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Background: Depressive symptom is the most common type of psychiatric co-morbidity among persons with epilepsy. Epilepsy patients are identified as at higher risk of suffering depressive symptom explicitly in low- and middle-income countries due to poor mental health care systems and financial burdens. The co-occurrence of depressive symptom among epilepsy patients deteriorates the prognosis of the disease and diminishes the quality of life of both the patients and their families. However, there is limited evidence on the prevalence of depressive symptom and associated factors in Ethiopia. Therefore, this study is intended to assess the prevalence of depressive symptom and associated factors among epilepsy patients attending in Amhara region, Ethiopia. Method: A multi-center institution-based cross-sectional study was done among epilepsy patients attending at Amhara region, Ethiopia. The Hospital Anxiety Depression tool was used to assess depressive symptom. To determine the factors associated with depressive symptom, a binary logistic regression model was used. Adjusted Odds Ratio (AOR) with the 95% Confidence Interval (CI) was reported in the multivariable binary logistic regression analysis. Results: About 406 participants were registered in the study with a response rate of 97.6%. The prevalence of depressive symptom among epilepsy patients was 53.9% [95%CI: 49.1%, 58.8%]. In the multivariable binary logistic regression analysis, taking polytherapy treatment [AOR = 1.87, 95% CI: 1.04, 3.36], perceived stigma [AOR = 5.73, 95%CI: 3.11, 10.55], poor antiepileptic medication adherence [AOR = 3.33, 95%CI: 1.30, 8.54] and having poor [AOR = 5.83, 95%CI: 2.44, 13.90] and moderate social support [AOR = 3.08, 95%CI: 1.34, 7.09] were significantly associated with depressive symptom. Conclusions: This study revealed that the magnitude of depressive symptom among epilepsy patients in Ethiopia was relatively high and multiple factors determined the likelihood of depressive symptom. Thus, healthcare providers and concerned stakeholders should strengthen comprehensive health education to reduce the magnitude and consequences of depressive symptom among this segment of the population. Moreover, strong social support with special attention should be given to epilepsy patients. [ABSTRACT FROM AUTHOR]

Previous studies reported that depressive symptoms were associated with a high risk of all-cause mortality. However, the effect of different long-term depressive symptom trajectory patterns on the risk of all-cause mortality has not been evaluated. Our research aimed to explore the association between different depressive symptom trajectories and the risk of all-cause mortality in Chinese adults. The data we used were from the China Health and Retirement Longitudinal Study. In total, 13,624 subjects aged over 45 years were ultimately included in the analysis. Group-based trajectory modeling was used to identify the different trajectories of depressive symptoms. The multivariable Cox regression model was used to examine the association between long-term depressive symptom trajectories and all-cause mortality. The results show that a total of five depressive symptom trajectories were identified in our study, including stable-low, stable-moderate, increasing, decreasing and stable-high. Compared with individuals in the stable-low depressive symptom trajectories group, those in the increasing and stable-high trajectory groups possessed a greater mortality rate, with a multivariable-adjusted hazard ratio (95% CIs) for mortality were 1.30 (1.06, 1.60) and 1.59 (1.26, 2.02), respectively. In addition, we have not identified the significant risk of all-cause mortality in people with decreased and stable-moderate symptom trajectories. Moreover, the risk of all-cause mortality had an increasing trend among the different trajectory groups. In the sensitivity analysis, the association was robust in most of the subgroups. In conclusion, people with increasing and persistent higher depressive symptom trajectories were associated with an increased risk of all-cause mortality. [ABSTRACT FROM AUTHOR]

Objective: The effect of Meaning-Centered Interventions (MCI) in advanced cancer patients requires further comprehensive research. Methods: Two researchers independently searched the PubMed, EMBASE, SCOPUS, Cochrane, and PsycINFO databases to investigate the impact of MCI on anxiety and depressive symptoms, sense of meaning, and quality of life (QoL) in patients with advanced cancer from inception to April 2024. Statistical analyses were conducted using standardized mean difference (SMD) as the effect size with Stata 17.0 software for analysis, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was employed to assess the certainty of evidence. Results: Data from 12 eligible studies, involving a total of 1,459 participants, were included in the review. The analysis found that 3 studies with 321 participants reported an improvement in the quality of life (QoL) of patients with advanced cancer within one month after the intervention, compared to the control group (SMD, 0.27; 95% CI, 0.03 to 0.52; I2 = 0%; p = 0.03). However, this effect did not persist during the 2–6 months following the intervention. In addition, 4 studies with 434 participants indicated that MCI was associated with an enhanced sense of meaning (SMD, 0.22; 95% CI, 0.09 to 0.36; I2 = 0%; p = 0.002). Furthermore, 8 studies with 1,192 participants and 7 studies with 1,156 participants found that MCI was associated with a reduction in depressive symptoms (SMD, -0.15; 95% CI, -0.24 to -0.05; I2 = 44.8%; p = 0.002) and anxiety symptoms (SMD, -0.16; 95% CI, -0.26 to -0.07; I2 = 46.3%; p = 0.001), respectively. Conclusions: Moderate-quality evidence indicates that MCI enhances the sense of meaning among patients with advanced cancer and reduces depressive and anxiety symptoms, but it does not improve their QoL. [ABSTRACT FROM AUTHOR]

Objectives: This study investigates the effect of dietary fiber on the prevention of depressive symptoms. Methods: In a cohort of 88,826 Korean adults (57,284 men and 31,542 women), we longitudinally evaluated the risk of depressive symptoms according to quartiles of dietary fiber intake for 5.8 years of follow-up. A food frequency questionnaire was used in evaluating dietary fiber intake. Depressive symptoms were assessed by the Center for Epidemiological Studies-Depression (CES-D) scale, in which CES-D ≥ 16 was defined as depressive symptoms. The Cox proportional hazards model was used to calculate the adjusted hazard ratio (HR) and 95% confidence intervals (CI) for depressive symptoms (adjusted HR [95% CI]). Subgroup analysis was performed for gender and BMI (≥25 or <25). Result: In men, the risk of depressive symptoms significantly decreased with the increase of dietary fiber (quartile 1: reference, quartile 2: 0.93 [0.87–0.99], quartile 3: 0.91 [0.85–0.98] and quartile 4: 0.84 [0.77–0.92]). This association was more prominently observed in men with BMI ≥ 25 (quartile 1: reference, quartile 2: 0.95 [0.86–1.06], quartile 3: 0.88 [0.79–0.99] and quartile 4: 0.84 [0.73–0.97]). Women did not show a significant association between quartile groups of dietary fiber intake and the risk of depressive symptoms across subgroup analysis for BMI. Conclusion: High intake of dietary fiber is potentially effective in reducing depressive symptoms in Korean men. The protective effect of dietary fiber on depressive symptoms may vary by gender and obesity. [ABSTRACT FROM AUTHOR]

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This study aimed to assess its relationship between physical activity with health-related indicators in older population of the China. Cross-sectional data of 1,327 individuals aged 60–79 years were analyzed. Based on the Fifth National Physical Fitness Monitoring Program, depressive symptom and loneliness were measured using the Patient Health Questionnaire-9 and Emotional versus Social Loneliness Scales, respectively. Sleep quality was evaluated through self-designed questionnaire and hypertension was defined as blood pressure > 140/90 mmHg. International Physical Activity Questionnaire-Long Form was conducted to assess the physical activity (minutes and frequency) in different domains (domestic, transport, work, and leisure). Multivariable-adjusted binary logistic regression models estimated for the prevalence of health-related indicators, considering PA level, duration, frequency, and combinations of different domains of PA. In the study, favorable associations were observed between moderate to high level PA and reductions in 4 health-related indicators, especially for active frequency. Moreover, a combination of transport, domestic, and leisure PA was found to be a general protective factor for health-related indicators. In summary, this study highlights the positive impact of PA on older adults' health and provides valuable insights into the role of different PA patterns, offering a theoretical basis for developing PA guidelines, policies, and health interventions. [ABSTRACT FROM AUTHOR]

