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Use THE definitive reference for laboratory medicine and clinical pathology! Tietz Textbook of Laboratory Medicine, 7th Edition provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Comprehensive coverage includes the latest advances in topics such as clinical chemistry, genetic metabolic disorders, molecular diagnostics, hematology and coagulation, clinical microbiology, transfusion medicine, and clinical immunology. From a team of expert contributors led by Nader Rifai, this reference includes access to wide-ranging online resources on Expert Consult — featuring the comprehensive product with fully searchable text, regular content updates, animations, podcasts, over 1300 clinical case studies, lecture series, and more. - Authoritative, current content helps you perform tests in a cost-effective, timely, and efficient manner; provides expertise in managing clinical laboratory needs; and shows how to be responsive to an ever-changing environment. - Current guidelines help you select, perform, and evaluate the results of new and established laboratory tests. - Expert, internationally recognized chapter authors present guidelines representing different practices and points of view. - Analytical criteria focus on the medical usefulness of laboratory procedures. - Use of standard and international units of measure makes this text appropriate for any user, anywhere in the world. - Elsevier eBooks+ provides the entire text as a fully searchable eBook, and includes animations, podcasts, more than 1300 clinical case studies, over 2500 multiple-choice questions, a lecture series, and more, all included with print purchase. - NEW! 19 additional chapters highlight various specialties throughout laboratory medicine. - NEW! Updated, peer-reviewed content provides the most current information possible. - NEW! The largest-ever compilation of clinical cases in laboratory medicine is included with print purchase on Elsevier eBooks+. - NEW! Over 100 adaptive learning courses included with print purchase on Elsevier eBooks+ offer the opportunity for personalized education.

This textbook describes several diseases and clinical conditions, from physiopathological mechanisms to main clinical pictures, highlighting the importance of laboratory medicine, with the aim to provide the necessary tools for guiding correct laboratory findings interpretation. Indeed, it is now widely recognized that laboratory medicine has a pivotal role in clinical medicine, significantly influencing clinical decisions. Thus, it is crucial to understand and use laboratory data appropriately. This book has the great advantage of describing each topic exhaustively in order to facilitate its understanding. Specifically, it describes both diseases with a high incidence in the population, such as Diabetes Mellitus, Cardiovascular Diseases, Dyslipidemias, and Autoimmune Diseases, as well as rare diseases, such as Hereditary Metabolic Diseases. In addition, unusual topics are treated, such as Clinical Biochemistry of the Mind, as well as hot topics, such as Biological Drugs, Biobanks, Health Technology Assessment, and Omics Sciences. Finally, the book includes a chapter on the new health emergency, the SARS-CoV-2 pandemic. Two appendices are provided at the end of the book: a table summarizing the reference range and decisional cut-off for the main laboratory parameters and instructions on performing a venous blood sample. The book will be an invaluable tool for medical and biomedical students, as well as for practitioners.

The information nurses need…when, where, and how they need it! Nursing-focused and easy-to-read, this full-color manual delivers all the information you need to understand how tests work, interpret their results, and provide quality patient care—pre-test, intra-test, and post-test. Tests and procedures are listed in alphabetical order by their complete name for quick reference. The integrated index allows fast searches by abbreviation, synonym, disease/disorder, specimen type, or test classification.

