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205 results on '"de Rooij T."'

1. LiMeS-Lab: An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors

Author

Tanke, V. F. B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G. J., van Dommelen, J. A. W., van Eck, H. J. N., Geers, M. G. D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H. M., Vernimmen, J. W. M., Vos, E. G. P., and Morgan, T. W.

Published
2023
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2. Electronic reporting of rare endocrine conditions within a clinical network:results from the EuRRECa project

Author

Ali, S. R., Bryce, J., Priego-Zurita, A. L., Cherenko, M., Smythe, C., de Rooij, T. M., Cools, M., Danne, T., Katugampola, H., Dekkers, O. M., Hiort, O., Linglart, A., Netchine, I., Nordenstrom, A., Attila, P., Persani, L., Reisch, N., Smyth, A., Sumnik, Z., Taruscio, D., Visser, W. E., Pereira, A. M., Appelman-Dijkstra, N. M., Ahmed, S. F., Ali, S. R., Bryce, J., Priego-Zurita, A. L., Cherenko, M., Smythe, C., de Rooij, T. M., Cools, M., Danne, T., Katugampola, H., Dekkers, O. M., Hiort, O., Linglart, A., Netchine, I., Nordenstrom, A., Attila, P., Persani, L., Reisch, N., Smyth, A., Sumnik, Z., Taruscio, D., Visser, W. E., Pereira, A. M., Appelman-Dijkstra, N. M., and Ahmed, S. F.

Abstract

Objective: The European Registries for Rare Endocrine Conditions (EuRRECa, eurreb. eu) includes an e-reporting registry (e-REC) used to perform surveillance of conditions within the European Reference Network (ERN) for rare endocrine conditions (Endo-ERN). The aim of this study was to report the experience of e-REC over the 3.5 years since its launch in 2018. Methods: Electronic reporting capturing new encounters of Endo-ERN conditions was performed monthly through a bespoke platform by clinicians registered to participate in e-REC from July 2018 to December 2021. Results: The number of centres reporting on e-REC increased to a total of 61 centres from 22 countries. A median of 29 (range 11, 45) paediatric and 32 (14, 51) adult centres had reported cases monthly. A total of 9715 and 4243 new cases were reported in adults (age ≥18 years) and children, respectively. In children, sex development conditions comprised 40% of all reported conditions and transgender cases were most frequently reported, comprising 58% of sex development conditions. The median number of sex development cases reported per centre per month was 0.6 (0, 38). Amongst adults, pituitary conditions comprised 44% of reported conditions and pituitary adenomas (69% of cases) were most commonly reported. The median number of pituitary cases reported per centre per month was 4 (0.4, 33). Conclusions: e-REC has gained increasing acceptability over the last 3.5 years for capturing brief information on new encounters of rare conditions and shows wide variations in the rate of presentation of these conditions to centres within a reference network. Significance statement Endocrinology includes a very wide range of rare conditions and their occurrence is often difficult to measure. By using an electronic platform that allowed monthly reporting of new clinical encounters of several rare endocrine conditions within a defined network that consisted of several reference centres in Europe, the EuRRECa project sh

Published
2023

3. LiMeS-Lab: An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors

Author

Tanke, V. F.B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G.J., van Dommelen, J. A.W., van Eck, H. J.N., Geers, M. G.D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H.M., Vernimmen, J. W.M., Vos, E. G.P., Morgan, T. W., Tanke, V. F.B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G.J., van Dommelen, J. A.W., van Eck, H. J.N., Geers, M. G.D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H.M., Vernimmen, J. W.M., Vos, E. G.P., and Morgan, T. W.

Abstract

The liquid metal shield laboratory (LiMeS-Lab) will provide the infrastructure to develop, test, and compare liquid metal divertor designs for future fusion reactors. The main research topics of LiMeS-lab will be liquid metal interactions with the substrate material of the divertor, the continuous circulation and capillary refilling of the liquid metal during intense plasma heat loading and the retention of plasma particles in the liquid metal. To facilitate the research, four new devices are in development at the Dutch Institute for Fundamental Energy Research and the Eindhoven University of Technology: LiMeS-AM: a custom metal 3D printer based on powder bed fusion; LiMeS-Wetting, a plasma device to study the wetting of liquid metals on various substrates with different surface treatments; LiMeS-PSI, a linear plasma generator specifically adapted to operate continuous liquid metal loops. Special diagnostic protection will also be implemented to perform measurements in long duration shots without being affected by the liquid metal vapor; LiMeS-TDS, a thermal desorption spectroscopy system to characterize deuterium retention in a metal vapor environment. Each of these devices has specific challenges due to the presence and deposition of metal vapors that need to be addressed in order to function. In this paper, an overview of LiMeS-Lab will be given and the conceptual designs of the last three devices will be presented.

Published
2023

5. Long-term survival and secondary procedures after open or endovascular repair of abdominal aortic aneurysms

Author

van Schaik, Theodorus G., Yeung, Kak K., Verhagen, Hence J., de Bruin, Jorg L., van Sambeek, Marc R.H.M., Balm, Ron, Zeebregts, Clark J., van Herwaarden, Joost A., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A.A., Buth, J., Pattynama, P. M., Verhoeven, E. L.G., van Voorthuisen, A. E., Balm, R., Cuypers, P. W.M., Prinssen, M., van Sambeek, M. R.H.M., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J.H.M., de Mol, B. A.J.M., van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., de Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., van der Ham, A. C., van der Velden, J. J.I.M., van Sterkenburg, S. M.M., ten Haken, G. B., Bruijninckx, C. M.A., van Overhagen, H., Nolthenius, Tutein R.P., Hendriksz, T. R., Teijink, J. A.W., Odink, H. F., de Smet, A. A.E.A., Vroegindeweij, D., van Loenhout, R. M.M., Rutten, M. J., Hamming, J. F., Lampmann, L. E.H., Bender, M. H.M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J.C., van Dortmont, L. M.C., van der Vliet, A. J., Kool, Schultze L.J., Boomsma, J. H.B., van Dop, H. R., de Mol van Otterloo, J. C.A., de Rooij, T. P.W., Smits, T. M., Yilmaz, E. N., van den Berg, F. G., Visser, M. J.T., van der Linden, E., Schurink, G. W.H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., and Vermassen, F. E.G.

Published
2017
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6. Meta‐analysis of individual‐patient data from EVAR‐1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years

