1. Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
- Author
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Simoes, Margarida Pires, Hodcroft, Emma B., Simmonds, Peter, Albert, Jan, Alidjinou, Enagnon K., Ambert-Balay, Katia, Andrés, Cristina, Antón, Andrés, Auvray, Christelle, Bailly, Jean Luc, Baldanti, Fausto, Bastings, Capser, Beard, Stuart, Berengua, Carla, Berginc, Natasa, Bloemen, Mandy, Blomqvist, Soile, Bosma, Froukje, Böttcher, Sindy, Bubba, Laura, Buderus, Stafan, Cabrerizo, Maria, Calvo, Cristina, Celma, Cristina, Ceriotti, Ferruccio, Clark, Gemma, Costa, Inës, Coste-Burel, Marianne, Couderé, Karen, Cremer, Jeroen, Del Cuerpo Casas, Margarita, Daehne, Theo, De Beer, Jessica, De Ceano-Vivas, Maria, De Gascun, Cillian, De Rougemont, Alexis, Dean, Jonathan, Dembinski, Jennifer L., Diedrich, Sabine, Diez-Domingo, Javier, Dillner, Lena, Dorenberg, Dagny H., Ducancelle, Alexandra, Dudman, Susanne, Dyrdak, Robert, Eis-Huebinger, Anna Maria, Falces-Romero, Iker, Farkas, Agnes, Feeney, Susan, Fernandez-Garcia, Maria D., Flipse, Jacky, Franck, Kristina T., Galli, Cristina, Garrigue, Isabelle, Geeraedts, Felix, Georgieva, Irina, Giardina, Federica, Guiomar, Raquel, Hauzenberger, Elenor, Heikens, Esther, Henquell, Cécille, Hober, Didier, Hönemann, Mario, Howson-Wells, Hannah, Hruškar, Željka, Ikonen, Niina, Imbert, Berthemarie, Jansz, Arjan R., Jeannoël, Marion, Jiřincová, Helena, Josset, Laurence, Keeren, Kathrin, Kramer-Lindhout, Naomie, Krokstad, Sidsel, Lazrek, Mouna, Le Guillou-Guillemette, Hélène, Lefeuvre, Caroline, Lind, Andreas, Lunar, Maja M., Maier, Melanie, Marque-Juillet, Stéphanie, McClure, C. Patrick, McKenna, James, Meijer, Adam, Menasalvas Ruiz, Ana, Mengual-Chuliá, Beatriz, Midgley, Sofie, Mirand, Audrey, Molenkamp, Richard, Montes, Milagrosa, Moreno-Docón, Antonio, Morley, Ursula, Murk, Jean Luc, Navascués-Ortega, Ana, Nijhuis, Roel, Nikolaeva-Glomb, Lubomira, Nordbø, Svein A., Numanovic, Sanela, Oggioni, Massimo, Oñate Vergara, Eider, Pacaud, Jordi, Pacreau, Marie L., Panning, Marcus, Pariani, Elena, Pekova, Lili, Pellegrinelli, Laura, Petrovec, Miroslav, Pietsch, Corinna, Pilorge, Léa, Piñeiro, Luis, Piralla, Antonio, Poljak, Mario, Prochazka, Birgit, Rabella, Nuria, Rahamat-Langendoen, Janette C., Rainetova, Petra, Reynders, Marijke, Riezebos-Brilman, Annelies, Roorda, Lieuwe, Savolainen-Kopra, Carita, Schuffenecker, Isabelle, Smeets, Leo C., Stoyanova, Asya, Stefic, Karl, Swanink, Caroline, Tabain, Irena, Tjhie, Jeroen, Thouault, Luc, Tumiotto, Camille, Uceda Renteria, Sara, Uršič, Tina, Vallet, Sophie, Van Ranst, Marc, Van Wunnik, Peter, Verweij, Jaco J., Vila, Jorgina, Wintermans, Bas, Wollants, Elke, Wolthers, Katja C., Xavier López-Labrador, F., Fischer, Thea Kolsen, Harvala, Heli, Benschop, Kimberley