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Tidal Cities was an interdisciplinary, transnational experiment that brought together an environmental anthropologist, an urban geographer, and two landscape architects/artists. We aimed at co-creating a visualization-based pedagogical tool for contemplating and teaching manifold relations between the city and the sea, drawing on ethnographic material from Metro Manila and Jakarta. The project was designed during the COVID-19 pandemic, and its digital format integrated an immersive role play component to spark further debate among tertiary students. Players were encouraged to critically reflect on and engage with trajectories and contestations around coastal planning and urban placemaking, particularly in spaces of informality beset by recurrent flooding, tenurial insecurity, and dispossession. While engaging with the poetics and politics of 2D visual representation, we reflect on the thinking behind the game´s pedagogical co-design and a number of paradoxes that arose from two test-runs with departmental students, researchers, and teaching faculty in Bremen, Germany.

Abstract Objective Falls take a high priority among the prevalent medical conditions in old age. Despite this, a history of falls or the risk of future falls is not routinely assessed or properly managed in medical clinics in Sri Lanka. This study was done to evaluate the prevalence and factors associated with falls and recurrent falls among older adults attending medical clinics in four selected tertiary care centres in the country. Methods A cross-sectional study was carried out at four centres (Teaching Hospital Karapitiya, Colombo South Teaching Hospital, Colombo North Teaching Hospital and University Hospital-Kotelawala Defence University) with 704 older adults, aged 65 years and above, attending medical clinics for more than six consecutive months. Information related to falls and possible associated factors (socio-demographic, behavioural, environmental and biological) were collected using an interviewer-administered questionnaire. Results The Mean (SD) age of the participants was 72.5(5.5) years and 58.7% were females. Of the 704 total sample, 220 (31.3%, 95% CI 28–35%) participants experienced at least one fall after the age of 65, and 12.8% (95% CI 10–15%) (n = 90) experienced recurrent falls (two or more falls within the last 12 months). Falls were associated with gender, level of education, marital status, and physical dependence (p

The possession of smart devices has ingrained itself into daily life. Therefore, smart devices, such as IoT and smartphones, are crucial sources of evidence in instances where criminal activity occurs. Due to the challenges in traditional digital forensic techniques involving smart devices, it has been recently proposed in the literature to leverage electromagnetic side-channel analysis (EM-SCA) for the purpose. This paper identifies and discusses an important barrier that exists in the application of EM-SCA for digital forensics that hinders its successful use, namely, the issue of cross-device portability of machine learning (ML) models that are used for EM-SCA. Firstly, the paper empirically evaluates the possibility of using trained ML models to extract forensic insights from EM radiation data of IoT devices. During this empirical study, the inability to reuse a trained ML model across different devices is identified. Secondly, the paper surveys the literature in search of related work that has studied the use of EM-SCA to gather information from smart devices. The purpose of the survey is to identify whether any existing work has been able to introduce potential approaches to enable cross-device portability of ML models in EM-SCA. The findings of this survey point to the fact that the identified problem still exists and requires further studies opening the door to future research.

Abstract Background Anxiety, depression, and Type D personality are strongly correlated with the prognosis of IHD and the effectiveness of therapy. The main purpose of this study was to assess the proportions and associations of anxiety, depression, and Type D personality among clinically stable IHD patients (aged 18–60) treated at an outpatient clinic operated by a government hospital in Sri Lanka, who were diagnosed with IHD within the preceding three months. Methods A cross-sectional study design was analysed using SPSS® version 23.0. The validated Sinhalese version of the Hospital Anxiety and Depression Scale (HADS) was used to measure anxiety and depression, while the DS-14 was used to determine Type D personality traits. Results Among the 399 patients, 29.8% (n = 119) had anxiety, 24.8% (n = 99) had depression, and 24.6% (n = 24.6) had Type D personality. The level of anxiety had a significant association with depression (p = 0.002) and Type D personality (p = 0.003). Furthermore, depression was significantly associated with ethnicity (p = 0.014), occupation (p = 0.010), and type D personality (p = 0.009). Type D personality was the strongest predictor of anxiety, with patients being 1.902 times more likely to experience anxiety (95% CI 1.149–3.148; p = 0.012). Anxiety was a significant predictor of depression, with patients being 1.997 times more likely to experience depression (95% CI 1.210–3.296; p = 0.007). Non-Sinhalese ethnic background was also a significant predictor of depression (OR: 0.240; 95% CI 0.073–0.785; p = 0.018). Anxiety increased the likelihood of having Type D personality traits by 1.899 times (95% CI 1.148–3.143; p = 0.013). Conclusion The current study recommends the importance of screening and treating the psychological risk factors of IHD patients parallel to their IHD treatment to improve their prognosis. These insights highlight the need for targeted interventions that address depression, anxiety and the impact of Type D personality traits in enhancing the overall management and prognosis of IHD.

