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580 results on '"di Meo, Nicola"'

7. Dermoscopy/Confocal Microscopy for Melanoma Diagnosis

Author

Lee, Katie J., di Meo, Nicola, Yélamos, Oriol, Malvehy, Josep, Zalaudek, Iris, Soyer, H. Peter, Balch, Charles M., editor, Atkins, Michael B., editor, Garbe, Claus, editor, Gershenwald, Jeffrey E., editor, Halpern, Allan C., editor, Kirkwood, John M., editor, McArthur, Grant A., editor, Thompson, John F., editor, and Sober, Arthur J., editor

Published
2020
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8. Staphylococcus lugdunensis cutaneous infection with sporotrichoid distribution

Author

di Meo, Nicola, Trevisini, Sara, Noal, Cecilia, Nan, Katiuscia, and Trevisan, Giusto

Subjects
staphylococcus, lugdunensis, infection, sporothrichoid
Abstract

We report the occurrence of Staphylococcus lugdunensis cutaneous infection with sporotrichoid distribution of the left lower limb of a 60-year-old man. Recent studies have confirmed that Staphylococcus lugdunensis is a significant pathogen in causing skin and soft tissue infections that usually manifest in abscesses, surgical wound infections, and cellulitis. It used to be considered a skin commensal bacteria, but if unrecognized it can lead to  fulminant endocarditis, meningitis, skin abscesses, peritonitis, and spondylodiscitis.

Published
2017

9. Trichophyton indotineae , an Emerging Drug-Resistant Dermatophyte: A Review of the Treatment Options.

Author

Sonego, Benedetta, Corio, Andrea, Mazzoletti, Vanessa, Zerbato, Verena, Benini, Alessandro, di Meo, Nicola, Zalaudek, Iris, Stinco, Giuseppe, Errichetti, Enzo, and Zelin, Enrico

Subjects
TRICHOPHYTON, MYCOSES, FILAMENTOUS fungi, TERBINAFINE, GRISEOFULVIN, DERMATOMYCOSES
Abstract

Background: Dermatophytosis is a prevalent superficial infection caused by filamentous fungi, primarily affecting the skin and/or its appendages. In recent years, there has been a notable increase in mycotic strains resistant to standard antifungal therapies, including Trichophyton indotineae, a dermatophyte of the Trichophyton mentagrophytes complex. This review aims to provide a comprehensive overview of the treatment options for T. indotineae, elucidating their effectiveness in managing this challenging mycotic infection. Methods: For this review, a search was conducted in the PubMed, Scopus, Web of Science, Embase, and Google Scholar databases, encompassing all published data until March 2024. English-language articles detailing therapy outcomes for patients confirmed to be affected by T. indotineae, identified through molecular analysis, were included. Results: Itraconazole was shown to be a good therapeutic choice, particularly when administered at a dosage of 200 mg/day for 1–12 weeks. Voriconazole was also demonstrated to be effective, while terbinafine exhibited a reduced response rate. Griseofulvin and fluconazole, on the other hand, were found to be ineffective. Although topical treatments were mostly ineffective when used alone, they showed promising results when used in combination with systemic therapy. Mutational status was associated with different profiles of treatment response, suggesting the need for a more tailored approach. Conclusions: When managing T. indotineae infections, it is necessary to optimize therapy to mitigate resistances and relapse. Combining in vitro antifungal susceptibility testing with mutational analysis could be a promising strategy in refining treatment selection. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Sporotrichoid Mycobacterium marinum infection in an elderly woman

Author

di Meo, Nicola, Stinco, Giuseppe, Trevisini, Sara, De Marchi, Sergio, Albano, Antonio, and Trevisan, Giusto

Abstract

We describe the case of an elderly woman who acquired a Mycobacterium marinum infection following skin exposure to the bacteria through a small wound on her right ring finger, obtained while preparing fish. The resultant sporotrichoid nodules of the right hand and the distal forearm, refractory to the initial therapy with doxycycline and rifampicin, were successfully treated with oral regimen of clarithromycin.

Published
2015

12. Giant melanoma of the abdomen: case report and revision of the published cases

Author

di Meo, Nicola, Stinco, Giuseppe, Gatti, Alessandro, Errichetti, Enzo, Bonin, Serena, Albano, Antonio, Trevisini, Sara, and Trevisan, Guisto

Abstract

Malignant melanoma presenting as a giant cutaneous mass is rarely observed in clinical practice. A few patients with giant melanoma have been reported, Herein, we document our experience with a patient with giant cutaneous melanoma of the abdomen and review the features of previously reported individuals.

Published
2014

13. Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review.