Introduction: This study examines the association between Meat, Egg, and Dairy (MED) product consumption and depressive symptoms among older adults in China, focusing on rural/urban and gender differences. Methods: This study employed data from the latest wave (year 2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and Ordinary Least Squares (OLS) models were applied to examine the association between MED consumption and depression levels. Findings: The findings revealed a consistent negative relationship between MED consumption and depression, with higher MED intake associated with lower depression levels. Urban residents and males exhibited higher MED consumption, which correlated with less depressive symptoms. However, the impact of MED consumption on depression varied by subgroups; urban older adults benefited more from MED consumption than their rural counterparts, and the relationship between MED intake and depression was more pronounced in males than in females. The study highlighted the influence of socio-demographic factors, such as literacy, income, and self-rated health, on depression levels. Discussion: The results suggested that MED consumption may offer protective effects on mental health in older adults, although the association may not be causal. The study underscored the need for further research to explore the complex interplay between diet and mental health in older adults, particularly in diverse cultural contexts. [ABSTRACT FROM AUTHOR]

Objective: Resilience has been recently considered one of the possible mechanisms for the association between morningness–eveningness and depression. Meanwhile, anxiety is closely associated with mood disorder, but its association with morningness–eveningness is unclear. Therefore, this study aimed to explore the mediating effects of resilience and anxiety on morningness–eveningness and depression as the possible mechanisms. Methods: This study included patient group and nonpatient group. Patient group consists of 743 patients with mood disorders [Major Depressive Disorder (MDD), 233; Bipolar Disorder I (BDI), 113; Bipolar Disorder II (BDII), 397] whereas nonpatient group consists of 818 individuals without mood disorder. The Composite Scale of Morningness, Connor–Davidson Resilience Scale, Self-Rating Depression Scale, and Beck Anxiety Inventory were used to evaluate morningness–eveningness, resilience, anxiety, and depression, respectively. Results: Our model provided a good fit for the data. The association between morningness–eveningness and depression symptoms was partially serially mediated by resilience and anxiety in both the patient and nonpatient groups. The patient group exhibited significantly stronger morningness–eveningness toward resilience and anxiety than the nonpatient group. In the indirect effect of morningness–eveningness on depression, group differences exist only through each mediation of resilience and anxiety, not through serial mediation. Conclusion: Our results expand on the mechanism underlying the association between morningness–eveningness and depression. They highlight the importance of morningness–eveningness modification to increase resilience and the need to consider anxiety jointly in this process. [ABSTRACT FROM AUTHOR]

Experiencing prejudice and discrimination from family has been found to be positively associated with mental health problems among sexual minorities. Emerging evidence also shows the value of contextualizing the internalization of minority stress by considering individual cultural factors, such as filial piety. We examined whether authoritarian filial piety (AFP) and reciprocal filial piety (RFP) moderated the link between distal stressors in one's family and mental health outcomes. A total of 362 (56.9% male; age: M = 24.55, SD = 6.60) Chinese lesbian, gay, bisexual, queer/questioning, and other non‐heterosexual (LGBQ+) individuals participated in this study. They provided demographic information and completed a battery of measures for AFP and RFP, sexual orientation‐based prejudice and discrimination in family of origin (SOPDF), depressive symptoms, and life satisfaction. Structural equation modeling results showed that SOPDF had a positive and negative link with depressive symptoms and life satisfaction, respectively. In addition, we identified AFP and RFP as significant moderators for the association between SOPDF and depressive symptoms, and the association between SOPDF and life satisfaction, respectively. Specifically, the positive effect of SOPDF on depressive symptoms was greater for participants with higher levels of AFP; the negative effect of SOPDF on life satisfaction was greater for participants who endorsed higher levels of RFP. Our findings corroborated past studies' conclusion about the detrimental impact of familial sexual stigma on LGBQ+ people's mental health. Furthermore, such impact on negative and positive mental health outcomes are respectively conditioned by the degree to which LGBQ+ individuals endorse AFP and RFP. These findings underscore the importance for therapists who endorse family therapy to help LGBQ+ clients navigate familial sexual stigma and consider the role of filial piety beliefs in shaping the impact of familial sexual stigma on these clients' mental health. [ABSTRACT FROM AUTHOR]

Objectives: This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X‐ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis. Methods: We designed a cross‐sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self‐reported or graded by the Kellgren–Lawrence score after an objective X‐ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ). Results: We included 22,566 older adults (≥60 years; 10,961 had self‐reported arthritis) for functional disability analysis (2377 older adults with data on X‐ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self‐reported arthritis) for depressive symptom analysis. After controlling for all covariates, self‐reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X‐ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744). Conclusions: Self‐reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X‐ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis. [ABSTRACT FROM AUTHOR]

Objective: This study examines the mediating role of cognitive flexibility in the relationship between home-school co-education (H-SCE) and depressive symptom among vocational college students in urban and rural areas of China. Methods: Utilizing the Theory of Overlapping Spheres of Influence, this research explores how H-SCE influences depressive symptom, considering cognitive flexibility as a key mediating factor. The study utilized established scales, including the Inventory of Parent and Peer Attachment (IPPA) for parent-child relationships, the Student-Teacher Relationship Scale (STRS), the Cognitive Flexibility Inventory (CFI), and the Center for Epidemiologic Studies Depression Scale (CES-D10). Results: A total of 1090 valid questionnaires were analyzed, revealing a significant negative correlation between H-SCE and depressive symptom. Cognitive flexibility was found to partially mediate this relationship, suggesting that enhanced cognitive adaptability, fostered through effective H-SCE, can reduce depressive symptom by helping students better cope with stressors. Conclusion: These findings underscore the importance of fostering strong collaboration between families and schools to enhance cognitive resilience and mitigate psychological challenges faced by vocational students, providing a foundation for targeted interventions to promote mental well-being. [ABSTRACT FROM AUTHOR]

Background/Objectives: Light therapy has emerged as a promising non-pharmacological treatment for depressive symptoms. This meta-analysis aims to evaluate the effectiveness of light therapy specifically for depressive symptoms in elderly populations, with a focus on how different light intensities and spectra influence treatment outcomes. Methods: A systematic search targeting studies on light therapy for depressive symptoms in older adults was performed across multiple databases, including PubMed, Google Scholar, PsycINFO, and EMBASE, covering studies from database inception until July 2024. A total of 565 records were identified, with 461 studies remaining after removing duplicates. Following the screening of titles and abstracts, 54 studies underwent full-text review, resulting in the inclusion of 22 studies with a total of 1290 participants (687 in the intervention group and 603 in the control group). Results: The overall effect size for light therapy on depressive symptoms was moderate (Hedges' g = 0.525, p < 0.001). Higher light intensities (10,000 lux and above) demonstrated significantly greater effectiveness compared to lower intensities. White light had the most substantial effect, while bluish light showed moderate efficacy. Significant heterogeneity was observed across studies (I2 = 80.459%), indicating variability in treatment outcomes based on study design, intensity, and light spectrum. Conclusions: This meta-analysis confirms that light therapy is an effective treatment for reducing depressive symptoms in older adults, particularly at higher intensities and with specific light spectra such as white light. Given the heterogeneity in results, future research should focus on optimizing treatment parameters to enhance clinical outcomes within this population. [ABSTRACT FROM AUTHOR]

ABSTRACT This study examined the sequential dual mediating effects of negative parenting attitudes, smartphone dependence and aggression on depressive symptoms among adolescents. Data were obtained from the 2018 Korean Children and Youth Panel Survey (KCYPS) conducted by the National Youth Policy Institute. Using a multistage stratified cluster sampling method, the 2018 KCYPS comprehensively examined various aspects of the growth and development of children and adolescents. The study sample included a nationally representative sample of 2541 adolescents. PROCESS macro Model 6 was used to examine the sequential dual mediating model that not only examines the effects of negative parenting attitudes on smartphone dependence and aggression but also establishes the sequential causal relationship between smartphone dependence and aggression, ultimately confirming the direct and indirect effects on depressive symptoms of adolescents. The significance of the mediation effect was verified by applying the bootstrapping method. The findings demonstrated that negative parenting attitudes increased smartphone dependence, which, in turn, elevated depressive symptoms among adolescents. Furthermore, negative parenting attitudes increased smartphone dependence, which heightened aggression, ultimately contributing to depressive symptoms among adolescents. Based on these findings, this study has practical and policy implications for preventing depressive symptoms among adolescents. Prioritizing efforts to reduce smartphone dependence and aggression among adolescents while promoting positive parenting attitudes can play a crucial role in addressing this issue. [ABSTRACT FROM AUTHOR]

