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226 results on '"de Smet, B."'

8. Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type

Author

Camenzind, Edoardo, Boersma, Eric, Wijns, William, Mauri, Laura, Rademaker-Havinga, Tessa, Ordoubadi, Farzin Fath, Suttorp, Maarten J., Al Kurdi, Mohammad, Steg, Ph Gabriel, Camenzind, E, Mauri, L, OʼNeill, W, Serruys, P W, Steg, PhG, Wijns, W, Verheugt, FWA, Bertrand, ME, Califf, R, DeMets, D, Wallentin, L, Bocksch, W, Bosmans, J, Garcia, H, Garg, S, Hanet, C, Herrman, J-PR, Kelbaek, H, Mc Fadden, E, Radke, PW, Rutsch, W, Tilsted, HH, Wykrzykowska, J, Alvarez, C, Rodriguez, A, Meredith, I, Muller, D, Whitbourn, R, Worthley, S, Whelan, A, Walters, D, Shetty, S, New, G, Cox, S, Batra, R, van Gaal, W, Bellamy, G, Mayr, H, Heigert, M, Huber, K, Leisch, F, Wijns, W, Desmet, W, Boland, J, Schroeder, E, Chenu, P, Legrand, V, Labinaz, M, Teefy, P, Bertrand, O, Gao, R, Ge, J, Kala, P, Cervinka, P, Ureña, P, Hartikainen, J, Steg, G, Fajadet, J, Carrie, D, Gilard, M, Barragan, P, Lablanche, J-M, Koning, R, Eltchaninoff, H, Darremont, O, Leroy, F, Bertrand, B, Robert, G, Schiele, F, Chassaing, S, Bressollette, E, Brunel, P, Quilliet, L, Brunet, J, Pansieri, M, Sideris, G, Stratiev, V, Teiger, E, Lebreton, H, Bonnet, J-L, Karsenty, B, Delarche, N, Lusson, J-R, Cassagnes, J, Brachmann, J, Kurowski, V, Buerke, M, Schieffer, B, Scholtz, W, Wiemer, M, Fichtlscherer, S, Schächinger, V, Kupatt, C, Boekstegers, P, Genth-Zotz, S, Bode, C, Frey, N, Neumann, F-J, Witzenbichler, B, Pels, K, Strasser, R, Kuck, K-H, Hauptmann, K-E, Baldus, S, Heitzer, T, Haude, M, Hoffmann, E, Jung, W, Hoffmann, S, Schmitt, C, Dissmann, M, Pauschinger, M, Werner, G, Braun-Delleus, R, Burkhardt, D, Manz, M, Voudris, V, Sionis, D, Kang-Yin, M-L, Tse, T-S, Merkely, B, Mehta, A, Parikh, K, Kumar, V, Chandra, P, Rath, P, Hiremath, S, Crean, P, Daly, K, Kornowski, R, Kerner, A, Mosseri, M, Jafari, G, Giudice, P, Trani, C, Manari, A, Prati, F, Pangrazi, A, Bolognese, L, Jeong, M-H, Kim, M-Y, Kim, H-S, Park, S-J, Erglis, A, Kalnins, A, Wagner, D, Zambahari, R, Ong, T-K, Sim, K, den Heijer, P, Appelman, Y, Suttorp, M-J, de Smet, B, Koolen, J, Stella, P, Harding, S, Warwick, J, Maslowski, A, Abernethy, M, Devlin, G, Rotevatn, S, Myreng, Y, Ciecwierz, D, Peruga, J, Reczuch, K, Campante Teles, R, Farto, P, Abreu, E, Leitão-Marques, A, Pereira, H, Vinereanu, D, Alkasab, S, Mhish, H, Al Kurdi, M, Al Turki, F, Wong, P, Teo, S-G, Goicolea Ruigomez, F-J, Valdés Chávarri, M, Bethencourt Gonzalez, A, Iñiguez Romo, A, López Minguez, J, Hernández García, J-M, Diaz Fernández, J, Ruiz Salmeron, R, Martinez Elbal, L, Zueco, J, López-Palop, RF, Melgares, R, Diderholm, E, Kåregren, A, Herterich, O, Olivencrona, G, Fröbert, O, Roffi, M, Verin, V, Girod, G, Vuilliomenet, A, Hsieh, I-C, Wu, C-J, Gershlick, A, Densem, C, Doshi, S, Manoharan, G, McCarthy, P, De Belder, M, Mills, J, Fath-Ordoubadi, F, Simpson, I, Greenwood, J, Chamberlain-Webber, R, Khan, Z, Cotton, J, Gunning, M, Smith, D, Talwar, S, Holmberg, S, Purcell, I, Anderson, R, Alamgir, F, Beatt, K, Kelly, P, Moussavian, M, Aji, J, Prashad, R, Zankar, A, Banerjee, S, Lewis, S, McLaurin, B, Douglas, J, Brener, S, Gupta, A, Walters, L, Driesman, M, Aycock, R, Mego, C, Fisher, D, Frankel, R, and Satler, L

Published
2014
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17. Abstracts of papers and posters