Author

Powell, J. T., Sweeting, M. J., Ulug, P., Blankensteijn, J. D., Lederle, F. A., Becquemin, J.‐P., Greenhalgh, R. M., Greenhalgh, R. M., Beard, J. D., Buxton, M. J., Brown, L. C., Harris, P. L., Powell, J. T., Rose, J. D. G., Russell, I. T., Sculpher, M. J., Thompson, S. G., Lilford, R.J., Bell, P. R. F., Greenhalgh, R. M., Whitaker, S.C., Poole‐Wilson, the late P.A., Ruckley, C. V., Campbell, W. B., Dean, M. R. E., Ruttley, M. S. T., Coles, E. C., Powell, J. T., Halliday, A., Gibbs, S. J., Brown, L. C., Epstein, D., Sculpher, M. J., Thompson, S. G., Hannon, R. J., Johnston, L., Bradbury, A. W., Henderson, M. J., Parvin, S. D., Shepherd, D. F. C., Greenhalgh, R. M., Mitchell, A. W., Edwards, P. R., Abbott, G. T., Higman, D. J., Vohra, A., Ashley, S., Robottom, C., Wyatt, M. G., Rose, J. D. G., Byrne, D., Edwards, R., Leiberman, D. P., McCarter, D. H., Taylor, P. R., Reidy, J. F., Wilkinson, A. R., Ettles, D. F., Clason, A. E., Leen, G. L. S., Wilson, N. V., Downes, M., Walker, S. R., Lavelle, J. M., Gough, M. J., McPherson, S., Scott, D. J. A., Kessell, D. O., Naylor, R., Sayers, R., Fishwick, N. G., Harris, P. L., Gould, D. A., Walker, M. G., Chalmers, N. C., Garnham, A., Collins, M. A., Beard, J. D., Gaines, P. A., Ashour, M. Y., Uberoi, R., Braithwaite, B., Whitaker, S. C., Davies, J. N., Travis, S., Hamilton, G., Platts, A., Shandall, A., Sullivan, B. A., Sobeh, M., Matson, M., Fox, A. D., Orme, R., Yusef, W., Doyle, T., Horrocks, M., Hardman, J., Blair, P. H. B., Ellis, P. K., Morris, G., Odurny, A., Vohra, R., Duddy, M., Thompson, M., Loosemore, T. M. L., Belli, A. M., Morgan, R., Adiseshiah, M., Brookes, J. A. S., McCollum, C. N., Ashleigh, R., Aukett, M., Baker, S., Barbe, E., Batson, N., Bell, J., Blundell, J., Boardley, D., Boyes, S., Brown, O., Bryce, J., Carmichael, M., Chance, T., Coleman, J., Cosgrove, C., Curran, G., Dennison, T., Devine, C., Dewhirst, N., Errington, B., Farrell, H., Fisher, C., Fulford, P., Gough, M., Graham, C., Hooper, R., Horne, G., Horrocks, L., Hughes, B., Hutchings, T., Ireland, M., Judge, C., Kelly, L., Kemp, J., Kite, A., Kivela, M., Lapworth, M., Lee, C., Linekar, L., Mahmood, A., March, L., Martin, J., Matharu, N., McGuigen, K., Morris‐Vincent, P., Murray, S., Murtagh, A., Owen, G., Ramoutar, V., Rippin, C., Rowley, J., Sinclair, J., Spencer, S., Taylor, V., Tomlinson, C., Ward, S., Wealleans, V., West, J., White, K., Williams, J., Wilson, L., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A. A., Buth, J., Pattynama, P. M., Verhoeven, E. L. G., van Voorthuisen, A. E., Blankensteijn, J. D., Balm, R., Buth, J., Cuypers, P. W. M., Grobbee, D. E., Prinssen, M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., Baas, A. F., Hunink, M. G., van Engelshoven, J. M., Jacobs, M. J. H. M., de Mol, B. A. J. M., van Bockel, J. H., Balm, R., Reekers, J., Tielbeek, X., Verhoeven, E. L. G., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., Prinssen, M., Balm, R., Blankensteijn, J. D., Buth, J., Cuypers, P. W. M., van Sambeek, M. R. H. M., Verhoeven, E. L. G., de Bruin, J. L., Baas, A. F., Blankensteijn, J. D., Prinssen, M., Buth, J., Tielbeek, A.V., Blankensteijn, J. D., Balm, R., Reekers, J. A., van Sambeek, M. R. H. M., Pattynama, P., Verhoeven, E. L. G., Prins, T., van der Ham, A. C., van der Velden, J. J. I. M., van Sterkenburg, S. M. M., ten Haken, G. B., Bruijninckx, C. M. A., van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A. W., Odink, H. F., de Smet, A. A. E. A., Vroegindeweij, D., van Loenhout, R. M. M., Rutten, M. J., Hamming, J. F., Lampmann, L. E. H., Bender, M. H. M., Pasmans, H., Vahl, A. C., de Vries, C., Mackaay, A. J. C., van Dortmont, L. M. C., van der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H. B., van Dop, H. R., de Mol van Otterloo, J. C. A., de Rooij, T. P. W., Smits, T. M., Yilmaz, E. N., Wisselink, W., van den Berg, F. G., Visser, M. J. T., van der Linden, E., Schurink, G. W. H., de Haan, M., Smeets, H. J., Stabel, P., van Elst, F., Poniewierski, J., Vermassen, F. E. G., Lederle, F. A., Freischlag, J. A., Kohler, T. R., Latts, E., Matsumura, J., Padberg, F. T., Jr, Kyriakides, T. C., Swanson, K. M., Guarino, P., Peduzzi, P., Antonelli, M., Cushing, C., Davis, E., Durant, L., Joyner, S., Kossack, the late A., Kyriakides, T. C., LeGwin, Mary, McBride, V., OʼConnor, T., Poulton, J., Stratton, the late S., Zellner, S., Snodgrass, A. J., Thornton, J., Swanson, K. M., Haakenson, C. M., Stroupe, K.T., Jonk, Y., Hallett, J. W., Hertzer, N., Towne, J., Katz, D. A., Karrison, T., Matts, J. P., Marottoli, R., Kasl, S., Mehta, R., Feldman, R., Farrell, W., Allore, H., Perry, E., Niederman, J., Randall, F., Zeman, M., Beckwith, the late D., OʼLeary, T. J., Huang, G. D., Latts, E., Bader, M., Ketteler, E. R., Kingsley, D. D., Marek, J. M., Massen, R. J., Matteson, B. D., Pitcher, J. D., Langsfeld, M., Corson, J. D., Goff, J. M., Jr, Kasirajan, K., Paap, C., Robertson, D. C., Salam, A., Veeraswamy, R., Milner, R., Kasirajan, K., Guidot, J., Lal, B. K., Busuttil, S. J., Lilly, M. P., Braganza, M., Ellis, K., Patterson, M. A., Jordan, W. D., Whitley, D., Taylor, S., Passman, M., Kerns, D., Inman, C., Poirier, J., Ebaugh, J., Raffetto, J., Chew, D., Lathi, S., Owens, C., Hickson, K., Dosluoglu, H. H., Eschberger, K., Kibbe, M. R., Baraniewski, H. M., Matsumura, J., Endo, M., Busman, A., Meadows, W., Evans, M., Giglia, J. S., El Sayed, H., Reed, A. B., Ruf, M., Ross, S., Jean‐Claude, J. M., Pinault, G., Kang, P., White, N., Eiseman, M., Jones, the late R., Timaran, C. H., Modrall, J. G., Welborn, M. B., III, Lopez, J., Nguyen, T., Chacko, J. K. Y., Granke, K., Vouyouka, A. G., Olgren, E., Chand, P., Allende, B., Ranella, M., Yales, C., Whitehill, T. A., Krupski, the late W. C., Nehler, M. R., Johnson, S. P., Jones, D. N., Strecker, P., Bhola, M. A., Shortell, C. K., Gray, J. L., Lawson, J. H., McCann, R., Sebastian, M.W., Kistler Tetterton, J., Blackwell, C., Prinzo, P. A., Lee, N., Padberg, F. T., Jr, Cerveira, J. J., Lal, B. K., Zickler, R. W., Hauck, K. A., Berceli, S. A., Lee, W. A., Ozaki, C. K., Nelson, P. R., Irwin, A. S., Baum, R., Aulivola, B., Rodriguez, H., Littooy, F. N., Greisler, H., OʼSullivan, M. T., Kougias, P., Lin, P. H., Bush, R. L., Guinn, G., Bechara, C., Cagiannos, C., Pisimisis, G., Barshes, N., Pillack, S., Guillory, B., Cikrit, D., Lalka, S. G., Lemmon, G., Nachreiner, R., Rusomaroff, M., OʼBrien, E., Cullen, J. J., Hoballah, J., Sharp, W. J., McCandless, J. L., Beach, V., Minion, D., Schwarcz, T. H., Kimbrough, J., Ashe, L., Rockich, A., Warner‐Carpenter, J., Moursi, M., Eidt, J. F., Brock, S., Bianchi, C., Bishop, V., Gordon, I. L., Fujitani, R., Kubaska, S. M., III, Behdad, M., Azadegan, R., Ma Agas, C., Zalecki, K., Hoch, J. R., Carr, S. C., Acher, C., Schwarze, M., Tefera, G., Mell, M., Dunlap, B., Rieder, J., Stuart, J. M., Weiman, D. S., Abul‐Khoudoud, O., Garrett, H. E., Walsh, S. M., Wilson, K. L., Seabrook, G. R., Cambria, R. A., Brown, K. R., Lewis, B. D., Framberg, S., Kallio, C., Barke, R. A., Santilli, S. M., dʼAudiffret, A. C., Oberle, N., Proebstle, C., Johnson, L. L., Jacobowitz, G. R., Cayne, N., Rockman, C., Adelman, M., Gagne, P., Nalbandian, M., Caropolo, L. J., Pipinos, I. I., Johanning, J., Lynch, T., DeSpiegelaere, H., Purviance, G., Zhou, W., Dalman, R., Lee, J. T., Safadi, B., Coogan, S. M., Wren, S. M., Bahmani, D. D., Maples, D., Thunen, S., Golden, M. A., Mitchell, M. E., Fairman, R., Reinhardt, S., Wilson, M. A., Tzeng, E., Muluk, S., Peterson, N. M., Foster, M., Edwards, J., Moneta, G. L., Landry, G., Taylor, L., Yeager, R., Cannady, E., Treiman, G., Hatton‐Ward, S., Salabsky, the late B., Kansal, N., Owens, E., Estes, M., Forbes, B. A., Sobotta, C., Rapp, J. H., Reilly, L. M., Perez, S. L., Yan, K., Sarkar, R., Dwyer, S. S., Perez, S., Chong, K., Kohler, T. R., Hatsukami, T. S., Glickerman, D. G., Sobel, M., Burdick, T. S., Pedersen, K., Cleary, P., Back, M., Bandyk, D., Johnson, B., Shames, M., Reinhard, R. L., Thomas, S. C., Hunter, G. C., Leon, L. R., Jr, Westerband, A., Guerra, R. J., Riveros, M., Mills, J. L., Sr, Hughes, J. D., Escalante, A. M., Psalms, S. B., Day, N. N., Macsata, R., Sidawy, A., Weiswasser, J., Arora, S., Jasper, B. J., Dardik, A., Gahtan, V., Muhs, B. E., Sumpio, B. E., Gusberg, R. J., Spector, M., Pollak, J., Aruny, J., Kelly, E. L., Wong, J., Vasilas, P., Joncas, C., Gelabert, H. A., DeVirgillio, C., Rigberg, D. A., Cole, L., Becquemin, J.‐P., Marzelle, J., Becquemin, J.‐P., Sapoval, M., Becquemin, J.‐P., Favre, J.‐P., Watelet, J., Lermusiaux, P., Sapoval, M., Lepage, E., Hemery, F., Dolbeau, G., Hawajry, N., Cunin, P., Harris, P., Stockx, L., Chatellier, G., Mialhe, C., Fiessinger, J.‐N., Pagny, L., Kobeiter, H., Boissier, C., Lacroix, P., Ledru, F., Pinot, J.‐J., Deux, J.‐F., Tzvetkov, B., Duvaldestin, P., Watelet, J., Jourdain, C., David, V., Enouf, D., Ady, N., Krimi, A., Boudjema, N., Jousset, Y., Enon, B., Blin, V., Picquet, J., LʼHoste, P., Thouveny, F., Borie, H., Kowarski, S., Pernes, J.‐M., Auguste, M., Becquemin, J.‐P., Desgranges, P., Allaire, E., Marzelle, J., Kobeiter, H., Meaulle, P.‐Y., Chaix, D., Juliae, P., Fabiani, J. N., Chevalier, P., Combes, M., Seguin, A., Belhomme, D., Sapoval, M., Baque, J., Pellerin, O., Favre, J. P., Barral, X., Veyret, C., Watelet, J., Peillon, C., Plissonier, D., Thomas, P., Clavier, E., Lermusiaux, P., Martinez, R., Bleuet, F., C, Dupreix, Verhoye, J. P., Langanay, T., Heautot, J. F., Koussa, M., Haulon, S., Halna, P., Destrieux, L., Lions, C., Wiloteaux, S., Beregi, J. P., Bergeron, P., Pinot, J.‐J., Patra, P., Costargent, A., Chaillou, P., DʼAlicourt, A., Goueffic, Y., Cheysson, E., Parrot, A., Garance, P., Demon, A., Tyazi, A., Pillet, J.‐C., Lescalie, F., Tilly, G., Steinmetz, E., Favier, C., Brenot, R., Krause, D., Cercueil, J. P., Vahdat, O., Sauer, M., Soula, P., Querian, A., Garcia, O., Levade, M., Colombier, D., Cardon, J.‐M., Joyeux, A., Borrelly, P., Dogas, G., Magnan, P.‐É., Branchereau, A., Bartoli, J.‐M., Hassen‐Khodja, R., Batt, M., Planchard, P.‐F., Bouillanne, P.‐J., Haudebourg, P., Bayne, J., Gouny, P., Badra, A., Braesco, J., Nonent, M., Lucas, A., Cardon, A., Kerdiles, Y., Rolland, Y., Kassab, M., Brillu, C., Goubault, F., Tailboux, L., Darrieux, H., Briand, O., Maillard, J.‐C., Varty, K., and Cousins, C.