Abstract Background Parental history of diabetes is an established risk factor for type 2 diabetes mellitus (T2DM). There is limited data on the association of parental history with the prevalence of T2DM in Sri Lanka. The study aims to examine the prevalence and correlation of parental history and factors such as the onset age, glycaemic control, and self-reported dietary compliance among T2DM patients. With a rising incidence of T2DM in Sri Lanka, understanding the impact of parental history on age at diagnosis and glycemic control can aid in targeted screening and interventions. Methods A cross-sectional study was carried out on 500 T2DM patients attending a diabetes clinic in Galle, the capital of Southern Sri Lanka with a multiethnic population. Convenient sampling strategy was followed in the recruitment process and a questionnaire-based method was used to collect the data. All the collected data was analysed using SPSS V 25.0. Results 51.2% had a parental history of T2DM, and those with a positive parental history were diagnosed six years earlier than those with a negative parental history (p

Abstract When someone violates a social norm, others may think that some sanction would be appropriate. We examine how the experience of emotions like anger and disgust relate to the judged appropriateness of sanctions, in a pre-registered analysis of data from a large-scale study in 56 societies. Across the world, we find that individuals who experience anger and disgust over a norm violation are more likely to endorse confrontation, ostracism and, to a smaller extent, gossip. Moreover, we find that the experience of anger is consistently the strongest predictor of judgments of confrontation, compared to other emotions. Although the link between state-based emotions and judgments may seem universal, its strength varies across countries. Aligned with theoretical predictions, this link is stronger in societies, and among individuals, that place higher value on individual autonomy. Thus, autonomy values may increase the role that emotions play in guiding judgments of social sanctions.

Rainfall Intensity Duration Frequency (IDF) curves can be identified as a major role in the planning of urban drainage infrastructure. Sri Lanka, which is an island surrounded by the Indian Ocean, is frequently exposed to various climatic alterations. Sri Lanka has specific region-wise IDF relationships for the entire country, however, these IDF curves were developed more than 30 years ago. Many in-situ rainfall observations in Sri Lanka have insufficient record lengths and the absence of finer time scale records (e.g. 15 min, hourly) leading to unreliable IDF curve developments. Given this importance, the present paper demonstrates the application of Satellite-based Precipitation Product (SbPP) daily rainfall in developing IDF curves for Sri Lanka. Rainfall satellite estimates derived from Integrated Multi-satellite Retrievals for GPM (IMERG), Tropical Rainfall Measuring Mission (TRMM-3B42), and Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks – Climate Data Record (PERSIANN-CDR) have been used to evaluate the ability of application of remote sensing data to develop IDF curves for Sri Lanka against rain gauge (RG) data. Our study breaks new ground by generating 50 IDF curves tailored to specific locations covering the whole county Sri Lanka, using daily rainfall data from RGs and three SbPPs during the period between 1990 and 2019. This marks a significant departure from the conventional approach, offering a more granular understanding of rainfall patterns in the country. By providing IDF curves for individual locations, our research presents a novel contribution to Sri Lanka's IDF history. At first, to evaluate the accuracy of SbPPs, statistical analysis was conducted using continuous and categorical evaluation indices. Second, IDF curves were developed and compared with the presently available IDF curves. Results showcased that IMERG outperformed all SbPPs, while PERSIANN-CDR showed dire performances. The IMERG and TRMM-3B42 products tend to overestimate light precipitation regions in high elevations and overestimate heavy rainfall in low elevations compared to rain gauge data. Rainfall intensities derived by rain gauge data depicted relative changes within ±30% for shorter durations and ±20% for longer durations while SbPPs showed beyond ±30% difference concerning the previously developed IDFs. It was apparent that these products have significant inaccuracies which cannot be neglected when utilizing them in developing IDF curves. This study will be beneficial in solving design problems associated with urban runoff control and disposal where knowing the rainfall intensities of different return periods with different durations is vital.