Author

Anthonio, R. L., Willemsen, A. T. M., Visser, T., van Waarde, A., Elzinga, P., Weemaes, A., Meeder, J. G., Pruim, J., Visser, G., Blanksma, P. K., Vaalburg, W., Bloemen, P. G. M., Henricks, P. A. J., van Bloois, L., van den Tweel, M. C., Nijkamp, F. P., Crommelin, D. J. A., Storm, G., de Boer, A. H., Winter, H. M. I., Lerk, C. F., de Boer, J., Meurs, H., Bottone, A. E., Koopal, M., Visser, J. C., Zaagsma, J., Borger P., Kauffman H. F., Vijgen J. L. J., Postma D. S., Vellenga E., Buckley, Theresa L., Buikema, H., van Gilst, W. H., van Veldhuisen, D. J., de Smet, B. J. G. L., Scholtens, E., Lie, K. I., Wesseling, H., Cheung, P. K., Dijkhuis, F. W. D., Bakker, W. W., Visser, J., Coopes, R. P., Benthem, L., van der Leest, J., Roffel, A. F., Coppes, R. P., Zeilstra, L. J. W., Vissink, A., Konings, A. W. T., Dijkstra, M., Veld, G. In't, Müller, M., van den Berg, G. J., Kuipers, F., Vonk, R. J., Elsinga, P. H., Franssen, E. J. F., van der Graaf, W. T. A., de Vries, E. G. E., Visser, G. M., Vos, M. G., Braker, A. H., Visser, T. J., Visser, G. M., Engels, F., van Houwelingen, A. H., van de Velde, M. J., Gansevoort, R. T., Sluiter, W. J., Hemmelder, M. H., de Zeeuw, D., de Jong, P. E., Gelissen, H. P. M. M., Henning, R. H., Epema, A. H., van Eekeren, J., Hennis, P. J., Den Hertog, A., de Graaf, S. S. N., Kellie, S. J., Bloemhof, H., Johnston, I., Besser, M., Chaseling, R. W., Ouvrier, R. A., Uqes, D. R. A., De Haan, A., Geerligs, H. J., Huchshorn, J. P., Van Scharenburg, G. J. M., Wilschut, J., Haas, M., Kluppel, C. A., Meijer, D. K. F., Moolenaar, F., Heerdink, Eibert R., Leufkens, Hubert G., Herings, Ron M. C., Stricker, Bruno H. Ch., Bakker, Albert, Heesen W. F., Beltman F. W., Smit A. J., May J. F., Meyboom-de Jong B., Duin, M., van den Akker, J., te Pas, M. F. W., van Popta, J. P., Nelemans, S. A., van der Linde, H. J., de Boer, A., Sturmans, F., Hessel, E. M., Van Oosterhout, A. J. M., Hofstra, C. L., Garssen, J., van Loveren, H., Savelkoul, H. F. J., Hoekstra, Y., Weersink, E. J. M., de Jong, J. W., van der Belt-Gritter, B., Jonkman, Lisa M., Kemner, Chantal, Koelega, Harry S., van Engeland, Herman, Verbaten, Marinus N., Kalivianakis, M., Zijlstra, I., Verkade, H. J., Elzinga, H., Stellaard, F., Kamps, J. A. A. M., Swart, P. J., Morselt, H., Scherphof, G. L., Kenemans, J. L., Lorist, M. M., Koopen, N. R., Kraneveld, A. D., Koster, A. Si., Kuipers, M. E., Groenink, M., Huisman, H., Schuitemaker, H., Lau, H. S., van den Broek, I. J. P. M., van Dijk, A., Oostinga, J., Porsius, A. J., Lin, Y., Havinga, R., Meijer, R. J., van der Mark, Th. W., Koëter, G. H., Michels, A. A., Nguyen, V. -T., Bensaude, O., Kampinga, H. H., Mohede, Inge C. M., Van Antoon J. M., Molema, Grietje, Edgington, Thomas S., Thorpe, Philip E., Olinga, P., Sandker, G. W., Slooff, M. J. H., Merema, M. T., Groothuis, G. M. M., Hofman, G., Van Ark, I., Paulussen, J. J. C., Fischer, M. J. E., de Mol, N. J., Janssen, L. H. M., Peters, E. Th. J., van der Werf, G. Th., Haaijer-Ruskamp, F. M., Pinto, Yigal M., Rooks, Gerrit, Grandjean, Jean G., Ebels, Tjark, Schunkert, H., Redegeld, Frank A., Garssen, Johan, van Loveren, Henk, Rigter, Irma M., van Groningen, Muck, Boks, Gertjan J., Tollenaere, Jan P., Trollope, Keith I., Vinter, Jeremy G., Hashjin, Gudarz Sadeghi, Folkerts, Gert, van de Loo, Peet G. F., Santing, R. E., Olymulder, C. G., van der Molen, K., Pasman, Y., Scheerens, Heleen, Van Loveren, Henk, Seppenwoolde-Waasdorp, T. J. A., de Boer, P., Van Engelen, H. M. J., Thijssen, J. H. H., Maes, R. A. A., Smit, J., Smit, J. W., Steen, H., Steurs, M. H., Kuks, P. F. M., Leusink, J. A., Szabó, Balázs M., Crijns, Harry J. G. M., Wiesfeld, Ans C. P., Talsma, H., Borchert, J. C. H., van Steenbergen, M. J., Hennink, W. E., Teeuw, K. B., Cromheecke, H., Schreudering, A., Teisman, B. C. H., Maselbas, W., Wolters-Keulemans, G. T. P., Tieleman, R. G., de Langen, C. D. J., Bel, K., Crijns, H. J. G. M., Grandjean, J., Wijffels, M., Klimp, A. H., van de Meer, P. F., Allessie, M. A., van Patot, H. A. Tissot, de Jongh, B. M., Tuininga, Y. S., Brouwer, J., Haaksma, J., Man in't Veld, A. J., Blomjous, F. J., Vingerhoeds, M. H., Belliot, S. O., Haisma, H. J., Visscher, C. A., Huisman, R. M., Navis, G. J., de Vlieger, J. F., van den Wijngaard, P., Wilting, J., van Heuven-Nolsen, D., Voors, A. A., van Brussel, B. L., Plokker, H. W. M., Van Waardenburg R. C. A. M., Meijer, Prins J., De Vries, C., Mulder N. H., Wierenga, P. K., Wilschut J., Schoen P., and Bron R.

Published
1994
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20. The influence of dietary salt level on water consumption, farrowing, and reproductive performance of lactating sows

Author

Seynaeve, M., De Wilde, R., Janssens, G., and De Smet, B.

Subjects
Sows -- Food and nutrition, Salt in animal nutrition -- Research, Zoology and wildlife conservation
Abstract

'During two consecutive lactations using a switch-back design, 16 sows received a corn, cassava, barley, and soybean meal diet supplemented with either 8.5 or 1 g/kg of NaCl (.4% Na or .1% Na, respectively). The average daily water consumption during the 4-wk lactation period was greater (P Key Words: Sows, Sodium, Water Intake, Lactation, Salt, Reproduction

Published
1996

21. Corrigendum to 'European contribution to the study of ROS:A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)' [Redox Biol. 13 (2017) 94-162]

Author

Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M. M., Barbosa, R. M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S. P., Brito, P. M., Carrara, G., Casas, A. I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M. S., Costa, J. G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-Butuner, B., Dias, I. H.K., Dunn, J. D., Edson, A. J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A. S., Fladmark, K. E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J. A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L. O., Korac, B., Korkmaz, K. S., Koziel, R., Kračun, D., Krause, K. H., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., McBean, G. J., Meredith, S. P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P. A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I. T.N., Oelze, M., Oliveira, N. G., Palmeira, C. M., Papaevgeniou, N., Pavićević, A., Pedre, B., Peyrot, F., Phylactides, M., Pircalabioru, G. G., Pitt, A. R., Poulsen, H. E., Prieto, I., Rigobello, M. P., Robledinos-Antón, N., Rodríguez-Mañas, L., Rolo, A. P., Rousset, F., Ruskovska, T., Saraiva, N., Sasson, S., Schröder, K., Semen, K., Seredenina, T., Shakirzyanova, A., Smith, G. L., Soldati, T., Sousa, B. C., Spickett, C. M., Stancic, A., Stasia, M. J., Steinbrenner, H., Stepanić, V., Steven, S., Tokatlidis, K., Tuncay, E., Turan, B., Ursini, F., Vacek, J., Vajnerova, O., Valentová, K., Van Breusegem, F., Varisli, L., Veal, E. A., Yalçin, A. S., Yelisyeyeva, O., Žarković, N., Zatloukalová, M., Zielonka, J., Touyz, R. M., Papapetropoulos, A., Grune, T., Lamas, S., Schmidt, H. H.H.W., Di Lisa, F., and Daiber, A.

