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To examine the association between psychologist and nurse practitioner scope-of-practice (SoP) regulations and pediatric mental health service access. A nationally representative sample of children with mental health needs was identified using 5 years of National Survey of Children's Health (2016-2020). Utilization was measured in two ways: (1) unmet mental health care needs and (2) receipt of mental health medication. Expanded SoP for psychologists and nurse practitioners was measured based on the child's state of residence and the year of the survey. The associations between both SoP expansion and both outcomes were assessed using logistic regression models adjusted for multiple covariates. The probability of having unmet mental health needs was 5.4 percentage points lower (95% CI - 0.102, - 0.006) for children living in a state with psychologist SoP expansion; however, there was no significant difference in unmet mental health needs between states with and without NP SoP expansion. The probability of receiving a mental health medication was 2.0 percentage points higher (95% CI 0.007, 0.034) for children living in a state with psychologist SoP expansion. Conversely, the probability of receiving a mental health medication was 1.5 percentage points lower (95% CI - 0.023, - 0.007) for children living in a state with NP SoP expansion. Expanded SoP for psychologists is associated with improved access to pediatric mental health care in terms of both unmet need and receiving medication. Expanded SoP for NPs, however, was not associated with unmet need and lower receipt of medication.

Abstract Supervised machine learning (ML) offers an exciting suite of algorithms that could benefit research in sport science. In principle, supervised ML approaches were designed for pure prediction, as opposed to explanation, leading to a rise in powerful, but opaque, algorithms. Recently, two subdomains of ML–explainable ML, which allows us to “peek into the black box,” and interpretable ML, which encourages using algorithms that are inherently interpretable–have grown in popularity. The increased transparency of these powerful ML algorithms may provide considerable support for the hypothetico-deductive framework, in which hypotheses are generated from prior beliefs and theory, and are assessed against data collected specifically to test that hypothesis. However, this paper shows why ML algorithms are fundamentally different from statistical methods, even when using explainable or interpretable approaches. Translating potential insights from supervised ML algorithms, while in many cases seemingly straightforward, can have unanticipated challenges. While supervised ML cannot be used to replace statistical methods, we propose ways in which the sport sciences community can take advantage of supervised ML in the hypothetico-deductive framework. In this manuscript we argue that supervised machine learning can and should augment our exploratory investigations in sport science, but that leveraging potential insights from supervised ML algorithms should be undertaken with caution. We justify our position through a careful examination of supervised machine learning, and provide a useful analogy to help elucidate our findings. Three case studies are provided to demonstrate how supervised machine learning can be integrated into exploratory analysis. Supervised machine learning should be integrated into the scientific workflow with requisite caution. The approaches described in this paper provide ways to safely leverage the strengths of machine learning—like the flexibility ML algorithms can provide for fitting complex patterns—while avoiding potential pitfalls—at best, like wasted effort and money, and at worst, like misguided clinical recommendations—that may arise when trying to integrate findings from ML algorithms into domain knowledge. Key Points Some supervised machine learning algorithms and statistical models are used to solve the same problem, y = f(x) + ε, but differ fundamentally in motivation and approach. The hypothetico-deductive framework—in which hypotheses are generated from prior beliefs and theory, and are assessed against data collected specifically to test that hypothesis—is one of the core frameworks comprising the scientific method. In the hypothetico-deductive framework, supervised machine learning can be used in an exploratory capacity. However, it cannot replace the use of statistical methods, even as explainable and interpretable machine learning methods become increasingly popular. Improper use of supervised machine learning in the hypothetico-deductive framework is tantamount to p-value hacking in statistical methods.