Background Depression as a major mental health condition is commonly found in junior high school students. Peer attachment, emotional resilience and childhood abuse have been found to be associated with depressive symptoms, and it has been hypothesized that peer attachment and emotional resilience may play a chained effecting path in the relationship between childhood abuse and depressive symptoms in junior high school students. Objective To explore the relationship between childhood abuse and depressive symptom in junior high school students, analyze the effecting path of peer attachment and emotional resilience, thus to provide references for improving the mental health of junior high school students. Methods From May to July 2022, a cluster sampling technique was utilized to recruit 1 781 junior high school students from a junior high school in Anhui province. Childhood Trauma Questionnaire Short Form (CTQ-SF), Revised version of Inventory of Parent and Peer Attachment (IPPA-R), Adolescent' Emotional Resilience Questionnaire (AERQ) and Center for Epidemiological Studies Depression Scale (CES-D) were used as the measurement tools. Pearson correlation coefficient was calculated to assess the correlation among above scales. Process4. 2 and Bootstrapping method were employed to verify the effecting path of peer attachment and emotional resilience in the relationship between childhood abuse and depressive symptoms. Results CTQ-SF score was negatively correlated with IPPA-R peer attachment subscale score and AERQ score (r=-0. 527, -0. 495, P<0. 01) and positively correlated with CES-D score (r= 0. 669, P<0. 01) in junior high school students. IPPA-R peer attachment subscale score was positively correlated with AERQ score (r=0. 556, P<0. 01) and negatively correlated with CES-D score (r=-0. 599, P<0. 01) in junior high school students. AERQ score was negatively correlated with CES-D score (r=-0. 698, P<0. 01) in junior high school students. Childhood abuse in junior high school students was shown to be a positive predictor of depressive symptoms (β=0. 675, P<0. 01) and a negative predictor of peer attachment (β= -0. 824, P<0. 01) and emotional resilience (β =-0. 305, P<0. 01). Peer attachment and emotional resilience were independent effecting path between childhood abuse and depressive symptoms, with indirect effect size of 0. 093（95% CI：0. 066~0. 122) and 0. 108（95% CI: 0. 084~0. 133), respectively. Peer attachment and emotional resilience affected as a chain effecting path between childhood abuse and depressive symptoms, with indirect effect size of 0. 087（95% CI：0. 071~0. 105), accounting for 12. 89% of the total effect. Conclusion Childhood abuse in junior high school students can affect the presence of depressive symptom both directly and indirectly through either separate or chained effecting path of peer attachment and emotional resilience. [ABSTRACT FROM AUTHOR]

Purpose: To examine the influence of learning adjustment dimensions (motivation, attitude, ability, teaching pattern, and environment) on depressive symptoms in Chinese nursing freshmen, and the mediating role of psychological capital. Methods: A cross-sectional survey was conducted among 471 nursing freshmen at a university in May 2024. The anonymous self-reported questionnaire included the Patient Health Questionnaire, the Learning Adjustment Questionnaire, and the Psychological Capital Questionnaire. Data were analyzed using SPSS v25.0 and PROCESS v4.1 macro, including correlation and mediation analysis. Results: Learning adjustment had a significant direct effect on depressive symptoms among nursing freshmen (β = − 0.565, p < 0.001), and psychological capital partially mediated this relationship (β= − 0.156, 95% Boot CI [− 0.107, − 0.135]), suggesting psychological capital explains part of the link between poor learning adjustment and depressive symptoms. Conclusion: More attention should be paid to the mental health issues of freshmen. Addressing learning adjustment issues and fostering psychological capital among nursing freshmen may alleviate depressive symptoms, which will require relevant educational interventions and mental health support from university educators and counselors. [ABSTRACT FROM AUTHOR]

Objective: To explore the association between childhood growing environment and depressive symptoms in young old persons aged 60 to 74 years. Methods: The data of the fourth wave of China Health and Retirement Longitudinal Study in 2018 and the life course survey in 2014 were used to secondary analysis. A total of 7 642 young old persons aged 60 to 74 years were included, and the 10-item of the Center for Epidemiological Studies Depression (CES-D-10) scale was used to evaluate the depressive symptoms. The generalized linear mixed effects model was used to explore the relationship between childhood growing environment and depressive symptoms in the young old persons. Results: The detection rate of depressive symptoms occurrence in the young old persons was 37.2%. The risk factors of depressive symptoms included female (OR = 1.89), rural (OR = 1.35) having hunger experience (OR = 1.22), poor relationship with male dependents (OR = 1.72) female caregiver's experiences of being bedridden due to illness( OR = 1.38 ), community insecurity (OR = 1.59), more harmonious neighborhood relationship (OR = 1.2) and less harmonious neighborhood relationship (OR = 1.81) The protective factors of depressive symptoms occurrence included moderate (OR = 0.79) and high (OR = 0.5) per capita household income, and educated father( OR = 0.84 )(P<0.05) Conclusion: Childhood growing environment is an influential factor of depressive symptoms in the young old persons. The long-term health effects of childhood environment should be paid attention to. [ABSTRACT FROM AUTHOR]

Adolescents are at a high risk of depressive symptom. A substantial body of literature indicates that early environmental unpredictability (EU) significantly affects the likelihood of developing depressive symptom. However, only a few studies have focused on the mediating mechanisms underlying this relationship. Based on life history (LH) theory and the adaptive calibration model, this study constructed a chain-mediating model to examine whether the association between EU and depressive symptom among Chinese adolescents is mediated by sense of control and fast life history strategies. In total, 1838 Chinese adolescents (47.8 % women, mean age = 13.17 ± 0.99 years) participated in this study and responded to self-report measures of EU, fast LH strategies, sense of control, and depressive symptom. (1) There were significant correlations between EU, sense of control, fast LH strategies, and depressive symptom. (2) After controlling for the effects of sex, age and socioeconomic status, EU still had a significant positive effect on depressive symptom. (3) Adolescent depressive symptom was partly influenced by EU through three different pathways: the mediating role of sense of control, the mediating role of fast LH strategies, and the chain-mediating role of both sense of control and fast LH strategies. (4) There are significant gender differences in the above chain mediation models. The analysis is cross-sectional, which limits causal inference. These findings contribute to a more comprehensive understanding of risk factors for adolescent depressive symptom. The chain-mediating effect of a sense of control and fast LH strategies plays an important role in the occurrence of depressive symptom. • Association between EU and depressive symptom was examined among Chinese adolescents. • Chain-mediating model was employed based on life history theory and the adaptive calibration model. • Depressive symptom was influenced by environmental unpredictability through three pathways. • Sense of control and fast LH strategies had a chain mediating effect on environmental unpredictability and depressive symptom. [ABSTRACT FROM AUTHOR]

Abstract Background Depressive symptom is the most common type of psychiatric co-morbidity among persons with epilepsy. Epilepsy patients are identified as at higher risk of suffering depressive symptom explicitly in low- and middle-income countries due to poor mental health care systems and financial burdens. The co-occurrence of depressive symptom among epilepsy patients deteriorates the prognosis of the disease and diminishes the quality of life of both the patients and their families. However, there is limited evidence on the prevalence of depressive symptom and associated factors in Ethiopia. Therefore, this study is intended to assess the prevalence of depressive symptom and associated factors among epilepsy patients attending in Amhara region, Ethiopia. Method A multi-center institution-based cross-sectional study was done among epilepsy patients attending at Amhara region, Ethiopia. The Hospital Anxiety Depression tool was used to assess depressive symptom. To determine the factors associated with depressive symptom, a binary logistic regression model was used. Adjusted Odds Ratio (AOR) with the 95% Confidence Interval (CI) was reported in the multivariable binary logistic regression analysis. Results About 406 participants were registered in the study with a response rate of 97.6%. The prevalence of depressive symptom among epilepsy patients was 53.9% [95%CI: 49.1%, 58.8%]. In the multivariable binary logistic regression analysis, taking polytherapy treatment [AOR = 1.87, 95% CI: 1.04, 3.36], perceived stigma [AOR = 5.73, 95%CI: 3.11, 10.55], poor antiepileptic medication adherence [AOR = 3.33, 95%CI: 1.30, 8.54] and having poor [AOR = 5.83, 95%CI: 2.44, 13.90] and moderate social support [AOR = 3.08, 95%CI: 1.34, 7.09] were significantly associated with depressive symptom. Conclusions This study revealed that the magnitude of depressive symptom among epilepsy patients in Ethiopia was relatively high and multiple factors determined the likelihood of depressive symptom. Thus, healthcare providers and concerned stakeholders should strengthen comprehensive health education to reduce the magnitude and consequences of depressive symptom among this segment of the population. Moreover, strong social support with special attention should be given to epilepsy patients.

