko H, Doevendans, Pieter A F M, Tio, René A, de Winter, Robbert J, de Maat, Moniek P M, Iakoubova, Olga A, Sattar, Naveed, Shepherd, Jim, Westendorp, Rudi G J, and Jukema, J Wouter

Published
2011
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47. Correction: Faria, A.V.S. et al., Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients. J. Clin. Med. 2019, 8, 936

Author

Faria, Alessandra V. S., primary, Andrade, Sheila S., additional, Reijm, Agnes N., additional, Spaander, Manon C. W., additional, de Maat, Moniek P. M., additional, Peppelenbosch, Maikel P., additional, Ferreira-Halder, Carmen V., additional, and Fuhler, Gwenny M., additional

Published
2020
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