Abstract Background The intestinal barrier encompasses physical and immunological components that act to compartmentalize luminal contents, such as bacteria and endotoxins, from the host. It has been proposed that an age-related decline of intestinal barrier function may allow for the passage of luminal contents into the bloodstream, triggering a low-grade systemic inflammation termed inflamm-aging. Although there is mounting evidence to support this hypothesis in model species, it is unclear if this phenomenon occurs in humans. In addition, despite being well-established that biological sex impacts aging physiology, its influence on intestinal barrier function and inflamm-aging has not been explored. Results In this study, we observed sex differences in markers of intestinal barrier integrity, where females had increased epithelial permeability throughout life as compared to males. With age, females had an age-associated increase in circulating bacterial products and metabolites such as LPS and kynurenine, suggesting reduced barrier function. Females also had age-associated increases in established markers of inflamm-aging, including peripheral blood monocytes as well as TNF and CRP. To determine if impaired barrier function was driving inflamm-aging, we performed a mediation analysis. The results show that the loss of intestinal barrier integrity was not the mediator of inflamm-aging in humans. Instead, persistent, low-grade inflammation with age preceded the increase in circulating bacterial products, which we confirmed using animal models. We found, as in humans, that sex modified age-associated increases in circulating monocytes in mice, and that inflammation mediates the loss of intestinal barrier function. Conclusion Taken together, our results suggest that higher basal intestinal permeability in combination with age-associated inflammation, increases circulating LPS in females. Thus, targeting barrier permeability in females may slow the progression of inflamm-aging, but is unlikely to prevent it.

Abstract Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over time resulting in cyclic epidemics of pertussis. The messenger RNA (mRNA) vaccine platform provides an opportunity to address complex bacterial infections with an adaptable approach providing Th1-biased responses. In this study, immunogenicity and challenge models were used to evaluate the mRNA platform with multivalent vaccine formulations targeting both B. pertussis antigens and diphtheria and tetanus toxoids. Immunization with mRNA formulations were immunogenetic, induced antigen specific antibodies, as well as Th1 T cell responses. Upon challenge with either historical or contemporary B. pertussis strains, 6 and 10 valent mRNA DTP vaccine provided protection equal to that of 1/20th human doses of either DTaP or whole cell pertussis vaccines. mRNA DTP immunized mice were also protected from pertussis toxin challenge as measured by prevention of lymphocytosis and leukocytosis. Collectively these pre-clinical mouse studies illustrate the potential of the mRNA platform for multivalent bacterial pathogen vaccines.

This paper presents a framework to enable probabilistic assessment for braced excavation-induced structural damage on a regional scale. Random filed models are created to describe the uncertainties of spatially variable ground displacements induced by excavation, and random variables are adopted to model the uncertainties of soil stiffnesses, structural stiffnesses, and building weights. The uncertainties are propagated to the probability distributions of building characteristic tensile strains (εc) through a Monte-Carlo method, in which a 3-dimensional (3D) soil-structure interaction (SSI) model is evaluated in each simulation. With limit state functions defined based on εc, damage probabilities were quantified for all buildings in the region impacted by the excavation. Fragility heatmaps that can be used for estimating the probabilities of each possible damage state from impact level were also generated for each building. The framework is demonstrated with an excavation case history executed in Oslo, Norway. The 3D SSI model adopted in the framework can provide more accurate building response prediction than conventional 2D analysis. Meanwhile, the probabilistic assessment method provides a tool to quantify the uncertainty effect in the building assessment of large excavation construction.

This study examined the lived experiences of seven beginning secondary mathematics teachers in an upper Midwestern state who had experienced mentoring and remained in teaching. The study sought to identify the mentoring experiences beginning secondary mathematics teachers perceive as most beneficial to their professional growth. Data were collected through individual interviews and focus groups and were analyzed by coding significant words and statements. Findings suggest beginning secondary mathematics teachers experience various types of support from assigned mentors and informal supports from colleagues within the same building. Regular observations with constructive feedback were found to be highly valued by beginning teachers.

This study used a video-based educational leadership simulation to create a safe environment for professional discourse with school leaders. The researchers used a simulation about teacher-to-teacher bullying with actors of different genders as a prompt. Two simulations were used in this study, and both simulations followed the same script. However, the twist in this study is that one simulation was filmed with only male actors, and the other simulation was filmed with female actresses and male actors. Participants from both simulations were brought together after experiencing one of the two simulations. This study utilized a sequential explanatory mixed methods approach and post-simulation focus groups revealed three themes: some school leaders would treat females differently than males, some school leaders believed the leadership style was a factor, and some believed that gender was less of a factor than the unique teacher-principal relationship. The first conclusion of this study is that the relationship between the principal and the teacher is critical to how the principal responds to a scenario. The second conclusion is that facilitating simulations is an effective method to model a safe environment for discourse centered on sensitive topics.