Published
2017
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8. Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., Buchler M. W., Miao, Y, Lu, Z, Yeo, C, Vollmer, C, Fernandez-del Castillo, C, Ghaneh, P, Halloran, C, Kleeff, J, de Rooij, T, Werner, J, Falconi, M, Friess, H, Zeh, H, Izbicki, J, He, J, Laukkarinen, J, Dejong, C, Lillemoe, K, Conlon, K, Takaori, K, Gianotti, L, Besselink, M, Del Chiaro, M, Montorsi, M, Tanaka, M, Bockhorn, M, Adham, M, Olah, A, Salvia, R, Shrikhande, S, Hackert, T, Shimosegawa, T, Zureikat, A, Ceyhan, G, Peng, Y, Wang, G, Huang, X, Dervenis, C, Bassi, C, Neoptolemos, J, Buchler, M, Miao Y., Lu Z., Yeo C. J., Vollmer C. M., Fernandez-del Castillo C., Ghaneh P., Halloran C. M., Kleeff J., de Rooij T., Werner J., Falconi M., Friess H., Zeh H. J., Izbicki J. R., He J., Laukkarinen J., Dejong C. H., Lillemoe K. D., Conlon K., Takaori K., Gianotti L., Besselink M. G., Del Chiaro M., Montorsi M., Tanaka M., Bockhorn M., Adham M., Olah A., Salvia R., Shrikhande S. V., Hackert T., Shimosegawa T., Zureikat A. H., Ceyhan G. O., Peng Y., Wang G., Huang X., Dervenis C., Bassi C., Neoptolemos J. P., and Buchler M. W.

Abstract

Background: The aim was to evaluate the various operative techniques and outcomes used to manage the pancreatic transection plane (or stump) during a left (distal) pancreatectomy and to develop expert consensus guidelines. Methods: Evidence-based, clinically relevant questions were discussed and then were circulated among members of the International Study Group of Pancreatic Surgery. After agreement on the questions and statements, voting in a 9-point Likert scale was used to gauge the level of objective support for each. Results: Studies using the International Study Group of Pancreatic Surgery definition of postoperative pancreatic fistula including 16 randomized trials were reviewed to generate a series of statements set into 14 domains. There was strong consensus in the following statements: there was no difference in the postoperative pancreatic fistula rate after left pancreatectomy between the handsewn and stapler techniques; a stapling technique could not be used in all cases of left pancreatectomy; the use of an energy-based tissue sealant or a chemical sealant device or combinations of these did not impact the postoperative pancreatic fistula rate; there was no difference in the postoperative pancreatic fistula rate between the open, laparoscopic, or robotic approaches; and there are 1 or more clinically important, patient-related risk factors associated with the postoperative pancreatic fistula rate. There was weak or conditional agreement on the use of prophylactic somatostatin analogs, stents, stump closure, stump anastomosis, and the role of abdominal drains. Conclusion: Areas of strong consensus suggests a change in clinical practice and priority setting. Eight domains with lower agreement will require novel approaches and large multicenter studies to determine future key areas of practice.

Published
2020

9. Distal Fistula Risk Score (D-FRS): Design and Multicenter Internal-External Validation

Author

van Bodegraven, E., primary, De Pastena, M., additional, Mungroop, T., additional, Vissers, F., additional, Malleo, G., additional, Jones, L., additional, Alseidi, A., additional, Balduzzi, A., additional, de Rooij, T., additional, Seykora, T., additional, Paiella, S., additional, Klompmaker, S., additional, Marchegiani, G., additional, Trudeau, M., additional, van Eijck, C., additional, Koerkamp, B. Groot, additional, de Hingh, I., additional, Luyer, M., additional, Busch, O., additional, Salvia, R., additional, Steyerberg, E., additional, Hilal, M. Abu, additional, Vollmer, C., additional, Besselink, M., additional, and Bassi, C., additional

Published
2022
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10. Performance with robotic surgery versus 3D- and 2D-laparoscopy during pancreatic and biliary anastomoses in a biotissue model: Pooled analysis of two randomized trials

Author

Zwart, M., primary, Jones, L., additional, Fuente, I., additional, Balduzzi, A., additional, Takagi, K., additional, Novak, S., additional, Stibbe, L., additional, de Rooij, T., additional, van Hilst, J., additional, van Rijssen, B., additional, van Dieren, S., additional, Vanlander, A., additional, van den Boezem, P., additional, Daams, F., additional, Mieog, S., additional, Bonsing, B., additional, Rosman, C., additional, Festen, S., additional, Luyer, M., additional, Lips, D., additional, Moser, A., additional, Busch, O., additional, Hilal, M. Abu, additional, Hogg, M., additional, Stommel, M., additional, and Besselink, M., additional

Published
2021
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11. Performance with Robotic Surgery versus 3D- and 2D-laparoscopy during Pancreatic and Biliary Anastomoses in a Biotissue Model: Pooled Analysis of Two Randomized Trials

Author

Zwart, M.J., primary, Jones, L.R., additional, Fuente, I., additional, Balduzzi, A., additional, Takagi, K., additional, Novak, S., additional, Stibbe, L., additional, de Rooij, T., additional, van Hilst, J., additional, van Rijssen, L.B., additional, van Dieren, S., additional, Vanlander, A., additional, van den Boezem, P.B., additional, Daams, F., additional, Mieog, J.S.D., additional, Bonsing, B.A., additional, Rosman, C., additional, Festen, S., additional, Luyer, M.D., additional, Lips, D.J., additional, Moser, A.J., additional, Busch, O.R., additional, Abu Hilal, M., additional, Hogg, M.E., additional, Stommel, M.W.J., additional, and Besselink, M.G., additional

Published
2021
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12. Outcomes of a multicenter training program in robotic pancreatoduodenectomy (LAELAPS-3)

Author

Zwart, M., primary, Nota, C., additional, De Rooij, T., additional, Van Hilst, J., additional, Te Riele, W., additional, Van Santvoort, H., additional, Hagendoorn, J., additional, Borel Rinkes, I., additional, Tran, K., additional, Schelling G., Van Der, additional, Wijsman, J., additional, Schreinemakers, J., additional, Festen, S., additional, Daams, F., additional, Luyer, M., additional, De Hingh, I., additional, Mieog, S., additional, Bonsing, B., additional, Lips, D., additional, Abu Hilal, M., additional, Busch, O., additional, Saint-Marc, O., additional, Zeh, H., additional, Zureikat, A., additional, Hogg, M., additional, Molenaar, Q., additional, Besselink, M., additional, and Groot Koerkamp, B., additional

Published
2020
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13. Minimally Invasive versus Open Distal Pancreatectomy: An Individual Patient Data Meta-Analysis of Two Randomized Controlled Trials

