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The import of hydrogen and derivatives forms part of many national strategies and is fundamental to achieving climate protection targets. This paper provides an overview and technical comparison of import pathways for hydrogen and derivatives in terms of efficiency, technological maturity and development and construction times with a focus on the period up to 2030. The import of hydrogen via pipeline has the highest system efficiency at 57–67 % and the highest technological maturity with a technology readiness level (TRL) of 8–9. The import of ammonia and methanol via ship and of SNG via pipeline shows efficiencies in the range of 39–64 % and a technological maturity of TRL 7 to 9 when using point sources. Liquid hydrogen, LOHC and Fischer-Tropsch products have the lowest efficiency and TRL in comparison. The use of direct air capture (DAC) reduces efficiency and TRL considerably. Reconversion of the derivatives to hydrogen is also associated with high losses and is not achievable for all technologies on an industrial scale up to 2030. In the short to medium term, import routes for derivatives that can utilise existing infrastructures and mature technologies are the most promising for imports. In the long term, the most promising option is hydrogen via pipelines. [Display omitted] • Comparison of 19 import routes for hydrogen and its derivatives. • Comparative overview of technical key performance indicators such as efficiencies, technology readiness level and time constraints of each pathway. • Identification of the most promising import options via pipeline and ship up to 2030. • Identification of remaining research questions for upscaling import technologies. [ABSTRACT FROM AUTHOR]

In this paper, we study a robust, dynamic, continuous-time optimal consumption and portfolio allocation problem for investors with recursive preferences who have access to both stock and derivatives markets. We assume the stock price process follows a stochastic volatility model, with instantaneous precision as the unique state variable, allowing for discontinuities in all the dynamics. We obtain a closed-form approximate solution up to a system of ODEs to the optimization problem for a non-unitary value of the elasticity of intertemporal substitution of consumption, being able to derive an exact solution as a particular case. Our theoretical findings show that the optimal policies are remarkably affected by the ambiguity-aversion parameters to diffusive and jump risks. A detailed numerical analysis confirms the effectiveness of our theoretical results on real data. Finally, we prove that investors who do not believe in ambiguity may suffer considerable wealth losses. [ABSTRACT FROM AUTHOR]

This article deals with known challenges as well as new ones associated with the lexicographical solutions regarding derivatives in dictionaries. Five of Sweden's major monolingual dictionaries are being examined with the aim of describing and comparing their derivatives, with special focus on deverbal nouns with the suffix -ande. The research combines morphology, lexicography and metalexicography, aiming at presenting and discussing some of the key areas of lemma inclusion and word formation principles in Swedish monolingual, contemporary dictionaries. [ABSTRACT FROM AUTHOR]

Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated significant anticancer properties in a range of malignancies. However, its therapeutic efficacy is limited by its hydrophobicity, poor bioavailability, and systemic toxicity. Derivatives, analogues, and nanoformulations of CPT have been synthesized to overcome these limitations. The aim of this review is to comprehensively analyze existing studies to evaluate the therapeutic efficacy, mechanistic aspects, and clinical potential of CPT and its modified forms, including derivatives, analogues, and nanoformulations, in cancer treatment. A comprehensive literature review was performed using PubMed/Medline, Scopus, and Web of Science databases; articles were selected based on specific inclusion criteria, and data were extracted on the pharmacological profile, clinical studies, and therapeutic efficacy of CPT and its different forms. Current evidence suggests that derivatives and analogues of CPT have improved water solubility, bioavailability, and reduced systemic toxicity compared to CPT. Nanoformulations further enhance targeted delivery and reduce off-target effects. Clinical trials indicate promising outcomes with enhanced survival rates and lower side effects. CPT and its modified forms hold significant promise as potent anticancer agents. Ongoing research and clinical trials are essential for establishing their long-term efficacy and safety; the evidence overwhelmingly supports further development and clinical testing of these compounds. [ABSTRACT FROM AUTHOR]

The European Union's (EU) ambition is to encourage clearing at EU Central Counterparties (CCPs) and with EU clearing members (CMs). This is to reduce reliance on systemic non-EU CCPs, and to build a more attractive and robust EU clearing market. To achieve this, the European Market Infrastructure Regulation (EMIR) 3.0 requires EU CMs and clients subject to the clearing obligation to hold active accounts at EU CCPs. Although it is very unlikely that the watered-down compromise will fulfil the EU's ambition, more importantly it still risks diminishing the competitive position of EU companies, leading to EU clients who do not fall under the clearing obligation to use non-EU CMs, and directing non-EU clients' euro-denominated interest rate swaps trading activity towards non-EU dealers. This seems contradictory to the policy objective of building a strong EU Capital Markets Union (CMU). With regard to supervision, EMIR 3.0 is a missed opportunity for a centralised supervisory framework. Just enhancing the current decentralised supervision mechanism, which is based on cooperation and information sharing between National Competent Authorities (NCAs), is not enough. A European centralised supervisor will not only strengthen risk monitoring and (eventually) minimise systemic risks but will also reduce supervision costs, the number of procedures, divergent interpretations of EMIR rules and the exchange of data. Whereas the main focus with regard to EMIR 3.0 was geared towards the active account requirement and whether or not to centralise supervision of EU CCPs, regulators and market participants would be ill advised to let discussions over third-country CCP equivalence issues distract them from other important and persistent challenges in the derivatives clearing markets. There are currently three pressing issues that require attention: clearing access and capital rules, portability and clearing models, as well as liquidity and collateral optimisation. A failure to address them risks undermining the key driver for derivatives clearing, which is increasing financial stability. [ABSTRACT FROM AUTHOR]