Published
2018

22. VLIZ Jaarboek 2017

Author

Mees, J., Mertens, T., Seys, J., and De Smet, B.

Published
2018

29. Corrigendum to 'European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)' (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007))

Author

Egea, J. Fabregat, I. Frapart, Y.M. Ghezzi, P. Görlach, A. Kietzmann, T. Kubaichuk, K. Knaus, U.G. Lopez, M.G. Olaso-Gonzalez, G. Petry, A. Schulz, R. Vina, J. Winyard, P. Abbas, K. Ademowo, O.S. Afonso, C.B. Andreadou, I. Antelmann, H. Antunes, F. Aslan, M. Bachschmid, M.M. Barbosa, R.M. Belousov, V. Berndt, C. Bernlohr, D. Bertrán, E. Bindoli, A. Bottari, S.P. Brito, P.M. Carrara, G. Casas, A.I. Chatzi, A. Chondrogianni, N. Conrad, M. Cooke, M.S. Costa, J.G. Cuadrado, A. My-Chan Dang, P. De Smet, B. Debelec-Butuner, B. Dias, I.H.K. Dunn, J.D. Edson, A.J. El Assar, M. El-Benna, J. Ferdinandy, P. Fernandes, A.S. Fladmark, K.E. Förstermann, U. Giniatullin, R. Giricz, Z. Görbe, A. Griffiths, H. Hampl, V. Hanf, A. Herget, J. Hernansanz-Agustín, P. Hillion, M. Huang, J. Ilikay, S. Jansen-Dürr, P. Jaquet, V. Joles, J.A. Kalyanaraman, B. Kaminskyy, D. Karbaschi, M. Kleanthous, M. Klotz, L.O. Korac, B. Korkmaz, K.S. Koziel, R. Kračun, D. Krause, K.H. Křen, V. Krieg, T. Laranjinha, J. Lazou, A. Li, H. Martínez-Ruiz, A. Matsui, R. McBean, G.J. Meredith, S.P. Messens, J. Miguel, V. Mikhed, Y. Milisav, I. Milković, L. Miranda-Vizuete, A. Mojović, M. Monsalve, M. Mouthuy, P.A. Mulvey, J. Münzel, T. Muzykantov, V. Nguyen, I.T.N. Oelze, M. Oliveira, N.G. Palmeira, C.M. Papaevgeniou, N. Pavićević, A. Pedre, B. Peyrot, F. Phylactides, M. Pircalabioru, G.G. Pitt, A.R. Poulsen, H.E. Prieto, I. Rigobello, M.P. Robledinos-Antón, N. Rodríguez-Mañas, L. Rolo, A.P. Rousset, F. Ruskovska, T. Saraiva, N. Sasson, S. Schröder, K. Semen, K. Seredenina, T. Shakirzyanova, A. Smith, G.L. Soldati, T. Sousa, B.C. Spickett, C.M. Stancic, A. Stasia, M.J. Steinbrenner, H. Stepanić, V. Steven, S. Tokatlidis, K. Tuncay, E. Turan, B. Ursini, F. Vacek, J. Vajnerova, O. Valentová, K. Van Breusegem, F. Varisli, L. Veal, E.A. Yalçın, A.S. Yelisyeyeva, O. Žarković, N. Zatloukalová, M. Zielonka, J. Touyz, R.M. Papapetropoulos, A. Grune, T. Lamas, S. Schmidt, H.H.H.W. Di Lisa, F. Daiber, A.

Abstract

The authors regret that they have to correct the acknowledgement of the above mentioned publication as follows: This article/publication is based upon work from COST Action BM1203 (EU-ROS), supported by COST (European Cooperation in Science and Technology) which is funded by the Horizon 2020 Framework Programme of the European Union. COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. For further information see www.cost.eu. The authors would like to apologise for any inconvenience caused. © 2017 The Author(s)

Published
2018

30. European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017)

Author

Egea, J., Fabregat, I., Frapart, Y.M., Ghezzi, P., Görlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U.G., Lopez, M.G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O.S., Afonso, C.B., Andreadou, I., Antelmann, H., Antunes, F., Aslan, M., Bachschmid, M.M., Barbosa, R.M., Belousov, V., Berndt, C., Bernlohr, D., Bertrán, E., Bindoli, A., Bottari, S.P., Brito, P.M., Carrara, G., Casas, A.I., Chatzi, A., Chondrogianni, N., Conrad, M., Cooke, M.S., Costa, J.G., Cuadrado, A., My-Chan Dang, P., De Smet, B., Debelec-Butuner, B., Dias, I.H.K., Dunn, J.D., Edson, A.J., El Assar, M., El-Benna, J., Ferdinandy, P., Fernandes, A.S., Fladmark, K.E., Förstermann, U., Giniatullin, R., Giricz, Z., Görbe, A., Griffiths, H., Hampl, V., Hanf, A., Herget, J., Hernansanz-Agustín, P., Hillion, M., Huang, J., Ilikay, S., Jansen-Dürr, P., Jaquet, V., Joles, J.A., Kalyanaraman, B., Kaminskyy, D., Karbaschi, M., Kleanthous, M., Klotz, L.O., Korac, B., Korkmaz, K.S., Koziel, R., Kračun, D., Krause, K.H., Křen, V., Krieg, T., Laranjinha, J., Lazou, A., Li, H., Martínez-Ruiz, A., Matsui, R., McBean, G.J., Meredith, S.P., Messens, J., Miguel, V., Mikhed, Y., Milisav, I., Milković, L., Miranda-Vizuete, A., Mojović, M., Monsalve, M., Mouthuy, P.A., Mulvey, J., Münzel, T., Muzykantov, V., Nguyen, I.T.N., Oelze, M., Oliveira, N.G., Palmeira, C.M., and Papaevgeniou, N.