Abstract In this study, the effect of halide anions on the selectivity of the CO2 reduction reaction to CO was investigated in choline‐based ethylene glycol solutions containing different halides (ChCl : EG, ChBr : EG, ChI : EG). The CO2RR was studied using silver (Ag) and gold (Au) electrodes in a compact H‐cell. Our findings reveal that chloride effectively suppresses the hydrogen evolution reaction and enhances the selectivity of carbon monoxide production on both Ag and Au electrodes, with relatively high selectivity values of 84 % and 62 %, respectively. Additionally, the effect of varying ethylene glycol content in the choline chloride‐containing electrolyte (ChCl : EG 1 : X, X=2, 3, 4) was investigated to improve the current density during CO2RR on the Ag electrode. We observed that a mole ratio of 1 : 4 exhibited the highest current density with a comparable faradaic efficiency toward CO. Notably, an evident surface reconstruction process took place on the Ag surface in the presence of Cl− ions, whereas on Au, this phenomenon was less pronounced. Overall, this study provides new insights into anion‐induced surface restructuring of Ag and Au electrodes during CO2RR, and its consequences on the reduction performance on such surfaces in non‐aqueous electrolytes.

One of the world’s largest “blue carbon” ecosystems, Louisiana’s tidal wetlands on the US Gulf of Mexico coast, is rapidly being lost. Louisiana’s strong legal, regulatory, and monitoring framework, developed for one of the world’s largest tidal wetland systems, provides an opportunity for a programmatic approach to blue carbon accreditation to support restoration of these ecologically and economically important tidal wetlands. Louisiana’s coastal wetlands span ∼1.4 million ha and accumulate 5.5–7.3 Tg yr−1 of blue carbon (organic carbon), ∼6%–8% of tidal marsh blue carbon accumulation globally. Louisiana has a favorable governance framework to advance blue carbon accreditation, due to centralized restoration planning, long term coastal monitoring, and strong legal and regulatory frameworks around carbon. Additional restoration efforts, planned through Louisiana’s Coastal Master Plan, over 50 years are projected to create, or avoid loss of, up to 81,000 ha of wetland. Current restoration funding, primarily from Deepwater Horizon oil spill settlements, will be fully committed by the early 2030s and additional funding sources are required. Existing accreditation methodologies have not been successfully applied to coastal Louisiana’s ecosystem restoration approaches or herbaceous tidal wetland types. Achieving financial viability for accreditation of these restoration and wetland types will require expanded application of existing blue carbon crediting methodologies. It will also require expanded approaches for predicting the future landscape without restoration, such as numerical modeling, to be validated. Additional methodologies (and/or standards) would have many common elements with those currently available but may be beneficial, depending on the goals and needs of both the state of Louisiana and potential purchasers of Louisiana tidal wetland carbon credits. This study identified twenty targeted needs that will address data and knowledge gaps to maximize financial viability of blue carbon accreditation for Louisiana’s tidal wetlands. Knowledge needs were identified in five categories: legislative and policy, accreditation methodologies and standards, soil carbon flux, methane flux, and lateral carbon flux. Due to the large spatial scale and diversity of tidal wetlands, it is expected that progress in coastal Louisiana has high potential to be generalized to similar wetland ecosystems across the northern Gulf of Mexico and globally.

ABSTRACT Introduction This study aimed to investigate how shared decision‐making (SDM) and the use of different types of outcome information are applied in routine care management for people with multiple sclerosis (MS) in an academic outpatient clinic. Methods This qualitative study used the following: (a) observations of clinical encounters (N = 23) between patients and healthcare professionals (HCPs), (b) interviews with those patients (N = 17) and (c) interviews with those HCPs (N = 7). HCPs were not trained in SDM before the study. Audio recordings were transcribed literally. Transcriptions were analysed using qualitative thematic analysis. Results Outcome information was hardly discussed with patients, apart from clinical outcome information at an individual level, such as MRI or lab results. This use of clinical outcome information did not automatically lead to a process of SDM. HCPs tended to implicitly present choices to patients after signalling and discussing ‘problems’. In the interviews, patients indicated that they tended to consent to the advice given by HCPs and to prefer not too much change in treatment plans. However, they also emphasized the importance of being informed about available options with benefits and harms. We observed multiple discussions about patients' preferences, especially related to patients' experiences and priorities. Conclusions Overall, SDM and the use of different types of outcome information did not seem to be enacted in routine care management for people with MS, mostly because choices were not explicitly mentioned or discussed. However, discussions about patients' experiences and priorities did take place. Training HCPs further and developing patient information seem reasonable steps to proceed. Patient or Public Contribution People with MS contributed as research participants and provided us with their experiences in interviews. Furthermore, representatives of two patient organizations contributed to the study by reviewing the interview protocol for people with MS.

