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627 results on '"de Sauvage, Frederic"'

1. Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

Author

Taraborrelli, Lucia, Şenbabaoğlu, Yasin, Wang, Lifen, Lim, Junghyun, Blake, Kerrigan, Kljavin, Noelyn, Gierke, Sarah, Scherl, Alexis, Ziai, James, McNamara, Erin, Owyong, Mark, Rao, Shilpa, Calviello, Aslihan Karabacak, Oreper, Daniel, Jhunjhunwala, Suchit, Argiles, Guillem, Bendell, Johanna, Kim, Tae Won, Ciardiello, Fortunato, Wongchenko, Matthew J., de Sauvage, Frederic J., de Sousa e Melo, Felipe, Yan, Yibing, West, Nathaniel R., and Murthy, Aditya

Published
2023
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3. Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Author

Schmitt, Mark, Ceteci, Fatih, Gupta, Jalaj, Pesic, Marina, Böttger, Tim W., Nicolas, Adele M., Kennel, Kilian B., Engel, Esther, Schewe, Matthias, Callak Kirisözü, Asude, Petrocelli, Valentina, Dabiri, Yasamin, Varga, Julia, Ramakrishnan, Mallika, Karimova, Madina, Ablasser, Andrea, Sato, Toshiro, Arkan, Melek C., de Sauvage, Frederic J., and Greten, Florian R.

Published
2022
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4. Antibody targeting of E3 ubiquitin ligases for receptor degradation

Author

Marei, Hadir, Tsai, Wen-Ting K., Kee, Yee-Seir, Ruiz, Karen, He, Jieyan, Cox, Chris, Sun, Tao, Penikalapati, Sai, Dwivedi, Pankaj, Choi, Meena, Kan, David, Saenz-Lopez, Pablo, Dorighi, Kristel, Zhang, Pamela, Kschonsak, Yvonne T., Kljavin, Noelyn, Amin, Dhara, Kim, Ingrid, Mancini, Andrew G., Nguyen, Thao, Wang, Chunling, Janezic, Eric, Doan, Alexander, Mai, Elaine, Xi, Hongkang, Gu, Chen, Heinlein, Melanie, Biehs, Brian, Wu, Jia, Lehoux, Isabelle, Harris, Seth, Comps-Agrar, Laetitia, Seshasayee, Dhaya, de Sauvage, Frederic J., Grimmer, Matthew, Li, Jing, Agard, Nicholas J., and de Sousa e Melo, Felipe

Published
2022
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5. Lgr5+ telocytes are a signaling source at the intestinal villus tip.

Author

Bahar Halpern, Keren, Massalha, Hassan, Zwick, Rachel K, Moor, Andreas E, Castillo-Azofeifa, David, Rozenberg, Milena, Farack, Lydia, Egozi, Adi, Miller, Dan R, Averbukh, Inna, Harnik, Yotam, Weinberg-Corem, Noa, de Sauvage, Frederic J, Amit, Ido, Klein, Ophir D, Shoshkes-Carmel, Michal, and Itzkovitz, Shalev

Subjects
Intestinal Mucosa, Enterocytes, Intestine, Small, Stromal Cells, Animals, Mice, Inbred C57BL, Mice, Receptors, G-Protein-Coupled, Male, Wnt-5a Protein, Intestine, Small, Inbred C57BL, Receptors, G-Protein-Coupled
Abstract

The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated profound zonation of epithelial gene expression along the villus axis, but the mechanisms shaping this spatial variability are unknown. Here, we combine laser capture micro-dissection and single cell RNA sequencing to uncover spatially zonated populations of mesenchymal cells along the crypt-villus axis. These include villus tip telocytes (VTTs) that express Lgr5, a gene previously considered a specific crypt epithelial stem cell marker. VTTs are elongated cells that line the villus tip epithelium and signal through Bmp morphogens and the non-canonical Wnt5a ligand. Their ablation is associated with perturbed zonation of enterocyte genes induced at the villus tip. Our study provides a spatially-resolved cell atlas of the small intestinal stroma and exposes Lgr5+ villus tip telocytes as regulators of the epithelial spatial expression programs along the villus axis.