Abstract Previous studies reported that depressive symptoms were associated with a high risk of all-cause mortality. However, the effect of different long-term depressive symptom trajectory patterns on the risk of all-cause mortality has not been evaluated. Our research aimed to explore the association between different depressive symptom trajectories and the risk of all-cause mortality in Chinese adults. The data we used were from the China Health and Retirement Longitudinal Study. In total, 13,624 subjects aged over 45 years were ultimately included in the analysis. Group-based trajectory modeling was used to identify the different trajectories of depressive symptoms. The multivariable Cox regression model was used to examine the association between long-term depressive symptom trajectories and all-cause mortality. The results show that a total of five depressive symptom trajectories were identified in our study, including stable-low, stable-moderate, increasing, decreasing and stable-high. Compared with individuals in the stable-low depressive symptom trajectories group, those in the increasing and stable-high trajectory groups possessed a greater mortality rate, with a multivariable-adjusted hazard ratio (95% CIs) for mortality were 1.30 (1.06, 1.60) and 1.59 (1.26, 2.02), respectively. In addition, we have not identified the significant risk of all-cause mortality in people with decreased and stable-moderate symptom trajectories. Moreover, the risk of all-cause mortality had an increasing trend among the different trajectory groups. In the sensitivity analysis, the association was robust in most of the subgroups. In conclusion, people with increasing and persistent higher depressive symptom trajectories were associated with an increased risk of all-cause mortality.

Abstract This study aimed to assess its relationship between physical activity with health-related indicators in older population of the China. Cross-sectional data of 1,327 individuals aged 60–79 years were analyzed. Based on the Fifth National Physical Fitness Monitoring Program, depressive symptom and loneliness were measured using the Patient Health Questionnaire-9 and Emotional versus Social Loneliness Scales, respectively. Sleep quality was evaluated through self-designed questionnaire and hypertension was defined as blood pressure > 140/90 mmHg. International Physical Activity Questionnaire-Long Form was conducted to assess the physical activity (minutes and frequency) in different domains (domestic, transport, work, and leisure). Multivariable-adjusted binary logistic regression models estimated for the prevalence of health-related indicators, considering PA level, duration, frequency, and combinations of different domains of PA. In the study, favorable associations were observed between moderate to high level PA and reductions in 4 health-related indicators, especially for active frequency. Moreover, a combination of transport, domestic, and leisure PA was found to be a general protective factor for health-related indicators. In summary, this study highlights the positive impact of PA on older adults’ health and provides valuable insights into the role of different PA patterns, offering a theoretical basis for developing PA guidelines, policies, and health interventions.

BackgroundDepression as a major mental health condition is commonly found in junior high school students. Peer attachment， emotional resilience and childhood abuse have been found to be associated with depressive symptoms， and it has been hypothesized that peer attachment and emotional resilience may play a chained effecting path in the relationship between childhood abuse and depressive symptoms in junior high school students.ObjectiveTo explore the relationship between childhood abuse and depressive symptom in junior high school students， analyze the effecting path of peer attachment and emotional resilience， thus to provide references for improving the mental health of junior high school students.MethodsFrom May to July 2022， a cluster sampling technique was utilized to recruit 1 781 junior high school students from a junior high school in Anhui province. Childhood Trauma Questionnaire Short Form （CTQ-SF）， Revised version of Inventory of Parent and Peer Attachment （IPPA-R）， Adolescent' Emotional Resilience Questionnaire （AERQ） and Center for Epidemiological Studies Depression Scale （CES-D） were used as the measurement tools. Pearson correlation coefficient was calculated to assess the correlation among above scales. Process4.2 and Bootstrapping method were employed to verify the effecting path of peer attachment and emotional resilience in the relationship between childhood abuse and depressive symptoms.ResultsCTQ-SF score was negatively correlated with IPPA-R peer attachment subscale score and AERQ score （r=-0.527， -0.495， P

Abstract Objectives This study aimed to examine the associations of arthritis with functional disability and depressive symptoms among general US adults. Additionally, it explored the relationship between radiographic knee osteoarthritis (assessed by X‐ray examination) and functional disability. Above findings seek to highlight the need for comprehensive physical and mental health management in individuals with arthritis. Methods We designed a cross‐sectional study utilizing multivariable logistic regression models to examine the associations. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were documented in a crude model and three adjusted models. Participants were from the National Health and Nutrition Examination Survey (NHANES) 1988–1994 and 1999–2018. Arthritis was self‐reported or graded by the Kellgren–Lawrence score after an objective X‐ray examination. Functional disability included disability in activities of daily living (ADL disability), instrumental activities of daily living (IADL disability), and mobility disability. Depressive symptom was assessed using the Patient Health Questionnaire (PHQ). Results We included 22,566 older adults (≥60 years; 10,961 had self‐reported arthritis) for functional disability analysis (2377 older adults with data on X‐ray examination; 1012 had radiographic knee osteoarthritis) and 32,056 adults (≥20 years; 9175 had self‐reported arthritis) for depressive symptom analysis. After controlling for all covariates, self‐reported arthritis was associated with ADL disability (odds ratios [OR]: 2.677; 95% confidence interval [CI]: 2.499–2.868), IADL disability (OR: 2.064; 95% CI: 1.940–2.196), and mobility disability (OR: 2.954; 95% CI: 2.778–3.142), and depressive symptom (OR: 2.177; 95% CI: 1.979–2.395). In participants with data on X‐ray examination, radiographic knee osteoarthritis was only associated with mobility disability (OR: 1.437; 95% CI: 1.183–1.744). Conclusions Self‐reported arthritis was associated with ADL disability, IADL disability and mobility disability, and depressive symptoms. Among participants with X‐ray data, radiographic knee osteoarthritis was only associated with mobility disability in general US adults. Appropriate managements of both physical and mental health are needed for individuals with arthritis.

BackgroundThe high-quality development of manufacturing in China has spurred industrial transformation and upgrading, placing higher demands on the skills of employees in the electronic manufacturing industry. This situation may induce psychological health problems such as job burnout and depressive symptoms in the employees, and also lead to insomnia, which has become a public health problem that urgently needs attention and solution. ObjectiveTo investigate the relationship between job burnout, depressive symptoms, and insomnia among employees in the electronic manufacturing industry. MethodsA total of 3034 employees from four electronic manufacturing companies in Beijing City, Shanghai City, and Guangdong Province were selected using judgment sampling from September to November 2019. The Maslach Burnout Inventory-General Survey, Patient Health Questionnaire-9, and Self-Administered Sleep Questionnaire were used to collect data. The correlation between job burnout, depressive symptoms, and insomnia was evaluated by hierarchical regression. ResultsA total of 3034 survey questionnaires were distributed, and 2614 valid questionnaires were collected, with a response effectiveness rate of 86.2%. The reporting rates of job burnout, depressive symptoms, and insomnia among employees in the electronic manufacturing industry were 47.2%, 19.5%, and 29.1%, respectively. The reporting rates of insomnia of employees in the job burnout group and depressive symptoms group were higher than those in the non-job burnout group and non-depressive symptoms group (35.3% vs. 23.6%, 47.2% vs. 24.7%, P＜0.001). The results of hierarchical regression showed that job burnout explained 2.8% of the variation of insomnia (P

Abstract Based on Chinese Students’ Fitness Health Examination, this study sought to investigate the relationships between depressive symptoms and family environment, physical activity, dietary habits, sleep and sedentary behavior among children and adolescents. A cross-sectional study was carried out to estimate the prevalence of depressive symptoms in 32,389 participants (grades 4-12) using the CES-D. Logistic regression was used to evaluate the relationships between lifestyle determinants and depressive symptoms, and a random forest model was used to rank the importance of those determinants. The overall prevalence of depressive symptoms was 39.93%. Students with depressive symptoms had higher grades, lower parental educational levels and unhealthy lifestyles (P