Introduction Vaccines are essential to prevent infection and reduce the morbidity of infectious diseases. Previous evidence has shown that migrants and refugees are particularly vulnerable to exclusion and discrimination, and low COVID-19 vaccine intention and uptake were observed among refugees globally. This study aimed to develop and internally validate prediction models of COVID-19 vaccine uptake by nationality.Methods This is a nested prognostic population-based cross-sectional analysis. Data were collected between June and October 2022 in Sin-El-Fil, a district of Beirut, Lebanon. The study population included a random sample of Lebanese adults and all Syrian adults residing in areas of low socioeconomic status. Data were collected through a telephone survey. The main outcome was the uptake of at least one dose of the COVID-19 vaccine. Predictors of COVID-19 vaccine uptake were assessed using the Least Absolute Shrinkage and Selection Operator regression for Lebanese and Syrian nationalities in separate models.Results Of 2028 participants, 79% were Lebanese, 18% Syrians and 3% of other nationalities. COVID-19 vaccination uptake was higher among Lebanese (85% (95% CI 82% to 86%) compared to Syrians (47% (95% CI 43% to 51%)) (p

Background Cytoreductive surgery is critical for optimal tumor clearance in advanced epithelial ovarian cancer (EOC). Despite best efforts, some patients may experience R2 (>1 cm) resection, while others may not undergo surgery at all. We aimed to compare outcomes between advanced EOC patients undergoing R2 resection and those who had no surgery. Methods Retrospective data from 51 patients with R2 resection were compared to 122 patients with no surgery between January 2015 and December 2019 at a UK tertiary referral centre. Progression-free survival (PFS) and overall survival (OS) were the study endpoints. Principal Component Analysis and Term Frequency – Inverse Document Frequency scores were utilized for data discrimination and prediction of R>2 cm from computed tomography pre-operative reports, respectively. Results No statistical significance was observed, except for age (73 vs 67 years in the no- surgery vs R2 group, P : .001). Principal Components explained 34% of data variances. Reasons for no surgery included age, co-morbidities, patient preference, refractory disease, patient deterioration or disease progression, and absence of measurable intra- abdominal disease). The median PFS and OS were 12 and 14 months for no-surgery, vs 14 and 26 months for R2 ( P : .138 and P : .001, respectively). Serous histology and performance status independently predicted PFS in both no-surgery and R2 cohorts. In the no-surgery cohort, serous histology independently predicted OS, while in the R2 cohorts, both serous histology and adjuvant chemotherapy were independent prognostic features for OS. The bi-grams “abdominopelvic ascites” and “solid omental” were amongst those best discriminating between R>2 cm and R1-2 cm. Conclusions R2 resection and no-surgery cohorts displayed unfavourable prognosis with a notable degree of uniformity. When cytoreduction results in suboptimal results, the survival benefit may still be higher compared to those who underwent no surgery.

This paper presents an uncertainty quantification problem involving high-dimensional uncertainty inputs and a nonlinear structural analysis model. The uncertainty quantification problem can be considered a high-dimensional numerical integration with a nonlinear integrand. The crude Monte Carlo, multi-fidelity Monte Carlo, and randomized quasi-Monte Carlo methods are applied to solve the numerical integration problem, and numerical experiments are conducted to compare the efficiency of the Monte Carlo methods. It is shown that both multi-fidelity Monte Carlo and randomized quasi-Monte Carlo may significantly improve the efficiency of the studied problem. The randomized quasi-Monte Carlo method is easier to implement, but a carefully selected quasi-random sample and more sophisticated variance estimation are needed to successfully apply the randomized quasi-Monte Carlo method.