Kurz nach der deutschen Wiedervereinigung übernahm Manfred Dietel die Leitung des berühmten Rudolf-Virchow-Hauses. Zweiundzwanzig Jahre lang führte er das Institut für Pathologie der Charité, diente als Dekan und Ärztlicher Direktor und hatte entscheidenden Anteil am Auf- und Umbau des traditionsreichen Berliner Krankenhauses. Nach einer kurzen Darstellung seines Werdegangs schildert Manfred Dietel die turbulenten Ereignisse und kontroversen wissenschaftspolitischen Auseinandersetzungen, die sich nach der Wende in der Berliner Universitätsmedizin abspielten. Spannend und eindrücklich beleuchtet er die oft unglückliche Rolle des Berliner Senats wie auch hausinterne Ost-West-Konflikte und die schwierige Position des Wissenschaftsrates in dieser bewegten Zeit. Anschließend bietet der Autor eine ebenso verständliche wie anschauliche Einführung in das faszinierende Fach der'klinischen und molekularen Pathologie'. Die Integration neuer immunologischer und molekularer Techniken hat diesem für die klinische Diagnostik so zentralen Fach in den letzten drei Jahrzehnten – speziell in der Krebsdiagnostik – einen enormen Bedeutungszuwachs beschert. So entwickelte sich etwa die histologische Gewebediagnostik von einer zumeist deskriptiven zur eher prädiktiven, sprich die Therapieentscheidung direkt beeinflussenden, Disziplin. Der Beitrag, den die Pathologie der Charité durch jahrelange intensive Forschungsarbeit in der Onkologie dazu geleistet hat, ist kaum zu überschätzen und wird exemplarisch dargestellt. Abgerundet werden die Innenansichten durch die amüsante Skizzierung besonderer Ereignisse und origineller Aktivitäten sowie persönlicher Erfahrungen. Originell und humorvoll berichtet Manfred Dietel in diesem Buch von den komplexen Abläufen in der weltberühmten Charité und präsentiert so bewegende Einblicke in eine prägende Zeit der Medizingeschichte.

There is a dearth of quality books concentrating on this pertinent topic Lab Investigations in Rheumatic Diseases. This book aims to fill this void, with 15 well thought out chapters dealing with all available investigations used in the management of rheumatic diseases.

Conventional methods of detecting disease remission in cancers such as leukemia rely on microscopic analysis of tissue samples. Measurable (or minimal) residual disease (MRD) describes the presence of disease beyond the levels of sensitivity afforded by microscopy. Fast Facts: Measurable Residual Disease describes what is meant by MRD, the opportunities and challenges afforded by its identification and the advantages and disadvantages of the methods used for its detection. Specific examples are given to illustrate the implications of detecting MRD in different disease scenarios, with emphasis on acute myeloid and lymphoblastic leukemias. With the recognition and monitoring of MRD likely to play an increasingly important role in disease prognosis and subsequent treatment direction, this accessible resource is ideal for any healthcare professional wanting to know more about this exciting and fast-moving area.

The seventh edition of this concise, highly practical guide to the interpretation of normal and abnormal laboratory results is fully revised and expanded, with updates on established and familiar tests, as well as interpretations on recent developments.With increasing responsibility being placed on primary care, the book includes guidelines on specific clinical conditions such as heart failure, management of female infertility, specific lipid monitoring in diabetes and guidance for monitoring renal failure. It also includes suggestions for appropriate laboratory tests in certain clinical situations, for example: dementia screen, screening tests when a patient presents with a neuropathy, and appropriate tests for patients presenting with hypertension, chronic fatigue syndrome, erectile dysfunction and gynaecomastia. Completely up-to-date, A Guide to Laboratory Investigations, Seventh Edition remains an essential handbook for all primary care professionals professionals and a valuable reference for medical students and hospital physicians in training and in practice.

A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules. With this desirability in mind, the book unites different techniques through which extremely small-sized particles can be utilized as a successful carrier for curing chronic as well as life-threatening diseased conditions. This is a highly informative and prudently organized book, providing scientific insight for readers with an interest in nanotechnology. Beginning with an overview of nanocarriers, the book impetuses on to explore other essential ways through which these carriers can be employed for drug delivery to varieties of administrative routes. This book discusses the functional and significant features of nanotechnology in terms of Lymphatic and other drug targeting deliveries. The book is presenting depth acquaintance for various vesicular and particulate nano-drug delivery carriers, utilized successfully in Pharmaceutical as well as in Cosmeceutical industries along with brief information on their related toxicities. In addition, the work also explores the potential applications of nanocarriers in biotechnology sciences for the prompt and safe delivery of nucleic acid, protein, and peptide-based drugs. An exclusive section in the book illuminates the prominence and competent applicability of nanotechnology in the treatment of oral cancer. The persistence of this book is to provide basic to advanced information for different novel carriers which are under scale-up consideration for the extensive commercialization. The book also includes recent discoveries and the latest patents of such nanocarriers. The cutting-edge evidence of these nanocarriers available in this book is beneficial to students, research scholars, and fellows for promoting their advanced research.