BackgroundMetacognition， the capacity to monitor and control one's cognitive processes， has been identified as a crucial component of effective decision-making and behavioral adaptation. Previous research has revealed cognitive deficits in patients with major depressive disorder （MDD）， while findings about metacognitive capacities in patients with MDD have been inconsistent across studies， and the exact relationship between metacognitive capacities and clinical symptoms in MDD patients remains uncertain.ObjectiveTo examine the metacognitive capacities of adolescent hospitalized patients with MDD and to explore its relationship with depressive and anxiety symptoms， thus providing an unprecedented insight into the prevention of MDD.MethodsA coherent 56 adolescent hospitalized patients with MDD in the Psychiatry Department at the Affiliated Hospital of Southwest Medical University from March 2022 to June 2023 and met the diagnostic criteria for depression as defined by the Diagnostic and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） were enrolled as MDD group. At the same time， 62 healthy individuals matched with the age and sex of the MDD group residing in Luzhou were concurrently selected as control group. The metacognitive ability of the two groups was evaluated by perceptual decision-making task and confidence rating task， and the indicators included confidence deviation， reaction time of confidence evaluation and metacognitive efficiency. Additionally， the severity of depressive and anxiety symptoms was measured with Beck Depression Inventory （BDI） and Beck Anxiety Inventory （BAI）. Pearson correlation analysis was utilized to examine the relationship between metacognitive capacities and clinical symptoms.ResultsMDD group scored higher on BDI and BAI when compared with control group （t=-13.722， -9.674， P0.05）. In terms of metacognitive performance， MDD group reported a reduction in overall confidence， confidence in correct decisions， confidence in incorrect decisions and metacognitive efficiency compared with control group （t=3.044， 2.769， 2.836， 3.667， P0.05）. Furthermore， metacognitive efficiency in MDD patients exhibited negative correlation with both BDI and BAI scores （r=-0.269， -0.290， P

Abstract Background The exact mechanisms underlying depression are not well understood. Chronic, low-grade inflammation is believed to play an important role in its development. The present study investigates the potential association between depressive symptoms and the neutrophil-to-lymphocyte ratio (NLR). Methods Seven data cycles of the National Health and Nutrition Examination Survey were extracted. Multivariable logistic regression and a generalized additive model were employed to determine the association. Results Thirty thousand eight hundred ninety-six subjects were analyzed. The results indicated that anhedonia and fatigue were significantly associated with NLR. Additionally, the generalized additive model results indicated a non-linear relationship between anhedonia, sleep disturbance and NLR. Subgroup analyses demonstrated that the correlation between anhedonia and NLR was significant in the above-60-year-old group (OR: 1.63, 95% CI: 1.14–2.33) and the male group (OR: 1.50, 95% CI: 1.07–2.10). Sleep disturbance was associated with NLR in the female group (OR: 1.36, 95% CI: 1.04–1.77). Fatigue was associated with NLR (OR: 1.30, 95% CI: 1.02–1.67) in the female group, as was the case in the non-Hispanic White group (OR: 1.32, 95% CI: 1.02–1.70). Conclusions There were associations between NLR and specific symptoms, and these associations varied across demographic subgroups. There was a non-linear association between anhedonia, sleep disturbance and NLR. These findings could potentially contribute to the advancement of precision medicine within the field of mental health.

Abstract Background The unprecedented pandemic situation of COVID-19 has had a negative impact on the mental health of many people, especially among the "old-old" older adults who are aged 75 or older. Therefore, the aim of this study is to investigate the changes in depression among "old-old" older adults before and after the onset of COVID-19, and the extent to which depression affects suicidal ideations. Method The 12th to 16th Korea Welfare Panel Study(KoWePS) conducted from 2017 to 2021 was used for analysis. For this study, 771 older individuals with complete data to estimate the degree of change of depression were selected as the final analysis subjects. Result A Growth Mixture Modeling(GMM) analysis was conducted, resulting in the classification of two groups: an increasing group and a decreasing group. The study findings showed that "old-old" older individuals with high levels of depression, specifically those in the decreasing group, may be more susceptible to suicidal ideation. Despite this steep change slope, the decreasing group still exhibited a higher level of depression in 2021 compared to the increasing group. As per characteristics, the decreasing group, which showed a higher prevalence of suicidal ideation, had a higher proportion of women and individuals with lower levels of education, those living alone, and a lower household income compared to the increasing group. Conclusion It is important to note that although the study emphasized the need to prioritize intervention for the decreasing group with consistently high levels of depression, the majority of individuals belong to the increasing group, which exhibited a gradual increase in depression levels over time. Therefore, intervention plans should be developed concurrently for both groups. Also, it is crucial to implement proactive efforts targeting groups with understandings of these characteristics when establishing preventative measures for depression and suicidal ideation among "old-old" older adults.

Abstract Aims Depressive symptoms are comorbid with coronary heart disease (CHD). There is a controversial debate about whether screening and intervention for depressive symptoms could improve cardiovascular prognosis. This study characterizes the prevalence, characteristics, cardiovascular prognosis and management need of depressive symptoms among CHD patients. Methods CHD patients were recruited between November 18, 2020 and November 26, 2021. Depressive symptoms were evaluated with the Patient Health Questionnaire (PHQ-9). During the 12-month follow-up, cardiovascular disease (CVD) was the endpoint. Time-to-event data were estimated by Kaplan-Meier curves and Cox models. Results Of 582 patients (25% women), 21.0% had mild depressive symptoms, and 7.5% had moderate-to-severe depressive symptoms during hospitalization. Mild and moderate-to-severe depressive symptoms were risk factor-adjusted predictors of the primary composite endpoints (adjusted HR = 2.20; 95%CI 1.19–4.03, and adjusted HR = 2.70; 95%CI 1.23–5.59, respectively). Platelet count and low-density lipoprotein were higher in mild depressive symptoms compared to no depressive symptoms. Conclusion Depressive symptoms are prevalent in CHD patients. Mild and moderate-to-severe depressive symptoms are associated with higher risk of further CVD in CHD patients. Platelet function and behavioral mechanisms may contribute to this association. Trial registration This research was registered at https://www.chictr.org.cn . Full data of first registration is 11/09/2020. The registration number is ChiCTR2000038139.

Abstract Background Taiwan became an aged society in March 2018, and it is expected to become a super-aged society by 2025. The trend of increasing proportions of older adults continuing to work is inevitable. However, few studies have been conducted to investigate the effects of employment on the mental health of older adults. Therefore, we longitudinally explored the relationship between employment status and depressive symptoms in Taiwanese older adults. Methods The study included 5,131 individuals aged 50 and above, of which 55.6% were men, who had participated in the national-wide Taiwan Longitudinal Study of Aging in 1996, 1999, 2003, and 2007. Of them, 1,091 older adults had completed all four surveys. Depressive symptoms were assessed using the Center for Epidemiological Studies of Depression scale; the total score on this scale ranges from 0 to 30. Employment status was assessed during each survey wave. Logistic regression was performed using a cross-sectional design. The effects of unemployment on depressive symptoms were analyzed using a generalized estimating equation model with a repeated measures design. Results In each survey wave, employed older adults exhibited better mental health than did unemployed ones. After adjustments for potential confounders, unemployment was found to exert a significant adverse effect on depressive symptoms. The repeated measures analysis revealed that employment protected against depressive symptoms, as noted in the subsequent surveys conducted after 3 to 4 years (aOR [95% CI] = 0.679 [0.465–0.989]). Conclusion Employment may reduce the risk of depressive symptoms in community-dwelling older adults in Taiwan.

Abstract Background Separating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects. Methods Residential mobility consisted of the number and total distance of moves before age 17. Based on 3071 twins from the FinnTwin12 cohort, we used linear regression to assess the association of age at separation and residential mobility with General Behavior Inventory (GBI) scores at age 17 and in young adulthood. A higher GBI score indicated more depressive symptoms occurred. Then, the mixed model for repeated measures (MMRM) was used to visualize the scores’ trajectory and test the associations, controlling for "baseline" state. Twin analyses with a bivariate cross-lagged path model were performed between the difference in GBI scores, between cotwins, and separation status for the potential genetic influence. Results Compared to twins separated before age 17, twins who separated later had significantly lower GBI scores at age 17 and in young adulthood. In MMRM, separation at a later age and a higher number of moves were associated with a higher GBI score in young adulthood. A small genetic effect was detected wherein GBI within-pair differences at age 17 were associated with separation status before age 22 (coefficient: 0.01). Conclusion The study provides valid evidence about the influence of siblings and family on depressive symptoms in later adolescence and young adulthood while finding some evidence for a reverse direction effect. This suggests more caution in the interpretation of results. A strong association between residential mobility and depressive symptoms was affirmed, although further detailed research is needed.

