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9. Barium titanate nanoparticles and hypergravity stimulation improve differentiation of mesenchymal stem cells into osteoblasts

Author

Rocca A, Marino A, Rocca V, Moscato S, de Vito G, Piazza V, Mazzolai B, Mattoli V, Ngo-Anh TJ, and Ciofani G

Subjects
Medicine (General), R5-920
Abstract

Antonella Rocca,1,2 Attilio Marino,1,2 Veronica Rocca,3 Stefania Moscato,4 Giuseppe de Vito,5,6 Vincenzo Piazza,5 Barbara Mazzolai,1 Virgilio Mattoli,1 Thu Jennifer Ngo-Anh,7 Gianni Ciofani1 1Istituto Italiano di Tecnologia, Center for Micro-BioRobotics @SSSA, Pontedera, Italy, 2Scuola Superiore Sant’Anna, The BioRobotics Institute, Pontedera, Italy, 3Università di Pisa, Dipartimento di Ingegneria dell’Informazione, Pisa, Italy, 4Università di Pisa, Dipartimento di Medicina Clinica e Sperimentale, Pisa, Italy, 5Istituto Italiano di Tecnologia, Center for Nanotechnology Innovation @NEST, Pisa, Italy, 6Scuola Normale Superiore, NEST, Pisa, Italy, 7Directorate of Human Spaceflight and Operations, European Space Agency, Noordwijk, the Netherlands Background: Enhancement of the osteogenic potential of mesenchymal stem cells (MSCs) is highly desirable in the field of bone regeneration. This paper proposes a new approach for the improvement of osteogenesis combining hypergravity with osteoinductive nanoparticles (NPs).Materials and methods: In this study, we aimed to investigate the combined effects of hypergravity and barium titanate NPs (BTNPs) on the osteogenic differentiation of rat MSCs, and the hypergravity effects on NP internalization. To obtain the hypergravity condition, we used a large-diameter centrifuge in the presence of a BTNP-doped culture medium. We analyzed cell morphology and NP internalization with immunofluorescent staining and coherent anti-Stokes Raman scattering, respectively. Moreover, cell differentiation was evaluated both at the gene level with quantitative real-time reverse-transcription polymerase chain reaction and at the protein level with Western blotting.Results: Following a 20 g treatment, we found alterations in cytoskeleton conformation, cellular shape and morphology, as well as a significant increment of expression of osteoblastic markers both at the gene and protein levels, jointly pointing to a substantial increment of NP uptake. Taken together, our findings suggest a synergistic effect of hypergravity and BTNPs in the enhancement of the osteogenic differentiation of MSCs.Conclusion: The obtained results could become useful in the design of new approaches in bone-tissue engineering, as well as for in vitro drug-delivery strategies where an increment of nanocarrier internalization could result in a higher drug uptake by cell and/or tissue constructs. Keywords: mesenchymal stem cells, hypergravity, barium titanate nanoparticles, osteogenesis

Published
2015

10. Barium titanate core – gold shell nanoparticles for hyperthermia treatments

Author

FarrokhTakin E, Ciofani G, Puleo GL, de Vito G, Filippeschi C, Mazzolai B, Piazza V, and Mattoli V