Author

Zelin, Enrico, Mazzoletti, Vanessa, Cavallo, Francesco, Nardello, Carlotta, Corio, Andrea, Toffoli, Ludovica, Tagliaferri, Luca, Conforti, Claudio, Di Meo, Nicola, and Zalaudek, Iris

Subjects
HEDGEHOG signaling proteins, IMMUNE checkpoint inhibitors, LITERATURE reviews, RADIOTHERAPY, CEMIPLIMAB, HEAD & neck cancer
Abstract

Locally advanced (laBSCs) and metastatic basosquamous carcinomas (mBSCs) represent a therapeutic challenge. By definition, these forms are not amenable to surgery or radiotherapy, but according to literature reports, sonic hedgehog pathway inhibitors (HHIs), anti‐programmed death 1 receptor antibodies (anti‐PD‐1), and other treatment approaches involving chemotherapy, surgery, and radiotherapy have been used. This work features 5 real‐life cases of advanced BSCs, treated at the Dermato‐Oncology Unit of Trieste (Maggiore Hospital, University of Trieste). In addition, a review of the current treatment options reported in the literature for laBSC and mBSC is provided, collecting a total of 17 patients. According to these preliminary data, HHIs such as sonidegib and vismodegib could represent a safe and effective first line of treatment, while the anti‐PD‐1 cemiplimab may be useful as a second‐line option. Chemotherapy and combined approaches involving surgery and radiotherapy have been also reported to be suitable in some patients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Cutaneous B-Cell Chronic Lymphocytic Leukaemia resembling a Granulomatous Rosacea

Author

di Meo, Nicola, Stinco, Giuseppe, and Trevisan, Giusto

Subjects
b cll, granulomatous rosacea, leukemia cutis.
Abstract

B-cell chronic lymphocytic leukemia (B-CLL) is a low-grade lymphoproliferative disease. Cutaneous involvement of B-CLL is limited and, in most cases, it represents non-specific manifestations related to an impaired immune system. Leukemic skin infiltrates (leukemia cutis) occur in 4–20% of patients. Herein we report the case of a 65-year-old woman with B-CLL presenting with papular, nodular, and plaque skin infiltrates affecting the nose, mimicking granulomatous rosacea. We discuss several aspects of rare cutaneous manifestations of B-CLL involving the face.

Published
2013

20. The history of Lyme disease in Italy and its spread in the Italian territory

Author

Trevisan, Giusto, primary, Ruscio, Maurizio, additional, Cinco, Marina, additional, Nan, Katiuscia, additional, Forgione, Patrizia, additional, Di Meo, Nicola, additional, Tranchini, Paolo, additional, Nacca, Massimo, additional, Trincone, Silvana, additional, Rimoldi, Sara Giordana, additional, Giacomet, Vania, additional, Ricci, Michela, additional, Melandri, Davide, additional, Artioli, Stefania, additional, Monteforte, Patrizia, additional, Stinco, Giuseppe, additional, and Bonin, Serena, additional

Published
2023
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22. Dermoscopy/Confocal Microscopy

Author

Lee, Katie J., primary, di Meo, Nicola, additional, Yélamos, Oriol, additional, Malvehy, Josep, additional, Zalaudek, Iris, additional, and Soyer, H. Peter, additional

Published
2019
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32. Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer

Author

Lasorsa, Francesco, primary, di Meo, Nicola Antonio, additional, Rutigliano, Monica, additional, Ferro, Matteo, additional, Terracciano, Daniela, additional, Tataru, Octavian Sabin, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2023
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34. Cutaneous melanoma frequencies and seasonal trend in 20 years of observation of a population characterised by excessive sun exposure

Author

Bonin Serena, Albano Antonio, di Meo Nicola, Gatti Alessandro, Stinco Giuseppe, Zanconati Fabrizio, and Trevisan Giusto

Subjects
cutaneous melanoma, sun exposure, frequencies, multiple melanomas, gender related differences, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Background. Cutaneous melanoma is an aggressive form of skin cancer. It has become an increasingly common neoplasm in the most developed countries, especially among individuals of European origin.

Published
2015
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36. Renal Cell Carcinoma as a Metabolic Disease: An Update on Main Pathways, Potential Biomarkers, and Therapeutic Targets

Author

di Meo, Nicola Antonio, primary, Lasorsa, Francesco, additional, Rutigliano, Monica, additional, Loizzo, Davide, additional, Ferro, Matteo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Pandolfo, Savio Domenico, additional, Autorino, Riccardo, additional, Crocetto, Felice, additional, Montanari, Emanuele, additional, Spilotros, Marco, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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37. MUC1 Tissue Expression and Its Soluble Form CA15-3 Identify a Clear Cell Renal Cell Carcinoma with Distinct Metabolic Profile and Poor Clinical Outcome

Author

Lucarelli, Giuseppe, primary, Rutigliano, Monica, additional, Loizzo, Davide, additional, di Meo, Nicola Antonio, additional, Lasorsa, Francesco, additional, Mastropasqua, Mauro, additional, Maiorano, Eugenio, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Battaglia, Michele, additional, and Ditonno, Pasquale, additional

Published
2022
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42. Uncommon lymphocutaneous cellulitis after insect bite: a case report of primary cutaneous nocardiosis and literature review

Author

Lovecchio, Antonio, Bazzacco, Giulia, DI BELLA, Stefano, DI MEO, Nicola, Luzzati, Roberto, Lovecchio, Antonio, Bazzacco, Giulia, DI BELLA, Stefano, DI MEO, Nicola, and Luzzati, Roberto

Subjects
nocardia, cutaneous nocardiosis, cutaneous nocardiosi, insect bite, actinomycetes, immunocompetent, actinomycete, Case Report
Abstract