Background: The exact mechanisms underlying depression are not well understood. Chronic, low-grade inflammation is believed to play an important role in its development. The present study investigates the potential association between depressive symptoms and the neutrophil-to-lymphocyte ratio (NLR). Methods: Seven data cycles of the National Health and Nutrition Examination Survey were extracted. Multivariable logistic regression and a generalized additive model were employed to determine the association. Results: Thirty thousand eight hundred ninety-six subjects were analyzed. The results indicated that anhedonia and fatigue were significantly associated with NLR. Additionally, the generalized additive model results indicated a non-linear relationship between anhedonia, sleep disturbance and NLR. Subgroup analyses demonstrated that the correlation between anhedonia and NLR was significant in the above-60-year-old group (OR: 1.63, 95% CI: 1.14–2.33) and the male group (OR: 1.50, 95% CI: 1.07–2.10). Sleep disturbance was associated with NLR in the female group (OR: 1.36, 95% CI: 1.04–1.77). Fatigue was associated with NLR (OR: 1.30, 95% CI: 1.02–1.67) in the female group, as was the case in the non-Hispanic White group (OR: 1.32, 95% CI: 1.02–1.70). Conclusions: There were associations between NLR and specific symptoms, and these associations varied across demographic subgroups. There was a non-linear association between anhedonia, sleep disturbance and NLR. These findings could potentially contribute to the advancement of precision medicine within the field of mental health. [ABSTRACT FROM AUTHOR]

Background: The unprecedented pandemic situation of COVID-19 has had a negative impact on the mental health of many people, especially among the "old-old" older adults who are aged 75 or older. Therefore, the aim of this study is to investigate the changes in depression among "old-old" older adults before and after the onset of COVID-19, and the extent to which depression affects suicidal ideations. Method: The 12th to 16th Korea Welfare Panel Study(KoWePS) conducted from 2017 to 2021 was used for analysis. For this study, 771 older individuals with complete data to estimate the degree of change of depression were selected as the final analysis subjects. Result: A Growth Mixture Modeling(GMM) analysis was conducted, resulting in the classification of two groups: an increasing group and a decreasing group. The study findings showed that "old-old" older individuals with high levels of depression, specifically those in the decreasing group, may be more susceptible to suicidal ideation. Despite this steep change slope, the decreasing group still exhibited a higher level of depression in 2021 compared to the increasing group. As per characteristics, the decreasing group, which showed a higher prevalence of suicidal ideation, had a higher proportion of women and individuals with lower levels of education, those living alone, and a lower household income compared to the increasing group. Conclusion: It is important to note that although the study emphasized the need to prioritize intervention for the decreasing group with consistently high levels of depression, the majority of individuals belong to the increasing group, which exhibited a gradual increase in depression levels over time. Therefore, intervention plans should be developed concurrently for both groups. Also, it is crucial to implement proactive efforts targeting groups with understandings of these characteristics when establishing preventative measures for depression and suicidal ideation among "old-old" older adults. [ABSTRACT FROM AUTHOR]

The link between activity (physical, social and cognitive) and cognitive functioning (CF) is complex; theoretical evidence indicated that it was mediated by depressive symptomology. The current study intended to elucidate how depressive symptomology mediates between different dimensions of activity and cognitive functioning by taking into account negative emotionality (i.e., personality variable) as a covariate. This study recruited 350 community-dwelling older adults in Rawalpindi, Pakistan through a purposive sampling technique. Cognitive functioning was measured by Montreal Cognitive Assessment (MoCA), Baecke Physical Activity Questionnaire (BPAQ) assessed physical activity, social activity was examined using Lubben's Social Network Scale (LSNS-6), Late Life Cognitive Activity (LLCA) measure was used to assess cognitive activity, negative emotionality was assessed using Negative Emotional Scale from Short form of Big Five Inventory and depressive symptomology was measured using Geriatric Depression Scale (GDS). Hayes process model 4 was utilized to test the mediation effects in this correlational study. Physical activity (r =.454, p <.01), social activity (r =.586, p <.01) and cognitive activity r =.632, p <.01) have significant positive associations whereas negative emotionality (r = −.609, p <.01) and depressive symptoms (r = −.733, p <.001) have significant negative associations with cognitive functioning. Moreover, depressive symptoms partially mediated the relationship between social activity and cognitive functioning (β in direct model = 0.322, p <.001; β in full mediational model = 0.078, p =.003) and for cognitive activity and cognitive functioning (β in direct model = 0.324, p <.001; β in full mediational model = 0.161, p <.001) but fail to mediate between physical activity and cognitive functioning after controlling for the effects of negative emotionality. Altogether, this study's findings suggest that different domains of activity exert significant effects on depressive symptomology and cognitive functioning in the aging population. Understanding these results can help to optimize activity (physical, social, and cognitive) interventions to improve cognitive aging and minimize depressive symptomology. [ABSTRACT FROM AUTHOR]

Major depressive disorder (MDD) is a serious and disabling condition characterized by abnormal mood changes. Clinical guidelines for depression treatment recommend antidepressant medications, with benzodiazepines acting as short-term synergists. However, little is currently known about the prevalence and associated clinical risk factors of benzodiazepine use among Chinese patients with MDD. This study aimed to explore the prevalence and clinical risk factors associated with benzodiazepine use in this population. A total of 2742 patients with MDD (males/females = 816/1926, aged 14–60 years) participated in this cross-sectional observational study. General information and psychosis assessments were collected online. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), anxiety symptoms using the Generalized Anxiety Disorder-7 (GAD-7), and sleep problems and suicidal tendencies using the third and ninth items of the PHQ-9. Multivariable logistic regression analysis models were employed to identify factors associated with benzodiazepine use. The prevalence of benzodiazepine use among patients with MDD was 42.9 %. Among these patients, 99.6 % used a single benzodiazepine, with oxazepam being the most frequently prescribed. Age, severity of sleep problems, depressive symptoms, and anxiety symptoms were significantly correlated with benzodiazepine use (all P < 0.001). The cross-sectional design of this study precludes establishing causal relationships. Our findings indicate a high prevalence of benzodiazepine use among Chinese patients with MDD. Factors such as severe depressive symptoms, anxiety symptoms, age, and sleep problems appear to be associated with benzodiazepine use. These results underscore the importance of vigilance regarding benzodiazepine use in patients with MDD. • Prevalence of benzodiazepine use in patients with MDD in China is notably high. • Age is significantly associated with increased risks of benzodiazepine use. • Anxiety, depressive symptoms or sleep problem contribute to the use of benzodiazepine. [ABSTRACT FROM AUTHOR]

This study aimed to verify the relationship between parental abuse, ego-resilience, social stigma, career barriers, and depressive symptoms among out-of-school youths. The data of 522 adolescents (mean age = 18.01 years) from the Dropout Youth Panel Survey conducted by the National Youth Policy Institute were used. A hierarchical multiple regression analysis indicated that female adolescents reported more depressive symptoms than male adolescents. The family economic status and ego-resilience were negatively related to depressive symptoms. Parental abuse was positively associated with depressive symptoms. In particular, social stigma and career barriers were positively related to depressive symptoms. Notably, social stigma and career barriers explained 17.7% of the variance in depressive symptoms. The results of this study suggest that society needs to reduce the social stigma and career barriers perceived by out-of-school youth. Professional counselors and social workers could help these individuals by providing them information and advice for their careers and reducing perceived social stigma. [ABSTRACT FROM AUTHOR]

Aims: Depressive symptoms are comorbid with coronary heart disease (CHD). There is a controversial debate about whether screening and intervention for depressive symptoms could improve cardiovascular prognosis. This study characterizes the prevalence, characteristics, cardiovascular prognosis and management need of depressive symptoms among CHD patients. Methods: CHD patients were recruited between November 18, 2020 and November 26, 2021. Depressive symptoms were evaluated with the Patient Health Questionnaire (PHQ-9). During the 12-month follow-up, cardiovascular disease (CVD) was the endpoint. Time-to-event data were estimated by Kaplan-Meier curves and Cox models. Results: Of 582 patients (25% women), 21.0% had mild depressive symptoms, and 7.5% had moderate-to-severe depressive symptoms during hospitalization. Mild and moderate-to-severe depressive symptoms were risk factor-adjusted predictors of the primary composite endpoints (adjusted HR = 2.20; 95%CI 1.19–4.03, and adjusted HR = 2.70; 95%CI 1.23–5.59, respectively). Platelet count and low-density lipoprotein were higher in mild depressive symptoms compared to no depressive symptoms. Conclusion: Depressive symptoms are prevalent in CHD patients. Mild and moderate-to-severe depressive symptoms are associated with higher risk of further CVD in CHD patients. Platelet function and behavioral mechanisms may contribute to this association. Trial registration: This research was registered at https://www.chictr.org.cn. Full data of first registration is 11/09/2020. The registration number is ChiCTR2000038139. [ABSTRACT FROM AUTHOR]

