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1. Procedural-Related Bleeding in Hospitalized Patients With Liver Disease (PROC-BLeeD): An International, Prospective, Multicenter Observational Study

Author

Intagliata, Nicolas M., Rahimi, Robert S., Higuera-de-la-Tijera, Fatima, Simonetto, Douglas A., Farias, Alberto Queiroz, Mazo, Daniel F., Boike, Justin R., Stine, Jonathan G., Serper, Marina, Pereira, Gustavo, Mattos, Angelo Z., Marciano, Sebastian, Davis, Jessica P.E., Benitez, Carlos, Chadha, Ryan, Méndez-Sánchez, Nahum, deLemos, Andrew S., Mohanty, Arpan, Dirchwolf, Melisa, Fortune, Brett E., Northup, Patrick G., Patrie, James T., and Caldwell, Stephen H.

Published
2023
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6. Contributors

Author

Allampati, Sanath, primary, Ayles, Helen M., additional, Bacon, Bruce R., additional, Bailey, Sarah Lou, additional, Balistreri, William F., additional, Bang, Ji Young, additional, Benias, Petros C., additional, Berenguer, Marina, additional, Bethea, Emily D., additional, Bhamidimarri, Kalyan Ram, additional, Bowlus, Christopher L., additional, Cardenas, Andres, additional, Carrion, Andres F., additional, Choi, Steve S., additional, Chopra, Sanjiv, additional, Chung, Raymond T., additional, Cobbold, Jeremy F.L., additional, Curry, Michael P., additional, Czaja, Albert J., additional, de Castro, Teresita Gomez, additional, deLemos, Andrew S., additional, Di Bisceglie, Adrian M., additional, Diehl, Anna Mae, additional, Fontana, Robert J., additional, Friedman, Lawrence S., additional, Ginès, Pere, additional, Grace, Norman D., additional, Han, Steven-Huy B., additional, Hirschfield, Gideon M., additional, House, Michael G., additional, Waasdorp Hurtado, Christine E., additional, Jacobson, Ira M., additional, Kowdley, Kris V., additional, Lai, Michelle, additional, Lefkowitch, Jay H., additional, Lertudomphonwanit, Chatmanee, additional, Lewis, James H., additional, Lillemoe, Keith D., additional, Lo Re, Vincent, additional, Manickavasagan, Hanisha, additional, Martin, Paul, additional, Mayo, Marlyn J., additional, Mitchell, Mack C., additional, Mullen, Kevin D., additional, Muñoz, Santiago J., additional, Neuschwander-Tetri, Brent A., additional, Nguyen, Kelvin T., additional, Patidar, Kavish R., additional, Pringle, Patricia, additional, Procaccini, Nicholas J., additional, Puleo, James, additional, Reddy, K. Rajender, additional, Rosen, Hugo R., additional, Sanyal, Arun J., additional, Schilsky, Michael L., additional, Sherman, Stuart, additional, Sokol, Ronald J., additional, Spengler, Erin, additional, Stoffel, Elena M., additional, Summerfield, John A., additional, Tapper, Elliot B., additional, Tran, Tram T., additional, Vinaixa, Carmen, additional, Webb, Gwilym J., additional, Weine, Douglas M., additional, Wolf, Jacqueline L., additional, Wong, Florence S., additional, and Zhang, Wei, additional

Published
2018
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12. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

Author

Wagschal, Alexandre, Najafi-Shoushtari, S Hani, Wang, Lifeng, Goedeke, Leigh, Sinha, Sumita, deLemos, Andrew S, Black, Josh C, Ramírez, Cristina M, Li, Yingxia, Tewhey, Ryan, Hatoum, Ida, Shah, Naisha, Lu, Yong, Kristo, Fjoralba, Psychogios, Nikolaos, Vrbanac, Vladimir, Lu, Yi-Chien, Hla, Timothy, de Cabo, Rafael, Tsang, John S, Schadt, Eric, Sabeti, Pardis C, Kathiresan, Sekar, Cohen, David E, Whetstine, Johnathan, Chung, Raymond T, Fernández-Hernando, Carlos, Kaplan, Lee M, Bernards, Andre, Gerszten, Robert E, and Näär, Anders M

Subjects
MicroRNA -- Research, Genome-wide association studies -- Analysis, Cholesterol -- Physiological aspects -- Genetic aspects, Triglycerides -- Physiological aspects -- Genetic aspects, Biological sciences, Health
Abstract