The quest for and development of combinational chemotherapeutic medicines with various modes of action and low side effects is an essential element of cancer treatment. Aside from developing wholly novel drugs with chemical properties that are obviously distinct from current ones, another strategy involves combining two or more pharmacophores into a sinSgle molecule. The method for making several 1,2,4-triazole derivatives is detailed in the scheme. By 5-Mercapto-3-pyrimidinyl-1,2,4 triazole with various substituted benzyl halides, a total of 7 distinct 1,2,4-triazole derivatives were obtained. Combustion Analysis, TLC, IR, MS and other methods were used to confirm the physical and analytical properties of the newly synthesized 1,2,4-triazole derivatives. Compounds TP1-TP7 exhibit IC50 values ranging from 41.12 M to 61.11 M, with compound TP6 having the greatest activity against the murine melanoma (B16F10) cell line. TP6 was discovered to have more strong anticancer action in anti-cancer screening. As a result, we believe that the findings of this study may pave the way for the creation of anticancer drugs with high efficacy and fewer side effects. As a result, 1,2,4-triazol-3-pyrimidine-based compounds may have a broad anticancer range and serve as a potential lead molecule in different malignancies. [ABSTRACT FROM AUTHOR]

This article illustrates two fundamental uses of credit default swaps (CDS) in managing bond portfolios. The applications include CDSs in a buy-and-hold strategy to optimize a portfolio's return-to-risk profile and employing CDS indices to efficiently replicate corporate bond returns. Each application is thoroughly examined, demonstrating how CDS can serve as a versatile tool for mitigating credit risk while striving for higher returns. [ABSTRACT FROM AUTHOR]

In this article, five in-depth illustrations of practical applications of various derivatives for risk control for asset management are provided. The illustrations are presented using stock index futures, interest-rate derivatives (Treasury futures and interest rate swaps), options, and equity swaps. The cases presented bridge the gap between theoretical finance and practical application, making it invaluable for those involved in risk management for portfolio managers. [ABSTRACT FROM AUTHOR]

This article provides applications of derivatives to asset allocation and multi-asset management. The four applications include using futures for top-down asset allocation, deploying portable alpha strategies using derivatives to achieve desired convexity in payoff profiles, developing effective hedging strategies, and using derivatives for active speculative views by proprietary traders. [ABSTRACT FROM AUTHOR]

This article analyzes the public comments submitted to the Commodity Futures Trading Commission (CFTC), 2010–2014, in response to proposed rules for implementing the Dodd‐Frank reforms. By addressing a fine‐grained typology of commenting organizations to a topic model of the combined comments, we illuminate a new pattern of public engagement in financial regulation. Contrary to the economic concept of regulatory capture, our data show no sharp divide between the suppliers of complex derivatives (the dealer banks) and their customers in other parts of the finance industry. In keeping with the general concept of financialization—but contrary to its strongest versions—our data show distinctly delimited evidence of a convergence between the banks and other sectors. Instead of either capture or all‐embracing financialization, the comments submitted to the CFTC display an overriding opposition in the justifications used by commenters to explain their preferences. Commenters from the financial services and allied sectors consistently adopt a language of technical legitimation. Commenters in agriculture, livestock, retail energy, and many nonmarket organizations adopt a language of moral justification. The clarity of the divide between these two idioms indicates that the underlying purposes of new financial instruments are now being questioned. Even in the realm of esoteric financial instruments such as derivatives, the moral economy of market competition is once again subject to debate among market participants as well as observers. [ABSTRACT FROM AUTHOR]

Griseofulvin (GF), which is mainly extracted from Penicillium griseofulvum, is a heat-resistant, chlorine-containing non-polyene antifungal antibiotic. Previous research shows that GF has a variety of pharmacological effects, such as antiinflammatory, antifungal, antiviral, and antitumor effects. In recent years, GF has received extensive attention for its antitumor effects as a natural compound, offering a low price, a wide range of uses, and other beneficial characteristics. However, no comprehensive review of GF pharmacological activity in tumors has been published so far. In order to fully elucidate the antitumor activities of GF, this review focuses on the antitumor potential and toxicity of GF and its derivatives, based on a literature search using PubMed, Web of Science, and other databases, to lay a good foundation for further research of GF and the development of new drugs for antitumor activities. [ABSTRACT FROM AUTHOR]

This article examines the role of derivatives in the context of the recent crisis in the UK pension system, specifically in liability-driven investment schemes. It unveils derivatives' role as instruments that multiply and propagate losses among market participants once specific events (worst-case scenarios) materialise. This article questions the role of derivatives as risk-management and risk-diversification tools, given their employment, in this case as in others before, for speculative purposes. Critically, with speculation came higher than desirable levels of leverage that these financial products elicited, causing in the process a series of systemic concerns. While much criticism has been directed at post-2008 regulation, and particularly at clearing and margin requirements, this article proposes a broader view of the problems posed by derivatives in the different contexts of their applications. More specifically, attention is drawn to legal doctrines that could be redeployed for the purpose of mitigating the speculative nature of derivatives. [ABSTRACT FROM AUTHOR]

The enmein-type diterpenoids are a class of anticancer ent-Kaurane diterpnoids that have received much attention in recent years. Herein, a novel 1,14-epoxy enmein-type diterpenoid 4, was reported in this project for the first time. A series of novel enmein-type diterpenoid derivatives were also synthesized and tested for anticancer activities. Among all the derivatives, compound 7h exhibited the most significant inhibitory effect against A549 cells (IC50 = 2.16 µM), being 11.03-folds better than its parental compound 4. Additionally, 7h exhibited relatively weak anti-proliferative activity (IC50 > 100 µM) against human normal L-02 cells, suggesting that it had excellent anti-proliferative selectivity for cancer cells. Mechanism studies suggested that 7h induced G0/G1 arrest and apoptosis in A549 cells by inhibiting the PI3K/AKT/mTOR pathway. This process was associated with elevated intracellular ROS levels and collapsed MMP. In summary, these data identified 7h as a promising lead compound that warrants further investigation of its anticancer properties. [ABSTRACT FROM AUTHOR]

Isatin, a chemical derivative of indole, has emerged as a significant entity in organic synthesis since its discovery in 1841. Occurring naturally in various plants and animals, isatin serves as the precursor to numerous derivatives exhibiting diverse biological and pharmacological activities. This comprehensive review highlights the multifaceted pharmacological properties of isatin and its derivatives, ranging from anticonvulsant and anticancer activities to antimicrobial and antioxidative effects. The review explores the potential therapeutic applications of isatin-based compounds across various medical conditions, emphasizing their versatility in drug development. Additionally, the neuroprotective and neurobehavioral effects of isatin are discussed, along with its potential in addressing neurodegenerative diseases. Overall, this review underscores the significant attention drawn by isatin in pharmacological research and its promising role in advancing therapeutic interventions. [ABSTRACT FROM AUTHOR]