Published
2020

6. Obligate role for Rock1 and Rock2 in adult stem cell viability and function

Author

Sambandam, Arivazhagan, Storm, Elaine, Tauc, Helen, Hackney, Jason A., Garfield, David, Caplazi, Patrick, Liu, John, Zhang, Juan, Zhang, Hua, Duggan, Jeff, Jeet, Surinder, Gierke, Sarah, Chang, Patrick, Wu, Xiumin, Newman, Robert, Tam, Lucinda, Alcantar, Tuija, Wang, Lifen, Roose-Girma, Meron, Modrusan, Zora, Lee, Wyne P., Jasper, Heinrich, de Sauvage, Frederic, and Pappu, Rajita

Published
2023
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7. Disruption of stem cell niche–confined R-spondin 3 expression leads to impaired hematopoiesis

Author

Kurtova, Antonina V., Heinlein, Melanie, Haas, Simon, Velten, Lars, Dijkgraaf, Gerrit J. P., Storm, Elaine E., Kljavin, Noelyn M., Boumahdi, Soufiane, Himmels, Patricia, Herault, Aurelie, Mancini, Andrew, Koeppen, Hartmut, Dail, Monique, Yan, Qingxiang, Zhang, Jianhuan, Koch, Ute, Radtke, Freddy, Modrusan, Zora, Metcalfe, Ciara, Piskol, Robert, and de Sauvage, Frederic J.

Published
2023
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8. Atoh1+ secretory progenitors possess renewal capacity independent of Lgr5+ cells during colonic regeneration

Author

Castillo‐Azofeifa, David, Fazio, Elena N, Nattiv, Roy, Good, Hayley J, Wald, Tomas, Pest, Michael A, de Sauvage, Frederic J, Klein, Ophir D, and Asfaha, Samuel

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Regenerative Medicine, Digestive Diseases, Animals, Basic Helix-Loop-Helix Transcription Factors, Cells, Cultured, Colitis, Colon, Homeostasis, Intestine, Small, Keratin-19, Mice, Receptor, Notch1, Receptors, G-Protein-Coupled, Regeneration, Stem Cells, Atoh1, colitis, Krt19, Notch1, stem cells, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

During homeostasis, the colonic epithelium is replenished every 3-5 days by rapidly cycling Lgr5+ stem cells. However, various insults can lead to depletion of Lgr5+ stem cells, and colonic epithelium can be regenerated from Lgr5-negative cells. While studies in the small intestine have addressed the lineage identity of the Lgr5-negative regenerative cell population, in the colon this question has remained unanswered. Here, we set out to identify which cell(s) contribute to colonic regeneration by performing genetic fate-mapping studies of progenitor populations in mice. First, using keratin-19 (Krt19) to mark a heterogeneous population of cells, we found that Lgr5-negative cells can regenerate colonic crypts and give rise to Lgr5+ stem cells. Notch1+ absorptive progenitor cells did not contribute to epithelial repair after injury, whereas Atoh1+ secretory progenitors did contribute to this process. Additionally, while colonic Atoh1+ cells contributed minimally to other lineages during homeostasis, they displayed plasticity and contributed to epithelial repair during injury, independent of Lgr5+ cells. Our findings suggest that promotion of secretory progenitor plasticity could enable gut healing in colitis.

Published
2019

9. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

Author

Nusse, Ysbrand M, Savage, Adam K, Marangoni, Pauline, Rosendahl-Huber, Axel KM, Landman, Tyler A, de Sauvage, Frederic J, Locksley, Richard M, and Klein, Ophir D

Subjects
Biomedical and Clinical Sciences, Immunology, Stem Cell Research, Regenerative Medicine, Prevention, Digestive Diseases, Stem Cell Research - Nonembryonic - Non-Human, Underpinning research, 1.1 Normal biological development and functioning, Aetiology, 2.1 Biological and endogenous factors, Animals, Antigens, Ly, Epithelial Cells, Female, Fetus, Helminths, Interferon-gamma, Intestines, Male, Membrane Proteins, Mice, Mice, Inbred C57BL, Nematospiroides dubius, Parasites, Receptors, G-Protein-Coupled, Stem Cell Niche, Stem Cells, Strongylida Infections, General Science & Technology
Abstract