Author

Korrel, M., primary, Vissers, F., additional, Van Hilst, J., additional, De Rooij, T., additional, Dijkgraaf, M., additional, Festen, S., additional, Groot Koerkamp, B., additional, Busch, O., additional, Luyer, M., additional, Sandström, P., additional, Abu Hilal, M., additional, Besselink, M., additional, and Björnsson, B., additional

Published
2020
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14. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., van Santvoort, H. C., de Boer, M. T., Boerma, D., van den Boezem, P. B., van Dam, R. M., Dejong, C. H., van Duyn, E. B., van Eijck, C. H., Gerhards, M. F., de Hingh, I. H., Kazemier, G., de Kleine, R. H., van Laarhoven, C. J., Patijn, G. A., Steenvoorde, P., Suker, M., Hilal, M. Abu, RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Heelkunde (9), Surgery, Groningen Institute for Organ Transplantation (GIOT), Value, Affordability and Sustainability (VALUE), AGEM - Re-generation and cancer of the digestive system, CCA - Cancer Treatment and quality of life, Epidemiology and Data Science, APH - Methodology, AGEM - Digestive immunity, and CCA - Cancer Treatment and Quality of Life

Subjects
Male, Cost effectiveness, SURGERY, Cost-Benefit Analysis, INTERNATIONAL STUDY-GROUP, OPEN ILEOCOLIC RESECTION, law.invention, BODY-IMAGE, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Postoperative Complications, 0302 clinical medicine, Robotic Surgical Procedures, Quality of life, Randomized controlled trial, law, Hospital Costs/statistics & numerical data, Outcome Assessment, Health Care, 80 and over, Single-Blind Method, Hospital Costs, Laparoscopy, Netherlands, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, Multicenter Study, Patient Satisfaction, 030220 oncology & carcinogenesis, Randomized Controlled Trial, Original Article, 030211 gastroenterology & hepatology, Female, Quality-Adjusted Life Years, Adult, medicine.medical_specialty, Pancreatectomy/economics, COSMESIS, 03 medical and health sciences, Outcome Assessment (Health Care), All institutes and research themes of the Radboud University Medical Center, Pancreatectomy, Patient satisfaction, medicine, Journal Article, Humans, Comparative Study, Aged, Laparoscopy/economics, business.industry, Cosmesis, Original Articles, Recovery of Function, Confidence interval, Surgery, Quality-adjusted life year, Postoperative Complications/economics, DEFINITION, Quality of Life, Robotic Surgical Procedures/economics, business, Follow-Up Studies
Abstract

Background Minimally invasive distal pancreatectomy decreases time to functional recovery compared with open distal pancreatectomy, but the cost-effectiveness and impact on disease-specific quality of life have yet to be established. Methods The LEOPARD trial randomized patients to minimally invasive (robot-assisted or laparoscopic) or open distal pancreatectomy in 14 Dutch centres between April 2015 and March 2017. Use of hospital healthcare resources, complications and disease-specific quality of life were recorded up to 1 year after surgery. Unit costs of hospital healthcare resources were determined, and cost-effectiveness and cost–utility analyses were performed. Primary outcomes were the costs per day earlier functional recovery and per quality-adjusted life-year. Results All 104 patients who had a distal pancreatectomy (48 minimally invasive and 56 open) in the trial were included in this study. Patients who underwent a robot-assisted procedure were excluded from the cost analysis. Total medical costs were comparable after laparoscopic and open distal pancreatectomy (mean difference €–427 (95 per cent bias-corrected and accelerated confidence interval €–4700 to 3613; P = 0·839). Laparoscopic distal pancreatectomy was shown to have a probability of at least 0·566 of being more cost-effective than the open approach at a willingness-to-pay threshold of €0 per day of earlier recovery, and a probability of 0·676 per additional quality-adjusted life-year at a willingness-to-pay threshold of €80 000. There were no significant differences in cosmetic satisfaction scores (median 9 (i.q.r. 5·75–10) versus 7 (4–8·75); P = 0·056) and disease-specific quality of life after minimally invasive (laparoscopic and robot-assisted procedures) versus open distal pancreatectomy. Conclusion Laparoscopic distal pancreatectomy was at least as cost-effective as open distal pancreatectomy in terms of time to functional recovery and quality-adjusted life-years. Cosmesis and quality of life were similar in the two groups 1 year after surgery.

Published
2019
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15. Minimally invasive versus open distal pancreatectomy: an individual patient data meta-analysis of two randomized controlled trials

Author

Korrel, M. (Maarten), Vissers, F.L. (Frederique L.), van Hilst, J. (Jony), de Rooij, T. (Thijs), Dijkgraaf, M.G.W. (Marcel), Festen, S. (Sebastiaan), Groot Koerkamp, B. (Bas), Busch, O.R.C. (Olivier), Luyer, M. (Misha), Sandström, P. (Per), Abu Hilal, M. (Mohammad), Besselink, M.G. (Marc), Björnsson, B. (Bergthor), Korrel, M. (Maarten), Vissers, F.L. (Frederique L.), van Hilst, J. (Jony), de Rooij, T. (Thijs), Dijkgraaf, M.G.W. (Marcel), Festen, S. (Sebastiaan), Groot Koerkamp, B. (Bas), Busch, O.R.C. (Olivier), Luyer, M. (Misha), Sandström, P. (Per), Abu Hilal, M. (Mohammad), Besselink, M.G. (Marc), and Björnsson, B. (Bergthor)

Abstract

Background: Minimally invasive distal pancreatectomy (MIDP) has been suggested to reduce postoperative outcomes as compared to open distal pancreatectomy (ODP). Recently, the first randomized controlled trials (RCTs) comparing MIDP to ODP were published. This individual patient data meta-analysis compared outcomes after MIDP versus ODP combining data from both RCTs. Methods: A systematic literature search was performed to identify RCTs on MIDP vs. ODP, and individual patient data were harmonized. Primary endpoint was the rate of major (Clavien-Dindo ≥ III) complications. Sensitivity analyses were performed in high-risk subgroups. Results: A total of 166 patients from the LEOPARD and LAPOP RCTs were included. The rate of major complications was 21% after MIDP vs. 35% after ODP (adjusted odds ratio 0.54; p = 0.148). MIDP significantly reduced length of hospital stay (6 vs. 8 days, p = 0.036), and delayed gastric emptying (4% vs. 16%, p = 0.049), as compared to ODP. A trend towards higher rates of postoperative pancreatic fistula was observed after MIDP (36% vs. 28%, p = 0.067). Outcomes were comparable in high-risk subgroups. Conclusion: This individual patient data meta-analysis showed that MIDP, when performed by trained surgeons, may be regarded as the preferred approach for distal pancreatectomy. Outcomes are improved after MIDP as compared to ODP, without obvious downsides in high-risk subgroups.

Published
2020
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16. Minimally Invasive versus Open Distal Pancreatectomy for Ductal Adenocarcinoma (DIPLOMA)

Author

van Hilst, J, de Rooij, T, Klompmaker, S, Rawashdeh, M, Aleotti, F, Al-Sarireh, B, Alseidi, A, Ateeb, Z, Balzano, G, Berrevoet, F, Bjornsson, B, Boggi, U, Busch, Or, Butturini, G, Casadei, R, Del Chiaro, M, Chikhladze, S, Cipriani, F, van Dam, R, Damoli, I, van Dieren, S, Dokmak, S, Edwin, B, van Eijck, C, Fabre, Jm, Falconi, M, Farges, O, Fernandez-Cruz, L, Forgione, A, Frigerio, I, Fuks, D, Gavazzi, F, Gayet, B, Giardino, A, Koerkamp, Bg, Hackert, T, Hassenpflug, M, Kabir, I, Keck, T, Khatkov, I, Kusar, M, Lombardo, C, Marchegiani, G, Marshall, R, Menon, Kv, Montorsi, M, Orville, M, de Pastena, M, Pietrabissa, A, Poves, I, Primrose, J, Pugliese, R, Ricci, C, Roberts, K, Rosok, B, Sahakyan, Ma, Sanchez-Cabus, S, Sandstrom, P, Scovel, L, Solaini, L, Soonawalla, Z, Souche, Fr, Sutcliffe, Rp, Tiberio, Ga, Tomazic, A, Troisi, R, Wellner, U, White, S, Wittel, Ua, Zerbi, A, Bassi, C, Besselink, Mg, and Abu Hilal, M

Subjects
Male, robot-assisted, laparoscopic, Pancreatectomy, Postoperative Complications, Robotic Surgical Procedures, Humans, Minimally Invasive Surgical Procedures, distal pancreatectomy, Propensity Score, Aged, Neoplasm Staging, Retrospective Studies, Incidence, Carcinoma, Length of Stay, left pancreatectomy, minimally invasive, Pancreatic Ductal, Europe, Female, Laparoscopy, Pancreatic Neoplasms, Survival Rate, Treatment Outcome, Carcinoma, Pancreatic Ductal
Published
2019

17. Added value of 3D-vision during laparoscopic biotissue pancreatico- and hepaticojejunostomy (LAELAPS 3D2D): an international randomized cross-over trial