We propose a model‐guided option‐implied ambiguity measure to capture uncertainty regarding the return distribution of a risky asset underlying a set of options, and investigate its predictive power on the asset return. A representative investor's ambiguous beliefs or prior distributions on the underlying asset returns are extracted from the market prices of options, the expected volatility of which is then defined as the option‐implied ambiguity and is calculated in line with Brenner and Izhakian. Simulated paths of the calibrated models are utilized to compute all pertinent probability characteristics from a forward‐looking perspective. The empirical results with SSE 50 ETF options indicate that the proposed option‐implied ambiguity has strong predictive power for future returns of SSE 50 ETF. Out‐of‐sample tests also verify the significant predictive ability of the option‐implied ambiguity to the equity returns. [ABSTRACT FROM AUTHOR]

The objective of the study is to explore the motives of investors to invest in derivative markets. It is a quantitative study where a survey method was used to collect data from the investors using a probability sampling method. The data was analyzed using PLS-SEM to test the conceptual model. The results of the study show that speculation, hedging, and financial literacy are strong predictors of investors' motives to invest in the derivatives market. The R2 was O.447 implying speculation, hedging, and financial literacy explain 44.7% of the variance of the dependent variable, that is, the motives of investors to invest in equity derivatives, and the adjusted R-square is O.432 (43.2%) which validates the model. Few studies explore the reasons to invest in derivatives using secondary data. However, to the best of the author's knowledge studies exploring the motives of investors are rare, and there have been none using primary data from an Indian perspective. The study provides empirical evidence that could be useful to companies, investors, brokers, and policymakers to understand the motives of investors to invest in derivatives. [ABSTRACT FROM AUTHOR]

When undergraduate students learn the application of differentiation, they are expected to comprehend the concept of differentiation first, make connections between particular constructs within differentiation and strengthen the coherence of these connections. Undergraduate students struggle to comprehend kinematics as a rate of change in their efforts to solve contextual problems. This study sought to explore undergraduate students' construction of connections and the underlying structures of these relationships as they learn calculus of motion. The action-process-object-schema and Triad theories were used to explore undergraduate students' construction of connections in differentiation and the underlying structures of these relationships as they learn the calculus of motion. This study was qualitative which involved a case study of 202 undergraduate mathematics students registered for a Bachelor of Education degree. Data were collected through an individual written test by the whole class and semi-structured interviews with ten students purposively selected from the class. The interviews were meant to clarify some of the responses raised in test. The findings revealed that students' challenges in differentiating the given function were insignificant, but they need help to make connections of differentiation to its application to kinematics. Furthermore, students' coherence of the connection among displacement, velocity and acceleration was weak, coupled by their failure to consider the point when the object was momentarily at rest (which is central in optimization). The results of this study have some implications for instructors. The teaching of calculus and other 456 mathematical concepts should connect to the real-life application of those concepts so that 457 students can make meaningful interrelationships thereof. Kinematics for differentiation paves way for kinematics under the application of integration hence students' optimal conceptualization is of utmost importance. [ABSTRACT FROM AUTHOR]

Probability Matrix, it is necessary to obtain energy options pricing. The paper found the true probabilities of transition from the current state of the market to other states. The energy options pricing including effects of Political tensions is proposed. The methods are based on true probabilities of transition to the next state of the energy market. It can be used to predict the movement of the underlying asset of energy options (oil and gas derivatives pricing). For example, one strategy might be to compare the energy sources at the beginning 2022 (before 24.02.2024) with the current state of the market. The results show that this matrix can be implemented in energy options pricing, which represents the true probabilities of transition from the current state of the market to modern state. Practical implementation is an investment strategy in oil and gas futures that should include the median of a given distribution with the current state of the market after beginning of Russia-Ukraine conflict. The absence of arbitrage opportunities is a fundamental principle underlying modern financial pricing theory. This concept is peculiar to the statement of the fundamental theorem of asset pricing. The results prove idea that at a fixed point in time is the information about some market quotations of American Call options can be determined. The results have a set of quotes that are available in both directions: both for strikes and for periods to maturity. [ABSTRACT FROM AUTHOR]

Longfei Lin,1,* Yuling Liu,1,* Ruying Tang,1 Shilan Ding,1 Hongmei Lin,2,3 Hui Li1,4 1Institute Chinese Materia Medica China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 2Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3National Medical Products Administration Key Laboratory for Research Evaluation of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Li, Institute Chinese Materia Medica China Academy of Chinese Medical Sciences, Beijing, 100700, People’s Republic of China, Email lihuizys@126.com Hongmei Lin, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China, Email lhmtcm@126.comAbstract: Evodiamine (EVO) is a tryptamine indole alkaloid and the main active ingredient in Evodia rutaecarpa. In recent years, the antitumor, cardioprotective, anti-inflammatory, and anti-Alzheimer’s disease effects of EVO have been reported. EVO exerts antitumor effects by inhibiting tumor cell activity and proliferation, blocking the cell cycle, promoting apoptosis and autophagy, and inhibiting the formation of the tumor microvasculature. However, EVO has poor solubility and low bioavailability. Several derivatives with high antitumor activity have been discovered through the structural optimization of EVO, and new drug delivery systems have been developed to improve the solubility and bioavailability of EVO. Current research found that EVO could have toxic effects, such as hepatotoxicity, nephrotoxicity, and cardiac toxicity. This article reviews the pharmacological activity, derivatives, drug delivery systems, toxicity, and pharmacokinetics of EVO and provides research ideas and references for its further in-depth development and clinical applications.Keywords: evodiamine, pharmacology, derivatives, drug delivery systems

The objective of the study is to explore the motives of investors to invest in derivative markets. It is a quantitative study where a survey method was used to collect data from the investors using a probability sampling method. The data was analyzed using PLS-SEM to test the conceptual model. The results of the study show that speculation, hedging, and financial literacy are strong predictors of investors’ motives to invest in the derivatives market. The R2 was 0.447 implying speculation, hedging, and financial literacy explain 44.7% of the variance of the dependent variable, that is, the motives of investors to invest in equity derivatives, and the adjusted R-square is 0.432 (43.2%) which validates the model. Few studies explore the reasons to invest in derivatives using secondary data. However, to the best of the author’s knowledge studies exploring the motives of investors are rare, and there have been none using primary data from an Indian perspective. The study provides empirical evidence that could be useful to companies, investors, brokers, and policymakers to understand the motives of investors to invest in derivatives.