Subjects
Medicine (General), R5-920
Abstract

Elmira FarrokhTakin,1,2 Gianni Ciofani,1 Gian Luigi Puleo,1 Giuseppe de Vito,3,4 Carlo Filippeschi,1 Barbara Mazzolai,1 Vincenzo Piazza,3 Virgilio Mattoli1 1Center for Micro-BioRobotics @SSSA, Fondazione Istituto Italiano di Tecnologia, Pontedera, Pisa, Italy; 2The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera, Pisa, Italy; 3Center for Nanotechnology Innovation @NEST, Fondazione Istituto Italiano di Tecnologia, Pisa, Italy; 4NEST, Scuola Normale Superiore, Pisa, Italy Abstract: The development of new tools and devices to aid in treating cancer is a hot topic in biomedical research. The practice of using heat (hyperthermia) to treat cancerous lesions has a long history dating back to ancient Greece. With deeper knowledge of the factors that cause cancer and the transmissive window of cells and tissues in the near-infrared region of the electromagnetic spectrum, hyperthermia applications have been able to incorporate the use of lasers. Photothermal therapy has been introduced as a selective and noninvasive treatment for cancer, in which exogenous photothermal agents are exploited to achieve the selective destruction of cancer cells. In this manuscript, we propose applications of barium titanate core–gold shell nanoparticles for hyperthermia treatment against cancer cells. We explored the effect of increasing concentrations of these nanoshells (0–100 µg/mL) on human neuroblastoma SH-SY5Y cells, testing the internalization and intrinsic toxicity and validating the hyperthermic functionality of the particles through near infrared (NIR) laser-induced thermoablation experiments. No significant changes were observed in cell viability up to nanoparticle concentrations of 50 µg/mL. Experiments upon stimulation with an NIR laser revealed the ability of the nanoshells to destroy human neuroblastoma cells. On the basis of these findings, barium titanate core–gold shell nanoparticles resulted in being suitable for hyperthermia treatment, and our results represent a promising first step for subsequent investigations on their applicability in clinical practice. Keywords: barium titanate nanoparticles, gold nanoshells, NIR stimulation, human neuroblastoma

Published
2013

11. Enhancing cognitive functioning in the elderly: multicomponent vs resistance training

Author

Forte R, Boreham CA, Costa Leite J, De Vito G, Brennan L, Gibney ER, and Pesce C

Subjects
executive function, functional mobility, physical training, physical fitness, aging, Geriatrics, RC952-954.6
Abstract

Roberta Forte,1,2 Colin AG Boreham,1 Joao Costa Leite,3 Giuseppe De Vito,1 Lorraine Brennan,3 Eileen R Gibney,3 Caterina Pesce21Institute for Sport and Health, University College Dublin, Dublin, Ireland; 2Department of Human Movement and Sport Science, University of Rome "Foro Italico," Rome, Italy; 3Institute of Food and Health, University College Dublin, Dublin, IrelandPurpose: The primary purpose of this study was to compare the effects of two different exercise training programs on executive cognitive functions and functional mobility in older adults. A secondary purpose was to explore the potential mediators of training effects on executive function and functional mobility with particular reference to physical fitness gains.Methods: A sample of 42 healthy community dwelling adults aged 65 to 75 years participated twice weekly for 3 months in either: (1) multicomponent training, prioritizing neuromuscular coordination, balance, agility, and cognitive executive control; or (2) progressive resistance training for strength conditioning. Participants were tested at baseline (T1), following a 4-week control period (T2), and finally at postintervention (T3) for executive function (inhibition and cognitive flexibility) and functional mobility (maximal walking speed with and without additional task requirements). Cardiorespiratory and muscular fitness were also assessed as potential mediators.Results: Indices of inhibition, the functions involved in the deliberate withholding of prepotent or automatic responses, and measures of functional mobility improved after the intervention, independent of training type. Mediation analysis suggested that different mechanisms underlie the effects of multicomponent and progressive resistance training. While multicomponent training seemed to directly affect inhibitory capacity, resistance training seemed to affect it indirectly through gains in muscular strength. Physical fitness and executive function variables did not mediate functional mobility changes.Conclusion: These results confirm that physical training benefits executive function and suggest that different training types might lead to such benefits through different pathways. Both types of training also promoted functional mobility in older adulthood; however, neither inhibitory capacity, nor muscular strength gains seemed to explain functional mobility outcomes.Keywords: executive function, functional mobility, physical training, physical fitness, aging

Published
2013

12. Alpha-melanocyte stimulatory hormone: a novel player in post-prandial glucose disposal in skeletal muscle in humans

Author

Swan, P, Johnson, B, Samarasinghe, S, De Vito, G, Cowley, M, Le Roux, C, Miras, A, and Docherty, N

Subjects
Endocrinology & Metabolism, Science & Technology, 1116 Medical Physiology, 1103 Clinical Sciences, Life Sciences & Biomedicine, hormones, hormone substitutes, and hormone antagonists
Abstract