Author

Zwart, M., primary, Fuente, I., additional, Van Hilst, J., additional, De Rooij, T., additional, Van Dieren, S., additional, Van Rijssen, L., additional, Schijven, M., additional, Busch, O., additional, Luyer, M., additional, Lips, D., additional, Festen, S., additional, Hilal, M., additional, and Besselink, M., additional

Published
2020
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18. A nationwide training program for robotic pancreatoduodenectomy (LAELAPS-3): analysis of the first trained surgeons and first 87 patients

Author

Zwart, M., primary, De Rooij, T., additional, Van hilst, J., additional, Stommel, M., additional, Van den Boezem, P., additional, Wijsman, J., additional, Van der Schelling, G., additional, Schreinemakers, J., additional, Daams, F., additional, Zonderhuis, B., additional, Kazemier, G., additional, Mieog, S., additional, Vahrmeijer, A., additional, Swijnenburg, R., additional, Bonsing, B., additional, Besselink, M., additional, Koerkamp, B Groot, additional, and DPCG, For the, additional

Published
2020
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21. The inflammatory response after laparoscopic and open pancreatoduodenectomy and the association with complications in a multicenter randomized controlled trial

Author

Van Hilst, J., primary, Brinkman, D., additional, De Rooij, T., additional, Van Dieren, S., additional, Gerhards, M., additional, De Hingh, I., additional, Luyer, M., additional, Marsman, H., additional, Karsten, T., additional, Busch, O., additional, Festen, S., additional, Heger, M., additional, and Besselink, M., additional

Published
2020
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22. Costs and quality of life in a randomized trial comparing minimally invasive and open distal pancreatectomy (LEOPARD trial)

Author

Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators, Perfusie, MS CGO, Cancer, van Hilst, J., Strating, E. A., de Rooij, T., Daams, F., Festen, S., Groot Koerkamp, B., Klaase, J. M., Luyer, M., Dijkgraaf, M. G., Besselink, M. G., and on behalf of the Dutch Pancreatic Cancer Group and LEOPARD trial collaborators

Published
2019

23. Minimally invasive pancreatic surgery: A stepwise nationwide introduction

Author

de Rooij, T., Besselink, Marc G. H., Busch, Olivier R. C., Abu Hilal, M., Luyer, M. D., Graduate School, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, CCA - Treatment and quality of life, Besselink, M.G., Busch, O.R., Luyer, M.D., and Faculteit der Geneeskunde

Abstract

Thijs de Rooij doet onderzoek naar de landelijke introductie van minimaal-invasieve alvleesklierchirurgie. Hij richt zich met name op de alvleesklierstaartresectie en de pancreatoduodenectomie, twee procedures die met name uitgevoerd worden voor de behandeling van alvleesklierkanker. Hij bekijkt of een laparoscopische of robot-geassisteerde benadering voor dit type chirurgie van toegevoegde waarde zijn. In eerste instantie rolt hij onder intensieve begeleiding landelijke introductieprogramma’s uit en bekijkt hij of deze introductie veilig is verlopen. Hierna worden de uitkomsten vergeleken met de conventionele ‘open’ benadering voor alvleesklierchirurgie. Hij analyseert voornamelijk de operatieve uitkomsten, complicaties, opnameduur, kwaliteit van leven en kosten, onder andere in landelijke gerandomiseerd gecontroleerde studies.

Published
2018

24. Variation in hospital mortality after pancreatoduodenectomy is related to failure to rescue rather than major complications: a nationwide audit

Author

van Rijssen, L., primary, Zwart, M., additional, Van Dieren, S., additional, De Rooij, T., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Van Eijck, C., additional, Gerhards, M., additional, Gerritsen, J., additional, Van Der Harst, E., additional, De Hingh, I., additional, De Jong, K., additional, Kazemier, G., additional, Klaase, J., additional, Van Der Kolk, M., additional, van Laarhoven, C., additional, Luyer, M., additional, Molenaar, I., additional, Patijn, G., additional, Rupert, C., additional, Scheepers, J., additional, Van Der Schelling, G., additional, Vahrmeijer, A., additional, Busch, O., additional, Van Santvoort, H., additional, Groot Koerkamp, B., additional, and Besselink, M., additional

Published
2019
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25. Worldwide survey on opinions and use of minimally invasive pancreatic resection

Author

van Hilst, J., primary, de Rooij, T., additional, Hilal, M. Abu, additional, Asbun, H., additional, Barkun, J., additional, Boggi, U., additional, Busch, O., additional, Conlon, K., additional, Dijkgraaf, M., additional, Han, H., additional, Hansen, P., additional, Kendrick, M., additional, Montagnini, A., additional, Palanivelu, C., additional, Røsok, B., additional, Shrikhande, S., additional, Wakabayashi, G., additional, Zeh, H., additional, Vollmer, C., additional, Kooby, D., additional, and Besselink, M., additional

Published
2019
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26. Minimally invasive versus open distal pancreatectomy for ductal adenocarcinoma (DIPLOMA): a pan-European propensity score matched study

Author

van Hilst, J., primary, de Rooij, T., additional, Klompmaker, S., additional, Rawashdeh, M., additional, Aleotti, F., additional, Al-Sarireh, B., additional, Alseidi, A., additional, Ateeb, Z., additional, Balzano, G., additional, Berrevoet, F., additional, Björnsson, B., additional, Boggi, U., additional, Busch, O., additional, Butturini, G., additional, Casadei, R., additional, del Chiaro, M., additional, Cipriani, F., additional, van Dam, R., additional, Damoli, I., additional, Dokmak, S., additional, Edwin, B., additional, van Eijck, C., additional, Fabre, J., additional, Falconi, M., additional, Farges, O., additional, Fernández-Cruz, L., additional, Forgione, A., additional, Frigerio, I., additional, Fuks, D., additional, Gavazzi, F., additional, Gayet, B., additional, Giardino, A., additional, Groot Koerkamp, B., additional, Hackert, T., additional, Hassenpflug, M., additional, Kabir, I., additional, Keck, T., additional, Khatkov, I., additional, Klock, A., additional, Kusar, M., additional, Lombardo, C., additional, Marchegiani, G., additional, Marshall, R., additional, Menon, K., additional, Montorsi, M., additional, Nowbray, N., additional, Orville, M., additional, Pietrabissa, A., additional, Poves, I., additional, Primrose, J., additional, Pugliese, R., additional, Ricci, C., additional, Roberts, K., additional, Røsok, B., additional, Sahakyan, M., additional, Sánchez-Cabús, S., additional, Sandström, P., additional, Scovel, L., additional, Solaini, L., additional, Soonawalla, Z., additional, Souche, R., additional, Sutcliffe, R., additional, Tiberio, G., additional, Tomazic, A., additional, Troisi, R., additional, Wellner, U., additional, White, S., additional, Wittel, U., additional, Zerbi, A., additional, Bassi, C., additional, Besselink, M., additional, and Abu Hilal, M., additional

Published
2019
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28. Additional value of 3d-vision during laparoscopic pancreatoduodenectomy bio tissue drills (LAELAPS 3D2D): A randomized controlled cross-over trial

Author

Zwart, M.J.W., primary, van Hilst, J., additional, Fuente, I.P., additional, de Rooij, T., additional, van Dieren, S., additional, van Rijssen, L.B., additional, Schijven, M.P., additional, Busch, O.R.C., additional, Luyer, M.D., additional, Lips, D.J., additional, Festen, S., additional, and Besselink, M.G.H., additional

Published
2018
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30. Minimally invasive versus open pancreatoduodenectomy (LEOPARD-2): Study protocol for a randomized controlled trial

Author

de Rooij, T. (Thijs), van Hilst, J. (Jony), Bosscha, K. (Koop), Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Hingh, I.H.J.T. (Ignace) de, Karsten, T.M. (Thomas), Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Santvoort, H.C. (Hjalmar) van, Tran, T.C.K. (T.C. Khé), Busch, O.R.C. (Olivier), Festen, S. (Sebastiaan), Besselink, M.G. (Marc), de Rooij, T. (Thijs), van Hilst, J. (Jony), Bosscha, K. (Koop), Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Hingh, I.H.J.T. (Ignace) de, Karsten, T.M. (Thomas), Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Santvoort, H.C. (Hjalmar) van, Tran, T.C.K. (T.C. Khé), Busch, O.R.C. (Olivier), Festen, S. (Sebastiaan), and Besselink, M.G. (Marc)

Abstract

Background: Data from observational studies suggest that minimally invasive pancreatoduodenectomy (MIPD) is superior to open pancreatoduodenectomy regarding intraoperative blood loss, postoperative morbidity, and length of hospital stay, without increasing total costs. However, several case-matched studies failed to demonstrate superiority of MIPD, and large registry studies from the USA even suggested increased mortality for MIPDs performed in low-volume (< 10 MIPDs annually) centers. Randomized controlled multicenter trials are lacking but clearly required. We hypothesize that time to functional recovery is shorter after MIPD compared with open pancreatoduodenectomy, even in an enhanced recovery setting. Methods/design: LEOPARD-2 is a randomized controlled, parallel-group, patient-blinded, multicenter, phase 2/3, superiority trial in centers that completed the Dutch Pancreatic Cancer Group LAELAPS-2 training program for laparoscopic pancreatoduodenectomy or LAELAPS-3 training program for robot-assisted pancreatoduodenectomy and have performed ≥ 20 MIPDs. A total of 136 patients with symptomatic benign, premalignant, or malignant disease will be randomly assigned to undergo minimally invasive or open pancreatoduodenectomy in an enhanc