• Various derivatives of PAHs were found in air and soil from petrochemical facility. • Generation of NPAHs during petroleum smelting should be faster than halogenated PAHs. • Petrochemical workers in this facility faced potential high cancer risk for PAHs. • Non-targeted screening found additional toxic PAHs analogs in petrochemical area. This study investigated environmental distribution and human exposure of polycyclic aromatic hydrocarbons (PAHs) and their derivatives in one Chinese petroleum refinery facility. It was found that, following with high concentrations of 16 EPA PAHs (∑Parent-PAHs) in smelting subarea of studied petroleum refinery facility, total derivatives of PAHs [named as XPAHs, including nitro PAHs (NPAHs), chlorinated PAHs (Cl-PAHs), and brominated PAHs (Br-PAHs)] in gas (mean= 1.57 × 104 ng/m3), total suspended particulate (TSP) (mean= 4.33 × 103 ng/m3) and soil (mean= 4.37 × 103 ng/g) in this subarea had 1.76–6.19 times higher levels than those from other subareas of this facility, surrounding residential areas and reference areas, indicating that petroleum refining processes would lead apparent derivation of PAHs. Especially, compared with those in residential and reference areas, gas samples in the petrochemical areas had higher ∑NPAH/∑PAHs (mean=2.18), but lower ∑Cl-PAH/∑PAHs (mean=1.43 × 10−1) and ∑Br-PAH/∑PAHs ratios (mean=7.49 × 10−2), indicating the richer nitrification of PAHs than chlorination during petrochemical process. The occupational exposure to PAHs and XPAHs in this petroleum refinery facility were 24–343 times higher than non-occupational exposure, and the ILCR (1.04 × 10−4) for petrochemical workers was considered to be potential high risk. Furthermore, one expanded high-resolution screening through GC Orbitrap/MS was performed for soils from petrochemical area, and another 35 PAHs were found, including alkyl-PAHs, phenyl-PAHs and other species, indicating that profiles and risks of PAHs analogs in petrochemical areas deserve further expanded investigation. [Display omitted] [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Boronate esters are highly valued in synthetic and pharmaceutical industries for their versatility in creating C—C and C—X bonds. They also find applications as catalysts in chemical transformations as well as stimuli‐responsive materials in materials science. Some alkyl boronates themselves also show promising applications in medicinal chemistry. In the past few decades, chemists have been devoted to developing new methods or new starting materials for synthesizing boronate esters. Carboxylic acids and their derivatives are privileged chemical entities due to their readily availability or natural abundance, structural diversity, and chemical stability. Hence, the transformation of carboxylic acid and their derivatives to alkyl/aryl boronate esters has seen its fast development in the past decade. This review summarized the state‐to‐art development of decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives to aryl and alkyl boronate esters. Key Scientists: The decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives started only in the past decade. In 2016, the decarbonylative borylation of carboxylic esters and amides was reported by Zhuangzhi Shi and Magnus Reuping's groups. Then, in 2017, studies on the decarboxylative borylation of redox‐active esters such as NHPI esters started to receive increasing attention by Aggarwal, Baran, Fu, Glorius, and Li's groups. From 2018 to 2023, large numbers of studies on the decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives using transition‐metal‐catalyst, organo‐catalyst, or under photochemical or electrochemical conditions emerged. Due to space limitations, only pictures of scientists who have contributed more than two works in this area are shown herein. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Boronate esters are highly valued in synthetic and pharmaceutical industries for their versatility in creating C—C and C—X bonds. They also find applications as catalysts in chemical transformations as well as stimuli‐responsive materials in materials science. Some alkyl boronates themselves also show promising applications in medicinal chemistry. In the past few decades, chemists have been devoted to developing new methods or new starting materials for synthesizing boronate esters. Carboxylic acids and their derivatives are privileged chemical entities due to their readily availability or natural abundance, structural diversity, and chemical stability. Hence, the transformation of carboxylic acid and their derivatives to alkyl/aryl boronate esters has seen its fast development in the past decade. This review summarized the state‐to‐art development of decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives to aryl and alkyl boronate esters. Key Scientists: The decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives started only in the past decade. In 2016, the decarbonylative borylation of carboxylic esters and amides was reported by Zhuangzhi Shi and Magnus Reuping's groups. Then, in 2017, studies on the decarboxylative borylation of redox‐active esters such as NHPI esters started to receive increasing attention by Aggarwal, Baran, Fu, Glorius, and Li's groups. From 2018 to 2023, large numbers of studies on the decarboxylative and decarbonylative borylation of carboxylic acids and their derivatives using transition‐metal‐catalyst, organo‐catalyst, or under photochemical or electrochemical conditions emerged. Due to space limitations, only pictures of scientists who have contributed more than two works in this area are shown herein. [ABSTRACT FROM AUTHOR]

The field of analytical chemistry has been significantly advanced by the availability of state-of-the-art instrumentation, allowing for the development of novel applications in this field. However, in many cases, the direct interpretation of the recorded data is often not straightforward, hence some level of pre-processing is required (e.g., baseline correction, derivatives, normalization, smoothing). These techniques have become a critical first step for the successful analysis of the data recorded, and it is recommended to use them before the application of chemometrics (e.g., classification, calibration development). The aim of this paper is to provide with an overview of the most used pre-processing methods applied to instrumental analytical methods (e.g., spectroscopy, chromatography). Examples of their application in near infrared and UV-VIS spectroscopy as well as in gas chromatography will be also discussed. Overall, this paper provides with a comprehensive understanding of pre-processing techniques in analytical chemistry, highlighting their importance during the analysis and interpretation of data, as well as during the development of accurate and reliable chemometric models. [ABSTRACT FROM AUTHOR]