Published
2018

31. Introduction: revolution and counter-revolution in Egypt\ud

Author

Tansel, C.B. and De Smet, B.

Abstract

This introduction to the ROAPE debate reasserts the centrality of revolutionary theory\ud to understand the dynamics of social and political struggles in contemporary Middle East and\ud North Africa. Framed around the conceptual and political interventions brought about by Brecht\ud De Smet’s Gramsci on Tahrir (2016), we discuss the utility of Gramscian concepts in explaining the\ud trajectories of social mobilisations in the peripheries of global capitalism.\ud

Published
2017

32. Swinging beats : transient heart block in cardiac lymphoma

Author

Buikema, J W, Goodyer, W R, Koudstaal, S, van 't Sant, J, Verheggen, P W, de Vrey, E A, de Smet, B J, Buikema, J W, Goodyer, W R, Koudstaal, S, van 't Sant, J, Verheggen, P W, de Vrey, E A, and de Smet, B J

Published
2018

33. Functional trait responses to sediment deposition reduce macrofauna-mediated ecosystem functioning in an estuarine mudflat

Author

Mestdagh, S., Bagaço, L., Braeckman, U., Ysebaert, T., De Smet, B., Moens, T., van Colen, C., Mestdagh, S., Bagaço, L., Braeckman, U., Ysebaert, T., De Smet, B., Moens, T., and van Colen, C.

Abstract

Human activities, among which dredging and land use change in river basins, are altering estuarine ecosystems. These activities may result in changes in sedimentary processes, affecting biodiversity of sediment macrofauna. As macrofauna controls sediment chemistry and fluxes of energy and matter between water column and sediment, changes in the structure of macrobenthic communities could affect the functioning of an entire ecosystem. We assessed the impact of sediment deposition on intertidal macrobenthic communities and on rates of an important ecosystem function, i.e. sediment community oxygen consumption (SCOC). An experiment was performed with undisturbed sediment samples from the Scheldt river estuary (SW Netherlands). The samples were subjected to four sedimentation regimes: one control and three with a deposited sediment layer of 1, 2 or 5 cm. Oxygen consumption was measured during incubation at ambient temperature. Luminophores applied at the surface, and a seawater–bromide mixture, served as tracers for bioturbation and bio-irrigation, respectively. After incubation, the macrofauna was extracted, identified, and counted and then classified into functional groups based on motility and sediment reworking capacity. Total macrofaunal densities dropped already under the thinnest deposits. The most affected fauna were surficial and low-motility animals, occurring at high densities in the control. Their mortality resulted in a drop in SCOC, which decreased steadily with increasing deposit thickness, while bio-irrigation and bioturbation activity showed increases in the lower sediment deposition regimes but decreases in the more extreme treatments. The initial increased activity likely counteracted the effects of the drop in low-motility, surficial fauna densities, resulting in a steady rather than sudden fall in oxygen consumption. We conclude that the functional identity in terms of motility and sediment reworking can be crucial in our understanding of the regula

Published
2018

34. Swinging beats: transient heart block in cardiac lymphoma

Author

Circulatory Health, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Team Medisch, Buikema, J W, Goodyer, W R, Koudstaal, S, van 't Sant, J, Verheggen, P W, de Vrey, E A, de Smet, B J, Circulatory Health, Arts Assistenten Cardiologie, Onderzoek Precision medicine, Team Medisch, Buikema, J W, Goodyer, W R, Koudstaal, S, van 't Sant, J, Verheggen, P W, de Vrey, E A, and de Smet, B J

Published
2018

35. Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type

Author

Camenzind, Edoardo, Boersma, Eric, Wijns, William, Mauri, Laura, Rademaker-Havinga, Tessa, Ordoubadi, Farzin Fath, Suttorp, Maarten J., Al Kurdi, Mohammad, Steg, Ph Gabriel, Camenzind, E., Mauri, L., O'Neill, W., Serruys, P W., Steg, PhG, Wijns, W., Verheugt, FWA, Bertrand, ME, Califf, R., DeMets, D., Wallentin, L., Bocksch, W., Bosmans, J., Garcia, H., Garg, S., Hanet, C., Herrman, J-PR, Kelbaek, H., Mc Fadden, E., Radke, PW, Rutsch, W., Tilsted, HH, Wykrzykowska, J., Alvarez, C., Rodriguez, A., Meredith, I., Muller, D., Whitbourn, R., Worthley, S., Whelan, A., Walters, D., Shetty, S., New, G., Cox, S., Batra, R., van Gaal, W., Bellamy, G., Mayr, H., Heigert, M., Huber, K., Leisch, F., Desmet, W., Boland, J., Schroeder, E., Chenu, P., Legrand, V., Labinaz, M., Teefy, P., Bertrand, O., Gao, R., Ge, J., Kala, P., Cervinka, P., Ureña, P., Hartikainen, J., Steg, G., Fajadet, J., Carrie, D., Gilard, M., Barragan, P., Lablanche, J-M, Koning, R., Eltchaninoff, H., Darremont, O., Leroy, F., Bertrand, B., Robert, G., Schiele, F., Chassaing, S., Bressollette, E., Brunel, P., Quilliet, L., Brunet, J., Pansieri, M., Sideris, G., Stratiev, V., Teiger, E., Lebreton, H., Bonnet, J-L, Karsenty, B., Delarche, N., Lusson, J-R, Cassagnes, J., Brachmann, J., Kurowski, V., Buerke, M., Schieffer, B., Scholtz, W., Wiemer, M., Fichtlscherer, S., Schächinger, V., Kupatt, C., Boekstegers, P., Genth-Zotz, S., Bode, C., Frey, N., Neumann, F-J, Witzenbichler, B., Pels, K., Strasser, R., Kuck, K-H, Hauptmann, K-E, Baldus, S., Heitzer, T., Haude, M., Hoffmann, E., Jung, W., Hoffmann, S., Schmitt, C., Dissmann, M., Pauschinger, M., Werner, G., Braun-Delleus, R., Burkhardt, D., Manz, M., Voudris, V., Sionis, D., Kang-Yin, M-L, Tse, T-S, Merkely, B., Mehta, A., Parikh, K., Kumar, V., Chandra, P., Rath, P., Hiremath, S., Crean, P., Daly, K., Kornowski, R., Kerner, A., Mosseri, M., Jafari, G., Giudice, P., Trani, C., Manari, A., Prati, F., Pangrazi, A., Bolognese, L., Jeong, M-H, Kim, M-Y, Kim, H-S, Park, S-J, Erglis, A., Kalnins, A., Wagner, D., Zambahari, R., Ong, T-K, Sim, K., den Heijer, P., Appelman, Y., Suttorp, M-J, de Smet, B., Koolen, J., Stella, P., Harding, S., Warwick, J., Maslowski, A., Abernethy, M., Devlin, G., Rotevatn, S., Myreng, Y., Ciecwierz, D., Peruga, J., Reczuch, K., Campante Teles, R., Farto, P., Abreu, E., Leitão-Marques, A., Pereira, H., Vinereanu, D., Alkasab, S., Mhish, H., Al Kurdi, M., Al Turki, F., Wong, P., Teo, S-G, Goicolea Ruigomez, F-J, Valdés Chávarri, M., Bethencourt Gonzalez, A., Iñiguez Romo, A., López Minguez, J., Hernández García, J-M, Diaz Fernández, J., Ruiz Salmeron, R., Martinez Elbal, L., Zueco, J., López-Palop, RF, Melgares, R., Diderholm, E., Kåregren, A., Herterich, O., Olivencrona, G., Fröbert, O., Roffi, M., Verin, V., Girod, G., Vuilliomenet, A., Hsieh, I-C, Wu, C-J, Gershlick, A., Densem, C., Doshi, S., Manoharan, G., McCarthy, P., De Belder, M., Mills, J., Fath-Ordoubadi, F., Simpson, I., Greenwood, J., Chamberlain-Webber, R., Khan, Z., Cotton, J., Gunning, M., Smith, D., Talwar, S., Holmberg, S., Purcell, I., Anderson, R., Alamgir, F., Beatt, K., Kelly, P., Moussavian, M., Aji, J., Prashad, R., Zankar, A., Banerjee, S., Lewis, S., McLaurin, B., Douglas, J., Brener, S., Gupta, A., Walters, L., Driesman, M., Aycock, R., Mego, C., Fisher, D., Frankel, R., and Satler, L.