Published
2018
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31. Worldwide survey on current use, value and safe implementation of minimally invasive pancreatic resection

Author

van Hilst, J., primary, de Rooij, T., additional, Abu Hilal, M., additional, Asbun, H., additional, Barkun, J., additional, Boggi, U., additional, Busch, O., additional, Conlon, K., additional, Dijkgraaf, M., additional, Han, H., additional, Hansen, P., additional, Kendrick, M., additional, Montagnini, A., additional, Palanivelu, C., additional, Rosok, B., additional, Shrikhande, S., additional, Wakabayashi, G., additional, Zeh, H., additional, Vollmer, C., additional, Kooby, D., additional, and Besselink, M., additional

Published
2017
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32. Minimally invasive versus open distal pancreatectomy (LEOPARD): Study protocol for a randomized controlled trial

Author

de Rooij, T. (Thijs), van Hilst, J. (Jony), Vogel, J.A. (Jantien A.), van Santvoort, H.C. (Hjalmar C.), Boer, M.T. (Marieke) de, Boerma, D. (Djamila), Boezem, P.B. van den, Bonsing, B.A. (Bert), Bosscha, K. (Koop), Coene, P-P. (Peter Paul), Daams, F. (Freek), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Eijck, C.H.J. (Casper) van, Festen, S. (Sebastiaan), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Dejong, C.H. (Cees), Kazemier, G. (Geert), Klaase, J.M. (Joost), Kleine, R.H.J. (Ruben) de, Laarhoven, C.J. (Cees) van, Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Nieuwenhuijs, V.B. (Vincent), Patijn, G.A. (Gijs A.), Roos, D. (Daphne), Scheepers, J.J. (Joris J.), Schelling, G. van der, Steenvoorde, P. (Pascal), Swijnenburg, R.-J. (Rutger-Jan), Wijsman, J.H.H. (Jan), Abu Hilal, M., Busch, O.R.C. (Olivier), Besselink, M.G. (Marc), de Rooij, T. (Thijs), van Hilst, J. (Jony), Vogel, J.A. (Jantien A.), van Santvoort, H.C. (Hjalmar C.), Boer, M.T. (Marieke) de, Boerma, D. (Djamila), Boezem, P.B. van den, Bonsing, B.A. (Bert), Bosscha, K. (Koop), Coene, P-P. (Peter Paul), Daams, F. (Freek), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Eijck, C.H.J. (Casper) van, Festen, S. (Sebastiaan), Gerhards, M.F. (Michael), Groot Koerkamp, B. (Bas), Hagendoorn, J. (Jeroen), Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Dejong, C.H. (Cees), Kazemier, G. (Geert), Klaase, J.M. (Joost), Kleine, R.H.J. (Ruben) de, Laarhoven, C.J. (Cees) van, Lips, D.J., Luyer, M. (Misha), Molenaar, I.Q. (I. Quintus), Nieuwenhuijs, V.B. (Vincent), Patijn, G.A. (Gijs A.), Roos, D. (Daphne), Scheepers, J.J. (Joris J.), Schelling, G. van der, Steenvoorde, P. (Pascal), Swijnenburg, R.-J. (Rutger-Jan), Wijsman, J.H.H. (Jan), Abu Hilal, M., Busch, O.R.C. (Olivier), and Besselink, M.G. (Marc)

Abstract

Background: Observational cohort studies have suggested that minimally invasive distal pancreatectomy (MIDP) is associated with better short-term outcomes compared with open distal pancreatectomy (ODP), such as less intraoperative blood loss, lower morbidity, shorter length of hospital stay, and reduced total costs. Confounding by indication has probably influenced these findings, given that case-matched studies failed to confirm the superiority of MIDP. This accentuates the need for multicenter randomized controlled trials, which are currently lacking. We hypothesize that time to functional recovery is shorter after MIDP compared with ODP even in an enhanced recovery setting. Methods: LEOPARD is a randomized controlled, parallel-group, patient-blinded, multicenter, superiority trial in all 17 centers of the Dutch Pancreatic Cancer Group. A total of 102 patients with symptomatic benign, premalignant or malignant disease will be randomly allocated to undergo MIDP or ODP in an enhanced recovery setting. The primary outcome is time (days) to functional recovery, defined as all of the following: independently mobile at the preoperative level, sufficient pain control with oral medication alone, ability to maintain sufficient (i.e. >50%) daily required caloric intake, no intravenous fluid administration and no signs of infection. Secondary outcomes are operative and postoperative outcomes, including clinically relevant complications, mortality, quality of life and costs. Discussion: The LEOPARD trial is designed to investigate whether MIDP reduces the time to functional recovery compared with ODP in an enhanced recovery setting. Trial registration: Dutch Trial Register, NTR5188. Registered on 9 April 2015

Published
2017
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33. Laparoscopic surgery for pancreatic neoplasms: the European association for endoscopic surgery clinical consensus conference

Author

Edwin, B, Sahakyan, M, Abu Hilal, M, Besselink, M, Braga, M, Fabre, J, Fernández-Cruz, L, Gayet, B, Kim, S, Khatkov, I, Baichorov, M, De Rooij, T, Genç, C, Haugvik, S, Izrailov, R, Khisamov, A, Sánchez-Cabús, S, Souche, R, Van Hilst, J, Edwin, Bjørn, Sahakyan, Mushegh A., Abu Hilal, Mohammad, Besselink, Marc G., Braga, Marco, Fabre, Jean-Michel, Fernández-Cruz, Laureano, Gayet, Brice, Kim, Song Cheol, Khatkov, Igor E., Baichorov, Magomet E., De Rooij, Thijs, Genç, Cansu G., Haugvik, Sven-Petter, Izrailov, Roman E., Khisamov, Arthur A., Sánchez-Cabús, Santiago, Souche, Régis, Van Hilst, Jony, Edwin, B, Sahakyan, M, Abu Hilal, M, Besselink, M, Braga, M, Fabre, J, Fernández-Cruz, L, Gayet, B, Kim, S, Khatkov, I, Baichorov, M, De Rooij, T, Genç, C, Haugvik, S, Izrailov, R, Khisamov, A, Sánchez-Cabús, S, Souche, R, Van Hilst, J, Edwin, Bjørn, Sahakyan, Mushegh A., Abu Hilal, Mohammad, Besselink, Marc G., Braga, Marco, Fabre, Jean-Michel, Fernández-Cruz, Laureano, Gayet, Brice, Kim, Song Cheol, Khatkov, Igor E., Baichorov, Magomet E., De Rooij, Thijs, Genç, Cansu G., Haugvik, Sven-Petter, Izrailov, Roman E., Khisamov, Arthur A., Sánchez-Cabús, Santiago, Souche, Régis, and Van Hilst, Jony

Abstract

Background: Introduced more than 20 years ago, laparoscopic pancreatic surgery (LAPS) has not reached a uniform acceptance among HPB surgeons. As a result, there is no consensus regarding its use in patients with pancreatic neoplasms. This study, organized by the European Association for Endoscopic Surgery (EAES), aimed to develop consensus statements and clinical recommendations on the application of LAPS in these patients. Methods: An international panel of experts was selected based on their clinical and scientific expertise in laparoscopic and open pancreatic surgery. Each panelist performed a critical appraisal of the literature and prepared evidence-based statements assessed by other panelists during Delphi process. The statements were further discussed during a one-day face-to-face meeting followed by the second round of Delphi. Modified statements were presented at the plenary session of the 24th International Congress of the EAES in Amsterdam and in a web-based survey. Results: LAPS included laparoscopic distal pancreatectomy (LDP), pancreatoduodenectomy (LPD), enucleation, central pancreatectomy, and ultrasound. In general, LAPS was found to be safe, especially in experienced hands, and also advantageous over an open approach in terms of intraoperative blood loss, postoperative recovery, and quality of life. Eighty-five percent or higher proportion of responders agreed with the majority (69.5%) of statements. However, the evidence is predominantly based on retrospective case–control studies and systematic reviews of these studies, clearly affected by selection bias. Furthermore, no randomized controlled trials (RCTs) have been published to date, although four RCTs are currently underway in Europe. Conclusions: LAPS is currently in its development and exploration stages, as defined by the international IDEAL framework for surgical innovation. LDP is feasible and safe, performed in many centers, while LPD is limited to few centers. RCTs and registry studies