Background and Aims: Studies in rodents demonstrate that increases in circulating pituitary‐derived alpha‐melanocyte stimulatory hormone (α‐MSH) contribute to post‐prandial glycaemic control. Moreover, intravenous administration of exogenous α‐MSH lowers glucose excursions during oral glucose tolerance testing (OGTT) in mice. We set out to interrogate whether this action translated to human physiology both in vivo and in vitro Methods: Using a randomized double‐blinded cross‐over design, fifteen healthy volunteers received infusions of physiological saline, 15, 150 and 1500 ng/kg/hr α‐MSH initiated 30 minutes prior to the administration of a standard OGTT. Plasma glucose and insulin was measured during the OGTT. To assess the effect of α‐MSH on glucose disposal into skeletal muscle disposal, 15 subjects underwent sequential hyperinsulinaemic‐euglycaemic clamp, concomitant to either saline or 150ng/kg/hr α‐MSH infusion. In a separate cohort of healthy volunteers (n = 6), vastus lateralis muscle biopsies were obtained and used to establish cultures of primary human myotubes. Tritiated 2‐deoxy‐D‐glucose was used to monitor glucose uptake in response to α‐MSH. Results: Infusion of α‐MSH (1500ng/kg/hr) reduced the incremental area under the curve (iAUC) for plasma glucose (p = 0.02), and plasma insulin (p = 0.006) by approximately 20%. At high steady state insulin concentrations in clamp studies, α‐MSH increased glucose requirements for the maintenance of euglycaemia. Primary human myotube cultures expressed melanocortin receptor subtypes (MC1R>MC3R≈MC4R) and both 10nM and 100nM α‐MSH increased glucose uptake by two‐fold versus vehicle (p = 0.001). Conclusions: These findings substantiate a role for peripheral α‐MSH as a hitherto undescribed component of the endocrine control of glycaemia in human physiology.

Published
2022

13. Effects of short-term unloading and active recovery on human motor unit properties, neuromuscular junction transmission and transcriptomic profile

Author

Sarto, F, Stashuk, DW, Franchi, MV, Monti, E, Zampieri, S, Valli, G, Sirago, G, Candia, J, Hartnell, LM, Paganini, M, McPhee, JS, De Vito, G, Ferrucci, L, Reggiani, C, Narici, MV, Sarto, F, Stashuk, DW, Franchi, MV, Monti, E, Zampieri, S, Valli, G, Sirago, G, Candia, J, Hartnell, LM, Paganini, M, McPhee, JS, De Vito, G, Ferrucci, L, Reggiani, C, and Narici, MV

Abstract

Electrophysiological alterations of the neuromuscular junction (NMJ) and motor unit potential (MUP) with unloading are poorly studied. We aimed to investigate these aspects and the underlying molecular mechanisms with short-term unloading and active recovery (AR). Eleven healthy males underwent a 10-day unilateral lower limb suspension (ULLS) period, followed by 21-day AR based on resistance exercise. Quadriceps femoris (QF) cross-sectional area (CSA) and isometric maximum voluntary contraction (MVC) were evaluated. Intramuscular electromyographic recordings were obtained during 10% and 25% MVC isometric contractions from the vastus lateralis (VL). Biomarkers of NMJ molecular instability (serum c-terminal agrin fragment, CAF), axonal damage (neurofilament light chain) and denervation status were assessed from blood samples and VL biopsies. NMJ and ion channel transcriptomic profiles were investigated by RNA-sequencing. QF CSA and MVC decreased with ULLS. Increased CAF and altered NMJ transcriptome with unloading suggested the emergence of NMJ molecular instability, which was not associated with impaired NMJ transmission stability. Instead, increased MUP complexity and decreased motor unit firing rates were found after ULLS. Downregulation of ion channel gene expression was found together with increased neurofilament light chain concentration and partial denervation. The AR period restored most of these neuromuscular alterations. In conclusion, the human NMJ is destabilized at the molecular level but shows functional resilience to a 10-day unloading period at least at relatively low contraction intensities. However, MUP properties are altered by ULLS, possibly due to alterations in ion channel dynamics and initial axonal damage and denervation. These changes are fully reversed by 21 days of AR. (Figure presented.). Key points: We used integrative electrophysiological and molecular approaches to comprehensively investigate changes in neuromuscular integrity and functi