Subjects
animal structures, cardiovascular diseases, equipment and supplies
Abstract

Aim To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES). Methods and results Of 8709 patients in PROTECT, 4357 were randomized to E-ZES and 4352 to C-SES. Aspirin was to be given indefinitely, and clopidogrel/ticlopidine for ≥3 months or up to 12 months after implantation. Main outcome measures were definite or probable stent thrombosis at 3 years. Multivariable Cox regression analysis was applied, with stent type, DAPT, and their interaction as the main outcome determinants. Dual antiplatelet therapy adherence remained the same in the E-ZES and C-SES groups (79.6% at 1 year, 32.8% at 2 years, and 21.6% at 3 years). We observed a statistically significant (P = 0.0052) heterogeneity in treatment effect of stent type in relation to DAPT. In the absence of DAPT, stent thrombosis was lower with E-ZES vs. C-SES (adjusted hazard ratio 0.38, 95% confidence interval 0.19, 0.75; P = 0.0056). In the presence of DAPT, no difference was found (1.18; 0.79, 1.77; P = 0.43). Conclusion A strong interaction was observed between drug-eluting stent type and DAPT use, most likely prompted by the vascular healing response induced by the implanted DES system. These results suggest that the incidence of stent thrombosis in DES trials should not be evaluated independently of DAPT use, and the optimal duration of DAPT will likely depend upon stent type (Clinicaltrials.gov number NCT00476957)

Published
2017

36. Global and regional dissemination and evolution of $\textit{Burkholderia pseudomallei}$

Author

Chewapreecha, C, Holden, MTG, Vehkala, M, Välimäki, N, Yang, Z, Harris, SR, Mather, AE, Tuanyok, A, De Smet, B, Le Hello, S, Bizet, C, Mayo, M, Wuthiekanun, V, Limmathurotsakul, D, Phetsouvanh, R, Spratt, BG, Corander, J, Keim, P, Dougan, G, Dance, DAB, Currie, BJ, Parkhill, J, Peacock, SJ, Dougan, Gordon [0000-0003-0022-965X], Parkhill, Julian [0000-0002-7069-5958], Peacock, Sharon [0000-0002-1718-2782], and Apollo - University of Cambridge Repository

Subjects
DNA, Bacterial, Asia, Burkholderia pseudomallei, Virulence, Asia, Eastern, Australia, Malaysia, Sequence Analysis, DNA, Evolution, Molecular, Melioidosis, Animals, Humans, Americas, Asia, Southeastern
Abstract

The environmental bacterium $\textit{Burkholderia pseudomallei}$ causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 $\textit{B. pseudomallei}$isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

Published
2017
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40. Corrigendum to “European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” [Redox Biol. 13 (2017) 94–162]