Abstract Some anti‐mycobacterial drugs are known to cause QT interval prolongation, potentially leading to life‐threatening ventricular arrhythmia. However, the highest leprosy and tuberculosis burden occurs in settings where electrocardiographic monitoring is challenging. The feasibility and accuracy of alternative strategies, such as the use of automated measurements or a mobile electrocardiogram (mECG) device, have not been evaluated in this context. As part of the phase II randomized controlled BE‐PEOPLE trial evaluating the safety of bedaquiline‐enhanced post‐exposure prophylaxis (bedaquiline and rifampicin, BE‐PEP, versus rifampicin, SDR‐PEP) for leprosy, all participants had corrected QT intervals (QTc) measured at baseline and on the day after receiving post‐exposure prophylaxis. The accuracy of mECG measurements as well as automated 12L‐ECG measurements was evaluated. In total, 635 mECGs from 323 participants were recorded, of which 616 (97%) were of sufficient quality for QTc measurement. Mean manually read QTc on 12L‐ECG and mECG were 394 ± 19 and 385 ± 18 ms, respectively (p

Abstract The ‘landscape of fear’ concept offers valuable insights into wildlife behaviour, yet its practical integration into habitat management for conservation remains underexplored. In this study, conducted in the subtropical monsoon grasslands of Bardia National Park, Nepal, we aimed to bridge this gap through a multi‐year, landscape‐scale experimental investigation in Bardia National Park, Nepal. The park has the highest density of tigers (with an estimated density of ~7 individuals per 100 km2) in Nepal, allowing us to understand the effect of habitat management on predation risk and resource availability especially for three cervid species: chital (Axis axis), swamp deer (Rucervus duvaucelii) and hog deer (Axis porcinus). We used plots with varying mowing frequency (0–4 times per year), size (ranging from small: 49 m2 to large: 3600 m2) and artificial fertilisation type (none, phosphorus, nitrogen) to assess the trade‐offs between probable predation risk and resources for these cervid species, which constitute primary prey for tigers in Nepal. Our results showed distinct responses of these deer to perceived predation risk within grassland habitats. Notably, these deer exhibited heightened use of larger plots, indicative of a perceived sense of safety, as evidenced by the higher occurrence of pellet groups in the larger plots (mean = 0.1 pellet groups m−2 in 3600 m2 plots vs. 0.07 in 400 m2 and 0.05 in 49 m2 plots). Furthermore, the level of use by the deer was significantly higher in larger plots that received mowing and fertilisation treatments compared to smaller plots subjected to similar treatments. Of particular interest is the observation that chital and swamp deer exhibited greater utilisation of the centre (core) areas within the larger plots (mean = 0.21 pellet groups m−2 at the centre vs. 0.13 at the edge) despite the edge (periphery) also provided attractive resources to these deer. In contrast, hog deer did not display any discernible reaction to the experimental treatments, suggesting potential species‐specific variations in response to perceived predation risk arising from management interventions. Our findings emphasise the importance of a sense of security as a primary determinant of habitat selection for medium‐sized deer within managed grassland environments. These insights carry practical implications for park managers, providing a nuanced understanding of integrating the ‘landscape of fear’ into habitat management strategies. This study emphasises that the ‘landscape of fear’ concept can and should be integrated into habitat management to maintain delicate predator–prey dynamics within ecosystems.

Abstract Cloud microphysics is a critical aspect of the Earth's climate system, which involves processes at the nano‐ and micrometer scales of droplets and ice particles. In climate modeling, cloud microphysics is commonly represented by bulk models, which contain simplified process rates that require calibration. This study presents a framework for calibrating warm‐rain bulk schemes using high‐fidelity super‐droplet simulations that provide a more accurate and physically based representation of cloud and precipitation processes. The calibration framework employs ensemble Kalman methods including Ensemble Kalman Inversion and Unscented Kalman Inversion to calibrate bulk microphysics schemes with probabilistic super‐droplet simulations. We demonstrate the framework's effectiveness by calibrating a single‐moment bulk scheme, resulting in a reduction of data‐model mismatch by more than 75% compared to the model with initial parameters. Thus, this study demonstrates a powerful tool for enhancing the accuracy of bulk microphysics schemes in atmospheric models and improving climate modeling.