Nocardia is a genus of aerobic actinomycetes that are usually responsible for opportunistic infection in immunocompromised patients. Less frequently nocardiosis can interest immunocompetent population, causing especially primary cutaneous infections. Cutaneous involvement by Nocardia spp. may occur mostly as one of four clinical manifestations: superficial cellulitis or abscess, mycetoma, lymphocutaneous (also defined “sporotrichoid”) infection and secondary cutaneous involvement from systemic disease. Infections usually present after minor local injury, especially in traumatic outdoor activities (e.g. gardeners, farmers, road accidents), with subsequent environmental contamination of the wound. In sporadic cases cutaneous infection follows an insect bite. Microbiological diagnosis is often difficult to obtain and N. brasiliensis is the species isolated in most cases (80%). We present the case of a 45-year-old female with fever and a painful and necrotizing lesion on her right leg with secondary ascending lesions occurred on the homolateral knee and consensual groin lymphadenopathy after insect sting (maybe a spider bite). Cultures on skin biopsy identified Nocardia brasiliensis. Infection was completely healed after 5 months of targeted antibiotic therapy. In addition, we performed a literature review of all cutaneous nocardiosis cases in immunocompetent individuals, finding that only in 22 cases the infection presented after insect bite; in most of these cases lymphocutaneous manifestation was seen and N. brasiliensis was the Nocardia species isolated. Our case, along with others in literature, reveals that the real burden of soft-tissues nocardiosis seems low but probably many cases might go undiagnosed because of difficulties in microbiology diagnosis. Primary cutaneous nocardiosis should be included in the diagnostic pathway in cases of cellulitis following insect bite or sting, especially when localized to extremities.

Published
2022

44. Immune Checkpoint Inhibitors in Renal Cell Carcinoma: Molecular Basis and Rationale for Their Use in Clinical Practice.

Author

Lasorsa, Francesco, di Meo, Nicola Antonio, Rutigliano, Monica, Milella, Martina, Ferro, Matteo, Pandolfo, Savio Domenico, Crocetto, Felice, Tataru, Octavian Sabin, Autorino, Riccardo, Battaglia, Michele, Ditonno, Pasquale, and Lucarelli, Giuseppe

Subjects
IMMUNE checkpoint inhibitors, IPILIMUMAB, RENAL cancer, THERAPEUTICS, IMMUNE checkpoint proteins, DIAGNOSIS
Abstract

Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most common cancer in women worldwide. There is plenty of evidence about the role of the immune system in surveillance against tumors. Thanks to a better understanding of immunosurveillance mechanisms, immunotherapy has been introduced as a promising cancer treatment in recent years. Renal cell carcinoma (RCC) has long been thought chemoresistant but highly immunogenic. Considering that up to 30% of the patients present metastatic disease at diagnosis, and around 20–30% of patients undergoing surgery will suffer recurrence, we need to identify novel therapeutic targets. The introduction of immune checkpoint inhibitors (ICIs) in the clinical management of RCC has revolutionized the therapeutic approach against this tumor. Several clinical trials have shown that therapy with ICIs in combination or ICIs and the tyrosine kinase inhibitor has a very good response rate. In this review article we summarize the mechanisms of immunity modulation and immune checkpoints in RCC and discuss the potential therapeutic strategies in renal cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Metabolomic Approaches for Detection and Identification of Biomarkers and Altered Pathways in Bladder Cancer

Author

di Meo, Nicola Antonio, primary, Loizzo, Davide, additional, Pandolfo, Savio Domenico, additional, Autorino, Riccardo, additional, Ferro, Matteo, additional, Porta, Camillo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Crocetto, Felice, additional, Tataru, Octavian Sabin, additional, Rutigliano, Monica, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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46. Novel Insights into Autophagy and Prostate Cancer: A Comprehensive Review

Author

Loizzo, Davide, primary, Pandolfo, Savio Domenico, additional, Rogers, Devin, additional, Cerrato, Clara, additional, di Meo, Nicola Antonio, additional, Autorino, Riccardo, additional, Mirone, Vincenzo, additional, Ferro, Matteo, additional, Porta, Camillo, additional, Stella, Alessandro, additional, Bizzoca, Cinzia, additional, Vincenti, Leonardo, additional, Spilotros, Marco, additional, Rutigliano, Monica, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, and Lucarelli, Giuseppe, additional

Published
2022
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50. Bilateral ovarian involvement as the first site of melanoma metastasis: a case report and review of the literature

Author

Conforti, Claudio, Retrosi, Chiara, Vezzoni, Roberta, Magaton-Rizzi, Giovanni, Giuffrida, Roberta, Degrassi, Ferruccio, Cova, Maria A, Zalaudek, Iris, Di Meo, Nicola, Conforti, Claudio, Retrosi, Chiara, Vezzoni, Roberta, Magaton-Rizzi, Giovanni, Giuffrida, Roberta, Degrassi, Ferruccio, Cova, Maria A, Zalaudek, Iri, and Di Meo, Nicola

Subjects
gyneceology, metastase, melanoma, metastases
Abstract

N/A

Published
2021

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