Author

Egea, J., primary, Fabregat, I., additional, Frapart, Y.M., additional, Ghezzi, P., additional, Görlach, A., additional, Kietzmann, T., additional, Kubaichuk, K., additional, Knaus, U.G., additional, Lopez, M.G., additional, Olaso-Gonzalez, G., additional, Petry, A., additional, Schulz, R., additional, Vina, J., additional, Winyard, P., additional, Abbas, K., additional, Ademowo, O.S., additional, Afonso, C.B., additional, Andreadou, I., additional, Antelmann, H., additional, Antunes, F., additional, Aslan, M., additional, Bachschmid, M.M., additional, Barbosa, R.M., additional, Belousov, V., additional, Berndt, C., additional, Bernlohr, D., additional, Bertrán, E., additional, Bindoli, A., additional, Bottari, S.P., additional, Brito, P.M., additional, Carrara, G., additional, Casas, A.I., additional, Chatzi, A., additional, Chondrogianni, N., additional, Conrad, M., additional, Cooke, M.S., additional, Costa, J.G., additional, Cuadrado, A., additional, My-Chan Dang, P., additional, De Smet, B., additional, Debelec-Butuner, B., additional, Dias, I.H.K., additional, Dunn, J.D., additional, Edson, A.J., additional, El Assar, M., additional, El-Benna, J., additional, Ferdinandy, P., additional, Fernandes, A.S., additional, Fladmark, K.E., additional, Förstermann, U., additional, Giniatullin, R., additional, Giricz, Z., additional, Görbe, A., additional, Griffiths, H., additional, Hampl, V., additional, Hanf, A., additional, Herget, J., additional, Hernansanz-Agustín, P., additional, Hillion, M., additional, Huang, J., additional, Ilikay, S., additional, Jansen-Dürr, P., additional, Jaquet, V., additional, Joles, J.A., additional, Kalyanaraman, B., additional, Kaminskyy, D., additional, Karbaschi, M., additional, Kleanthous, M., additional, Klotz, L.O., additional, Korac, B., additional, Korkmaz, K.S., additional, Koziel, R., additional, Kračun, D., additional, Krause, K.H., additional, Křen, V., additional, Krieg, T., additional, Laranjinha, J., additional, Lazou, A., additional, Li, H., additional, Martínez-Ruiz, A., additional, Matsui, R., additional, McBean, G.J., additional, Meredith, S.P., additional, Messens, J., additional, Miguel, V., additional, Mikhed, Y., additional, Milisav, I., additional, Milković, L., additional, Miranda-Vizuete, A., additional, Mojović, M., additional, Monsalve, M., additional, Mouthuy, P.A., additional, Mulvey, J., additional, Münzel, T., additional, Muzykantov, V., additional, Nguyen, I.T.N., additional, Oelze, M., additional, Oliveira, N.G., additional, Palmeira, C.M., additional, Papaevgeniou, N., additional, Pavićević, A., additional, Pedre, B., additional, Peyrot, F., additional, Phylactides, M., additional, Pircalabioru, G.G., additional, Pitt, A.R., additional, Poulsen, H.E., additional, Prieto, I., additional, Rigobello, M.P., additional, Robledinos-Antón, N., additional, Rodríguez-Mañas, L., additional, Rolo, A.P., additional, Rousset, F., additional, Ruskovska, T., additional, Saraiva, N., additional, Sasson, S., additional, Schröder, K., additional, Semen, K., additional, Seredenina, T., additional, Shakirzyanova, A., additional, Smith, G.L., additional, Soldati, T., additional, Sousa, B.C., additional, Spickett, C.M., additional, Stancic, A., additional, Stasia, M.J., additional, Steinbrenner, H., additional, Stepanić, V., additional, Steven, S., additional, Tokatlidis, K., additional, Tuncay, E., additional, Turan, B., additional, Ursini, F., additional, Vacek, J., additional, Vajnerova, O., additional, Valentová, K., additional, Van Breusegem, F., additional, Varisli, L., additional, Veal, E.A., additional, Yalçın, A.S., additional, Yelisyeyeva, O., additional, Žarković, N., additional, Zatloukalová, M., additional, Zielonka, J., additional, Touyz, R.M., additional, Papapetropoulos, A., additional, Grune, T., additional, Lamas, S., additional, Schmidt, H.H.H.W., additional, Di Lisa, F., additional, and Daiber, A., additional

Published
2018
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41. A case study on the growth of Lanice conchilega (Pallas, 1766) aggregations and their ecosystem engineering impact on sedimentary processes

Author

Alves, R.M.S., Van Colen, C., Vincx, M., Vanaverbeke, J., De Smet, B., Guarini, J.-M., Rabaut, M., Bouma, T.J., Alves, R.M.S., Van Colen, C., Vincx, M., Vanaverbeke, J., De Smet, B., Guarini, J.-M., Rabaut, M., and Bouma, T.J.

Abstract

Ecosystem engineers are organisms that modulate natural resources enabling the survival of other species. They drive environmental change and contribute to several coastal functional attributes such as landscape heterogeneity, sedimentary processes, and coastal protection. Our study focuses on the case of Lanice conchilega, a tube-building ecosystem engineer whose aggregations impact sedimentary processes. This polychaete forms biogenic tube aggregations distributed on the coasts of the northern hemisphere from the shallow intertidal to depths of 1900 m. The aggregations engineer sedimentary processes autogenically by altering water flow at the benthic-boundary layer, and harbor highly diverse infaunal communities as a consequence. This study evaluates the relationships between intertidal L. conchilega aggregations and sedimentary processes at the intertidal zone of a sandy beach in northern France. Three experiments were executed to investigate (1) the effects of L. conchilega presence on sedimentary processes, as well as (2) the impacts of sedimentation on L. conchilega survival and patch growth, and (3) assess small-scale spatial heterogeneity in density and ecosystem engineering in L. conchilega aggregations. Weekly estimations of sedimentary properties in-situ showed that net deposition is significantly higher inside L. conchilega aggregations than in bare sand; whereas sediment mixing depth is noticeably reduced in comparison and regardless of patch tidal height. Variations in tube density above 3200 ind m-2 did not significantly impact sedimentary properties suggesting that the relationship between flow attenuation and tube density is nonlinear. In-situ monitoring of L. conchilega aggregations revealed different temporal trends for tube density and EPS content at the sediment surface between the center and edges of patches. This hints at the presence of environmental gradients within ag