Abstract Introduction Prick‐to‐prick (PTP) test with fresh food is accepted as a reliable tool for measuring sensitization to fruits and vegetables. Not all fruits and vegetables are available throughout the year. The objective of this study was to investigate whether skin prick test (SPT) performed with frozen juice of fruits and vegetables (FJFV) is a good alternative to PTP tests performed with fresh fruits and vegetables (FFV). Methods Adult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra‐class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated. Results Thirty‐six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72). Conclusions Results of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.

Abstract Previously, we showed that quantification of lymphoma‐associated miRNAs miR‐155‐5p, ‐127‐3p and let‐7a‐5p levels in plasma extracellular vesicles (EVs) report treatment response in patients with classic Hodgkin lymphoma (cHL). Prior to clinical implementation, quality control (QC) steps and validation are required to meet international regulatory standards. Most published EV‐based diagnostic assays have yet to meet these requirements. In order to advance the assay towards regulatory compliance (e.g., IVDR 2017/746), we incorporated three QC steps in our experimental EV‐miRNA quantitative real‐time reverse‐transcription PCR (q‐RT‐PCR) assay in an ISO‐13485 certified quality‐management system (QMS). Liposomes encapsulated with a synthetic (nematode‐derived) miRNA spike‐in controlled for EV isolation by automated size‐exclusion chromatography (SEC). Additional miRNA spike‐ins controlled for RNA isolation and cDNA conversion efficiency. After deciding on quality criteria, in total 107 out of 120 samples from 46 patients passed QC. Generalized linear mixed‐effect modelling with bootstrapping determined the diagnostic performance of the quality‐controlled data at an area under the curve (AUC) of 0.84 (confidence interval [CI]: 0.76–0.92) compared to an AUC of 0.87 (CI: 0.80–0.94) of the experimental assay. After the inclusion of QC steps, the accuracy of the assay was determined to be 78.5% in predicting active disease status in cHL patients during treatment. We demonstrate that a quality‐controlled plasma EV‐miRNA assay is technically robust, taking EV‐miRNA as liquid biopsy assay an important step closer to clinical evaluation.

Abstract This work demonstrates a method to design photonic surfaces by combining femtosecond laser processing with the inverse design capabilities of tandem neural networks that directly link laser fabrication parameters to their resulting textured substrate optical properties. High throughput fabrication and characterization platforms are developed that generate a dataset comprising 35280 unique microtextured surfaces on stainless steel with corresponding measured spectral emissivities. The trained model utilizes the nonlinear one‐to‐many mapping between spectral emissivity and laser parameters. Consequently, it generates predominantly novel designs, which reproduce the full range of spectral emissivities (average root‐mean‐squared‐error < 2.5%) using only a compact region of laser parameter space 25 times smaller than what is represented in the training data. Finally, the inverse design model is experimentally validated on a thermophotovoltaic emitter design application. By synergizing laser‐matter interactions with neural network capabilities, the approach offers insights into accelerating the discovery of photonic surfaces, advancing energy harvesting technologies.

With the recent advances in the biogeotechnics field and specifically microbially induced calcite precipitation (MICP), cone penetration testing (CPT) has become a valuable tool to overcome the challenges associated with intact sampling of improved soils, evaluate the spatial extent and magnitude of the applied MICP treatment, and assess the consequential improvement of engineering properties. Although the CPT cone tip resistance (qc) can effectively monitor the improvement of densified clean sands, no relationship exists to estimate cementation and strength parameters in MICP-treated sands. This paper proposes a relationship between the apparent cohesion (c) stemming from the MICP-induced cementation bonds at particle contacts and the change in tip resistance (qc) in initially loose sands. To develop a broadly useful correlation, available experimental CPT data in biocemented soils were used to guide computation simulations using a direct axisymmetric model of cone penetration in biocemented sands. The CPT numerical model uses the finite-difference method with a rezoning algorithm for large-deformation problems along with the Mohr-Coulomb constitutive model. The biocemented sand was characterized by Mohr-Coulomb strength parameters and an elastic shear modulus informed by shear-wave velocity measurements (Vs). The correlation parameters of interest were identified (c, qc, and Vs), and results of the numerical simulations were validated against available experimental data. Once validated, the numerical simulations were extended to different initial conditions, and the trends between parameters of interest were analyzed and interpreted. Results from the simulations are consistent with experimental data and show an increase in the cone tip resistance as the cementation level increases. The cementation level is modeled through apparent cohesion and the shear stiffness model parameters, which both increase as the cementation level increases. A linear relationship is proposed between the apparent cohesion and the change in cone tip resistance as a function of the confining stress.

