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Background Diagnosis of fibrous tumors can be challenging and expensive due to the use of special stains. Objective Determine the usefulness of fluorescence microscopy in the evaluation of elastic pattern on H&E stained slides. Methods A total of 228 slides were evaluated by fluorescence microscopy for elastic tissue patterns and sensitivity and specificity determined for relevant comparisons. Results Fluorescence microscopy was found to be useful especially in the case of distinguishing dermatofibroma (DF) vs dermatofibrosarcoma protuberans (DFSP) and also dermatomyofibroma (DMF) vs other fibrous tumors. Limitations In some cases, excessive background staining made it difficult to interpret. Conclusion Evaluation of elastic tissue patterns by fluorescence microscopy in fibrous tumors is a cheap and efficient means to further delineate these often challenging tumors.

Resume Introduction Le dermatomyofibrome (DMF) est une tumeur benigne rare et peu connue des dermatologues. Il possede pourtant certaines caracteristiques cliniques, histologiques et immunohistochimiques qui permettent de le differencier des autres tumeurs fibreuses. Materiel et methodes Nous decrivons les aspects cliniques, histologiques et immunohistochimiques de huit cas de DMF identifies entre 2008 et 2019 au laboratoire de dermatopathologie de Strasbourg. Resultats Il y avait 5 femmes et 3 hommes, d’âge moyen au diagnostic de 21 ans et 9 mois (9 a 54 ans). La taille variait de 1 a 11 cm. La localisation preferentielle etait le haut du corps (6 cas), un cas etait sur l’abdomen et un cas etait sur le flanc. Il s’agissait d’un nodule ou d’une plaque unique lisse d’evolution lentement progressive, de couleur erythemateuse ou chamois. La plaque de grande taille etait dure et entrainait une gene fonctionnelle pour les mouvements du cou. On avait dans tous les cas une proliferation dermique de cellules fusiformes monomorphes paralleles a l’epiderme, sans atypie ni mitose. L’hypoderme etait envahi dans cinq cas. La calponine etait toujours exprimee sauf dans un cas. La caldesmone, la PS100 et la desmine n’etaient jamais exprimees. L’actine muscle lisse etait exprimee dans deux cas et on observait egalement dans ces deux cas une expression de la stromelysine 3. Le CD34 etait exprime dans deux cas. Discussion Le DMF est une tumeur evolutive qui peut atteindre de grands diametres et doit faire l’objet d’une exerese totale pour en eviter l’extension. Les diagnostics differentiels sont le dermatofibrosarcome de Darier–Ferrand, l’histiocytofibrome, les hamartomes conjonctifs, la myofibromatose et les cheloides. Un faisceau d’arguments cliniques (jeune âge, lesion extensive), histologiques (proliferation dermique horizontale) et immunohistochimiques (expression de calponine) permettent de l’identifier.

Dermatomyofibroma (DMF) is an uncommon benign myofibroblastic tumor most frequently seen in adult women; however, there are several reports of pediatric dermatomyofibroma.1,2 Lesions typically appear as long-standing, asymptomatic, skin-colored to red-brown, indurated plaques.1 DMF typically presents as a single lesion, with multiple DMFs representing an exceedingly rare presentation.3 Here, we present a case of multiple DMFs in a pediatric patient with a history of embryonal rhabdomyosarcoma and propose a possible association between multiple DMFs and embryonal tumors.

Dermatomyofibroma is a rare cutaneous mesenchymal tumor of benign fibroblastic and myofibroblastic derivations. It predominantly affects young women, and it usually presents as a reddish-brown plaque or nodule, which is commonly located over the upper trunk. We report the case of a 41-year-old female patient who presented with progressive linear dermatomyofibroma over the nape of her neck. This case report expands the knowledge about the clinical and histopathological features of this rare, benign and cutaneous tumor.

We present two infants with histologically confirmed congenital dermatomyofibromas. Congenital cases are rare with only one prior case reporting presence since birth. Given the benign nature of the lesions and propensity of dermatomyofibromas to resolve without intervention in young male patients, no additional treatments were pursued.

Dermatomyofibroma is a rare mesenchymal tumor of skin. The major differential diagnosis is dermatofibrosarcoma protuberans. Both lesions are composed of spindle-shaped cells which are CD34-positive. In contrast to the malignant counterpart, the tumor cells in dermatomyofibroma are without any evidence of COL1A1-PDGFB gene rearrangement. We present a case of axillary dermatomyofibroma in a 31-year-old woman. A hitherto undescribed clinical phenomenon is a maintained horripilation in contrast to dermatofibrosarcoma protuberans.