Published
2022

14. Sleep disorders and night-shift work in nursing students: a cross-sectional study

Author

Belingheri, M, Luciani, M, Ausili, D, Paladino, M, DI MAURO, S, DE VITO, G, Riva, M, Michael Belingheri, Michela Luciani, Davide Ausili, Maria Emilia Paladino, Stefania Di Mauro, Giovanni De Vito, Michele A. Riva, Belingheri, M, Luciani, M, Ausili, D, Paladino, M, DI MAURO, S, DE VITO, G, Riva, M, Michael Belingheri, Michela Luciani, Davide Ausili, Maria Emilia Paladino, Stefania Di Mauro, Giovanni De Vito, and Michele A. Riva

Abstract

Background: University students are known to have higher sleep disorders prevalence than the general population. Among them, nursing students are even more susceptible to sleep disorders. This study evaluates sleep disorders’ risk factors among nursing students and their potential association with symptoms and assesses whether night shifts affect sleep quality by increasing the prevalence of sleep disorders. Methods: A total of 202 nursing students were included; a self-administered questionnaire was used to collect data on sociodemographic and academic characteristics (i.e., gender, age, height, weight, and year of nursing program) and risk factors for sleep disorders (e.g., smoking, lack of physical activity, and coffee intake late in the evening). The survey included the General Health Questionnaire to assess perceived stress, the Sleep and Daytime Habits Questionnaire, and the Epworth Sleepiness Scale to assess sleep disorders symptoms. Results: A high level of perceived stress is associated with sleep disorders symptoms and with poor sleep quality. Daytime symptoms are also associated with smoking. Students who drink coffee late in the evening report fewer nighttime symptoms. Night shifts and their increasing number are not associated with sleep disorders symptoms. The perception of an unsatisfying academic performance is associated with daytime symptoms and poor sleep quality. Conclusions: Although night shifts seem to not affect sleep quality among nursing students, sleep disorders represent a critical issue in this population since sleep disorders symptoms may result in errors, accidents, or low academic performance.

Published
2022

20. Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults

Author

Bauer, J. M., Mikusova, L., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., Mets, T., Wijers, S. L. J., Garthoff, J. A., Luiking, Y., Sieber, C., Cederholm, T., Mcmurdo, M. E. T., Seal, C., Ceda, G. P., De Vito, G., Donders, G., Drey, M., Greig, C., Holmback, U., Narici, M., Mcphee, J., Poggiogalle, E., Power, D., Scafoglieri, A., Schultz, R., Internal medicine, Research in Geriatrics and Gerontology, Gerontology, Rehabilitation Research, Physical Medicine and Rehabilitation, Frailty in Ageing, Vriendenkring VUB, Geriatrics, Physiotherapy, Human Physiology and Anatomy, and Body Composition and Morphology

Subjects
Male, safety, Sarcopenia, Aging, medicine.medical_specialty, chemistry.chemical_element, Parathyroid hormone, Renal function, 030209 endocrinology & metabolism, Calcium, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, Leucine, law, Internal medicine, medicine, Vitamin D and neurology, Humans, ddc:610, 030212 general & internal medicine, Vitamin D, Aged, Nutrition, Medicine(all), Nutrition and Dietetics, business.industry, Safety, Tolerability, Whey protein, medicine.disease, Näringslära, Whey Proteins, chemistry, Dietary Supplements, Original Article, Female, Geriatrics and Gerontology, business, Kidney disease
Abstract