This study examines the effect of SFAS 161, Disclosures about Derivative Instruments and Hedging Activities, on stock price informativeness. FASB issued SFAS 161, effective in 2008, to provide investors with an enhanced understanding of the objectives and implications of firms' use of derivatives and hedging activities. Our primary goal is to examine whether SFAS 161 facilitates the dissemination of firm-specific information to the market and thus increases stock price informativeness. Using a U.S. sample covering fiscal-years 2001–2018, this study employs a difference-in-difference research design and identifies the treatment group (derivatives users) by conducting a textual analysis of the firm's derivatives disclosures in the 10-K reports. The results show that for firms that engage in derivatives activities, stock price informativeness increases after the adoption of SFAS 161. We further find that the positive association between SFAS 161 adoption and stock price informativeness is more pronounced for firms with more readable derivatives disclosures. The results suggest that enhanced readability in derivative disclosures play an important role in reducing the information processing costs for investors. [ABSTRACT FROM AUTHOR]

Fluorouracil (5-Fu, 1) is an antimetabolite cancer drug and the first-line drug of anticancer administration by WHO that has been widely used worldwide for more than 50 years. The development of 5-fluorouracil is an effort to obtain higher activity, decrease side effects, and create a specific target receptor compared to 5-fluorouracil. In this research, a series of novel 5-Fluorouracil (5-Fu) derivatives has been synthesized based on a benzoylation reaction (Schotten-Baumann reaction) of N1-hydroxylated 5-Fu called compound 2, 5-fluoro-1-(hydroxymethyl)-uracil. The benzoyl chloride substituents used in this research, including 3-chlorobenzoyl (4a), 2-chlorobenzoyl (4b), 3-nitrobenzoyl (4c), 4-methoxy benzoyl (4d), 4-trifluoromethylbenzoyl (4e), 3,4-dichlorobenzoyl (4f), and 4-nitrobenzoyl (4g) chloride become (4a-4f)-5Fu. This research meticulously examined the conditions (time and reaction temperature) at the second step of the synthesis reaction (esterification), ensuring the reliability of the results. The best synthesis conditions for 4a, 4b, 4c, 4d, and 4g compounds were found to be reflux at 40°C for 6 hours, whereas 4e and 4f compounds reactions were performed in an ice bath for 11 and 17 hours, respectively. All product syntheses, 4a-4g compound, were purified using column chromatography and eluted using eluent hexane: acetone (6:4), and the yields of 4a-4g compounds were around 61-79%. The pure compounds were characterized using FTIR and 1HNMR spectrometer, further validating the research. Based on these findings, it can be concluded that all 5-Fu derivatives can be synthesized using the Schotten-Baumann reaction method.

In this article, we study the unicity of meromorphic functions concerning small functions and derivatives-differences. The results obtained in this article extend and improve some results of Chen et al. [Uniqueness problems on difference operators of meromorphic functions] and Chen and Huang [Uniqueness of meromorphic functions concerning their derivatives and shifts with partially shared values].

Abstract Photocatalysis is an environmentally friendly technology for the utilizations of solar energy and has garnered significant attention in both scientific and industrial sectors. Developing cost‐effective semiconductive materials is the core issue in photocatalysis. Bismuth‐based metal‐organic frameworks (Bi‐MOFs) have emerged as attractive candidates in various photocatalytic applications, and Bi‐MOFs derivatives further expand and consolidate their promising potential in the realm of photocatalysis. Various modification strategies including in‐situ tailoring or external doping, as well as meticulous design and selection of metal nodes and organic linkers allow for fine control over the surface multifunctionality in Bi‐MOF‐based and derived photocatalytic composites with adjustable energy band structures and enhanced photocatalytic performance. In this review, the recent progress in the synthesis of diverse Bi‐MOFs‐based materials, Bi‐MOFs derivatives, and their Bi‐containing semiconductive composites were systemically analyzed and reviewed. The state‐of‐the‐art research progresses in the applications of Bi‐MOFs and derivatives, as well as composites in photocatalytic water splitting for hydrogen production, photodegradation of organic pollutants, and photocatalytic carbon dioxide reduction are comprehensively summarized. The relationships between structures, properties, and photocatalytic performance of Bi‐based semiconductive composites are discussed in detail. In addition, the perspectives and future challenges on Bi‐MOFs‐based and derived materials for photocatalytic applications are also offered.

Minmin Jiang,1,* Yongxia Xie,2,* Ping Wang,1 Mengyu Du,3 Ying Wang,4 Shuxun Yan1 1Department of Endocrinology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 3The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 4Department of International Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuxun Yan; Ying Wang, Email ysx982001@163.com; wangying56994@126.comAbstract: Fibrosis leads to organ failure and death, which is the final stage of many chronic diseases. Triptolide (TPL) is a terpenoid extracted from the traditional Chinese medicine Tripterygium wilfordii Hook. F (TwHF). Triptolide and its derivatives (Omtriptolide, Minnelide, (5R)-5-hydroxytriptolide) have been proven to have a variety of pharmacological effects. This study comprehensively reviewed the antifibrotic mechanism of TPL and its derivatives, and discussed the application of advanced nanoparticles (NPs) drug delivery system in the treatment of fibrotic diseases by TPL. The results show that TPL can inhibit immune inflammatory response, relieve oxidative stress and endoplasmic reticulum stress (ERS), regulate collagen deposition and inhibit myofibroblast production to play an anti-fibrosis effect and reduce organ injury. A low dose of TPL has no obvious toxicity. Under pathological conditions, a toxic dose of TPL has a protective effect on organs. The emergence of TPL derivatives (especially Minnelide) and NPs drug delivery systems promotes the anti-fibrosis effect of TPL and reduces its toxicity, which may be the main direction of anti-fibrosis research in the future.Keywords: triptolide, derivatives, anti-fibrosis, nanoparticles

Abstract The derivation of polysaccharide has an important impact on its properties. The preparation process of phosphorylated-shaddock skin polysaccharides (SSP) and acetylated-SSP was optimized by the response surface method. The constructed model was accurate and reliable in predicting the substitution of acetylated-SSP and the phosphate content of phosphorylated-SSP. This method was simple and easy to operate, which provided a basis for the preparation of a large number of derivatives.