Published
2017

34. Minimally invasive versus open distal pancreatectomy (LEOPARD): study protocol for a randomized controlled trial

Author

de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, Besselink, MG, de Rooij, T, van Hilst, J, Vogel, J A, van Santvoort, HC, de Boer, MT, Boerma, D, van den Boezem, PB, Bonsing, BA, Bosscha, K, Coene, PP, Daams, F, van Dam, RM, Dijkgraaf, MG, van Eijck, Casper, Festen, S, Gerhards, MF, Groot Koerkamp, B, Hagendoorn, J, van der Harst, E, de Hingh, IH, DeJong, CH, Kazemier, G, Klaase, J, de Kleine, R H, van Laarhoven, CJ, Lips, DJ, Luyer, MD, Molenaar, IQ, Nieuwenhuijs, VB, Patijn, GA, Roos, D, Scheepers, JJ, van der Schelling, GP, Steenvoorde, P, Swijnenburg, RJ, Wijsman, JH, Abu Hilal, M, Busch, OR, and Besselink, MG

Published
2017

35. Quality of Life after Endovascular and Open AAA Repair. Results of a Randomised Triala

Author

Prinssen, M., Buskens, E., Blankensteijn, Jan D., Buth, J., Tielbeek, A. V., Verhoeven, E. L.G., Prins, T., Hamming, J. F., Lampmann, L. E.H., Schurink, G. W.H., de Haan, M., Balm, R., Reekers, J. A., Bender, M. H.M., Pasmans, H., Visser, M. J.T., van der Linden, E., Blankensteijn, J. D., de Smet, A. A.E.A., Vroegindeweij, D., van Sterkenburg, S. M.M., ten Haken, G. B., Boomsma, J. B.B., van Dop, H. R., de Mol van Otterloo, J. C.A., de Rooij, T. P.W., van Sambreek, M. R.H.M., Pattynama, P., Bruijninckx, C. M.A., van Overhagen, H., van der Ham, A. C., van der Velden, J. J.I.M., Wisselink, W., van den Berg, F. G., Tutein Nolthenius, R. P., Hendriksz, T. R., Vahl, A. C., de Vries, C., Mackaay, A. J.C., Smeets, H. J., van Dortmont, L. M.C., Elsman, B. H.P., Smits, T. M., van Loenhout, R. M.M., Rutten, M. J., Teijink, J. A.W., Odink, H. F., Yilmaz, E. N., den Butter, G., Poniewierski, J., Vermassen, F. E.G., Stabel, P., van Elst, F., Epidemiology and Data Science, Pathology, Surgery, ACS - Atherosclerosis & ischemic syndromes, and Radiology and nuclear medicine

Subjects
Male, Quality of life, medicine.medical_specialty, Time Factors, Health Status, Population, law.invention, Aortic aneurysm, Aneurysm, Randomized controlled trial, law, Surveys and Questionnaires, medicine, Humans, EVAR, Postoperative Period, education, Heart, lung and circulation [UMCN 2.1], Aged, Medicine(all), education.field_of_study, business.industry, Open AAA repair, Recovery of Function, medicine.disease, Abdominal aortic aneurysm, humanities, Surgery, Clinical trial, Randomised trail, Female, Cardiology and Cardiovascular Medicine, business, Vascular Surgical Procedures, Abdominal surgery, Aortic Aneurysm, Abdominal, DREAM-trial
Abstract

Contains fulltext : 57956.pdf (Publisher’s version ) (Closed access) AIM: To compare the quality of life (QoL) in the first postoperative year after elective endovascular abdominal aortic aneurysm repair (EVAR) and open repair (OR) in a randomised study. METHODS: In the Dutch Randomised Endovascular Aneurysm Management (DREAM) trial, patients are randomly allocated to EVAR or OR. QoL questionnaires (SF-36 and EuroQoL-5D) were sent to all patients preoperatively (PREOP) and at five time points in the first postoperative year (3W, 6W, 3M, 6M and 12M). Between November 1999 and August 2002, 153 patients (141 male; 12 female) were randomised (78 EVAR and 75 OR; one crossover from OR to EVAR). The EuroQoL-5D scores and the eight domains of the SF-36 for the two groups were compared using the Mann-Whitney test. Changes over time were analysed using the Wilcoxon sign test. RESULTS: There were no statistically significant differences in baseline characteristics (age, gender and SVS risk factors). The preoperative QoL scores of the study group were similar to the QoL scores of the general population of the same age. After 3W the OR group showed a significant decrease on the EuroQol-5D (p=0.022) and in six of the eight SF-36 domains. The EVAR group also showed a significant decrease on the EuroQol-5D (p=0.004) and in 5 of the 8 domains of the SF-36. At 6W the EuroQol-5D had recovered to baseline in the OR group and the decreased domains of the SF-36 had partially recovered. In the EVAR group the EuroQol-5D and three of the five decreased SF-36 domains, had returned to baseline. From 6M on, the OR group reported a significantly higher score on the EuroQoL-5D than the EVAR group (p=0.045 (6M) and p=0.001 (12M)). CONCLUSION: In the early postoperative period there is a small, yet significant QoL advantage for EVAR compared to OR. At 6 months and beyond, patients reported better QoL after OR than after EVAR.

Published
2004
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36. Technical Aspects of Laparoscopic Distal Pancreatectomy for Benign and Malignant Disease: Review of the Literature

Author

de Rooij, T., Sitarz, R., Busch, O. R., Besselink, M. G., and Abu Hilal, M.

Subjects
Article Subject
Abstract

Distal pancreatectomy is the standard curative treatment for symptomatic benign, premalignant, and malignant disease of the pancreatic body and tail. The most obvious benefits of a laparoscopic approach to distal pancreatectomy include earlier recovery and shorter hospital stay. Spleen-preserving distal pancreatectomy should be attempted in case of benign disease. Spleen preservation can be achieved preferably by preserving the splenic vessels (Kimura technique), but also by resecting the splenic vessels and maintaining vascularity through the short gastric vessels and left gastroepiploic artery (Warshaw technique). Several studies have suggested a higher rate of spleen preservation with laparoscopy. The radical antegrade modular pancreatosplenectomy has become mainstay for treating pancreatic cancer and can be performed laparoscopically as well. Evidence on the feasibility and safety of laparoscopic distal pancreatectomy for cancer is scarce. Despite the obvious advantages of laparoscopic surgery, postoperative morbidity remains relatively high, mainly because of the high incidence of pancreatic fistula. For decades, surgeons have tried to prevent these fistulas but to date no strategy has been confirmed to be effective in 2 consecutive randomized studies. Pragmatic multicenter studies focusing on technical aspects of laparoscopic distal pancreatectomy are lacking and should be encouraged.

Published
2015
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37. Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma : technique and results.

Author

Abu Hilal, M, Richardson, J R C, de Rooij, T, Dimovska, Eleonora, Al-Saati, H, Besselink, M G, Abu Hilal, M, Richardson, J R C, de Rooij, T, Dimovska, Eleonora, Al-Saati, H, and Besselink, M G

Abstract

BACKGROUND: Laparoscopic left pancreatectomy has been well described for benign pancreatic lesions, but its role in pancreatic adenocarcinoma remains open to debate. We report our results adopting a laparoscopic technique that obeys established oncologic principles of open distal pancreatosplenectomy. METHODS: This is a post hoc analysis of a prospectively kept database of 135 consecutive patients undergoing laparoscopic left pancreatectomy, performed across two sites in the UK and the Netherlands (07/2007-07/2015 Southampton and 10/2013-07/2015 Amsterdam). Primary outcomes were resection margin and lymph node retrieval. Secondary endpoints were other perioperative outcomes, including post-operative pancreatic fistula. Definition of radical resection was distance tumour to resection margin >1 mm. All patients underwent 'laparoscopic radical left pancreatosplenectomy' (LRLP) which involves 'hanging' the pancreas including Gerota's fascia, followed by clockwise dissection, including formal lymphadenectomy. RESULTS: LRLP for pancreatic adenocarcinoma was performed in 25 patients. Seven of the 25 patients (28 %) had extended resections, including the adrenal gland (n = 3), duodenojejunal flexure (n = 2) or transverse mesocolon (n = 3). Mean age was 68 years (54-81). Conversion rate was 0 %, mean operative time 240 min and mean blood loss 340 ml. Median intensive/high care and hospital stay were 1 and 5 days, respectively. Clavien-Dindo score 3+ complication rate was 12 % and ISGPF grade B/C pancreatic fistula rate 28 %; 90-day (or in-hospital) mortality was 0 %. The pancreatic resection margin was clear in all patients, and the posterior margin was involved (<1 mm) in 6 patients, meaning an overall R0 resection rate of 76 %. No resection margin was microscopically involved. Median nodal sample was 15 nodes (3-26). With an average follow-up of 17.2 months, 1-year survival was 88 %. CONCLUSIONS: A standardised laparoscopic approach to pancreatic adenocarcinoma in th

Published
2016
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38. Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score

Author

De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., Vermassen, F. E G, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., and Vermassen, F. E G

Published
2016

39. Outcomes of Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma in the Netherlands: A Nationwide Retrospective Analysis