This study examines various determinants of incentive intensity and the moderating effect of risk aversion on the relationship between incentive intensity and organisational performance. Prior studies have reported mixed results concerning the determinants of incentive intensity, and few studies have examined the moderation effect. We analysed empirical data from a cross-sectional survey of 600 Japanese organisations that manage foreign subsidiaries. The principal and agency structure can be seen in both participants (HQ and a foreign subsidiary) with the agency problem. The first determinant is environmental uncertainty, which is investigated in two types of uncertainties: market and general business environmental uncertainties. The findings suggest that general business environmental uncertainty is negatively associated with incentive intensity, but the negative effect of market environmental uncertainty on it depends on the prospect of incremental profits. The rest of the determinants are derived from the incentive intensity principle, including some features of management accounting systems. In this study, the effects of the determinants are supported as expected in principle. In particular, the incentive intensity is influenced by the prospect of incremental profits, an agent’s risk preference, and their responsiveness to incentives. As for the moderation effect, the positive effect of the incentive intensity on the performance is decreased by an agent’s risk aversion. Our empirical results explain mixed evidence in previous studies and are consistent with the agency theory.

Abstract The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat.

Aim: Cynometra cauliflora (namnam) belongs to the family Fabaceae and is native to eastern Peninsular Malaysia. It grows well with an annual rainfall of 1,500–2,000 mm. Even though a considerable amount of research has been carried out with C. caulifora, there is a dearth of information about biomolecules that may pave the way for drug discoveries and food supplements, which is a gap addressed in this study. Methods: The study presented in this paper has identified several antimicrobial, antioxidant, and anti-inflammatory substances, and an in silico approach was used to understand the behaviors of kaempferol-3-O-rhamnoside (K-3-Rh) and β-sitosterol acetate against Alzheimer’s disease (AD). The molecular dynamics (MD) simulations were performed with the selected protein ligand complex of two natural molecules and the synthetic ligand to analyze the dynamic behaviors and binding free energy throughout the 100 ns simulation time. Further, both natural molecules that were investigated comply with Lipinski’s drug-likeness rules. Results: The docking scores of both K-3-Rh and sitosterol were found to be compatible with the synthetic AD drug molecules [donepezil analogue (H0L)] used as a reference in the study. Hence, the phytochemicals of Cynometra caulifora showed comparatively similar potency against acetylcholinesterase (AChE). Conclusions: Overall, the potential binding affinity from molecular docking and static thermodynamics features from MD simulation suggest that K-3-Rh and β-sitosterol acetate could be considered as a potential therapeutic lead to inhibit AChE leading for AD treatment.

Abstract Ocean sustainability initiatives – in research, policy, management and development – will be more effective in delivering comprehensive benefits when they proactively engage with, invest in and use social knowledge. We synthesize five intervention areas for social engagement and collaboration with marine social scientists, and in doing so we appeal to all ocean science disciplines and non-academics working in ocean initiatives in industry, government, funding agencies and civil society. The five social intervention areas are: (1) Using ethics to guide decision-making, (2) Improving governance, (3) Aligning human behavior with goals and values, (4) Addressing impacts on people, and (5) Building transdisciplinary partnerships and co-producing sustainability transformation pathways. These focal areas can guide the four phases of most ocean sustainability initiatives (Intention, Design, Implementation, Evaluation) to improve social benefits and avoid harm. Early integration of social knowledge from the five areas during intention setting and design phases offers the deepest potential for delivering benefits. Later stage collaborations can leverage opportunities in existing projects to reflect and learn while improving impact assessments, transparency and reporting for future activities.

Abstract Introduction Laparoscopic colorectal cancer surgery has been gaining popularity in the last decade. However, there are concerns about adequate lymph node dissection and safe resection margins in laparoscopic colorectal cancer surgery. This study was aimed at comparing the lymph node (LN) clearance and surgical resection margins and 3-year survival for open and laparoscopic colorectal cancer surgery. Method A pre-tested interviewer administered questionnaire was used to assess the adoption of the laparoscopic approach by Sri Lankan surgeons. Data was collected prospectively from patients who underwent open or laparoscopic colorectal cancer surgery at the University Surgical Unit of the National Hospital of Sri Lanka from April 2016 to May 2019. The histopathology records were analysed to determine the longitudinal and circumferential resection margins(CRM) and the number of lymph nodes harvested. The resection margins were classified as positive or negative. The total number of LN examined was evaluated. Presence of local recurrence and liver metastasis was determined by contrast enhanced CT scan during 3-years of follow up. Chi square, T test and z test for proportions were used to compare CRM, LN harvest and survival rates between the groups. Results Of the surgeons interviewed only 11 (18.4%) performed laparoscopic colorectal cancer surgery. A total of 137 patients (83 males and 54 females) were studied. Eighty-one procedures were laparoscopic and 56 procedures were open. All patients had clear longitudinal resection margins. Seventy-eight patients in the laparoscopic group (96%) and 51 patients (91%) in the open group had clear CRM (p > 0.05). A total of 2188 LNs (mean 15.9) were resected in all procedures. Six-hundred-eighty-nine lymph nodes were removed during open procedures (mean 12.3, SD 0.4) and 1499 (mean 18.5, SD 0.6) were removed during laparoscopy (p