Background Metacognition, the capacity to monitor and control one's cognitive processes, has been identified as a crucial component of effective decision-making and behavioral adaptation. Previous research has revealed cognitive deficits in patients with major depressive disorder (MDD), while findings about metacognitive capacities in patients with MDD have been inconsistent across studies, and the exact relationship between metacognitive capacities and clinical symptoms in MDD patients remains uncertain. Objective To examine the metacognitive capacities of adolescent hospitalized patients with MDD and to explore its relationship with depressive and anxiety symptoms, thus providing an unprecedented insight into the prevention of MDD. Methods A coherent 56 adolescent hospitalized patients with MDD in the Psychiatry Department at the Affiliated Hospital of Southwest Medical University from March 2022 to June 2023 and met the diagnostic criteria for depression as defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) were enrolled as MDD group. At the same time, 62 healthy individuals matched with the age and sex of the MDD group residing in Luzhou were concurrently selected as control group. The metacognitive ability of the two groups was evaluated by perceptual decision-making task and confidence rating task, and the indicators included confidence deviation, reaction time of confidence evaluation and metacognitive efficiency. Additionally, the severity of depressive and anxiety symptoms was measured with Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) . Pearson correlation analysis was utilized to examine the relationship between metacognitive capacities and clinical symptoms. Results MDD group scored higher on BDI and BAI when compared with control group (t=-13. 722, -9. 674, P<0. 01). In terms of decision-making performance, no statistically significant difference was noted in accuracy and response time between two groups (t =-0. 655, 0. 975, P>0. 05). In terms of metacognitive performance, MDD group reported a reduction in overall confidence, confidence in correct decisions, confidence in incorrect decisions and metacognitive efficiency compared with control group (t= 3. 044, 2. 769, 2. 836, 3. 667, P<0. 01). MDD group demonstrated significantly longer confidence evaluation response time than that of control group (t=-2. 561, P<0. 05). Correlation analysis revealed that among the MDD patients, overall confidence, confidence in correct decisions and confidence in incorrect decisions were negatively correlated with BDI score (r=-0. 310, -0. 307, -0. 298, P<0. 05), and the overall confidence and confidence in correct decisions were negatively correlated with BAI score (r=-0. 284, -0. 280, P<0. 05), while no statistical significance existed in the correlation between confidence in incorrect decisions and BAI score (r=-0. 229, P>0. 05). Furthermore, metacognitive efficiency in MDD patients exhibited negative correlation with both BDI and BAI scores (r=-0. 269, -0. 290, P<0. 05). Conclusion Hospitalized adolescent patients with MDD have impaired metacognition, and metacognitive capacity is found to be associated with severity of depressive and anxiety symptoms. [ABSTRACT FROM AUTHOR]

Introduction: The prevalence of depression among blind people is higher than in sighted populations. The purpose of this study was to investigate the associations between time-related characteristics of visual impairment (i.e., onset and duration), as well as depressive symptoms, fatigue, sleepiness, and stress, in the context of self-reported total blindness and the inability to perceive light exposure. Methods: This study employed a cross-sectional design utilizing the combination of online survey and telephone survey. The Centre for Epidemiological Studies–Depression Inventory, the Fatigue Syndrome Inventory, the Epworth Sleepiness Scale, and the Perceived Stress Scale were selected for the self-reported questionnaires. For statistical analysis, independent t -tests, analysis of variance tests, Wilcoxon–Mann–Whitney tests, chi-square tests, multiple linear regression models, and multivariable ordinal logistic regressions were conducted using the R software program and its required packages. Results: A total of 154 respondents completed the online and telephone surveys. Although the number of years of experiencing blindness showed negative correlations with the scores of fatigue (r = −.16, p <.05), stress (r = −.18, p <.05), and depressive feelings (r = −.21, p <.05) in Model 1, the impacts of the onset of blindness on the depressive symptoms (β = −.02, p =.570) and the presence of severe depressive symptoms, OR = 1.42, 95% CI [0.49, 4.19], p =.518, were insignificant in Model 2. Discussion: Blindness seems to be regarded as a more severe chronic condition which affects individuals' psychological status. Given the effects of the limited range of social activities and daily tasks and the dramatically reduced accessible visual information inputs, the severe depressive symptoms in this group can be understood. Implications for Practitioners: Regular counseling and psychological services monitoring depressive symptoms, chronic fatigue, and severe distress should be continued even after the completion of rehabilitation programs. [ABSTRACT FROM AUTHOR]

Background: Loneliness, anxiety and depressive symptoms are common among older residents in long‐term care facilities (LTCFs), which can negatively impact their quality of life and increase mortality rates. Addressing these psychological health issues is an important task for nursing staff. There is a need for easy and accessible interventions to improve older residents' negative emotions. Tactile massage (TM) is a form of touch therapy that induces oxytocin, which can help individuals feel relaxed, experience pleasure and reduce anxiety. TM can also provide a sense of security and care for individuals. Objective: This study aimed to evaluate the effects of TM in improving older residents' psychological health in LTCFs. Design: In this study, we applied a two‐arm randomised controlled trial research design. Methods: We used convenience sampling to enrol 55 older residents in three long‐term care facilities who were randomly assigned to an intervention group and a comparison group. The intervention group received TM by research assistants on both hands for 15 min per time, twice a week for 4 weeks and the comparison group received regular care. Data were collected before and after the intervention. Generalised estimating equations (GEEs) were used to evaluate the effectiveness of the intervention. Results: There were no significant differences in loneliness, anxiety, depressive symptoms, happiness, ear temperature, heart rate or diastolic blood pressure between the two groups after the intervention. However, the intervention group had significant improvements in comfort (B = 0.86, p < 0.001), relaxation (B = 1.00, p < 0.001), respiratory rate (B = −0.16, p = 0.021) and systolic blood pressure (B = − 4.17, p = 0.002) compared to the control group. Conclusions: TM can help older residents who live in LTCFs feel relaxed and comfortable. Implications for Practice: TM can be easily implemented as it requires no tools. We recommend that nursing staff and healthcare professionals incorporate TM as part of their care routines. They also can encourage family members to perform TM on residents during their visits to enhance residents' comfort and relaxation. Reporting Method: The Consolidated Standards of Reporting Trials (CONSORT) checklist was used for this paper. Trial Registration: ClinicalTrials.gov (NCT05052138) [ABSTRACT FROM AUTHOR]

Background: Separating with close siblings and leaving the parental home at an early age represents a major life event for an adolescent (reflected by age at separation in a twin pair) and may predispose them to poor mental health. This study aims to examine the association of age at separation and residential mobility on depressive symptoms in late adolescence and young adulthood and to explore possible underlying genetic effects. Methods: Residential mobility consisted of the number and total distance of moves before age 17. Based on 3071 twins from the FinnTwin12 cohort, we used linear regression to assess the association of age at separation and residential mobility with General Behavior Inventory (GBI) scores at age 17 and in young adulthood. A higher GBI score indicated more depressive symptoms occurred. Then, the mixed model for repeated measures (MMRM) was used to visualize the scores' trajectory and test the associations, controlling for "baseline" state. Twin analyses with a bivariate cross-lagged path model were performed between the difference in GBI scores, between cotwins, and separation status for the potential genetic influence. Results: Compared to twins separated before age 17, twins who separated later had significantly lower GBI scores at age 17 and in young adulthood. In MMRM, separation at a later age and a higher number of moves were associated with a higher GBI score in young adulthood. A small genetic effect was detected wherein GBI within-pair differences at age 17 were associated with separation status before age 22 (coefficient: 0.01). Conclusion: The study provides valid evidence about the influence of siblings and family on depressive symptoms in later adolescence and young adulthood while finding some evidence for a reverse direction effect. This suggests more caution in the interpretation of results. A strong association between residential mobility and depressive symptoms was affirmed, although further detailed research is needed. [ABSTRACT FROM AUTHOR]