S.M., Simoes, Margarida Pires, Hodcroft, Emma B., Simmonds, Peter, Albert, Jan, Alidjinou, Enagnon K., Ambert-Balay, Katia, Andrés, Cristina, Antón, Andrés, Auvray, Christelle, Bailly, Jean Luc, Baldanti, Fausto, Bastings, Capser, Beard, Stuart, Berengua, Carla, Berginc, Natasa, Bloemen, Mandy, Blomqvist, Soile, Bosma, Froukje, Böttcher, Sindy, Bubba, Laura, Buderus, Stafan, Cabrerizo, Maria, Calvo, Cristina, Celma, Cristina, Ceriotti, Ferruccio, Clark, Gemma, Costa, Inës, Coste-Burel, Marianne, Couderé, Karen, Cremer, Jeroen, Del Cuerpo Casas, Margarita, Daehne, Theo, De Beer, Jessica, De Ceano-Vivas, Maria, De Gascun, Cillian, De Rougemont, Alexis, Dean, Jonathan, Dembinski, Jennifer L., Diedrich, Sabine, Diez-Domingo, Javier, Dillner, Lena, Dorenberg, Dagny H., Ducancelle, Alexandra, Dudman, Susanne, Dyrdak, Robert, Eis-Huebinger, Anna Maria, Falces-Romero, Iker, Farkas, Agnes, Feeney, Susan, Fernandez-Garcia, Maria D., Flipse, Jacky, Franck, Kristina T., Galli, Cristina, Garrigue, Isabelle, Geeraedts, Felix, Georgieva, Irina, Giardina, Federica, Guiomar, Raquel, Hauzenberger, Elenor, Heikens, Esther, Henquell, Cécille, Hober, Didier, Hönemann, Mario, Howson-Wells, Hannah, Hruškar, Željka, Ikonen, Niina, Imbert, Berthemarie, Jansz, Arjan R., Jeannoël, Marion, Jiřincová, Helena, Josset, Laurence, Keeren, Kathrin, Kramer-Lindhout, Naomie, Krokstad, Sidsel, Lazrek, Mouna, Le Guillou-Guillemette, Hélène, Lefeuvre, Caroline, Lind, Andreas, Lunar, Maja M., Maier, Melanie, Marque-Juillet, Stéphanie, McClure, C. Patrick, McKenna, James, Meijer, Adam, Menasalvas Ruiz, Ana, Mengual-Chuliá, Beatriz, Midgley, Sofie, Mirand, Audrey, Molenkamp, Richard, Montes, Milagrosa, Moreno-Docón, Antonio, Morley, Ursula, Murk, Jean Luc, Navascués-Ortega, Ana, Nijhuis, Roel, Nikolaeva-Glomb, Lubomira, Nordbø, Svein A., Numanovic, Sanela, Oggioni, Massimo, Oñate Vergara, Eider, Pacaud, Jordi, Pacreau, Marie L., Panning, Marcus, Pariani, Elena, Pekova, Lili, Pellegrinelli, Laura, Petrovec, Miroslav, Pietsch, Corinna, Pilorge, Léa, Piñeiro, Luis, Piralla, Antonio, Poljak, Mario, Prochazka, Birgit, Rabella, Nuria, Rahamat-Langendoen, Janette C., Rainetova, Petra, Reynders, Marijke, Riezebos-Brilman, Annelies, Roorda, Lieuwe, Savolainen-Kopra, Carita, Schuffenecker, Isabelle, Smeets, Leo C., Stoyanova, Asya, Stefic, Karl, Swanink, Caroline, Tabain, Irena, Tjhie, Jeroen, Thouault, Luc, Tumiotto, Camille, Uceda Renteria, Sara, Uršič, Tina, Vallet, Sophie, Van Ranst, Marc, Van Wunnik, Peter, Verweij, Jaco J., Vila, Jorgina, Wintermans, Bas, Wollants, Elke, Wolthers, Katja C., Xavier López-Labrador, F., Fischer, Thea Kolsen, Harvala, Heli, and Benschop, Kimberley S.M.
- Abstract
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.
- Published
- 2024