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10 results on '"de Rezende, Michelle Carvalho"'

3. The Th2 Response and Alternative Activation of Macrophages Triggered by Strongyloides venezuelensis Is Linked to Increased Morbidity and Mortality Due to Cryptococcosis in Mice

Author

Gouveia-Eufrasio, Ludmila, primary, de Freitas, Gustavo José Cota, additional, Costa, Marliete Carvalho, additional, Peres-Emidio, Eluzia Castro, additional, Carmo, Paulo Henrique Fonseca, additional, Rodrigues, João Gustavo Mendes, additional, de Rezende, Michelle Carvalho, additional, Rodrigues, Vanessa Fernandes, additional, de Brito, Camila Bernardo, additional, Miranda, Guilherme Silva, additional, de Lima, Pâmela Aparecida, additional, da Silva, Lívia Mara Vitorino, additional, Oliveira, Jefferson Bruno Soares, additional, da Paixão, Tatiane Alves, additional, da Glória de Souza, Daniele, additional, Fagundes, Caio Tavares, additional, Peres, Nalu Teixeira de Aguiar, additional, Negrão-Correa, Deborah Aparecida, additional, and Santos, Daniel Assis, additional

Published
2023
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4. Evaluation of Isotype-Based Serology for Diagnosis of Schistosoma Mansoni Infection in Individuals Living in Endemic Areas with Low Parasite Burden

Author

do Carmo Magalhães, Fernanda, primary, Moreira, João Marcelo Peixoto, additional, de Rezende, Michelle Carvalho, additional, Favero, Vivian, additional, Graeff-Teixeira, Carlos, additional, Coelho, Paulo Marcos Zech, additional, Carneiro, Mariângela, additional, Geiger, Stefan Michael, additional, and Negrão-Corrêa, Deborah, additional

Published
2023
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5. Experimental infection withSchistosoma mansoniisolated from the wild rodentHolochilus sciureusshows a low parasite burden but induces high schistosomiasis severity in BALB/c mice

Author

Miranda, Guilherme Silva, primary, Rodrigues, João Gustavo Mendes, additional, de Rezende, Michelle Carvalho, additional, Resende, Samira Diniz, additional, Camelo, Genil Mororó Araújo, additional, de Oliveira Silva, Jeferson Kelvin Alves, additional, Maggi, Laura, additional, Rodrigues, Vanessa Fernandes, additional, de Oliveira, Vinícius Gustavo, additional, and Negrão-Corrêa, Deborah Aparecida, additional

Published
2022
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8. Experimental infection with Schistosoma mansoni isolated from the wild rodent Holochilus sciureus shows a low parasite burden but induces high schistosomiasis severity in BALB/c mice.

Author

Miranda, Guilherme Silva, Mendes Rodrigues, João Gustavo, de Rezende, Michelle Carvalho, Resende, Samira Diniz, Araújo Camelo, Genil Mororó, de Oliveira Silva, Jeferson Kelvin Alves, Maggi, Laura, Rodrigues, Vanessa Fernandes, de Oliveira, Vinícius Gustavo, and Negrão-Corrêa, Deborah Aparecida

Abstract

Wild mammals, especially rodents, can participate in the life cycle of Schistosoma mansoni; however, the impact of these parasite strains on the severity of schistosomiasis remains unclear. The aim of this study was to comparatively evaluate the parasitological and immunopathological alterations induced by an S. mansoni strain isolated from the wild rodent Holochilus sciureus (HS strain) and a parasite strain isolated from a human (LE strain) in experimentally infected mice. Male BALB/c mice were subcutaneously infected with 50 cercariae/ mouse of either the HS or the LE strain and were evaluated for 12 weeks. In the experimental groups, the parasite burden was estimated by worm and egg (feces and tissues) count, and immunopathological alterations were evaluated in the liver and intestines. Compared to experimental infection with the LE parasite strain, HS-infected mice showed reduced number of parasite worms but higher fecundity rate, significant reduction in IL-5, IL-10 and IL-13 concentrations, lower EPO-activity in liver homogenate and higher concentrations of TNF-α, IFN-γ, IL-12 and IL-17 in the small intestine homogenate. Moreover, HS infection resulted in higher concentrations of NO end-products in both the liver and intestine, suggesting a predominance of the Th1/Th17 immune response. HS-infected mice also showed higher plasma transaminase levels, formed larger granulomas, and had a higher mortality rate in comparison with LE-infected mice. Data indicate that BALB/c mice infected with the HS strain of S. mansoni showed reduced susceptibility to the parasite but stronger tissue inflammation and high disease severity. [ABSTRACT FROM AUTHOR]

Published
2022
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