Ursolic acid (UA) and its derivatives have garnered significant attention due to their extensive pharmacological activity. UA is a pentacyclic triterpenoid found in a variety of plants, such as apples, rosemary, thyme, etc., and it possesses a range of pharmacological properties. Researchers have synthesized various derivatives of UA through structural modifications to enhance its potential pharmacological properties. Various in vitro and in vivo studies have indicated that UA and its derivatives possess diverse biological activities, such as anticancer, antifungal, antidiabetic, antioxidant, antibacterial, anti-inflammatory and antiviral properties. This review article provides a review of the biological activities of UA and its derivatives to show their valuable therapeutic properties useful in the treatment of different diseases, mainly focusing on the relevant structure-activity relationships (SARs), the underlying molecular targets/pathways, and modes of action. [ABSTRACT FROM AUTHOR]

Oxidative stress is considered one of the main reasons for the development of colorectal cancer (CRC). Depending on the stage of the disease, variable activity of the main antioxidant enzymes, i.e., superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), is observed. Due to limited treatment methods for CRC, new substances with potential antitumor activity targeting pathways related to oxidative stress are currently being sought, with substances of natural origin, including betulin, leading the way. The betulin molecule is chemically modified to obtain new derivatives with improved pharmacokinetic properties and higher biological activity. The aim of this study was to evaluate the effects of betulin and its new derivatives on viability and major antioxidant systems in colorectal cancer cell lines. The study showed that betulin and its derivative EB5 affect the antioxidant enzyme activity to varying degrees at both the protein and mRNA levels. The SW1116 cell line is more resistant to the tested compounds than RKO, which may be due to differences in the genetic and epigenetic profiles of these lines. [ABSTRACT FROM AUTHOR]

MXene have found extensive applications in various fields, including catalysis. Two predominant roles of MXene in catalysis are as catalyst carriers or as catalysts themselves. The former has received significant attention and is addressed in other publications. This review assesses MXene and its derivatives as direct catalysts, which is particularly intriguing due to its potential to reduce the design cost of catalysts. Moreover, an in‐depth discussion of this aspect aids in understanding the true role of MXene in catalysis, beyond its role as a catalyst carrier. For instance, MXene and its derivatives have been extensively employed as photocatalysts, with their catalytic activity significantly influenced by their structural characteristics. Furthermore, due to MXene's remarkable light absorption capacity, it is crucial to explore the contributions of photothermal generation or photocatalytic‐thermocatalytic synergistic effects. Additionally, MXene has demonstrated remarkable electrocatalytic performance in hydrogen production. Moreover, MXene exhibits promising applications in thermal catalysis, such as dehydrogenation and oxidation. A deeper understanding of these aspects can help researchers further design MXene‐based nanomaterials, or alleviate their oxidation. Finally, we offer insights into the future research directions of MXene from our perspective. This review could provide guidance for the design of novel MXene catalysts for industrial applications. [ABSTRACT FROM AUTHOR]

Electrocatalytic water splitting exhibits outstanding advantages for solving the critical problems of clean energy shortage and environmental pollution. Electric driven water splitting is a promising strategy for producing clean and renewable hydrogen. Metal-organic frameworks (MOFs) and their derivatives are considered as ideal porous materials for electrocatalytic H2 production, resulting from their tailorable structure, ultra-large surface area, and design flexibility. This review starts with the reaction principle of electrocatalytic water splitting, relevant factors that determine the electrocatalytic activity, and then summarizes and exemplifies the recent progress in the development of MOFs based- and derived-electrocatalysts for water splitting. Finally, we highlighted the many challenges exist in the water splitting field, and proposed some perspectives of MOFs based- and derived-electrocatalysts for H2 production from water splitting. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by the accumulation of amyloid-beta plaques and hyperphosphorylated tau proteins, leading to cognitive decline and neuronal death. However, despite extensive research, there are still no effective treatments for this condition. In this study, a series of chloride-substituted Ramalin derivatives is synthesized to optimize their antioxidant, anti-inflammatory, and their potential to target key pathological features of Alzheimer's disease. The effect of the chloride position on these properties is investigated, specifically examining the potential of these derivatives to inhibit tau aggregation and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) activity. Our findings demonstrate that several derivatives, particularly RA-3Cl, RA-4Cl, RA-26Cl, RA-34Cl, and RA-35Cl, significantly inhibit tau aggregation with inhibition rates of approximately 50%. For BACE-1 inhibition, Ramalin and RA-4Cl also significantly decrease BACE-1 expression in N2a cells by 40% and 38%, respectively, while RA-23Cl and RA-24Cl showed inhibition rates of 30% and 35% in SH-SY5Y cells. These results suggest that chloride-substituted Ramalin derivatives possess promising multifunctional properties for AD treatment, warranting further investigation and optimization for clinical applications. [ABSTRACT FROM AUTHOR]

There are not only vowel-initial suffixes but also consonant-initial suffixes in Kashika which when enters combination with stems, elicits morphophonemic changes in their derivatives. These morphophonemic features demonstrate a systematic patterning regardless of the grammatical word-class of the stems derived words. [ABSTRACT FROM AUTHOR]