Dermatomyofibroma is a rare, benign mesenchymal proliferation not commonly reported in children. Two patients with biopsy-proven dermatomyofibroma were identified (one female, one male) at our institution, both with rather atypical clinical presentations. The clinical and histopathologic findings and a review of the literature are presented here. Features of dermatomyofibroma should be recognized and differentiated from those of similar-appearing entities since the prognosis of this benign tumor is favorable after complete excision.

Dermatomyofibroma represents a rare benign fibroblastic/ myofibroblastic cutaneous tumor that mostly occurs in young adult women. It has been seldom reported in pediatric patients. In this analysis, the clinical, histopathological and immunohistochemical findings of 12 dermatomyofibromas occurring in patients up to 16 years of age are compared with those reported in adults. Six patients were male and six were female. Nine lesions were located on the neck, two on the back and one involved the chest. The usual presentation was as an asymptomatic plaque composed of bland spindled cells arranged in dermal fascicles that were oriented parallel to the epidermis. Immunohistochemically, the lesional cells expressed calponin in 11 cases, smooth muscle actin in six and muscle-specific actin in three. In contrast to prior reports from adults, dermatomyofibromas in pediatric patients do not show a female predilection. In addition, they are mostly located on the neck (56%), while in adults the most frequent location is the shoulder (35%). Dermatomyofibromas seem to stabilize after an initial period of enlargement. Punch biopsy and clinical follow up could be an alternative approach to the surgical excision in some cases of dermatomyofibroma, particularly in instances in which surgery might inflict cosmetic defects.

Background Dermatomyofibroma is a rare but distinct benign cutaneous mesenchymal neoplasm of fibroblastic/myofibroblastic differentiation. It is more common in adolescents and young adults, with a female preponderance. In most cases, the lesions are asymptomatic and small, measuring from 10 to 20 mm. Early and active lesions tend to be actin positive. Case report We present a) a new case of dermatomyofibroma in an 11-month-old male infant, the youngest case reported to date, and b) the second reported case of a giant annular dermatomyofibroma, measuring 10 cm × 6 cm, in a 52-year-old woman. In both cases, histological examination showed a spindle-cell proliferation embedded among the collagen fibers of the dermis, arranged predominantly parallel to the skin surface. In both cases the spindle cells stained positive for smooth muscle actin and the elastic fibers were increased and fragmented. Conclusion Dermatologists and pediatricians should be aware of this benign entity in order to avoid unnecessary treatment.

The fibrohistiocytic tumors of the skin are a heterogeneous group of dermal/subcutaneous mesenchymal neoplasms which show fibroblastic, myofibroblastic and histiocytic (macrophage-like) differentiation, often one beside the other in the same tumor. "Fibrohistiocytic" means in this context the morphologic similarity of the cells with fibroblasts and histiocytes. The WHO classification of 2005 includes the following entities as fibrohistiocytic tumors of the skin: BENIGN: 1. Fibrous histiocytoma (FH)/(synonymous: Dermatofibroma. Variants of FH: 1a. cellular fibrous histiocytoma, 1b. atypical (pseudosarcomatous) fibrous histiocytoma, 1c. aneurysmatic fibrous histiocytoma, 1d. epithelioid fibrous histiocytoma; 2. dermatomyofibroma; 3. (juvenile) xanthogranuloma. INTERMEDIATE: 4. plexiform fibrohistiocytic tumor; 5. dermatofibrosarcoma protuberans; 6. atypical Fibroxanthoma. MALIGNANT: 7. malignant fibrous histiocytoma. All these entities are reviewed in this paper with particular attention devoted to differential diagnostic considerations.

Dermatomyofibroma is a recently described plaque-like dermal tumour composed of myofibroblasts that usually presents around the shoulder, axilla and posterior neck, often in young adult females. Here, we present two cases, one from the posterior axilla of a 33-year-old female and one from the posterior neck of a 7-year-old male. Both were clinically red-brown lesions with histological and immunohistochemical features diagnostic of dermatomyofibroma. There was no evidence of aggressive biologic behaviour with 3 months and 2 months follow up, respectively. While the majority of dermatomyofibromas present in postpubescent females, the 7-year-old male exemplifies a subgroup occurring in male children which appears to show a particular predilection for the posterior neck.