Genome-wide association studies (GWASs) have linked genes to various pathological traits. However, the potential contribution of regulatory noncoding RNAs, such as microRNAs (miRNAs), to a genetic predisposition to pathological conditions has remained unclear. We leveraged GWAS meta-analysis data from [greater than] 188,000 individuals to identify 69 miRNAs in physical proximity to single-nucleotide polymorphisms (SNPs) associated with abnormal levels of circulating lipids. Several of these miRNAs (miR-128-1, miR-148a, miR-130b, and miR-301b) control the expression of key proteins involved in cholesterol-lipoprotein trafficking, such as the low-density lipoprotein (LDL) receptor (LDLR) and the ATP-binding cassette A1 (ABCA1) cholesterol transporter. Consistent with human liver expression data and genetic links to abnormal blood lipid levels, overexpression and antisense targeting of miR-128-1 or miR-148a in high-fat diet-fed C57BL/6J and Apoe-null mice resulted in altered hepatic expression of proteins involved in lipid trafficking and metabolism, and in modulated levels of circulating lipoprotein-cholesterol and triglycerides. Taken together, these findings support the notion that altered expression of miRNAs may contribute to abnormal blood lipid levels, predisposing individuals to human cardiometabolic disorders., Author(s): Alexandre Wagschal [1, 2]; S Hani Najafi-Shoushtari [1, 2]; Lifeng Wang [1, 2]; Leigh Goedeke [3]; Sumita Sinha [4]; Andrew S deLemos [5]; Josh C Black [1, 6]; Cristina [...]

Published
2015
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14. Contributors

Author

Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional

Published
2015
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18. 683 – Distinct Characteristics of Hepatocellular Carcinoma in Women: Results from a Large, Multicenter Study in the United States

Author

Phipps, Meaghan, primary, Livanos, Alexandra, additional, Guo, Averill, additional, Pomenti, Sydney, additional, Yeh, Jonathan, additional, Dakhoul, Lara, additional, Burney, Heather, additional, Kettler, Carla, additional, Liu, Hao, additional, Miller, Ethan D., additional, Gawrieh, Samer, additional, DeLemos, Andrew S., additional, Scanga, Andrew, additional, Chalasani, Naga P., additional, and Wattacheril, Julia, additional

Published
2019
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23. Su1524 - Sustained Elevation in Alkaline Phosphatase is Associated with Greater Disease Severity in Real World NAFLD

Author

DeLemos, Andrew S., primary, Barritt, A. Sidney, additional, Bhamidimarri, Kalyan R., additional, Landis, Charles, additional, Malahias, Laura, additional, Malespin, Miguel, additional, Schoen, Cheryl, additional, Taunk, Jawahar, additional, Thuluvath, Paul J., additional, Trinh, Huy N., additional, and Tetri, Brent, additional

Published
2018
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26. Risk factors for hepatocellular carcinoma in cirrhosis due to nonalcoholic fatty liver disease: A multicenter, case-control study

Author

Corey, Kathleen E, primary, Gawrieh, Samer, additional, deLemos, Andrew S, additional, Zheng, Hui, additional, Scanga, Andrew E, additional, Haglund, Jennifer W, additional, Sanchez, Jorge, additional, Danford, Christopher J, additional, Comerford, Megan, additional, Bossi, Krista, additional, Munir, Samina, additional, Chalasani, Naga, additional, and Wattacheril, Julia, additional

Published
2017
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27. Sa1532 Tenascin-C: A Novel Plasma Biomarker in Hepatitis C-Mediated Liver Disease

Author

Elam, April D., primary, Massengill, Danae L., additional, Benbow, Jennifer H., additional, Bossi, Krista, additional, Warner, Elizabeth B., additional, Culberson, Catherine R., additional, Zamor, Philippe J., additional, Schmeltzer, Paul, additional, Conner, Gregory, additional, Russo, Mark W., additional, DeLemos, Andrew S., additional, and Schrum, Laura, additional

Published
2016
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29. Colaboradores