Fluorouracil (5-Fu, 1) is an antimetabolite cancer drug and the first-line drug of anticancer administration by WHO that has been widely used worldwide for more than 50 years. The development of 5-fluorouracil is an effort to obtain higher activity, decrease side effects, and create a specific target receptor compared to 5-fluorouracil. In this research, a series of novel 5-Fluorouracil (5-Fu) derivatives has been synthesized based on a benzoylation reaction (Schotten-Baumann reaction) of N1-hydroxylated 5-Fu called compound 2, 5-fluoro-1- (hydroxymethyl)-uracil. The benzoyl chloride substituents used in this research, including 3-chlorobenzoyl (4a), 2-chlorobenzoyl (4b), 3-nitrobenzoyl (4c), 4-methoxy benzoyl (4d), 4-trifluoromethylbenzoyl (4e), 3,4-dichlorobenzoyl (4f), and 4-nitrobenzoyl (4g) chloride become (4a-4f)-5Fu. This research meticulously examined the conditions (time and reaction temperature) at the second step of the synthesis reaction (esterification), ensuring the reliability of the results. The best synthesis conditions for 4a, 4b, 4c, 4d, and 4g compounds were found to be reflux at 40°C for 6 hours, whereas 4e and 4f compounds reactions were performed in an ice bath for 11 and 17 hours, respectively. All product syntheses, 4a-4g compound, were purified using column chromatography and eluted using eluent hexane: acetone (6:4), and the yields of 4a-4g compounds were around 61-79%. The pure compounds were characterized using FTIR and 1HNMR spectrometer, further validating the research. Based on these findings, it can be concluded that all 5-Fu derivatives can be synthesized using the Schotten-Baumann reaction method. [ABSTRACT FROM AUTHOR]

Biomass and its derivatives have broad applications in the fields of bio-catalysis, energy storage, environmental remediation. The structure and components of biomass, which are vital parameters affecting corresponding performances of derived products, need to be fully understood for further regulating the biomass and its derivatives. Herein, tobacco is taken as an example of biomass to introduce the typical characterization techniques in unraveling the structural information, chemical components, and properties of biomass and its derivatives. Firstly, the structural information, chemical components and application for biomass are summarized. Then the characterization techniques together with the resultant structural information and chemical components are introduced. Finally, to promote a wide and deep study in this field, the perspectives and challenges concerning structure and composition charaterization in biomass and its derivatives are put forward. [ABSTRACT FROM AUTHOR]

PurposeAimDesign/Methodology/ApproachMain findingsPractical implicationsNovelty/ContributionTo ascertain how JSE-listed companies use derivatives to hedge.Determine whether JSE-listed companies apply established rationales for corporate hedging practices.This empirical study uses data from the Johannesburg Stock Exchange (JSE), South Africa, as a proxy for emerging markets.Binomial logistic regression, applied to the 200 largest non-financial firms (by market capitalization) on the JSE from 2005 to 2017, indicates that larger firms, higher leveraged firms, ones with better growth prospects, and less information asymmetry between directors and management are more likely to use derivatives to hedge.The findings suggest that some traditional determinants for corporate hedging practices apply in an emerging market context, but local conditions still remain an important consideration.By confirming the applicability of traditional hedging theories in an emerging market context, the study extends the theoretical understanding of corporate risk management. It supports the notion that established hedging rationales, such as reducing financial distress costs and addressing information asymmetry, are relevant across different economic contexts. [ABSTRACT FROM AUTHOR]

Thiazole derivatives are a class of heterocyclic compounds that have gained significant attention in medicinal chemistry due to their diverse biological activities and therapeutic potential. This research article provides a comprehensive overview of the synthesis strategies, structural characterization, and evaluation of the functional properties of thiazole derivatives. The thiazole nucleus, a five-membered aromatic heterocycle composed of one nitrogen, one sulfur, and three carbon atoms, serves as a versatile scaffold for drug development. Thiazolopyrimidine derivatives were synthesized through one-pot condensation of substituted thiourea in alcoholic KOH, reacting with aromatic aldehyde and a-halo acid. The structure of 5,7-diphenyl-2H-thiazolo[3,2-a] pyrimidin-3(5H)-one was confirmed by FTIR and mass spectral data. [ABSTRACT FROM AUTHOR]

This research deals with the derivatives that fall within the science of morphology, but the research studies these derivatives through their connotations in the poetry of Abu Firas Al-Hamdani. The research derives its importance through extracting derivatives from the poet's poetry and clarifying their significance. One of the reasons for choosing it was the necessity of shedding light on this poetry from a morphological perspective. The method followed is the descriptive and analytical method that relies on observing the phenomenon and extrapolating it. The research studied the concept of derivation from a linguistic and terminological point of view, providing an overview of the life and poetry of the poet Abu Firas Al-Hamdani. It then deals with the study of the types of derivatives such as the active participle, the active participle, the suspicious adjective, the nouns of time and place, the noun of the instrument, and the exaggerated forms, after which the significance of these derivatives in the poet's poetry can be investigated. Then a conclusion includes the most prominent findings of the research, and a list of the sources and references it used. [ABSTRACT FROM AUTHOR]

Brain-derived neurotrophic factor (BDNF) and its downstream tropomyosin receptor kinase B (TrkB) signaling pathway play pivotal roles in the resilience and action of antidepressant drugs, making them prominent targets in psychiatric research. Oxidative stress (OS) contributes to various neurological disorders, including neurodegenerative diseases, stroke, and mental illnesses, and exacerbates the aging process. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) serves as the primary cellular defense mechanism against OS-induced brain damage. Thus, Nrf2 activation may confer endogenous neuroprotection against OS-related cellular damage; notably, the TrkB/phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, stimulated by BDNF-dependent TrkB signaling, activates Nrf2 and promotes its nuclear translocation. However, insufficient neurotrophin support often leads to the downregulation of the TrkB signaling pathway in brain diseases. Thus, targeting TrkB activation and the Nrf2-ARE system is a promising therapeutic strategy for treating neurodegenerative diseases. Phytochemicals, including indole-3-carbinol (I3C) and its metabolite, diindolylmethane (DIM), exhibit neuroprotective effects through BDNF's mimetic activity; Akt phosphorylation is induced, and the antioxidant defense mechanism is activated by blocking the Nrf2-kelch-like ECH-associated protein 1 (Keap1) complex. This review emphasizes the therapeutic potential of I3C and its derivatives for concurrently activating neuronal defense mechanisms in the treatment of neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