Lateral spreading of an interlayered deposit adjacent to a meandering stream channel in Wufeng, Taiwan, during the 1999 Chi-Chi Earthquake is evaluated using two-dimensional (2D) nonlinear dynamic analyses (NDAs) with geostatistical modeling of the subsurface to assess their ability to approximate the observed magnitude and spatial extent of ground deformations, as well as identify the key factors and mechanisms that most contributed to the overall system response. In-situ data from borings and cone penetration tests (CPTs) depict thinly stratified overbank deposits of low-plasticity silty sands, silts, and clays, interlayered with laterally discontinuous channel-deposited sands. The three-dimensional (3D) subsurface is simulated using transition probability-based indicator geostatistics, conditioned on available CPT data and geological inferences. The NDAs are performed using the PM4Sand and PM4Silt constitutive models, within the FLAC finite difference program. Sensitivity analyses are performed to understand the influence of uncertainties in the stratigraphy, channel conditions, soil properties, input ground motions, constitutive model calibration protocols, and numerical boundary conditions, as well as the performance of alternate channel transects. Most analysis cases generally matched the maximum displacements observed near the channel but overestimated the extent of displacements away from the channel. The most favorable results were largely influenced by nonstationary stratigraphic trends and cyclic softening of fine-grained soils, in addition to the liquefaction of coarse-grained soils. This case history demonstrates the capabilities and limitations of current subsurface and NDA modeling procedures for predicting ground deformation patterns.

This study explores the methodology presented in four leading educational leadership journals for a period of three years to investigate the predominant methodologies reported in journals most read by faculty members in educational administration or leadership programs. This content analysis study uses frequency and percentages to gather data on the published methodologies of four educational leadership journals. We used an established coding protocol, and our coding was not interpretive. The analysis revealed that qualitative methods were published more frequently than quantitative methods in the leading educational leadership journals with an emphasis on studies using a descriptive qualitative design, a descriptive quantitative design, correlational research, and case studies. This study replicated a study conducted by Wells, Kolek, Williams, and Saunders (2015) which was a content analysis of three major higher education journals to examine the methodologic characteristics of published research from 1996-2000 and 2006-2010 respectively. The authors discuss the relevance of the study for EdD programs in Educational Administration/Leadership. The analysis may inform decisions about how to best develop scholar-practitioners' capacity to use systemic and systematic inquiry to solve complex problems of practice.

Abstract Objective The aim of this study was to describe the epilepsy phenotype in a large international cohort of patients with KBG syndrome and to study a possible genotype–phenotype correlation. Methods We collected data on patients with ANKRD11 variants by contacting University Medical Centers in the Netherlands, an international network of collaborating clinicians, and study groups who previously published about KBG syndrome. All patients with a likely pathogenic or pathogenic ANKRD11 variant were included in our patient cohort and categorized into an “epilepsy group” or “non‐epilepsy group”. Additionally, we included previously reported patients with (likely) pathogenic ANKRD11 variants and epilepsy from the literature. Results We included 75 patients with KBG syndrome of whom 26 had epilepsy. Those with epilepsy more often had moderate to severe intellectual disability (42.3% vs 9.1%, RR 4.6 [95% CI 1.7–13.1]). Seizure onset in patients with KBG syndrome occurred at a median age of 4 years (range 12 months – 20 years), and the majority had generalized onset seizures (57.7%) with tonic–clonic seizures being most common (23.1%). The epilepsy type was mostly classified as generalized (42.9%) or combined generalized and focal (42.9%), not fulfilling the criteria of an electroclinical syndrome diagnosis. Half of the epilepsy patients (50.0%) were seizure free on anti‐seizure medication (ASM) for at least 1 year at the time of last assessment, but 26.9% of patients had drug‐resistant epilepsy (failure of ≥2 ASM). No genotype–phenotype correlation could be identified for the presence of epilepsy or epilepsy characteristics. Significance Epilepsy in KBG syndrome most often presents as a generalized or combined focal and generalized type. No distinctive epilepsy syndrome could be identified. Patients with KBG syndrome and epilepsy had a significantly poorer neurodevelopmental outcome compared with those without epilepsy. Clinicians should consider KBG syndrome as a causal etiology of epilepsy and be aware of the poorer neurodevelopmental outcome in individuals with epilepsy.