Author

Abrahamian, Fredrick M., Allos, Ban Mishu, Apicella, Michael A., Ard, Kevin L., Arias, Cesar A., Augenbraun, Michael H., Averhoff, Francisco, Azar, Dimitri T., Baddour, Larry M., Baker, Carol J., Ballard, Ronald C., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Bell, Beth P., Bennett, John E., Bente, Dennis A., Berbari, Elie F., Bhimraj, Adarsh, Bisno, Alan L., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Bleck, Thomas P., Bobak, David A., Bonnez, William, Boothroyd, John C., Bosque, Patrick J., Bower, John, Bradsher, Robert W., Jr., Brown, Kevin E., Brown, Patricia D., Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Cano, Luz Elena, Carpenter, Charles C.J., Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chen, Sharon C-A., Chow, Anthony W., Cohen, Jeffrey I., Cohen, Myron S., Corey, Lawrence, Cover, Timothy L., Crossley, Kent B., Crumpacker, Clyde S., II, Currie, Bart J., D’Agata, Erika, Damon, Inger K., Darouiche, Rabih O., DeBiasi, Roberta L., Deepe, George S., Jr., Delemos, Andrew S., DeMuri, Gregory P., Dewar, Robin, Diaz, James H., Dienstag, Jules L., Dolin, Raphael, Donnenberg, Michael S., Donowitz, Gerald R., Dormitzer, Philip R., Drake, James M., Dumler, J. Stephen, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Edelstein, Paul H., Edwards, Morven S., Ellison, Richard T., III, Endy, Timothy P., Engleberg, N. Cary, Erdem, Hakan, Ernst, Joel D., Fairhurst, Rick M., Fairley, Jessica K., Falsey, Ann R., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Forster, Derek, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallo, Robert C., Gandhi, Tejal N., Garrett, Wendy S., Gaydos, Charlotte A., Geisbert, Thomas W., Gelfand, Jeffrey A., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Goldstein, Ellie J.C., Gordin, Fred M., Graman, Paul S., Griffin, Patricia M., Guerrant, Richard L., Gul, H. Cem, Haake, David A., Haas, David W., Haines, Charles, Hall, Caroline Breese, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hawkins, Claudia, Hay, Roderick J., Henderson, David K., Hill, David R., Hirsch, Martin S., Hodowanec, Aimee, Holzman, Robert S., Hook, Edward W., III, Hooton, Thomas M., Horowitz, Harold W., Horsburgh, C. Robert, Jr., Horton, James M., Hospenthal, Duane R., Iovine, Nicole M., Iredell, Jonathan R., Ison, Michael G., Janda, J. Michael, Janoff, Edward N., Johannsen, Eric C., Kaye, Donald, Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Klein, Jerome O., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Kontoyiannis, Dimitrios P., Koralnik, Igor J., Koshy, Anita A., Kovacs, Joseph A., Kozarsky, Phyllis, Krieger, John, Kuehnert, Matthew J., Kumar, Nalin M., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Lewis, Russell E., Lima, Aldo A.M., Limaye, Ajit P., Lipkin, W. Ian, Litman, Nathan, Lorber, Bennett, MacGregor, Rob Roy, Mackowiak, Philip A., Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Masur, Henry, McBride, John T., McCormack, William M., McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mikulska, Malgorzata, Miller, Robert F., Miller, Samuel I., Mitchell, David H., Modlin, John F., Mody, Rajal K., Montoya, José G., Moreillon, Philippe, Morris, J. Glenn, Jr., Munford, Robert S., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Narezkina, Anna, Nash, Theodore E., Nayak, Jennifer L., Neill, Marguerite A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Palraj, Raj, Pappas, Peter G., Pasternack, Mark S., Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Penn, Robert L., Perfect, John R., Perlman, Stanley, Petersen, Brett W., Peterson, Phillip K., Petri, William A., Jr., Petti, Cathy A., Phillips, Michael, Que, Yok-Ai, Radolf, Justin D., Raoult, Didier, Ray, Stuart C., Reboli, Annette C., Reitz, Marvin S., Jr., Renault, Cybèle A., Restrepo, Angela, Rex, John H., Rhee, Elizabeth G., Romero, José R., Rothman, Alan L., Roy, Craig R., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Safdar, Amar, Salazar, Juan C., Savoia, Maria C., Sax, Paul E., Scheld, W. Michael, Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Septimus, Edward J., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco R., Singh, Kamaljit, Singh, Nina, Singh, Upinder, Sinner, Scott W., Slater, Leonard N., Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Soper, David E., Sorrell, Tania C., Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Sterling, Timothy R., Stevens, Dennis L., Stratton, Charles W., IV, Suffredini, Anthony F., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Thio, Chloe Lynne, Thomas, David L., Thomas, Stephen J., Thorner, Anna R., Tobón, Angela María, Tramont, Edmund C., Treanor, John J., Tsibris, Athe M.N., Tunkel, Allan R., Turner, Ronald B., Tyler, Kenneth L., Uluer, Ahmet, van de Beek, Diederik, Vannier, Edouard G., Van Schooneveld, Trevor C., Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weisdorf, Daniel J., Weiss, Louis M., Welch, David F., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wilson, Walter R., Wright, William F., Young, Jo-Anne H., Young, Vincent B., Yun, Nadezhda, Zimmerli, Werner, and Zurlo, John J.

