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6 results on '"de Urturi, Diego Saenz"'

2. Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Author

Serrano-Maciá, Marina, Simón, Jorge, González-Rellan, Maria J., Azkargorta, Mikel, Goikoetxea-Usandizaga, Naroa, Lopitz-Otsoa, Fernando, De Urturi, Diego Saenz, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofia, Mercado-Gomez, Maria, Gutiérrez de Juan, Virginia, Bizkarguenaga, Maider, Fernández-Ramos, David, Buque, Xabier, Baselli, Guido A., Valenti, Luca V.C., Iruzubieta, Paula, Crespo, Javier, Villa, Erica, Banales, Jesus M., Avila, Matias A., Marin, Jose J.G., Aspichueta, Patricia, Sutherland, James, Barrio, Rosa, Mayor, Ugo, Elortza, Félix, Xirodimas, Dimitris P., Nogueiras, Rubén, Delgado, Teresa C., and Martínez-Chantar, María Luz

Published
2021
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3. The uptake of extracellular lipids promotes cholangiocarcinoma progression

Author

de Gauna, Mikel Ruiz, primary, Biancaniello, Francesca, additional, González-Romero, Francisco, additional, Rodrigues, Pedro Miguel, additional, Lapitz, Ainhoa, additional, Santos, Beatriz Gómez, additional, Olaizola, Paula, additional, Di Matteo, Sabina, additional, Aurrekoetxea, Igor, additional, Labiano, Ibone, additional, Nieva-Zuluaga, Ane, additional, Benito-Vicente, Asier, additional, Perugorria, María Jesús, additional, Apodaka-Biguri, Maider, additional, Paiva, Nuno, additional, de Urturi, Diego Saenz, additional, Buque, Xabier, additional, Delgado, Igotz, additional, Martín, Cesar Augusto, additional, Azkargorta, Mikel, additional, Elortza, Felix, additional, Calvisi, Diego, additional, Andersen, Jesper, additional, Alvaro, Domenico, additional, Cardinale, Vincenzo, additional, Bujanda, Luis, additional, Banales, Jesus Maria, additional, and Aspichueta, Patricia, additional

Published
2022
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4. Methionine adenosyltransferase 1a antisense oligonucleotides induce the fibroblast growth factor 21-driven recovery from obesity and associated hepatoesteatosis

Author

Buque, Xabier, primary, de Urturi, Diego Saenz, additional, Porteiro, Begoña, additional, Folgueira, Cintia, additional, Mora, Alfonso, additional, Delgado, Teresa Cardoso, additional, Prieto-Fernández, Endika, additional, Olaizola, Paula, additional, Santos, Beatriz Gómez, additional, Apodaka-Biguri, Maider, additional, Gonzalez-Romero, Francisco, additional, Nieva-Zuluaga, Ane, additional, de Gauna, Mikel Ruiz, additional, Goikoetxea, Naroa, additional, García Rodríguez, Juan Luis, additional, de Juan, Virginia Gutiérrez, additional, Aurrekoetxea, Igor, additional, Montalvo-Romeral, Valle, additional, Novoa, Eva, additional, Martin-Guerrero, Idoia, additional, Varela-Rey, Marta, additional, Bhanot, Sanjay, additional, Lee, Richard, additional, Banales, Jesus Maria, additional, Syn, Wing-Kin, additional, Sabio, Guadalupe, additional, Martínez-Chantar, María Luz, additional, Nogueiras, Ruben, additional, and Aspichueta, Patricia, additional

Published
2022
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5. The DNA damage response is involved in the metabolic dysregulation of MAFLD patients via inefficient fatty acid oxidation

Author

Santos, Beatriz Gómez, primary, Fernámdez-Puertas, Idoia, additional, Nieva-Zuluaga, Ane, additional, de Gauna, Mikel Ruiz, additional, Apodaka-Biguri, Maider, additional, González-Romero, Francisco, additional, de Urturi, Diego Saenz, additional, Delgado, Igotz, additional, Aurrekoetxea, Igor, additional, González, Lorena Mosteiro, additional, Olartekoetxea, Gaizka Errazti, additional, Gaztambide, Sonia, additional, Castaño González, Luis A, additional, Bujanda, Luis, additional, Banales, Jesus Maria, additional, Zubiaga, Ana, additional, Buque, Xabier, additional, and Aspichueta, Patricia, additional