Epithelial surfaces form critical barriers to the outside world and are continuously renewed by adult stem cells1. Whereas dynamics of epithelial stem cells during homeostasis are increasingly well understood, how stem cells are redirected from a tissue-maintenance program to initiate repair after injury remains unclear. Here we examined infection by Heligmosomoides polygyrus, a co-evolved pathosymbiont of mice, to assess the epithelial response to disruption of the mucosal barrier. H. polygyrus disrupts tissue integrity by penetrating the duodenal mucosa, where it develops while surrounded by a multicellular granulomatous infiltrate2. Crypts overlying larvae-associated granulomas did not express intestinal stem cell markers, including Lgr53, in spite of continued epithelial proliferation. Granuloma-associated Lgr5- crypt epithelium activated an interferon-gamma (IFN-γ)-dependent transcriptional program, highlighted by Sca-1 expression, and IFN-γ-producing immune cells were found in granulomas. A similar epithelial response accompanied systemic activation of immune cells, intestinal irradiation, or ablation of Lgr5+ intestinal stem cells. When cultured in vitro, granuloma-associated crypt cells formed spheroids similar to those formed by fetal epithelium, and a sub-population of H. polygyrus-induced cells activated a fetal-like transcriptional program, demonstrating that adult intestinal tissues can repurpose aspects of fetal development. Therefore, re-initiation of the developmental program represents a fundamental mechanism by which the intestinal crypt can remodel itself to sustain function after injury.

Published
2018

10. Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

Author

Kapoor, Varun N., Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E., Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X., Astarita, Jillian L., Krishnamurty, Akshay T., Carbone, Catherine B., Senbabaoglu, Yasin, Wang, Amber W., Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone, Tam, Lucinda, Doerr, Jonas, Chen, Mark Z., Lee, Wyne P., Modrusan, Zora, Yang, Yeqing Angela, Bourgon, Richard, Sandoval, Wendy, Shaw, Andrey S., de Sauvage, Frederic J., Mellman, Ira, Moussion, Christine, and Turley, Shannon J.

Published
2021
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12. Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

Author

Tian, Hua, Biehs, Brian, Chiu, Cecilia, Siebel, Christian W, Wu, Yan, Costa, Mike, de Sauvage, Frederic J, and Klein, Ophir D

Subjects
Biochemistry and Cell Biology, Biological Sciences, Digestive Diseases, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Stem Cell Research - Nonembryonic - Human, 1.1 Normal biological development and functioning, Underpinning research, Oral and gastrointestinal, Animals, Cell Differentiation, Cell Lineage, Cell Proliferation, Gene Expression Regulation, Homeostasis, Intestinal Mucosa, Mice, Receptors, Notch, Stem Cells, Wnt Signaling Pathway, Medical Physiology, Biological sciences
Abstract

Proper organ homeostasis requires tight control of adult stem cells and differentiation through the integration of multiple inputs. In the mouse small intestine, Notch and Wnt signaling are required both for stem cell maintenance and for a proper balance of differentiation between secretory and absorptive cell lineages. In the absence of Notch signaling, stem cells preferentially generate secretory cells at the expense of absorptive cells. Here, we use function-blocking antibodies against Notch receptors to demonstrate that Notch blockade perturbs intestinal stem cell function by causing a derepression of the Wnt signaling pathway, leading to misexpression of prosecretory genes. Importantly, attenuation of the Wnt pathway rescued the phenotype associated with Notch blockade. These studies bring to light a negative regulatory mechanism that maintains stem cell activity and balanced differentiation, and we propose that the interaction between Wnt and Notch signaling described here represents a common theme in adult stem cell biology.

Published
2015

14. Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

Author

Plaks, Vicki, Brenot, Audrey, Lawson, Devon A, Linnemann, Jelena R, Van Kappel, Eline C, Wong, Karren C, de Sauvage, Frederic, Klein, Ophir D, and Werb, Zena