If p(z) = Xn ν=0 aνz ν is a polynomial of degree n having all its zeros in |z| ≤ k, k ≥ 1, Jain [Bull. Math. Soc. Sci. Math. Roumania Tome, 59(2016), 339-347] proved max |z|=1 |p′ (z)| ≥ nAk max |z|=1 |p(z)|, where Ak = ( |a0| + |an|k n+1/ |ao|(1 + k n+1) + |an|(k n+1 + k 2n) ) . In this paper, we initially derive a generalized form that not only encompasses but also enhances the aforementioned inequality. Additionally, we extend this formulation to a more comprehensive result, thereby producing an improved outcome for certain established inequalities as a specific instance. [ABSTRACT FROM AUTHOR]

In modern cancer therapy, blockage of more than one target is a standard approach, and there are already many dual‐target drugs that can achieve multiple inhibition through a single molecule. Herein, we designed and synthesized a series of novel derivatives with signal transducer and activator of transcription 3 (STAT3) and histone deacetylase (HDAC) inhibitory activity through strategy of combining pharmacophore based on the STAT3 inhibitor E28 and HDAC inhibitor MS‐275. Among them, compound 24 (IC50 = 8.22 ± 0.27 μM) showed better anti‐tumor activity than the clinical Class I HDAC inhibitor MS‐275 (IC50 = 14.65 ± 0.24 μM) in MCF‐7 breast cancer cells. Furthermore, the dual inhibition to HDAC and STAT3 of compound 24 was validated by western blot analysis. The study provides new tool compounds for further exploration of STAT3–HDAC pathway inhibitor achieved with a single molecule. [ABSTRACT FROM AUTHOR]

The synthesis methods of isothiazolinone compounds, the modification methods of each site and the application progress in the fields of industry, agriculture and medicine are reviewed. The kind of compound has a wide range of biological activities, such as high efficiency, low toxicity and broad spectrum. It is mainly used in sterilization, algae killing, anticorrosion, antifouling and so on. It is a hot spot in the field of chemical research in recent years. At present, there are commercial products such as Kathon and Sea- Nine 211 (DCOIT). Isothiazolinone compounds play an important role in industrial and agricultural production and life. The application and research progress of isothiazolinone and its derivatives in medicine, pesticide, coating, textile, papermaking, leather making and other fields in recent years were discussed. Finally, the development direction and application prospect of isothiazolinone compounds were prospected. [ABSTRACT FROM AUTHOR]

Structural modification based on existing drugs, which ensures the safety of marketed drugs, is an essential approach in developing new drugs. In this study, we modified the structure of cabotegravir by introducing the front alkyne on the core structure through chemical reaction, resulting in the synthesis of 9 compounds resembling 1,2,3‐triazoles. The potential of these new cabotegravir derivatives as tumor suppressors in gastrointestinal tumors was investigated. Based on the MTT experiment, most compounds showed a reduction in the viability of KYSE30 and HCT116 cells. Notably, derivatives 5b and 5h exhibited the most significant inhibitory effects. To further explore the effects of derivatives 5b and 5h on gastrointestinal tumors, KYSE30 cells were chosen as a representative cell line. Both derivatives can effectively curtail the migration and invasion capabilities of KYSE30 cells and induce apoptosis in a dose‐dependent manner. We further demonstrated these derivatives induce cell apoptosis in KYSE30 cells by inhibiting the expression of Stat3 protein and Smad2/3 protein. Based on the above results, we suggest they show promise in developing drugs for esophageal squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Photocatalysis is an environmentally friendly technology for the utilizations of solar energy and has garnered significant attention in both scientific and industrial sectors. Developing cost‐effective semiconductive materials is the core issue in photocatalysis. Bismuth‐based metal‐organic frameworks (Bi‐MOFs) have emerged as attractive candidates in various photocatalytic applications, and Bi‐MOFs derivatives further expand and consolidate their promising potential in the realm of photocatalysis. Various modification strategies including in‐situ tailoring or external doping, as well as meticulous design and selection of metal nodes and organic linkers allow for fine control over the surface multifunctionality in Bi‐MOF‐based and derived photocatalytic composites with adjustable energy band structures and enhanced photocatalytic performance. In this review, the recent progress in the synthesis of diverse Bi‐MOFs‐based materials, Bi‐MOFs derivatives, and their Bi‐containing semiconductive composites were systemically analyzed and reviewed. The state‐of‐the‐art research progresses in the applications of Bi‐MOFs and derivatives, as well as composites in photocatalytic water splitting for hydrogen production, photodegradation of organic pollutants, and photocatalytic carbon dioxide reduction are comprehensively summarized. The relationships between structures, properties, and photocatalytic performance of Bi‐based semiconductive composites are discussed in detail. In addition, the perspectives and future challenges on Bi‐MOFs‐based and derived materials for photocatalytic applications are also offered. [ABSTRACT FROM AUTHOR]

Nanocellulose and its derivatives represent the most abundant biopolymers on Earth, offering a wide range of advantages, including versatility in preparation, customizable functional group incorporation, and compatibility with various materials. They open up new horizons in the development of various types of metal‐ion batteries (MIBs). This work concisely categorizes nanocellulose design strategies, including rational isolation, surface chemical enhancement, and effective physical treatments. Subsequently, an overview of recent advancements in utilizing nanocellulose and its derivatives to enhance the performance of MIBs, from lithium‐ion batteries (LIBs) to post lithium‐ion batteries (e.g., Na+, K+, Zn2+, Mg2+, Ca2+) are provided. The pivotal roles of nanocellulose in electrode design, interface engineering, electrolyte modification, and binder optimization are highlighted. Lastly, the challenges and prospects of utilizing nanocellulose and its derivatives in MIBs are delved into. This work aims to comprehensively cover recent developments in nanocellulose surface modification strategies and illuminate their current applications in emerging MIBs with impressive energy and power densities. [ABSTRACT FROM AUTHOR]