Published
2022
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6. E2F1 and E2F2-mediated repression of CPT2 establishes a lipid-rich tumor-promoting environment

Author

Gonzalez-Romero, Francisco, Mestre, Daniela, Aurrekoetxea, Igor, O'Rourke, Colm J., Andersen, Jesper B., Woodhoo, Ashwin, Tamayo-Caro, Miguel, Varela-Rey, Marta, Palomo-Irigoyen, Marta, Gomez-Santos, Beatriz, de Urturi, Diego Saenz, Nuñez-García, Maitane, García-Rodríguez, Juan L., Fernandez-Ares, Larraitz, Buque, Xabier, Iglesias-Ara, Ainhoa, Bernales, Irantzu, de Juan, Virginia Gutierrez, Delgado, Teresa C., Goikoetxea-Usandizaga, Naroa, Lee, Richard, Bhanot, Sanjay, Delgado, Igotz, Perugorria, Maria J., Errazti, Gaizka, Mosteiro, Lorena, Gaztambide, Sonia, de la Piscina, Idoia Martinez, Iruzubieta, Paula, Crespo, Javier, Banales, Jesus M., Martínez-Chantar, Maria L., Castaño, Luis, Zubiaga, Ana M., Aspichueta, Patricia, Gonzalez-Romero, Francisco, Mestre, Daniela, Aurrekoetxea, Igor, O'Rourke, Colm J., Andersen, Jesper B., Woodhoo, Ashwin, Tamayo-Caro, Miguel, Varela-Rey, Marta, Palomo-Irigoyen, Marta, Gomez-Santos, Beatriz, de Urturi, Diego Saenz, Nuñez-García, Maitane, García-Rodríguez, Juan L., Fernandez-Ares, Larraitz, Buque, Xabier, Iglesias-Ara, Ainhoa, Bernales, Irantzu, de Juan, Virginia Gutierrez, Delgado, Teresa C., Goikoetxea-Usandizaga, Naroa, Lee, Richard, Bhanot, Sanjay, Delgado, Igotz, Perugorria, Maria J., Errazti, Gaizka, Mosteiro, Lorena, Gaztambide, Sonia, de la Piscina, Idoia Martinez, Iruzubieta, Paula, Crespo, Javier, Banales, Jesus M., Martínez-Chantar, Maria L., Castaño, Luis, Zubiaga, Ana M., and Aspichueta, Patricia

Abstract

Lipid metabolism rearrangements in nonalcoholic fatty liver disease (NAFLD) contribute to disease progression. NAFLD has emerged as a major risk for hepatocellular carcinoma (HCC), where metabolic reprogramming is a hallmark. Identification of metabolic drivers might reveal therapeutic targets to improve HCC treatment. Here, we investigated the contribution of transcription factors E2F1 and E2F2 to NAFLD-related HCC and their involvement in metabolic rewiring during disease progression. In mice receiving a high-fat diet (HFD) and diethylnitrosamine (DEN) administration, E2f1 and E2f2 expressions were increased in NAFLD-related HCC. In human NAFLD, E2F1 and E2F2 levels were also increased and positively correlated. E2f1-/- and E2f2-/- mice were resistant to DEN-HFD-induced hepatocarcinogenesis and associated lipid accumulation. Administration of DEN-HFD in E2f1-/- and E2f2-/- mice enhanced fatty acid oxidation (FAO) and increased expression of Cpt2, an enzyme essential for FAO, whose downregulation is linked to NAFLD-related hepatocarcinogenesis. These results were recapitulated following E2f2 knockdown in liver, and overexpression of E2f2 elicited opposing effects. E2F2 binding to the Cpt2 promoter was enhanced in DEN-HFD-administered mouse livers compared with controls, implying a direct role for E2F2 in transcriptional repression. In human HCC, E2F1 and E2F2 expressions inversely correlated with CPT2 expression. Collectively, these results indicate that activation of the E2F1-E2F2-CPT2 axis provides a lipid-rich environment required for hepatocarcinogenesis.

Published
2021

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