Aims Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults. Methods A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-label extension (OLE). OLE participants were randomized to receive daily 1 or 2 servings of WP-MND (21 g protein, 3 g leucine, 10 µg vitD and 500 mg calcium per serving). Gastro-intestinal tolerability, kidney function and serum levels of calcidiol, parathyroid hormone (PTH) and calcium were evaluated at week 0, 13 and 26. Results and discussion In response to the high daily protein intake (median1.5; IQR: 1.3, 1.7 g/kg BW/day), the estimated glomerular filtration rate (eGFR) increased in the test group during the RCT (p = 0.013). The same trend was observed for those participants with moderate chronic kidney disease. During OLE no eGFR change was observed in any of the groups. Serum calcidiol and calcium reached a plateau after 13-week WP-MND supplementation. As expected, PTH significantly changed in the opposite direction, decreasing during RCT in the test group (T vs C: p n = 18; C: n = 2) and 6 developed albumin-corrected calcium levels > 2.55 mmol/L (T: n = 3; C: n = 3), without associated adverse events. Conclusion A 6 months intervention with up to 2 servings of WP-MND did neither result in kidney function deterioration nor symptoms of vitamin D or calcium toxicity. The product was overall well tolerated.

Published
2020
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25. La vaccinazione antinfluenzale negli studenti delle lauree di area sanitaria: valutazione delle conoscenze, attitudini e motivazione di adesione e astensione.

Author

Belingheri, M, Chittano Congeto, E, Paladino, M, De Vito, G, D’Orso, M, Latocca, R, Cesana, G, Riva, M, Belingheri M, Chittano Congeto E, Paladino ME, De Vito G, D’Orso MI, Latocca R, Cesana G, Riva MA, Belingheri, M, Chittano Congeto, E, Paladino, M, De Vito, G, D’Orso, M, Latocca, R, Cesana, G, Riva, M, Belingheri M, Chittano Congeto E, Paladino ME, De Vito G, D’Orso MI, Latocca R, Cesana G, and Riva MA

Published
2019

26. La prevalenza di patologie muscolo-scheletriche lavoro-correlate in una popolazione di soggetti che accedono ad un centro fisioterapico del Nord Italia

Author

Molteni, E, Negrelli, M, Riva, R, Pirovano, M, Scarabottolo, L, Turato, M, Belingheri, M, Riva, M, De Vito, G, Molteni E, Negrelli MN, Riva R, Pirovano M, Scarabottolo L, Turato M, Belingheri M, Riva MA, De Vito G, Molteni, E, Negrelli, M, Riva, R, Pirovano, M, Scarabottolo, L, Turato, M, Belingheri, M, Riva, M, De Vito, G, Molteni E, Negrelli MN, Riva R, Pirovano M, Scarabottolo L, Turato M, Belingheri M, Riva MA, and De Vito G

Published
2019

27. Allergia ad imenotteri in ambiente lavorativo

Author

Molteni, E, Scordo, F, Vergani, M, Vitale, A, Riva, M, De Vito, G, Molteni E, Scordo F, Vergani M, Vitale A, Riva MA, De Vito G., Molteni, E, Scordo, F, Vergani, M, Vitale, A, Riva, M, De Vito, G, Molteni E, Scordo F, Vergani M, Vitale A, Riva MA, and De Vito G.

Published
2019

29. Incidence of SARS-CoV-2 infection in health care workers from Northern Italy based on antibody status: immune protection from secondary infection- A retrospective observational case-control study

Author

Rovida, F, Cassaniti, I, Percivalle, E, Sarasini, A, Paolucci, S, Klersy, C, Cutti, S, Novelli, V, Marena, C, Luzzaro, F, De Vito, G, Schiavo, R, Cascio, G, Lilleri, D, Baldanti, F, Rovida, Francesca, Cassaniti, Irene, Percivalle, Elena, Sarasini, Antonella, Paolucci, Stefania, Klersy, Catherine, Cutti, Sara, Novelli, Viola, Marena, Carlo, Luzzaro, Francesco, De Vito, Giovanni, Schiavo, Roberta, Cascio, Giuliana Lo, Lilleri, Daniele, Baldanti, Fausto, Rovida, F, Cassaniti, I, Percivalle, E, Sarasini, A, Paolucci, S, Klersy, C, Cutti, S, Novelli, V, Marena, C, Luzzaro, F, De Vito, G, Schiavo, R, Cascio, G, Lilleri, D, Baldanti, F, Rovida, Francesca, Cassaniti, Irene, Percivalle, Elena, Sarasini, Antonella, Paolucci, Stefania, Klersy, Catherine, Cutti, Sara, Novelli, Viola, Marena, Carlo, Luzzaro, Francesco, De Vito, Giovanni, Schiavo, Roberta, Cascio, Giuliana Lo, Lilleri, Daniele, and Baldanti, Fausto