This paper describes a centrifuge study undertaken to investigate how sand gradation affects the system-level performance of embankments subjected to strong shaking. Current analysis and design practices are primarily based on knowledge from case history records of liquefaction, with the majority of those from sites consisting of clean, poorly graded sands. The narrow range of gradation characteristics represented in the case history database poses a challenge during the analysis of embankment structures traditionally constructed with, or founded on, more broadly graded soils. The tests herein were designed to elucidate how embankments uniformly constructed with a well graded and poorly graded sand perform differently during earthquake shaking. A centrifuge experiment test program was developed and conducted using the 9-m-radius centrifuge at the UC Davis Center for Geotechnical Modeling. The experiment design consisted of two submerged 10-degree embankments positioned side-by-side in the same rigid model container, with one embankment constructed with poorly graded sand and the other with well graded sand. The embankments were dry pluviated to the same relative density, but the absolute densities of the sands were different. The embankments were identically instrumented with dense arrays of in-situ sensors beneath the level ground above the slope and in the mid-slope to measure the dynamic response during liquefaction. Results showed that embankments constructed at equal relative densities would both liquefy (i.e., ru reach 1.0), but deformations were less severe for the embankments constructed with the well graded sand. Greater resistance to the generation and faster dissipation of excess porewater pressures, coupled with stronger dilatancy of the well graded sand increased embankment stability, curtailing liquefaction-induced deformations.

The piezocone (CPTu) dissipation test is used to characterize how the applied load from the penetrating cone is distributed between the soil and pore fluid during both penetrometer advancement and when penetration is paused. The coefficient of consolidation is often estimated from CPTu dissipation tests by interpreting the rate of excess porewater pressure (∆u) decay to static conditions during a pause in cone penetration. Most CPTu dissipation test interpretation methods are based on Terzaghi consolidation theory for ∆u dissipation at the cone shoulder (u2 position) or cone face (u1 position) and assume that radial ∆u dissipation dominates the response. However, several recent studies show that vertical ∆u migration does contribute to the response. This study uses a large deformation direct axisymmetric cone penetration model to characterize the soil-water mechanical response during CPTu dissipation tests, and in particular, the role of vertical ∆u dissipation on the response at the u1 and u2 positions. Large deformations around the penetrating cone are accommodated with an Arbitrary Lagrangian Eulerian approach. Soil behavior is modeled with the MIT-S1 constitutive model calibrated for Boston blue clay (BBC) soil behavior. ∆u dissipation following undrained cone penetration is simulated with coupled consolidation for BBC with over-consolidation ratios (OCR) of 1, 2, and 4 and a range of hydraulic conductivity anisotropy. The simulated u1 and u2 dissipation responses are presented to study how they are affected by OCR and hydraulic conductivity anisotropy. A correction factor is recommended to account for hydraulic conductivity anisotropy when interpreting the horizontal coefficient of consolidation from CPTu dissipation tests.

Abstract The uncertainty in soil hydraulic parameters is often not taken into account in process‐based hydrological modeling. Performing runs with 104 stochastic parameter realizations, we evaluated the propagation of uncertainty in the Van Genuchten–Mualem (VGM) parameters into estimates of the threshold values of soil water content used to calculate the total and readily available water, and on the long‐term (30 years) simulations of evaporation, transpiration, bottom flux, and runoff by the SWAP hydrological model. The simulated scenarios included weather data from a location in southeast Brazil and seven soils from the same region cropped with maize, comprising a wide range of texture classes. The results showed that uncertainties in VGM parameters affect the estimates of total and readily available water. Water balance components obtained by a deterministic simulation with average VGM parameters did not always agree with the average or median of stochastic simulations, and stochastic simulations including parameter uncertainties should be preferred. Variations in yearly rainfall characteristics were more important for bottom flux and evaporation, while transpiration and runoff were more strongly influenced by the variations in soil hydraulic properties.