Subjects
Biological Sciences, Regenerative Medicine, Cancer, Transplantation, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Breast Cancer, Pediatric, Animals, Animals, Newborn, CD24 Antigen, Diphtheria Toxin, Female, Green Fluorescent Proteins, Keratin-14, Mammary Glands, Animal, Mice, Mice, Inbred C57BL, Organogenesis, Receptors, G-Protein-Coupled, Regeneration, Sexual Maturation, Single-Cell Analysis, Tamoxifen, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Mammary epithelial stem cells are vital to tissue expansion and remodeling during various phases of postnatal mammary development. Basal mammary epithelial cells are enriched in Wnt-responsive cells and can reconstitute cleared mammary fat pads upon transplantation into mice. Lgr5 is a Wnt-regulated target gene and was identified as a major stem cell marker in the small intestine, colon, stomach, and hair follicle, as well as in kidney nephrons. Here, we demonstrate the outstanding regenerative potential of a rare population of Lgr5-expressing (Lgr5(+)) mammary epithelial cells (MECs). We found that Lgr5(+) cells reside within the basal population, are superior to other basal cells in regenerating functional mammary glands (MGs), are exceptionally efficient in reconstituting MGs from single cells, and exhibit regenerative capacity in serial transplantations. Loss-of-function and depletion experiments of Lgr5(+) cells from transplanted MECs or from pubertal MGs revealed that these cells are not only sufficient but also necessary for postnatal mammary organogenesis.

Published
2013

22. Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

Author

Tang, Tracy, primary, Tang, Jean Y., primary, Li, Dongwei, primary, Reich, Mike, primary, Callahan, Christopher A., primary, Fu, Ling, primary, Yauch, Robert L., primary, Wang, Frank, primary, Kotkow, Karen, primary, Chang, Kris S., primary, Shpall, Elana, primary, Wu, Angela, primary, Rubin, Lee L., primary, Marsters, James C., primary, Epstein, Ervin H., primary, Caro, Ivor, primary, and de Sauvage, Frederic J., primary

Published
2023
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23. Supplementary Figure from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

Author

Yurchenko, Andrey A., primary, Pop, Oltin T., primary, Ighilahriz, Meriem, primary, Padioleau, Ismael, primary, Rajabi, Fatemeh, primary, Sharpe, Hayley J., primary, Poulalhon, Nicolas, primary, Dreno, Brigitte, primary, Khammari, Amir, primary, Delord, Marc, primary, Alberti, Antonio, primary, Soufir, Nadem, primary, Battistella, Maxime, primary, Mourah, Samia, primary, Bouquet, Fanny, primary, Savina, Ariel, primary, Besse, Andrej, primary, Mendez-Lopez, Max, primary, Grange, Florent, primary, Monestier, Sandrine, primary, Mortier, Laurent, primary, Meyer, Nicolas, primary, Dutriaux, Caroline, primary, Robert, Caroline, primary, Saiag, Philippe, primary, Herms, Florian, primary, Lambert, Jerome, primary, de Sauvage, Frederic J., primary, Dumaz, Nicolas, primary, Flatz, Lukas, primary, Basset-Seguin, Nicole, primary, and Nikolaev, Sergey I., primary

Published
2023
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24. Supplementary Data from Frequency and Genomic Aspects of Intrinsic Resistance to Vismodegib in Locally Advanced Basal Cell Carcinoma

Author

Yurchenko, Andrey A., primary, Pop, Oltin T., primary, Ighilahriz, Meriem, primary, Padioleau, Ismael, primary, Rajabi, Fatemeh, primary, Sharpe, Hayley J., primary, Poulalhon, Nicolas, primary, Dreno, Brigitte, primary, Khammari, Amir, primary, Delord, Marc, primary, Alberti, Antonio, primary, Soufir, Nadem, primary, Battistella, Maxime, primary, Mourah, Samia, primary, Bouquet, Fanny, primary, Savina, Ariel, primary, Besse, Andrej, primary, Mendez-Lopez, Max, primary, Grange, Florent, primary, Monestier, Sandrine, primary, Mortier, Laurent, primary, Meyer, Nicolas, primary, Dutriaux, Caroline, primary, Robert, Caroline, primary, Saiag, Philippe, primary, Herms, Florian, primary, Lambert, Jerome, primary, de Sauvage, Frederic J., primary, Dumaz, Nicolas, primary, Flatz, Lukas, primary, Basset-Seguin, Nicole, primary, and Nikolaev, Sergey I., primary

Published
2023
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25. Supplementary Data Figures from A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

Author

Piskol, Robert, primary, Huw, Ling, primary, Sergin, Ismail, primary, Kljin, Christiaan, primary, Modrusan, Zora, primary, Kim, Doris, primary, Kljavin, Noelyn, primary, Tam, Rachel, primary, Patel, Rajesh, primary, Burton, Jeremy, primary, Penuel, Elicia, primary, Qu, Xueping, primary, Koeppen, Hartmut, primary, Sumiyoshi, Teiko, primary, de Sauvage, Frederic, primary, Lackner, Mark R., primary, de Sousa e Melo, Felipe, primary, and Kabbarah, Omar, primary