ABSTRACTThis paper explores the utilisation of gauge rainfall and satellite-based precipitation product (SPP)-TRMM3B42, to develop IDF curves for the Fiji Islands. The study compares the application of remote sensing data against rain gauge (RG) data for two main stations, Nadi and Nausori (1991 to 2020). The accuracy of SPPs is evaluated through statistical analysis, employing continuous and categorical evaluation indices. The results indicate that TRMM3B42 tends to overestimate light precipitation and underestimate heavy rainfall in low elevations when compared to rain gauge data. Rainfall intensities derived from satellite data exhibit relative changes within ± 10%. This study also performs future projections. Two greenhouse emission scenarios, Shared Socioeconomic Pathways (SSP) 2–4.5 and 5–8.5, are employed for IDF curve projection. The analysis reveals that changes in IDF curves are more pronounced for short-duration rainfall as compared to high-duration rainfall. Additionally, higher emission scenarios demonstrate greater changes compared to lower scenarios. These findings emphasise the importance of accounting for climate change and future projections in designing urban infrastructure, particularly considering potential urban expansion and human settlements. This study helps in solving design problems associated with urban runoff control and disposal where knowing the rainfall intensities of different return periods with different durations is vital.

Background: This study focused on evaluating the physiochemical characteristics and antibacterial activity of Octoprohibitin-encapsulated CNPs (Octoprohibitin-CNPs) against Acinetobacter baumannii. Methods: Octoprohibitin was encapsulated into CNPs via ionotropic gelation with carboxymethyl chitosan (CMC) and low molecular weight chitosan (CS). Octoprohibitin-CNPs were dispersed in phosphate-buffered saline and the release kinetic profile was determined. Then Octoprohibitin-CNPs were examined using field-emission transmission electron microscopy and physicochemical characterization was performed. Antibacterial activity of Octoprohibitin-CNPs against A. baumannii was evaluated. Biofilm inhibition and eradication assays were performed using the crystal violet (CV) staining-based method for biofilm quantification. Results: The average diameter, zeta potential, encapsulation efficiency, and loading capacity of Octoprohibitin-CNPs were 244.5 ± 21.97 nm, +48.57 ± 0.38 mV, and 85.7% and 34.2%, respectively. TEM analysis imaging revealed that Octoprohibitin-CNPs are irregularly shaped, with fewer aggregates than CNPs. Octoprohibitin-CNPs exhibited a biphasic release pattern, characterized by an initial rapid phase followed by a sustained release over time, extending up to 93.68 ± 6.48% total release until 96 h. In vitro, Octoprohibitin-CNPs showed lower cytotoxicity compared to Octoprohibitin alone. Time-kill kinetic and bacterial viability reduction assays showed Octoprohibitin-CNPs exhibited slightly higher antibacterial activity against A. baumannii than Octoprohibitin. Conclusions: Octoprohibitin-CNP-treated A. baumannii exhibited higher levels of morphological deviation, increased membrane permeability, and the production of reactive oxygen species, as well as antibiofilm activity with greater biofilm inhibition and eradication than Octoprohibitin. These findings show that Octoprohibitin-CNPs perform better against A. baumannii compared to Octoprohibitin alone.