Published
2017
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31. Colaboradores

Author

Aagaard, Kjersti, Abrahamian, Fredrick M., Allos, Ban Mishu, Andes, David R., Aoki, Fred Y., Apicella, Michael A., Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Augenbraun, Michael H., Averhoff, Francisco, Azar, Dimitri T., Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Ronald C., Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Bell, Beth P., Bennett, John E., Bente, Dennis A., Berbari, Elie F., Berman, Jonathan, Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birdsall, Holly H., Bisno, Alan L., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Bleck, Thomas P., Blijlevens, Nicole M.A., Bobak, David A., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Bower, John, Bradsher, Robert W., Jr., Brook, Itzhak, Brown, Kevin E., Brown, Patricia D., Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Calderwood, Stephen B., Cano, Luz Elena, Carpenter, Charles C.J., Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chambers, Henry F., Chapman, Stephen J., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chow, Anthony W., Clark, Rebecca A., Cohen, Jeffrey I., Cohen, Myron S., Cohen-Poradosu, Ronit, Cohn, Susan E., Connors, Mark, Corey, Lawrence, Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Craig, William A., Crossley, Kent B., Crumpacker, Clyde S., II, Curran, James W., Currie, Bart J., D’Agata, Erika, Damon, Inger K., Darouiche, Rabih O., DeBiasi, Roberta L., Deepe, George S., Jr., del Rio, Carlos, Delemos, Andrew S., DeLeo, Frank R., DeMuri, Gregory P., Densen, Peter, Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donnelly, J. Peter, Donnenberg, Michael S., Donowitz, Gerald R., Dormitzer, Philip R., Drake, James M., Dumler, J. Stephen, Dummer, J. Stephen, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Edelstein, Paul H., Edmond, Michael B., Edwards, John E., Jr., Edwards, Morven S., Eliopoulos, George M., Ellison, Richard T., III, Endy, Timothy P., Engleberg, N. Cary, Erdem, Hakan, Ernst, Joel D., Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Forster, Derek, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Tejal N., Garrett, Wendy S., Gaydos, Charlotte A., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Goldstein, Ellie J.C., Gordin, Fred M., Graman, Paul S., Grayson, M. Lindsay, Greene, Jeffrey Bruce, Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, H. Cem, Haake, David A., Haas, David W., Haines, Charles, Hall, Caroline Breese, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hawkins, Claudia, Hay, Roderick J., Hedberg, Craig W., Henderson, David K., Henderson, Donald A., High, Kevin P., Hill, Adrian V.S., Hill, David R., Hinman, Alan R., Hirsch, Martin S., Hodowanec, Aimee, Hohl, Tobias M., Holland, Steven M., Holzman, Robert S., Hook, Edward W., III, Hooper, David C., Hooton, Thomas M., Horowitz, Harold W., Horsburgh, C. Robert, Jr., Horton, James M., Hospenthal, Duane R., Hsueh, Kevin, Hughes, James M., Hynes, Noreen A., Iovine, Nicole M., Iredell, Jonathan R., Ison, Michael G., Janda, J. Michael, Janoff, Edward N., Johannsen, Eric C., Kashuba, Angela D.M., Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima, Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Klein, Jerome O., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kozarsky, Phyllis, Krieger, John, Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., Leggett, James E., Legido-Quigley, Helena, Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lipkin, W. Ian, Litman, Nathan, Lorber, Bennett, Luna, Ruth Ann, MacDougall, Conan, MacGregor, Rob Roy, Mackowiak, Philip A., Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McBride, John T., McCarthy, James S., McCormack, William M., McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mikulska, Malgorzata, Miller, Robert F., Miller, Samuel I., Mitchell, David H., Modlin, John F., Mody, Rajal K., Moellering, Robert C., Jr., Moffa, Matthew, Moir, Susan, Montoya, José G., Moore, Thomas A., Moreillon, Philippe, Morris, J. Glenn, Jr., Morse, Caryn Gee, Moseley, Robin, Munford, Robert S., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Murray, Patrick R., Musher, Daniel M., Nagel, Jerod L., Nannini, Esteban C., Narezkina, Anna, Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Osterholm, Michael T., Ostroff, Stephen M., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Pasternack, Mark S., Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Penn, Robert L., Perfect, John R., Perlman, Stanley, Petersen, Brett W., Peterson, Phillip K., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Raoult, Didier, Ravdin, Jonathan I., Ray, Stuart C., Reboli, Annette C., Reitz, Marvin S., Jr., Relman, David A., Renault, Cybèle A., Restrepo, Angela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romero, José R., Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Safdar, Amar, Sajadi, Mohammad M., Salazar, Juan C., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Scheld, W. Michael, Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schuchat, Anne, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Septimus, Edward J., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco R., Singh, Kamaljit, Singh, Nina, Singh, Upinder, Sinner, Scott W., Sivapalasingam, Sumathi, Slater, Leonard N., Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Soper, David E., Sorrell, Tania C., Steckelberg, James M., Steere, Allen C., Steigbigel, Neal H., Steinberg, James P., Stephens, David S., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Strahilevitz, Jacob, Stratton, Charles W., IV, Suffredini, Anthony F., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Thio, Chloe Lynne, Thomas, David L., Thomas, Lora D., Thomas, Stephen J., Thorner, Anna R., Tobón, Angela María, Tramont, Edmund C., Treanor, John J., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Turner, Ronald B., Tyler, Kenneth L., Uluer, Ahmet, van de Beek, Diederik, van der Velden, Walter J.F. M., Vannier, Edouard G., Van Schooneveld, Trevor C., Versalovic, James, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weisdorf, Daniel J., Weiss, Louis M., Welch, David F., Wellems, Thomas E., Wenzel, Richard P., Wharton, Melinda, White, A. Clinton, Jr., Whitley, Richard J., Wilson, Walter R., Wortmann, Glenn W., Wright, William F., Young, Jo-Anne H., Young, Vincent B., Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.