Published
2017

42. European contribution to the study of ROS:a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Author

Egea, J. (Javier), Fabregat, I. (Isabel), Frapart, Y. M. (Yves M.), Ghezzi, P. (Pietro), Görlach, A. (Agnes), Kietzmann, T. (Thomas), Kubaichuk, K. (Kateryna), Knaus, U. G. (Ulla G.), Lopez, M. G. (Manuela G.), Olaso-Gonzalez, G. (Gloria), Petry, A. (Andreas), Schulz, R. (Rainer), Vina, J. (Jose), Winyard, P. (Paul), Abbas, K. (Kahina), Ademowo, O. S. (Opeyemi S.), Afonso, C. B. (Catarina B.), Andreadou, I. (Ioanna), Antelmann, H. (Haike), Antunes, F. (Fernando), Aslan, M. (Mutay), Bachschmid, M. M. (Markus M.), Barbosa, R. M. (Rui M.), Belousov, V. (Vsevolod), Berndt, C. (Carsten), Bernlohr, D. (David), Bertrán, E. (Esther), Bindoli, A. (Alberto), Bottari, S. P. (Serge P.), Brito, P. M. (Paula M.), Carrara, G. (Guia), Casas, A. I. (Ana I.), Chatzi, A. (Afroditi), Chondrogianni, N. (Niki), Conrad, M. (Marcus), Cooke, M. S. (Marcus S.), Costa, J. G. (João G.), Cuadrado, A. (Antonio), My-Chan Dang, P. (Pham), De Smet, B. (Barbara), Debelec-Butuner, B. (Bilge), Dias, I. H. (Irundika H. K.), Dunn, J. D. (Joe D.an), Edson, A. J. (Amanda J.), El Assar, M. (Mariam), El-Benna, J. (Jamel), Ferdinandy, P. (Péter), Fernandes, A. S. (Ana S.), Fladmark, K. E. (Kari E.), Förstermann, U. (Ulrich), Giniatullin, R. (Rashid), Giricz, Z. (Zoltán), Görbe, A. (Anikó), Griffiths, H. (Helen), Hampl, V. (Vaclav), Hanf, A. (Alina), Herget, J. (Jan), Hernansanz-Agustín, P. (Pablo), Hillion, M. (Melanie), Huang, J. (Jingjing), Ilikay, S. (Serap), Jansen-Dürr, P. (Pidder), Jaquet, V. (Vincent), Joles, J. A. (Jaap A.), Kalyanaraman, B. (Balaraman), Kaminskyy, D. (Danylo), Karbaschi, M. (Mahsa), Kleanthous, M. (Marina), Klotz, L.-O. (Lars-Oliver), Korac, B. (Bato), Korkmaz, K. S. (Kemal S.ami), Koziel, R. (Rafal), Kračun, D. (Damir), Krause, K.-H. (Karl-Heinz), Křen, V. (Vladimír), Krieg, T. (Thomas), Laranjinha, J. (João), Lazou, A. (Antigone), Li, H. (Huige), Martínez-Ruiz, A. (Antonio), Matsui, R. (Reiko), McBean, G. J. (Gethin J.), Meredith, S. P. (Stuart P.), Messens, J. (Joris), Miguel, V. (Verónica), Mikhed, Y. (Yuliya), Milisav, I. (Irina), Milković, L. (Lidija), Miranda-Vizuete, A. (Antonio), Mojović, M. (Miloš), Monsalve, M. (María), Mouthuy, P.-A. (Pierre-Alexis), Mulvey, J. (John), Münzel, T. (Thomas), Muzykantov, V. (Vladimir), Nguyen, I. T. (Isabel T. N.), Oelze, M. (Matthias), Oliveira, N. G. (Nuno G.), Palmeira, C. M. (Carlos M.), Papaevgeniou, N. (Nikoletta), Pavićević, A. (Aleksandra), Pedre, B. (Brandán), Peyrot, F. (Fabienne), Phylactides, M. (Marios), Pircalabioru, G. G. (Gratiela G.), Pitt, A. R. (Andrew R.), Poulsen, H. E. (Henrik E.), Prieto, I. (Ignacio), Rigobello, M. P. (Maria P.ia), Robledinos-Antón, N. (Natalia), Rodríguez-Mañas, L. (Leocadio), Rolo, A. P. (Anabela P.), Rousset, F. (Francis), Ruskovska, T. (Tatjana), Saraiva, N. (Nuno), Sasson, S. (Shlomo), Schröder, K. (Katrin), Semen, K. (Khrystyna), Seredenina, T. (Tamara), Shakirzyanova, A. (Anastasia), Smith, G. L. (Geoffrey L.), Soldati, T. (Thierry), Sousa, B. C. (Bebiana C.), Spickett, C. M. (Corinne M.), Stancic, A. (Ana), Stasia, M. J. (Marie J.osé), Steinbrenner, H. (Holger), Stepanić, V. (Višnja), Steven, S. (Sebastian), Tokatlidis, K. (Kostas), Tuncay, E. (Erkan), Turan, B. (Belma), Ursini, F. (Fulvio), Vacek, J. (Jan), Vajnerova, O. (Olga), Valentová, K. (Kateřina), Van Breusegem, F. (Frank), Varisli, L. (Lokman), Veal, E. A. (Elizabeth A.), Yalçın, A. S. (A S.uha), Yelisyeyeva, O. (Olha), Žarković, N. (Neven), Zatloukalová, M. (Martina), Zielonka, J. (Jacek), Touyz, R. M. (Rhian M.), Papapetropoulos, A. (Andreas), Grune, T. (Tilman), Lamas, S. (Santiago), Schmidt, H. H. (Harald H. H. W.), Di Lisa, F. (Fabio), Daiber, A. (Andreas), Egea, J. (Javier), Fabregat, I. (Isabel), Frapart, Y. M. (Yves M.), Ghezzi, P. (Pietro), Görlach, A. (Agnes), Kietzmann, T. (Thomas), Kubaichuk, K. (Kateryna), Knaus, U. G. (Ulla G.), Lopez, M. G. (Manuela G.), Olaso-Gonzalez, G. (Gloria), Petry, A. (Andreas), Schulz, R. (Rainer), Vina, J. (Jose), Winyard, P. (Paul), Abbas, K. (Kahina), Ademowo, O. S. (Opeyemi S.), Afonso, C. B. (Catarina B.), Andreadou, I. (Ioanna), Antelmann, H. (Haike), Antunes, F. (Fernando), Aslan, M. (Mutay), Bachschmid, M. M. (Markus M.), Barbosa, R. M. (Rui M.), Belousov, V. (Vsevolod), Berndt, C. (Carsten), Bernlohr, D. (David), Bertrán, E. (Esther), Bindoli, A. (Alberto), Bottari, S. P. (Serge P.), Brito, P. M. (Paula M.), Carrara, G. (Guia), Casas, A. I. (Ana I.), Chatzi, A. (Afroditi), Chondrogianni, N. (Niki), Conrad, M. (Marcus), Cooke, M. S. (Marcus S.), Costa, J. G. (João G.), Cuadrado, A. (Antonio), My-Chan Dang, P. (Pham), De Smet, B. (Barbara), Debelec-Butuner, B. (Bilge), Dias, I. H. (Irundika H. K.), Dunn, J. D. (Joe D.an), Edson, A. J. (Amanda J.), El Assar, M. (Mariam), El-Benna, J. (Jamel), Ferdinandy, P. (Péter), Fernandes, A. S. (Ana S.), Fladmark, K. E. (Kari E.), Förstermann, U. (Ulrich), Giniatullin, R. (Rashid), Giricz, Z. (Zoltán), Görbe, A. (Anikó), Griffiths, H. (Helen), Hampl, V. (Vaclav), Hanf, A. (Alina), Herget, J. (Jan), Hernansanz-Agustín, P. (Pablo), Hillion, M. (Melanie), Huang, J. (Jingjing), Ilikay, S. (Serap), Jansen-Dürr, P. (Pidder), Jaquet, V. (Vincent), Joles, J. A. (Jaap A.), Kalyanaraman, B. (Balaraman), Kaminskyy, D. (Danylo), Karbaschi, M. (Mahsa), Kleanthous, M. (Marina), Klotz, L.-O. (Lars-Oliver), Korac, B. (Bato), Korkmaz, K. S. (Kemal S.ami), Koziel, R. (Rafal), Kračun, D. (Damir), Krause, K.-H. (Karl-Heinz), Křen, V. (Vladimír), Krieg, T. (Thomas), Laranjinha, J. (João), Lazou, A. (Antigone), Li, H. (Huige), Martínez-Ruiz, A. (Antonio), Matsui, R. (Reiko), McBean, G. J. (Gethin J.), Meredith, S. P. (Stuart P.), Messens, J. (Joris), Miguel, V. (Verónica), Mikhed, Y. (Yuliya), Milisav, I. (Irina), Milković, L. (Lidija), Miranda-Vizuete, A. (Antonio), Mojović, M. (Miloš), Monsalve, M. (María), Mouthuy, P.-A. (Pierre-Alexis), Mulvey, J. (John), Münzel, T. (Thomas), Muzykantov, V. (Vladimir), Nguyen, I. T. (Isabel T. N.), Oelze, M. (Matthias), Oliveira, N. G. (Nuno G.), Palmeira, C. M. (Carlos M.), Papaevgeniou, N. (Nikoletta), Pavićević, A. (Aleksandra), Pedre, B. (Brandán), Peyrot, F. (Fabienne), Phylactides, M. (Marios), Pircalabioru, G. G. (Gratiela G.), Pitt, A. R. (Andrew R.), Poulsen, H. E. (Henrik E.), Prieto, I. (Ignacio), Rigobello, M. P. (Maria P.ia), Robledinos-Antón, N. (Natalia), Rodríguez-Mañas, L. (Leocadio), Rolo, A. P. (Anabela P.), Rousset, F. (Francis), Ruskovska, T. (Tatjana), Saraiva, N. (Nuno), Sasson, S. (Shlomo), Schröder, K. (Katrin), Semen, K. (Khrystyna), Seredenina, T. (Tamara), Shakirzyanova, A. (Anastasia), Smith, G. L. (Geoffrey L.), Soldati, T. (Thierry), Sousa, B. C. (Bebiana C.), Spickett, C. M. (Corinne M.), Stancic, A. (Ana), Stasia, M. J. (Marie J.osé), Steinbrenner, H. (Holger), Stepanić, V. (Višnja), Steven, S. (Sebastian), Tokatlidis, K. (Kostas), Tuncay, E. (Erkan), Turan, B. (Belma), Ursini, F. (Fulvio), Vacek, J. (Jan), Vajnerova, O. (Olga), Valentová, K. (Kateřina), Van Breusegem, F. (Frank), Varisli, L. (Lokman), Veal, E. A. (Elizabeth A.), Yalçın, A. S. (A S.uha), Yelisyeyeva, O. (Olha), Žarković, N. (Neven), Zatloukalová, M. (Martina), Zielonka, J. (Jacek), Touyz, R. M. (Rhian M.), Papapetropoulos, A. (Andreas), Grune, T. (Tilman), Lamas, S. (Santiago), Schmidt, H. H. (Harald H. H. W.), Di Lisa, F. (Fabio), and Daiber, A. (Andreas)