Corticosteroid therapy, often in combination with inhibition of the renin-angiotensin system, is first-line therapy for primary focal and segmental glomerulosclerosis (FSGS) with nephrotic-range proteinuria. However, the response to treatment is variable, and therefore new approaches to indicate the response to therapy are required. Podocyte depletion is a hallmark of early FSGS, and here we investigated whether podocyte number, density and/or size in diagnostic biopsies and/or the degree of glomerulosclerosis could indicate the clinical response to first-line therapy. In this retrospective single center cohort study, 19 participants (13 responders, 6 non-responders) were included. Biopsies obtained at diagnosis were prepared for analysis of podocyte number, density and size using design-based stereology. Renal function and proteinuria were assessed 6 months after therapy commenced. Responders and non-responders had similar levels of proteinuria at the time of biopsy and similar kidney function. Patients who did not respond to treatment at 6 months had a significantly higher percentage of glomeruli with global sclerosis than responders (p

Maternal mortality in the United States has been on the rise. Every year, about 700 women die from pregnancy-related complications. Cardiovascular disease (CVD) accounts for a large majority of pregnancy-related deaths driven by the lack of recognition and delays in diagnosis due to the overlap of normal pregnancy symptoms with those of CVD. Risk factors for CVD including race, advanced maternal age, hypertension, diabetes, obesity, socioeconomic status, and geographic region play an important role in CVD-related deaths. Several risk assessment models are available to stratify women with a known diagnosis of CVD. However, most women who die from CVD during pregnancy or the postpartum period do not have a prior diagnosis of CVD, and cardiomyopathy is an important contributor. The California Maternal Quality Care Collaborative (CMQCC) developed an algorithm to screen all pregnant and postpartum women to allow stratification into low or high risk for CVD. The algorithm has been validated in diverse patient populations. We propose universal CVD screening for all women in the antepartum and postpartum period to identify women at risk and to provide education and awareness for both patients and healthcare providers. This screening tool would work to reduce the increasing rates of severe maternal mortality and morbidity while having a significant impact on healthcare costs in the United States.

Hunger and malnutrition continue to be significant challenges in developing nations, including Sri Lanka. To address this issue, the research paper presents "Saubhagya," an online web application that provides a platform for social assistance. The platform allows individuals to donate food and groceries to needy organizations such as blind, deaf, orphanages, making it a user-friendly and effective solution. Users are required to register as food donators, needy people(organizations), partners and food collection agents. The system connects these user groups when necessary, ensuring a smooth and efficient process. One unique feature of "Saubhagya" is its live capability of tracking food collection and delivery using GPS and Google Maps. This feature ensures that food donations are delivered to the right organizations promptly, promoting transparency, accountability, and communication among users. The research paper aims to evaluate the effectiveness of "Saubhagya" in reducing hunger and malnutrition in Sri Lanka through user feedback and system performance metrics. If successful, the platform can be scaled to other developing nations facing similar challenges. This research demonstrates the potential of digital platforms in addressing social and environmental challenges. By leveraging technology, collective action can be harnessed to create positive social impact. "Saubhagya" represents a significant step forward in the fight against hunger and malnutrition, and it is hoped that it can inspire others to use technology to address pressing global issues.

tRNA modifications are crucial in all organisms to ensure tRNA folding and stability, and accurate translation. In both the yeast Saccharomyces cerevisiae and the evolutionarily distant yeast Schizosaccharomyces pombe, mutants lacking certain tRNA body modifications (outside the anticodon loop) are temperature sensitive due to rapid tRNA decay (RTD) of a subset of hypomodified tRNAs. Here we show that for each of two S. pombe mutants subject to RTD, mutations in ribosomal protein genes suppress the temperature sensitivity without altering tRNA levels. Prior work showed that S. pombe trm8Δ mutants, lacking 7-methylguanosine, were temperature sensitive due to RTD, and that one class of suppressors had mutations in the general amino acid control (GAAC) pathway, which was activated concomitant with RTD, resulting in further tRNA loss. We now find that another class of S. pombe trm8Δ suppressors have mutations in rpl genes, encoding 60S subunit proteins, and that suppression occurs with minimal restoration of tRNA levels and reduced GAAC activation. Furthermore, trm8Δ suppression extends to other mutations in the large or small ribosomal subunit. We also find that S. pombe tan1Δ mutants, lacking 4-acetylcytidine, are temperature sensitive due to RTD, that one class of suppressors have rpl mutations, associated with minimal restoration of tRNA levels, and that suppression extends to other rpl and rps mutations. However, although S. pombe tan1Δ temperature sensitivity is associated with some GAAC activation, suppression by an rpl mutation only modestly inhibits GAAC activation. We propose a model in which ribosomal protein mutations result in reduced ribosome concentrations, leading to both reduced ribosome collisions and a reduced requirement for tRNA, with these effects having different relative importance in trm8Δ and tan1Δ mutants. This model is consistent with our results in S. cerevisiae trm8Δ trm4Δ mutants, known to undergo RTD, fueling speculation that this model applies across eukaryotes.

