1. Within-subject Consistency of Paired Associative Stimulation as Assessed by Linear Mixed Models
- Author
-
Jhm Tulen, de Wit My, Kushner Sa, Castricum J, Nicole S. Erler, Ype Elgersma, der Vaart Tv, Fani L, Ottenhoff Mj, Obdam If, Neurosciences, Epidemiology, Psychiatry, and Neurology
- Subjects
Paired associative stimulation ,medicine.medical_specialty ,SDG 3 - Good Health and Well-being ,business.industry ,Consistency (statistics) ,Within person ,Healthy volunteers ,Medicine ,Audiology ,business ,Generalized linear mixed model - Abstract
Paired associative stimulation (PAS) is a frequently used TMS paradigm that induces long-term potentiation in the human cortex. However, little is known about the within-subject consistency of PAS-induced effects. We determined PAS-induced effects and their consistency in healthy volunteers between two PAS sessions. Additionally, we assessed the benefit of applying linear mixed models (LMMs) to PAS data. Thirty-eight healthy volunteers underwent two identical PAS sessions with a >1 week interval. During each session, motor evoked potentials (MEPs) were assessed once before PAS induction and 3 times after at 30 min intervals. We did not detect any significant potentiation of MEP size after PAS induction. However, MEP size during PAS induction showed significant potentiation over time in both sessions (LR(1)=13.36, p
- Published
- 2018