This case report describes a 4-year-old boy with a dermatomyofibroma on the posterior aspect of the neck. Dermatomyofibroma is a recently described, rare, benign proliferation of myofibroblasts of the skin, mainly found in young women. Only a few cases have been reported in males. This entity is not generally well known and probably often misdiagnosed. To our knowledge the patient presented here is the youngest diagnosed thus far.

We present a rare case of a fibromatosis-like myofibroblastic tumour of the forearm with infiltration of muscular, neural, and vascular structures. This is a rare and transitional type of myofibroblastic tumour, and we emphasise important aspects of diagnosis, clinical features, interdisciplinary management, and differential diagnoses.

On the basis of two cases the differences between the plaque-like variant of dermatofibrosarcoma protuberans (PDFSP) and the plaque-like dermal fibromatosis (synonym: dermatomyofibroma; PDF) are presented. PDFSP and PDF are two clinically very similar dermal fibrous proliferations, but differentiation is important because of their different therapy and prognosis. Histologically and immunohistochemically PDFSP and PDF can be recognized as separate entities.

We report the case of a 9-year-old girl with a lesion on the posterior aspect of the neck, which was clinically compatible with granuloma annulare. An incisional biopsy was performed and the result of the biopsy was consistent with a fibrohistiocytic proliferation. After the total excision of the lesion, the definitive diagnosis of dermatomyofibroma was determined. Dermatomyofibroma is a benign and rare proliferation of myofibroblasts of the skin. Dermatomyofibroma is a solitary and slowly growing tumor. It is more common in adolescents and young adults, with a female preponderance. Dermatomyofibroma presents clinically as a papule or nodule. It may be slightly hyperpigmented. It is usually located on the upper trunk, axilla, upper arm, or neck. The treatment of choice is complete excision and the prognosis is excellent.

O Dermatomiofibroma está incluído no grupo de lesões neoplásicas mesenquimais benignas de linhagem fibroblástica e miofibroblástica da pele. É uma doença rara, havendo aproximadamente 100 casos descritos na literatura mundial até o momento. Este artigo relata o caso de uma mulher jovem com apresentação clínica típica e diagnóstico histopatológico de dermatomiofibroma. Foram realizadas colorações especiais que mostraram preservação das fibras colágenas e a imunohistoquímica revelou positividade para vimentina e negatividade para actina e S100. Por se tratar de doença rara, os achados histopatológicos são de grande importância, mas a supeição clínica é possível em casos típicos como este. Dermato myofibroma is included in the group of benign cutaneous mesenchymal neoplastic lesions of fibroblastic and myofibroblastic lineage. It's a rare disease and there are approximately only one hundred cases described worldwide in the medical literature up to now. The present study reports the case of a young woman with typical clinical cutaneous lesion and histopathological diagnosis of dermato myofibroma. Special stains were carried out which showed preserved collagen fibers and immunohistochemistry was positive for vimentin and negative for actin and S100. As it is a rare disease, the histopathological findings are of great importance but clinical suspicion is possible in typical cases such as this one.

We report on a case of multiple dermatomyofibromas on the posterior neck of a 10-year-old boy. Dermatomyofibroma is a benign proliferation of myofibroblasts of the skin. It is more common in adolescents and young adults, with a female preponderance. It usually appears as a single plaque or nodule. To our knowledge, this is the first case of multiple dermatomyofibromas reported in the literature.

Dermatomyofibroma is a rare benign cutaneous mesenchymal neoplasm of the fibroblasts and myofibroblasts. The majority of dermatomyofibromas present as red-brown discolored plaques or nodules, commonly located on the shoulder, upper arm, axilla, neck, and/or upper trunk. These lesions develop most frequently in young female patients at a mean of 28-years-of-age. Herein, a case of dermatomyofibroma is reported that developed in an infant. A 4-month-old boy presented with an ill-defined bluish firm plaque on the trunk that developed 1 month after birth. Histopathologically, there was proliferation of bland-looking spindle cells with fascicular arrangement in the dermis and subcutaneous tissue. Immunohistochemistry showed that most of the tumor cells expressed diffuse positivity for vimentin and smooth muscle actin, but were negative for S-100 protein, desmin, and CD34.