Due to the potential for severe maternal morbidity and even mortality, pregnancy-associated spontaneous coronary artery dissection (P-SCAD) often presents as a clinical conundrum. While current recommendations encourage coronary interventions when medically indicated even during pregnancy, the hesitation still understandably exists. Meanwhile, given the rarity of the condition, the guidelines for management are still based on expert consensus.

Refusal remains a core concern in processes of research across the sciences. Drawing on previous anthropological theorisations, this paper contemplates on the manifold ‘arts’ of refusal during ethnographic research praxis, drawing on diverse thematic experiences and contexts across coastal India, Malaysia, and Uganda. We argue for a concerted engagement with refusal as more than an act of withholding co-operation and as an expression of resistance. While recognizing refusal as a locally situated and historically contingent sensibility, we ask in what other ways might the more generative qualities of refusal be explored, paying particular attention to the performative nature of refusal itself that may entrench as much as reverse power differentials in the ‘field’. Drawing on decolonial and post-development epistemologies and diverse experiences as scholars situated and working across different geographies and disciplines, we explore the many entanglements, articulations, and enactments that remain ubiquitous in everyday ethnographic research praxis through several thematic angles. These include the negotiation of uneven (and often violent) forms of research collaboration and co-optation, the enactment of benevolent sexism as an ‘ethics of care’, and embodied practices such as silence(-ing), together with play and humour in participants’ critiques of scientific truth-telling. While illustrating subtler manifestations of refusal across ethnographic research-based encounters, we also contemplate pedagogical practices of un/learning (to ‘read’) and to teach the arts of identifying and productively working with the many appearances of refusal – both manifest and less visible.

Purpose: This study evaluated the reliability and validity of the Sinhala version of Katz index of activities of daily living (ADL) in assessing the functional status of older people aged >65 years. Materials and methods: The Katz index was translated to Sinhala, cross-culturally adapted and administered in two stages. In stage 01, 200 patients aged ≥65 years, selected randomly from out-patient medical clinics, were asked to fill the Sinhala version of Katz index along with the Sinhala version of the 10-item Barthel index (BI). The Katz index was re-administered after two weeks among a subgroup of 45 patients selected randomly. In stage 02, Katz index was administered among randomly selected 200 community dwelling older people, aged ≥65 years. In addition, performance-based physical functions [gait speed (GS) and short physical performance battery (SPPB)] were also measured. Results: The analysis of stage 01 data showed internal consistency measured with Cronbach's alpha of 0.82 and test-retest reliability evaluated with intra-class correlation (ICC) (95% CI) of 0.94 (0.89–0.96) (p

This paper examines the effects of audit quality and firm growth on the relationship between corporate cash holdings and firm performance by using a sample of about 2500 unique non-financial Indian firms from 2000 to 2017, consisting of 51,388 firm-year observations. The results obtained by controlling for potential endogeneity using the dynamic panel generalised method of moment (GMM) approach show that cash holdings have an inverse U-shaped (concave) relationship with firm performance, which is stronger for firms with higher audit quality than firms with lower audit quality. Our findings also show that firm growth affects the cash holdings and firm performance relationship and the moderating effect of audit quality. Our study highlights the need for corporate managers to consider firm performance, audit quality and firm growth levels in policy decisions on cash holdings.

The present study was designed to evaluate the effect of pectin supplemented feeds on the growth, gut morphology and immunology of Labeo rohita. Experimental feeds containing various concentrations of pectin including control (0%), T1 (0.5%), T2 (1.0%), T3 (2.0%), and T4 (4.0%) were administered to L. rohita twice per day at a rate of 3% body weight. There was a significant (P < 0.05) decrease in average final weight, weight gain%, net weight gain and specific growth rate observed in treatment groups in order of control > T1 > T2 > T3 > T4 while feed conversion ratio was significantly (P < 0.05) higher in T4 compared to the other groups T3 > T2 > T1 > control. Immunological parameters of peroxidase, protease and antiprotease (trypsin) showed significant (P T2 > T1 > control group. Total protein, protease and antiprotease activity were significantly (P < 0.05) higher in the control compared to treatment groups T1 > T2 > T3 > T4. An increased level of the non-starch polysaccharide pectin in feed caused acute effects on gut morphometry. Villus length, villus width, and an increase in mucosal folds were abnormal but no significant (P > 0.05) abnormality was observed in the control group. In the submucosal part of the intestine, hyperplasia was shown in loose connective tissues and in adipose tissue cells in the treated groups. In conclusion, dietary pectin supplementation from 0.5% to 4% had negative effects on the growth, immunological parameters and gut histomorphology of L. rohita.