Author

de Rooij, T. (Thijs), Tol, J.A. (Johanna A.), Eijck, C.H.J. (Casper) van, Boerma, D. (Djamila), Bonsing, B.A. (Bert), Bosscha, K. (Koop), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Goor, H. (Harry) van, Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Kazemier, G. (Geert), Klaase, J.M. (Joost), Molenaar, I.Q. (I. Quintus), Patijn, G.A. (Gijs A.), Santvoort, H.C. (Hjalmar) van, Scheepers, J.J. (Joris J.), Schelling, G. van der, Sieders, E. (Egbert), Busch, O.R.C. (Olivier), Besselink, M.G. (Marc), de Rooij, T. (Thijs), Tol, J.A. (Johanna A.), Eijck, C.H.J. (Casper) van, Boerma, D. (Djamila), Bonsing, B.A. (Bert), Bosscha, K. (Koop), Dam, R. (Ronald) van, Dijkgraaf, M.G.W. (Marcel), Gerhards, M.F. (Michael), Goor, H. (Harry) van, Harst, E. (Erwin) van der, Hingh, I.H.J.T. (Ignace) de, Kazemier, G. (Geert), Klaase, J.M. (Joost), Molenaar, I.Q. (I. Quintus), Patijn, G.A. (Gijs A.), Santvoort, H.C. (Hjalmar) van, Scheepers, J.J. (Joris J.), Schelling, G. van der, Sieders, E. (Egbert), Busch, O.R.C. (Olivier), and Besselink, M.G. (Marc)

Abstract

Background: Large multicenter series on outcomes and predictors of survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC) are scarce. Methods: Adults who underwent DP for PDAC in 17 Dutch pancreatic centers between January 2005 and September 2013 were analyzed retrospectively. The primary outcome was survival, and predictors of survival were identified using Cox regression analysis. Results: In total, 761 consecutive patients after DP were assessed, of whom 620 patients were excluded because of non-PDAC histopathology (n = 616) or a lack of data (n = 4), leaving a total of 141 patients included in the study

Published
2016
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40. Predicting reinterventions after open and endovascular aneurysm repair using the St George's Vascular Institute score

Author

Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Genetica Klinische Genetica, Arts Assistenten CTC, Psychiatrie_Medisch, Pathologie Pathologen staf, Arts-assistenten Radiologie, PCR MN, Other research (not in main researchprogram), JC Overig onderzoek, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., Vermassen, F. E G, Cardiovasculaire Epi Team 9, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Genetica Klinische Genetica, Arts Assistenten CTC, Psychiatrie_Medisch, Pathologie Pathologen staf, Arts-assistenten Radiologie, PCR MN, Other research (not in main researchprogram), JC Overig onderzoek, De Bruin, Jorg Lucas, Karthikesalingam, Alan, Holt, Peter J., Prinssen, Monique, Thompson, Matt M., Blankensteijn, Jan D., Grobbee, D. E., Blankensteijn, J. D., Bak, A. A A, Buth, J., Pattynama, P. M., Verhoeven, E. L G, Van Voorthuisen, A. E., Balm, R., Cuypers, P. W M, Prinssen, M., Van Sambeek, M. R H M, Baas, A. F., Hunink, M. G., Van Engelshoven, J. M., Jacobs, M. J H M, De Mol, B. A J M, Van Bockel, J. H., Reekers, J., Tielbeek, X., Wisselink, W., Boekema, N., Heuveling, L. M., Sikking, I., De Bruin, J. L., Tielbeek, A. V., Reekers, J. A., Pattynama, P., Prins, T., Van Der Ham, A. C., Van Der Velden, J. J I M, Van Sterkenburg, S. M M, Ten Haken, G. B., Bruijninckx, C. M A, Van Overhagen, H., Tutein Nolthenius, R. P., Hendriksz, T. R., Teijink, J. A W, Odink, H. F., De Smet, A. A E A, Vroegindeweij, D., Van Loenhout, R. M M, Rutten, M. J., Hamming, J. F., Lampmann, L. E H, Bender, M. H M, Pasmans, H., Vahl, A. C., De Vries, C., MacKaay, A. J C, Van Dortmont, L. M C, Van Der Vliet, A. J., Schultze Kool, L. J., Boomsma, J. H B, Van, H. R., De Mol Van Otterloo, J. C A, De Rooij, T. P W, Smits, T. M., Yilmaz, E. N., Van Den Berg, F. G., Visser, M. J T, Van Der Linden, E., Schurink, G. W H, De Haan, M., Smeets, H. J., Stabel, P., Van Elst, F., Poniewierski, J., and Vermassen, F. E G

Published
2016

41. Outcomes of Distal Pancreatectomy for Pancreatic Ductal Adenocarcinoma in the Netherlands: A Nationwide Retrospective Analysis

Author

de Rooij, T, Tol, JA, van Eijck, Casper, Boerma, D, Bonsing, BA, Bosscha, K, van Dam, RM, Dijkgraaf, MG, Gerhards, MF, van Goor, H, van der Harst, E, de Hingh, IH, Kazemier, G, Klaase, JM, Molenaar, IQ, Patijn, GA, van Santvoort, HC, Scheepers, JJ, van der Schelling, GP, Sieders, E, Busch, OR, Besselink, MG, de Rooij, T, Tol, JA, van Eijck, Casper, Boerma, D, Bonsing, BA, Bosscha, K, van Dam, RM, Dijkgraaf, MG, Gerhards, MF, van Goor, H, van der Harst, E, de Hingh, IH, Kazemier, G, Klaase, JM, Molenaar, IQ, Patijn, GA, van Santvoort, HC, Scheepers, JJ, van der Schelling, GP, Sieders, E, Busch, OR, and Besselink, MG

Abstract

Large multicenter series on outcomes and predictors of survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC) are scarce. Adults who underwent DP for PDAC in 17 Dutch pancreatic centers between January 2005 and September 2013 were analyzed retrospectively. The primary outcome was survival, and predictors of survival were identified using Cox regression analysis. In total, 761 consecutive patients after DP were assessed, of whom 620 patients were excluded because of non-PDAC histopathology (n = 616) or a lack of data (n = 4), leaving a total of 141 patients included in the study [45 % (n = 63) male, mean age 64 years (SD = 10)]. Multivisceral resection was performed in 43 patients (30 %) and laparoscopic resection was performed in 7 patients (5 %). A major complication (Clavien-Dindo score of III or higher) occurred in 46 patients (33 %). Mean tumor size was 44 mm (SD 23), and histopathological examination showed 70 R0 resections (50 %), while 30-day and 90-day mortality was 3 and 6 %, respectively. Overall, 63 patients (45 %) received adjuvant chemotherapy. Median survival was 17 months [interquartile range (IQR) 13-21], with a median follow-up of 17 months (IQR 8-29). Cumulative survival at 1, 3 and 5 years was 64, 29, and 22 %, respectively. Independent predictors of worse postoperative survival were R1/R2 resection [hazard ratio (HR) 1.6, 95 % confidence interval (CI) 1.1-2.4], pT3/pT4 stage (HR 1.9, 95 % CI 1.3-2.9), a major complication (HR 1.7, 95 % CI 1.1-2.5), and not receiving adjuvant chemotherapy (HR 1.5, 95 % CI 1.0-2.3). Survival after DP for PDAC is poor and is related to resection margin, tumor stage, surgical complications, and adjuvant chemotherapy. Further studies should assess to what extent prevention of surgical complications and more extensive use of adjuvant chemotherapy can improve survival.

Published
2016

45. Pan-European survey on laparoscopic pancreatic surgery

Author

De Rooij, T., primary, Besselink, M., additional, Shamali, A., additional, Butturini, G., additional, Busch, O., additional, Troisi, R., additional, Fernández-Cruz, L., additional, Topal, B., additional, Dagher, I., additional, Bassi, C., additional, and Abu Hilal, M., additional

Published
2016
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46. Multidisciplinary management of locally unresectable pancreatic ductal adenocarcinoma with induction chemotherapy, surgical exploration and irreversible electroporation: Prospective series of 132 consecutive patients

Author

Vogel, J., primary, de Rooij, T., additional, van Lienden, K., additional, Wilmink, J., additional, van Laarhoven, H., additional, van Hooft, J., additional, van Delden, O., additional, Dijkgraaf, M., additional, Martin, R., additional, Busch, O., additional, and Besselink, M., additional

Published
2016
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47. Electromagnetic guided bedside placement of nasoenteral feeding tubes by nurses versus endoscopic placement by gastroenterologists (CORE): A randomized controlled non-inferiority multicenter trial

Author

Gerritsen, A., primary, de Rooij, T., additional, Dijkgraaf, M.G., additional, Busch, O.R., additional, Bergman, J.J., additional, van Duijvendijk, P., additional, Bac, D.J., additional, Rosman, C., additional, Molenaar, I.Q., additional, Mathus-Vliegen, E.M., additional, and Besselink, M.G., additional

Published
2016
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50. Pancreatoduodenectomy with simultaneous colonic resection for cancer: A nationwide retrospective analysis

Author

Madelief Marsman, E., primary, de Rooij, T., additional, Boerma, D., additional, Bonsing, B.A., additional, van Dam, R.M., additional, van Dieren, S., additional, van Eijck, C.H., additional, Gerhards, M.F., additional, de Hingh, I.H., additional, Kazemier, G., additional, Klaase, J.M., additional, Molenaar, I.Q., additional, Patijn, G.A., additional, Pranger, B.K., additional, Scheepers, J.J., additional, Tanis, P.J., additional, Busch, O.R., additional, and Besselink, M.G., additional

Published
2016
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