Published
2023
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26. Supplementary Data Tables from A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon Cancer

Author

Piskol, Robert, primary, Huw, Ling, primary, Sergin, Ismail, primary, Kljin, Christiaan, primary, Modrusan, Zora, primary, Kim, Doris, primary, Kljavin, Noelyn, primary, Tam, Rachel, primary, Patel, Rajesh, primary, Burton, Jeremy, primary, Penuel, Elicia, primary, Qu, Xueping, primary, Koeppen, Hartmut, primary, Sumiyoshi, Teiko, primary, de Sauvage, Frederic, primary, Lackner, Mark R., primary, de Sousa e Melo, Felipe, primary, and Kabbarah, Omar, primary

Published
2023
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28. Supplementary Data from Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

Author

Tang, Tracy, primary, Tang, Jean Y., primary, Li, Dongwei, primary, Reich, Mike, primary, Callahan, Christopher A., primary, Fu, Ling, primary, Yauch, Robert L., primary, Wang, Frank, primary, Kotkow, Karen, primary, Chang, Kris S., primary, Shpall, Elana, primary, Wu, Angela, primary, Rubin, Lee L., primary, Marsters, James C., primary, Epstein, Ervin H., primary, Caro, Ivor, primary, and de Sauvage, Frederic J., primary

Published
2023
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29. Supplementary Table 3 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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33. Data from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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34. Supplementary Table 7 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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35. Supplementary Table 2 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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36. Data from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Author

Polson, Andrew G., primary, Calemine-Fenaux, Jill, primary, Chan, Pamela, primary, Chang, Wesley, primary, Christensen, Erin, primary, Clark, Suzanna, primary, de Sauvage, Frederic J., primary, Eaton, Dan, primary, Elkins, Kristi, primary, Elliott, J. Michael, primary, Frantz, Gretchen, primary, Fuji, Reina N., primary, Gray, Alane, primary, Harden, Kristin, primary, Ingle, Gladys S., primary, Kljavin, Noelyn M., primary, Koeppen, Hartmut, primary, Nelson, Christopher, primary, Prabhu, Saileta, primary, Raab, Helga, primary, Ross, Sarajane, primary, Stephan, Jean-Philippe, primary, Scales, Suzie J., primary, Spencer, Susan D., primary, Vandlen, Richard, primary, Wranik, Bernd, primary, Yu, Shang-Fan, primary, Zheng, Bing, primary, and Ebens, Allen, primary

Published
2023
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37. Supplementary Table 4 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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38. Data from Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Author

Gray, Daniel, primary, Jubb, Adrian M., primary, Hogue, Deborah, primary, Dowd, Patrick, primary, Kljavin, Noelyn, primary, Yi, Sothy, primary, Bai, Wei, primary, Frantz, Gretchen, primary, Zhang, Zemin, primary, Koeppen, Hartmut, primary, de Sauvage, Frederic J., primary, and Davis, David P., primary

Published
2023
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40. Supplementary Methods, Figure Legends 1-6 from Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Author

Dijkgraaf, Gerrit J. P., primary, Alicke, Bruno, primary, Weinmann, Lasse, primary, Januario, Thomas, primary, West, Kristina, primary, Modrusan, Zora, primary, Burdick, Dan, primary, Goldsmith, Richard, primary, Robarge, Kirk, primary, Sutherlin, Dan, primary, Scales, Suzie J., primary, Gould, Stephen E., primary, Yauch, Robert L., primary, and de Sauvage, Frederic J., primary

Published
2023
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41. Supplementary Figure 1 from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Author

Polson, Andrew G., primary, Calemine-Fenaux, Jill, primary, Chan, Pamela, primary, Chang, Wesley, primary, Christensen, Erin, primary, Clark, Suzanna, primary, de Sauvage, Frederic J., primary, Eaton, Dan, primary, Elkins, Kristi, primary, Elliott, J. Michael, primary, Frantz, Gretchen, primary, Fuji, Reina N., primary, Gray, Alane, primary, Harden, Kristin, primary, Ingle, Gladys S., primary, Kljavin, Noelyn M., primary, Koeppen, Hartmut, primary, Nelson, Christopher, primary, Prabhu, Saileta, primary, Raab, Helga, primary, Ross, Sarajane, primary, Stephan, Jean-Philippe, primary, Scales, Suzie J., primary, Spencer, Susan D., primary, Vandlen, Richard, primary, Wranik, Bernd, primary, Yu, Shang-Fan, primary, Zheng, Bing, primary, and Ebens, Allen, primary