Published
2016
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33. Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Author

Rottiers, Veerle, primary, Obad, Susanna, additional, Petri, Andreas, additional, McGarrah, Robert, additional, Lindholm, Marie W., additional, Black, Joshua C., additional, Sinha, Sumita, additional, Goody, Robin J., additional, Lawrence, Matthew S., additional, deLemos, Andrew S., additional, Hansen, Henrik F., additional, Whittaker, Steve, additional, Henry, Steve, additional, Brookes, Rohn, additional, Najafi-Shoushtari, Seyed Hani, additional, Chung, Raymond T., additional, Whetstine, Johnathan R., additional, Gerszten, Robert E., additional, Kauppinen, Sakari, additional, and Näär, Anders M., additional

Published
2013
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38. Review: Immunoglobulin G4-Associated Cholangitis: The Next Great Masquerader.

Author

deLemos, Andrew S. and Pratt, Daniel S.

Subjects
ADRENOCORTICAL hormones, HORMONE therapy, RITUXIMAB, ALLERGIES, AUTOIMMUNE diseases, BILE duct diseases, BIOPSY, BLOOD testing, ENDOSCOPIC retrograde cholangiopancreatography, IMMUNOGLOBULINS, IMMUNOHISTOCHEMISTRY, FIBROSIS, DIAGNOSIS
Abstract

The article discusses a case report on immunoglobulin G4 (IgG4)-associated cholangitis (IAC) by S. Gonzalez and colleagues, published within the issue. The condition refers to the biliary manifestations of IgG4-related systemic or sclerosing disease (ISD). Its history, epidemiology, diagnosis and treatment are also discussed.

Published
2013

40. Parvin-beta inhibits breast cancer tumorigenicity and promotes CDK9-mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation.

Author

Johnstone CN, Mongroo PS, Rich AS, Schupp M, Bowser MJ, Delemos AS, Tobias JW, Liu Y, Hannigan GE, and Rustgi AK

Subjects
Actinin genetics, Animals, Breast Neoplasms genetics, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Cell Transformation, Neoplastic genetics, Cyclin-Dependent Kinase 9 genetics, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Lipid Metabolism, Mice, Neoplasm Transplantation, PPAR gamma genetics, Phosphorylation, Phosphoserine metabolism, RNA, Messenger genetics, Transcription, Genetic genetics, Actinin metabolism, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Transformation, Neoplastic metabolism, Cell Transformation, Neoplastic pathology, Cyclin-Dependent Kinase 9 metabolism, PPAR gamma metabolism
Abstract

Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was evaluated. Particular emphasis was placed upon propagating MDA-MB-231 breast cancer cells in three-dimensional culture matrices. Interestingly, Parvin-beta reexpression in MDA-MB-231 cells increased the mRNA expression, serine 82 phosphorylation (mediated by CDK9), and activity of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), and there was a concomitant increase in lipogenic gene expression as a downstream effector of PPARgamma. Importantly, Parvin-beta suppressed breast cancer growth in vivo, with associated decreased proliferation. These data suggest that Parvin-beta might influence breast cancer progression.

Published
2008
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