Abstract

Objective: The protection from SARS-CoV-2 infection induced by SARS-CoV-2 anti-S1 and anti-S2 IgG antibody positivity resulting from natural infection was evaluated. Methods: The frequency of SARS-CoV-2 infection (as determined by virus RNA detection) was evaluated in a group of 1,460 seropositive and a control group of 8,150 seronegative healthcare workers in three Centres of Northern Italy in the period June-November 2020. Neutralizing serum titers were analyzed in seropositive subjects with or without secondary SARS-CoV-2 infection. Results: During the 6-month survey, 1.78% seropositive subjects developed secondary SARS-CoV-2 infection while 6.63% seronegative controls developed primary infection (odds ratio: 0.26; 95% confidence interval: 0.17-0.38). Secondary infection was associated with low or absent serum neutralizing titer (p<0.01) and was mildly symptomatic in 45.8% cases vs 71.4% symptomatic primary infections (odds ratio: 0.34; 95% confidence interval: 0.16-0.78). Conclusions: Immunity from natural infection appears protective from secondary infection; therefore, vaccination of seronegative subjects might be prioritized.

Published
2021

30. Applicazione della norma UNI EN 689:2019 per la valutazione dell'esposizione occupazionale ad agenti chimici: caso-studio in una fonderia

Author

Keller, M, Rovelli, S, Bonacina, F, Campagnolo, D, Fanti, G, Spinazzè, A, Borghi, F, Recchia, S, Cattaneo, A, De Vito, G, Cavallo, D, Keller, Marta, Rovelli, Sabrina, Bonacina, Fabio, Campagnolo, Davide, Fanti, Giacomo, Spinazzè, Andrea, Borghi, Francesca, Recchia, Sandro, Cattaneo, Andrea, De Vito, Giovanni, Cavallo, Domenico M., Keller, M, Rovelli, S, Bonacina, F, Campagnolo, D, Fanti, G, Spinazzè, A, Borghi, F, Recchia, S, Cattaneo, A, De Vito, G, Cavallo, D, Keller, Marta, Rovelli, Sabrina, Bonacina, Fabio, Campagnolo, Davide, Fanti, Giacomo, Spinazzè, Andrea, Borghi, Francesca, Recchia, Sandro, Cattaneo, Andrea, De Vito, Giovanni, and Cavallo, Domenico M.

Published
2021

34. Microbiological pollution and ocular infection in CAD operators: an on-site investigation

Author

Piccoli, B., Assini, R., Gambaro, S., Pastoni, F., D'Orso, M., Franceschin, S., Zampollo, F., and De Vito, G

Subjects
Ergonomics -- Research, Industrial microbiology -- Research, Eye -- Inflammation, Video equipment -- Health aspects, Architecture and design industries, Business
Abstract

Research with industrial operators at video display unit workstations and computer assisted design tasks suggests bacteria from working surfaces and equipment can be transferred to the eyes. Preventing eating at workstations, improved hand hygiene, and periodic checks for environmental sanitation and eye health could prevent eye infection rates.