Published
2023
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42. Supplementary Table 5 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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43. Supplementary Table 1 from Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Author

Dijkgraaf, Gerrit J. P., primary, Alicke, Bruno, primary, Weinmann, Lasse, primary, Januario, Thomas, primary, West, Kristina, primary, Modrusan, Zora, primary, Burdick, Dan, primary, Goldsmith, Richard, primary, Robarge, Kirk, primary, Sutherlin, Dan, primary, Scales, Suzie J., primary, Gould, Stephen E., primary, Yauch, Robert L., primary, and de Sauvage, Frederic J., primary

Published
2023
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45. Supplementary Table 6 from Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Author

Lee, Genee Y., primary, Haverty, Peter M., primary, Li, Li, primary, Kljavin, Noelyn M., primary, Bourgon, Richard, primary, Lee, James, primary, Stern, Howard, primary, Modrusan, Zora, primary, Seshagiri, Somasekar, primary, Zhang, Zemin, primary, Davis, David, primary, Stokoe, David, primary, Settleman, Jeffrey, primary, de Sauvage, Frederic J., primary, and Neve, Richard M., primary

Published
2023
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46. Supplementary Figures 1-6 from Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Author

Dijkgraaf, Gerrit J. P., primary, Alicke, Bruno, primary, Weinmann, Lasse, primary, Januario, Thomas, primary, West, Kristina, primary, Modrusan, Zora, primary, Burdick, Dan, primary, Goldsmith, Richard, primary, Robarge, Kirk, primary, Sutherlin, Dan, primary, Scales, Suzie J., primary, Gould, Stephen E., primary, Yauch, Robert L., primary, and de Sauvage, Frederic J., primary

Published
2023
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47. Supplementary Table 1 from Antibody-Drug Conjugates for the Treatment of Non–Hodgkin's Lymphoma: Target and Linker-Drug Selection

Author

Polson, Andrew G., primary, Calemine-Fenaux, Jill, primary, Chan, Pamela, primary, Chang, Wesley, primary, Christensen, Erin, primary, Clark, Suzanna, primary, de Sauvage, Frederic J., primary, Eaton, Dan, primary, Elkins, Kristi, primary, Elliott, J. Michael, primary, Frantz, Gretchen, primary, Fuji, Reina N., primary, Gray, Alane, primary, Harden, Kristin, primary, Ingle, Gladys S., primary, Kljavin, Noelyn M., primary, Koeppen, Hartmut, primary, Nelson, Christopher, primary, Prabhu, Saileta, primary, Raab, Helga, primary, Ross, Sarajane, primary, Stephan, Jean-Philippe, primary, Scales, Suzie J., primary, Spencer, Susan D., primary, Vandlen, Richard, primary, Wranik, Bernd, primary, Yu, Shang-Fan, primary, Zheng, Bing, primary, and Ebens, Allen, primary

Published
2023
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48. Data from Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

Author

Dijkgraaf, Gerrit J. P., primary, Alicke, Bruno, primary, Weinmann, Lasse, primary, Januario, Thomas, primary, West, Kristina, primary, Modrusan, Zora, primary, Burdick, Dan, primary, Goldsmith, Richard, primary, Robarge, Kirk, primary, Sutherlin, Dan, primary, Scales, Suzie J., primary, Gould, Stephen E., primary, Yauch, Robert L., primary, and de Sauvage, Frederic J., primary

Published
2023
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49. Supplementary Legends from Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Author

Gray, Daniel, primary, Jubb, Adrian M., primary, Hogue, Deborah, primary, Dowd, Patrick, primary, Kljavin, Noelyn, primary, Yi, Sothy, primary, Bai, Wei, primary, Frantz, Gretchen, primary, Zhang, Zemin, primary, Koeppen, Hartmut, primary, de Sauvage, Frederic J., primary, and Davis, David P., primary

Published
2023
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