Abstract

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed.

Published
2017

43. Recommendations for the use of bioresorbable vascular scaffolds in percutaneous coronary interventions

Author

Everaert, Bert, Wykrzykowska, JJ, Koolen, J, van der Harst, P, den Heijer, P, Henriques, JP, van der Schaaf, R, de Smet, B, Hofma, SH, Diletti, Roberto, Weevers, A, Hoorntje, J, Smits, P, van Geuns, Robert Jan, Everaert, Bert, Wykrzykowska, JJ, Koolen, J, van der Harst, P, den Heijer, P, Henriques, JP, van der Schaaf, R, de Smet, B, Hofma, SH, Diletti, Roberto, Weevers, A, Hoorntje, J, Smits, P, and van Geuns, Robert Jan

Published
2017

44. Lanice conchilega structures carbon flows in soft-bottom intertidal areas

Author

De Smet, B., van Oevelen, D., Vincx, M., Vanaverbeke, J., and Soetaert, K.

Subjects
Lanice conchilega
Abstract

Biogenic reefs constructed by the tube-building ecosystem engineer Lanice conchilega (Terrebilidae, Polychaeta) have profound structuring impacts on the benthic environment in that they alter the biogeochemical and physical properties of the sediment. This study provides new insights into the functioning and effects on food webs of L. conchilega reefs in intertidal sediments using linear inverse models to quantify the carbon flows in the food webs in the presence and absence of the tubeworm. The inverse food web models were based on an empirical dataset from 2 study sites, which provided biomass and stable isotope data, and information on general physiological constraints from the literature. Results of the model showed that the carbon input into reef food webs (mean ± SE; 191 ± 50 mmol C m-2 d-1) is ca. 40 times higher compared to bare sand areas (5 ± 2 mmol C m-2 d-1) and is mainly derived from organic matter (OM) in the water column. Most of the OM input towards these reefs is consumed by suspension-feeding macrofauna, particularly L. conchilega; however, the worm is not an important source of carbon for other macrofaunal organisms. The ratio of OM input to primary production indicates that the OM needs to be produced in an area at least 15 times larger than the reef area, demonstrating significant OM ‘focussing’ within the reef food web. The reef structures created by L. conchilega act as a trap for OM, resulting in an overall higher macrofaunal biomass and much more diverse food webs than in the absence of the tubeworm.

Published
2016

47. Predator effects on the feeding and bioirrigation activity of ecosystem-engineered Lanice conchilega reefs

Author

De Smet, B., Braeckman, U., Soetaert, K., Vincx, M., and Vanaverbeke, J.

Subjects
Lanice conchilega, Predation, Crangon crangon [brown shrimp]
Abstract

Ecosystem engineers can considerably affect the community composition, abundance and species richness of their environment. This study investigates the existence of positive or negative feedbacks of species that compose the community in intertidal biogenic reefs constructed by the ecosystem engineer Lanice conchilega. This tubeworm creates attractive nursery and feeding grounds for the predatory brown shrimp Crangon crangon, while at the same time is preyed upon by C. crangon. The effect of the predation pressure exerted by C. crangon on the bioirrigation and feeding activity of the tubeworm is up until now unknown and it is hypothesised that these activities are affected by the high densities of C. crangon in the reefs. A mesocosm experiment was set up to investigate the effects of predation pressure on the bioirrigation and feeding activity of L. conchilega in the i) absence; ii) restricted presence; and iii) unrestricted presence of C. crangon. Bioirrigation was quantified by the decrease of an artificially introduced bromide (Br-) tracer, while feeding activity was measured from the incorporation of 13C via stable isotope analysis. The bioirrigation rate of the L. conchilega reef equalled about 30 L·m- 2·d- 1 and was not affected by the presence of the predator. The food uptake of the tubeworm was however about three times lower in the unrestricted presence of C. crangon, presumably due to the retraction of the worm's body and tentacles in its tube induced by physical contact with the predator. Notwithstanding the impacted food uptake of L. conchilega, the tubeworm maintains its functional role in the presence of predators in soft-bottom intertidal areas.

Published
2016

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