Background: Taiwan became an aged society in March 2018, and it is expected to become a super-aged society by 2025. The trend of increasing proportions of older adults continuing to work is inevitable. However, few studies have been conducted to investigate the effects of employment on the mental health of older adults. Therefore, we longitudinally explored the relationship between employment status and depressive symptoms in Taiwanese older adults. Methods: The study included 5,131 individuals aged 50 and above, of which 55.6% were men, who had participated in the national-wide Taiwan Longitudinal Study of Aging in 1996, 1999, 2003, and 2007. Of them, 1,091 older adults had completed all four surveys. Depressive symptoms were assessed using the Center for Epidemiological Studies of Depression scale; the total score on this scale ranges from 0 to 30. Employment status was assessed during each survey wave. Logistic regression was performed using a cross-sectional design. The effects of unemployment on depressive symptoms were analyzed using a generalized estimating equation model with a repeated measures design. Results: In each survey wave, employed older adults exhibited better mental health than did unemployed ones. After adjustments for potential confounders, unemployment was found to exert a significant adverse effect on depressive symptoms. The repeated measures analysis revealed that employment protected against depressive symptoms, as noted in the subsequent surveys conducted after 3 to 4 years (aOR [95% CI] = 0.679 [0.465–0.989]). Conclusion: Employment may reduce the risk of depressive symptoms in community-dwelling older adults in Taiwan. [ABSTRACT FROM AUTHOR]

Background: Infertility constitutes a leading reproductive health problem with profound psychosocial outcomes, including elevated depressive symptoms that compromise quality of life (QoL). While the literature has suggested social support as a protective psychological mechanism, its role in depressive symptoms and QoL among women with infertility remains underexplored. This study aimed to examine the moderating effect of perceived social support on the relationship between depressive symptoms and QoL among South Korean women experiencing infertility. Methods: Utilizing a cross-sectional design, this study analyzed a secondary dataset comprising 186 South Korean women with infertility. Participants were asked to complete the online survey which included the following scales: The Korean adaptation of the Patient Health Questionnaire-9 (PHQ-9), the Multidimensional Scale of Perceived Social Support (MSPSS), and the Fertility Quality of Life (FertiQoL) tool. Moderation analysis was conducted using Hayes' PROCESS Macro 4.1 Model 1. Statistically significant effects were identified if the confidence intervals did not include zero. Depression acted as the predictor, social support as the moderator, and QoL as the dependent variable. Results: Depressive symptoms exhibited a moderate negative relationship with fertility QoL (r = −.41, p

IntroductionThis study examines the association between Meat, Egg, and Dairy (MED) product consumption and depressive symptoms among older adults in China, focusing on rural/urban and gender differences.MethodsThis study employed data from the latest wave (year 2018) of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), and Ordinary Least Squares (OLS) models were applied to examine the association between MED consumption and depression levels.FindingsThe findings revealed a consistent negative relationship between MED consumption and depression, with higher MED intake associated with lower depression levels. Urban residents and males exhibited higher MED consumption, which correlated with less depressive symptoms. However, the impact of MED consumption on depression varied by subgroups; urban older adults benefited more from MED consumption than their rural counterparts, and the relationship between MED intake and depression was more pronounced in males than in females. The study highlighted the influence of socio-demographic factors, such as literacy, income, and self-rated health, on depression levels.DiscussionThe results suggested that MED consumption may offer protective effects on mental health in older adults, although the association may not be causal. The study underscored the need for further research to explore the complex interplay between diet and mental health in older adults, particularly in diverse cultural contexts.

BackgroundWhile the association between depressive symptoms and deliberate self-harm in adolescence is extensively documented, the nature, bi-directionality, and longitudinal dynamics of this relationship remain underexplored. This study aims to investigate the causal and reciprocal relationship between depressive symptoms and deliberate self-harm among rural adolescents in western China.MethodsA 2-year panel study was conducted among 1,840 adolescents aged 10–18 attending rural junior and senior high schools in Sichuan Province, China. The Center for Epidemiologic Studies-Depression Scale (CES-D) and a global measure of self-reported deliberate self-harm were utilized to examine the relationship between depressive symptoms and deliberate self-harm using both classic and random intercept cross-lagged panel models. Multi-group comparisons were carried out for the gender, pubertal stage, and academic performance subgroups.ResultsPositive and statistically significant correlations were found between depressive symptoms and deliberate self-harm both within and across the three waves of the panel survey, after adjusting for covariates, among rural adolescents in western China (Range: 0.05–0.28, p

ObjectiveThis study examines the mediating role of cognitive flexibility in the relationship between home-school co-education (H-SCE) and depressive symptom among vocational college students in urban and rural areas of China.MethodsUtilizing the Theory of Overlapping Spheres of Influence, this research explores how H-SCE influences depressive symptom, considering cognitive flexibility as a key mediating factor. The study utilized established scales, including the Inventory of Parent and Peer Attachment (IPPA) for parent-child relationships, the Student-Teacher Relationship Scale (STRS), the Cognitive Flexibility Inventory (CFI), and the Center for Epidemiologic Studies Depression Scale (CES-D10).ResultsA total of 1090 valid questionnaires were analyzed, revealing a significant negative correlation between H-SCE and depressive symptom. Cognitive flexibility was found to partially mediate this relationship, suggesting that enhanced cognitive adaptability, fostered through effective H-SCE, can reduce depressive symptom by helping students better cope with stressors.ConclusionThese findings underscore the importance of fostering strong collaboration between families and schools to enhance cognitive resilience and mitigate psychological challenges faced by vocational students, providing a foundation for targeted interventions to promote mental well-being.

Abstract Objective Self-rated health (SRH) has been documented as an important predictor of quality of life among the elderly and its risk factors are vision-specific among elderly males. The aim of this study was to clarify vision-specific risk factors to SRH among elderly females without dementia in Chinese urban areas. Methods From March to November 2012, 2147 elderly women in Liaoning Province of China were selected using a stratified sampling method. After cognitive screening, 1956 participants without dementia were finally enrolled. A questionnaire including SRH, visual ability and factors including demographic characteristics, physical conditions, lifestyle factors, social psychological status and social activities were analyzed. Multivariate logistic regression was used to clarify the association of SRH with risk factors, while stepwise multivariate logistic regression was used to examine the vision-specific associations with SRH. Results The mean age was 73.6 ± 5.82 (mean ± SD). The percentages of good SRH in good and impaired visual ability groups were 36.2% and 24.4%, respectively. Most characteristics between elderly females with different visual abilities were significantly different. Visual ability had interactions with physical conditions, lifestyle factors and social activities to affect SRH. Among elderly females with good visual ability, depressive symptoms, rather than chronic disease had the strongest association with good SRH followed by marital status, regular diet, going out alone to distant places, taking a walk, smoking and alcohol consumption. In the impaired visual ability group, going out alone to distant places had the strongest association with good SRH followed by chronic disease, filial piety, taking a walk, participating in entertainment, ethnicity, quality of sleep, worrying about falling and alcohol consumption. Conclusions Good SRH status was at a low level especially among elderly females with impaired visual ability and the risk factors differed between elderly females with different visual abilities. Social psychological status was crucial for SRH among elderly females with good visual ability whereas physical conditions were prominent for impaired visual ability group.

Aerobic exercise has been shown to have established benefits on motor function in Parkinson's disease (PD). However, the impact of exercise on depressive symptoms in PD remains unclear. This study aimed to investigate the effects of regular exercise, specifically using a forced running wheel, on both motor performance and the prevalence of depression in a unilateral 6-OHDA-lesioned rat model of PD. The behavioral outcomes of exercise were assessed through the rotarod test (RT), forelimb adjusting step test (FAST), sucrose consumption test (SCT), and novelty sucrose splash test (NSST). Our data revealed evident depressive symptoms in the PD animals, characterized by reduced sucrose consumption in the SCT and diminished exploratory activity in the NSST compared to the naïve control group. Specifically, after 11 weeks of exercise, the PD exercise group demonstrated the most significant improvements in sucrose consumption in the SCT. Additionally, this group exhibited reduced immobility and increased exploratory behavior compared to the PD control group in the NSST. Furthermore, the PD exercise group displayed the greatest improvement in correcting forelimb stepping bias. Our results suggested that a regimen of running wheel exercise enhances motor abilities and mitigates the occurrence of depressive behaviors caused by 6-OHDA dopamine depletion in the PD rat model.