Purpose: Teacher wellbeing is critical given its impact on students' experience and achievement. This qualitative study provides insights into teacher wellbeing in Sri Lankan state universities. The study occurs during the coronavirus disease (COVID-19) pandemic, where institutions are stretched for resources and teachers sought better work-life balance while working from home. Design/methodology/approach: The study uses semi-structured interviews of teachers from four state universities in Sri Lanka to discover their strategies for managing teacher wellbeing and staying positive among negativities. Findings: It concludes that the strategies can be expounded to existing research and categorized under four overarching themes: Versatility and Devotion, Pillars of Support, Conformity over Individualism, and Avoidance and Detachment. Sri Lankan university teachers, like many of their global counterparts, believe in staying positive. Research limitations/implications: Like most qualitative research studies, if not all, this research studies the specific phenomenon of teacher wellbeing among university teachers in Sri Lanka. The findings, though supported, has its limitation to only public universities teachers thus cannot be generalized and may not apply to teacher wellbeing in private universities in Sri Lanka. Nevertheless, the application of the themes developed forms a valuable framework to support any future study of teacher wellbeing. The conceptual robustness of the findings will make this framework particularly useful for Sri Lanka and other South Asian countries. Practical implications: The findings will inform future studies on teacher wellbeing, particularly in other South Asian countries. This study may also be the impetus for starting a discourse on related policies in Sri Lanka. Social implications: Teacher wellbeing positively impacts teacher relations with peers and leadership, which has direct implications on student wellbeing. Happy teachers make happy students. Originality/value: The findings revealed eight strategies employed by Sri Lankan state university teachers. These strategies were framed under four overarching themes: Versatility and Devotion, Pillars of Support, Conformity over Individualism, and Avoidance and Detachment.

BackgroundHypoglycemia remains a challenge for roughly 25% of people with type 1 diabetes (T1D) despite using advanced technologies such as continuous glucose monitors (CGMs) or automated insulin delivery systems. Factors impacting hypoglycemia self-management behaviors (including reduced ability to detect hypoglycemia symptoms and unhelpful hypoglycemia beliefs) can lead to hypoglycemia development in people with T1D who use advanced diabetes technology. ObjectiveThis study aims to develop a scalable, personalized mobile health (mHealth) behavioral intervention program to improve hypoglycemia self-management and ultimately reduce hypoglycemia in people with T1D who use advanced diabetes technology. MethodsWe (a multidisciplinary team, including clinical and health psychologists, diabetes care and education specialists, endocrinologists, mHealth interventionists and computer engineers, qualitative researchers, and patient partners) jointly developed an mHealth text messaging hypoglycemia behavioral intervention program based on user-centered design principles. The following five iterative steps were taken: (1) conceptualization of hypoglycemia self-management processes and relevant interventions; (2) identification of text message themes and message content development; (3) message revision; (4) patient partner assessments for message readability, language acceptability, and trustworthiness; and (5) message finalization and integration with a CGM data–connected mHealth SMS text message delivery platform. An mHealth web-based SMS text message delivery platform that communicates with a CGM glucose information-sharing platform was also developed. ResultsThe mHealth SMS text messaging hypoglycemia behavioral intervention program HypoPals, directed by patients’ own CGM data, delivers personalized intervention messages to (1) improve hypoglycemia symptom detection and (2) elicit self-reflection, provide fact-based education, and suggest practical health behaviors to address unhelpful hypoglycemia beliefs and promote hypoglycemia self-management. The program is designed to message patients up to 4 times per day over a 10-week period. ConclusionsA rigorous conceptual framework, a multidisciplinary team (including patient partners), and behavior change techniques were incorporated to create a scalable, personalized mHealth SMS text messaging behavioral intervention. This program was systematically developed to improve hypoglycemia self-management in advanced diabetes technology users with T1D. A clinical trial is needed to evaluate the program’s efficacy for future clinical implementation.