Published
2001

40. Allergia ad imenotteri in ambiente lavorativo

Author

Molteni E, Scordo F, Vergani M, Vitale A, Riva MA, De Vito G., Molteni, E, Scordo, F, Vergani, M, Vitale, A, Riva, M, and De Vito, G

Subjects
MED/44 - MEDICINA DEL LAVORO, Occupational Health
Published
2019

43. Evoluzione storica della tutela del lavoratore portuale

Author

Riva, MA, Belingheri, M, De Vito, G, D’Orso, MI, Latocca, R, Cesana, G, Riva, M, Belingheri, M, De Vito, G, D’Orso, M, Latocca, R, and Cesana, G

Subjects
Occupational Medicine, MED/44 - MEDICINA DEL LAVORO
Published
2019

44. Allergia a veleno di imenotteri in lavoratori outdoor. Valutazione di efficacia terapeutica a 10 anni, cost-efficacia e obblighi del medico competente.

Author

De Vito, G, Marinelli, M, Sormani, M, Meroni, R, Vitale, A, Napolitano, M, Valsecchi, E, Belingheri, M, Riva, M, De Vito G, Marinelli M, Sormani M, Meroni R, Vitale A, NAPOLITANO, MARIA, VALSECCHI, ELEONORA, Belingheri M, Riva MA., De Vito, G, Marinelli, M, Sormani, M, Meroni, R, Vitale, A, Napolitano, M, Valsecchi, E, Belingheri, M, Riva, M, De Vito G, Marinelli M, Sormani M, Meroni R, Vitale A, NAPOLITANO, MARIA, VALSECCHI, ELEONORA, Belingheri M, and Riva MA.

Published
2018

45. Studio di comportamenti a rischio tra gli studenti dell’area medico-sanitaria per una promozione della salute per i lavoratori del futuro.

Author

Scordo, F, Riva, M, Butturini, F, Belingheri, M, Turato, M, Latocca, R, De Vito, G, SCORDO, FRANCESCO, Riva MA, Butturini F, Belingheri M, Turato M, Latocca R, De Vito G., Scordo, F, Riva, M, Butturini, F, Belingheri, M, Turato, M, Latocca, R, De Vito, G, SCORDO, FRANCESCO, Riva MA, Butturini F, Belingheri M, Turato M, Latocca R, and De Vito G.

Published
2018

47. Risk behaviors among Italian healthcare students: a cross-sectional study for health promotion of future healthcare workers

Author

Belingheri, M, Facchetti, R, Scordo, F, Butturini, F, Turato, M, De Vito, G, Cesana, G, Riva, MA, Belingheri, M, Facchetti, R, Scordo, F, Butturini, F, Turato, M, De Vito, G, Cesana, G, and Riva, M

Subjects
Male, Occupational Medicine, Alcohol Drinking, Universities, Health Personnel, education, MED/44 - MEDICINA DEL LAVORO, Health Promotion, smoking, binge drinking, Young Adult, Cross-Sectional Studies, Risk-Taking, risk behaviors, Prevalence, physical inactivity, Humans, Female, Original Article, Students, healthcare students
Abstract

Background: Risk behaviors are frequent among young adults and they are particularly relevant when considering healthcare students. Objectives: The study is aimed to examine the prevalence of smoking, binge drinking, physical inactivity, and excessive bodyweight in a population of healthcare students attending an Italian university. Methods: Healthcare students filled an anonymous multiple-choice questionnaire on the occasion of the occupational health visit that preceded their hospital internship. The questionnaire covered socio-demographic characteristics (including student’s working status and cohabitation) and risk behaviors. We evaluated the prevalence of risk behaviors and their association with socio-demographic characteristics. Results: The sample consisted of 494 students (65% women): 23.2% were smokers, 7.9% had excessive bodyweight, 35% did not practice any physical activity and 50% reported binge drinking at least once in the last 12 months. We found associations of male sex (30.5%) and being nursing students (29.9%) with smoking habit. The frequency of binge drinking was higher in men (38.4%), working students (53.9%), and among those who lived without family (50%). Physical inactivity was associated with female sex (44.2%) and living without family (57.1%). Finally, the co-presence of 2 risk behaviors or more was higher in men (36.8%), in nursing students (39.6%) and in working students (44.7%). Conclusions: Our findings regarding the prevalence of risk behaviors and their potential association with socio-demographic factors may be a clue to the definition of targeted strategies aimed at reducing of risk behaviors among healthcare students.

Published
2018

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