Mechanical skin lesions are a persistent issue under aquaculture operations compromising fish health and robustness. Using an established zebrafish model, the study compared the potential skin wound healing benefit of dietary supplementation with a single-strain yeast fraction rich in β-glucans (β-glucan diet) or with a multi-strain yeast fraction (MsYF). Adult zebrafish were divided into four triplicated groups (12 tanks; 25 fish/tank) as negative control (unwounded-basal diet); control (wounded-basal diet), β-glucan (wounded-β-glucan diet), and MsYF (wounded-MsYF diet) and, following 7-week of nutritional preparation, inflicted with a full-thickness skin wound using a biopsy punch. Wound healing was assessed macroscopically by measuring wound surface area (18 fish individually tracked/group) until full healing within 4 weeks; as well as by histopathological diagnostic, transcriptional and immunoblotting analysis at the wound site at 1, 4 and 9 day post-wound (dpw) over the early healing phase (re-epithelization and inflammation). Following an initial expansion, wound closure was first measured at 4 dpw in the β-glucan and MsYF groups showing a positive and significantly higher daily wound closure rate compared to the control. Later at 16 dpw, cumulative and daily wound closure were significantly higher in the MsYF compared to the β-glucan and control groups. Enhanced gross wound healing was confirmed by histopathological diagnosis of mitigated inflammation, earlier re-epithelization and significantly enhanced granulation tissue synthesis in the MsYF group. Targeted transcriptomic and proteomic markers documented an early up-regulation of matrix metalloproteinases and a dampening or quicker resolution of inflammatory and cellular stress markers in the healing tissues of the MsYF compared to the control group while the β-glucan diet overall elicited intermediary results. Overall, this study demonstrates that dietary supplementation with a yeast-based functional compound can modulate fish immune response in wound healing and promote early wound closure indicating a role for skin health management under aquaculture operations.

Generation and control of short pulse is desired for ultrafast applications. Here the authors demonstrate ultrafast pulse generation using self-evolving photonic crystal that can transition from high loss to low loss state based on dynamic dispersion compensation.

Short-wavelength lasers based on wide-bandgap GaN photonic crystals are promising for high-brightness illumination and materials processing. Here, the authors develop a nano-fabrication method for GaN/air photonic crystals, achieving high lasing operation performance in terms of output power, beam quality, and low threshold current.

Background: Ischemic heart disease (IHD) has been identified as the foremost cause of morbidity and mortality in Sri Lanka. Aims and Objectives: The main aim of this study was to develop a socio-culturally appropriate health counseling intervention protocol to enhance the adherence of prescribed physical activity, diet, and medication among IHD patients attending medical clinics in Sri Lanka. Materials and Methods: This protocol was designed to be used by health professionals and consisted of two sections – an assessment and an intervention. The intervention section integrated communication skills with motivational interviewing, goal setting, and problem-solving. A panel of five experts reviewed each section of the protocol, in a Delphi process. The ratings received at Delphi stage one that was evaluated for degree of consensus. The protocol was modified according to the comments received and resent for a second Delphi round. Again, the re-ratings were reevaluated for the degree of consensus. With regard to assessing consensus, each section was revised/removed if 70% or more of the re-ratings were at 0–3 and kept as the same if 70% or more of the re-ratings were at four or above. Results: All the subsections were rated in categories of four and above in both stages. Therefore, none of the sections was removed from the original protocol. Some modifications were done according to the suggestions received in the Delphi review. Conclusion: The finalized protocol would be initially implemented in selected hospitals in Galle district as a quasi-experimental study in the near future.

Summary: Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic determinants of health and disease between populations, as well as furthering genomic justice. Various common pan-population polymorphisms at CETP associate with serum lipid profiles and cardiovascular disease. Here, sequencing of CETP identified a missense variant rs1597000001 (p.Pro177Leu) specific to Māori and Pacific people that associates with higher HDL-C and lower LDL-C levels. Each copy of the minor allele associated with higher HDL-C by 0.236 mmol/L and lower LDL-C by 0.133 mmol/L. The rs1597000001 effect on HDL-C is comparable with CETP Mendelian loss-of-function mutations that result in CETP deficiency, consistent with our data, which shows that rs1597000001 lowers CETP activity by 27.9%. This study highlights the potential of population-specific genetic analyses for improving equity in genomics and health outcomes for population groups underrepresented in genomic studies.