Safely handle urine and body fluids | Process and analyze them effectively Here's a comprehensive and highly visual introduction to the theoretical knowledge and practical skills needed to safely handle and analyze non-blood body fluids. The authors'focused and reader-friendly approach begins with an emphasis on safety; introduces automation in urinalysis and body fluids analysis; and presents the foundational concepts of renal function and urinalysis. Then, step by step, you'll learn the critical lab procedures for the examination of urine, cerebrospinal fluid, semen, synovial fluid, serous fluid, bronchoalveolar lavage fluid, amniotic fluid, feces, and vaginal secretions.

El libro Enfoque clínico y de pruebas diagnósticas en parasitología es un texto guía para el aprendizaje, la enseñanza y el entrenamiento en el diagnóstico clínico y de laboratorio de las principales enfermedades humanas de origen parasitario y de interés en salud pública. Está dirigido al personal del área de la salud profesional y en formación, así como a docentes de la misma rama. El libro se divide en ocho capítulos, a través de los cuales el lector obtendrá una descripción general de la patología parasitaria, acompañada de una descripción detallada de las técnicas de laboratorio para la detección de los parásitos y, al final del texto, una correlación clínica que ofrece una orientación práctica en el abordaje diagnóstico del paciente. Asimismo, uno de los capítulos contiene la descripción detallada de los helmintos y protozoos de vehiculación hídrica y alimentar como evento de interés en salud comunitaria y en la industria de alimentos.

This book describes some of the key epidemiological principles, scientific approaches and quality assurance frameworks required to design and conduct biobank studies in various settings. Using examples from contemporary biobanks, the book addresses the design features and practical procedures needed in order to launch and manage biobank studies, including consent and regulatory approval, the organisation of field work, management of data and biological samples, follow-up and verification of disease outcomes, development of IT systems for data collection, quality assurance and study management. Over the last two decades, several large biobank studies have been initiated in different populations, intended to greatly enhance the development of precision medicine. Contemporary biobank studies are extremely large and complex, and involve several decades of follow-up. Such studies pose major challenges in terms of ensuring rapid recruitment, obtaining high-quality data, minimisingloss to follow-up, reliably classifying disease outcomes, and optimising the use of the biological samples collected. In this regard, the key to success lies not in planning the perfect study, but in planning the most appropriate, reliable, sustainable and future-proof study given the practical constraints of available resources, time and capacity. The authors of this handbook are epidemiologists, clinicians, software engineers, and laboratory and data scientists with extensive experience in conducting large biobank studies. The eight chapters can be read separately or together, and provide readers with essential information on how to design, implement and manage these studies. The state-of-the-art, innovative and scalable approaches and methodologies presented here are intended to stimulate the development of further population-based and hospital-based biobank studies in diverse populations.

This well-illustrated book covers the full range of lung and pleural diseases from the pathologic standpoint. It has been updated from the first edition by including the most recent molecular data for the different lung diseases, tumor as well as non-tumor ones. New diagnostic tests are included, new aspects for the understanding of diseases have been added. Both diseases of adults and pediatric lung diseases are presented. The chapter on lung development has been expanded due to the many new findings being reported since the first edition.The book will serve as an excellent guide to the diagnosis of these diseases, but in addition it explains the disease mechanisms and etiology. Genetics and molecular biology are also discussed whenever necessary for a full understanding. The author is an internationally recognized expert who runs courses on lung and pleural pathology attended by participants from all over the world. In compiling this book, he has drawn on more than 30 years'experience in the field.

Pediatric Reference Intervals, Eighth Edition, is a must-have for clinical chemists, hematologists, pathologists, endocrinologists and pediatricians. This trusted source enhances interpretation of patient results, allows comparison of test results using different methods, and helps optimize patient care. This updated edition is a valuable reference, providing instant and accurate reference intervals for over 250 chemistry and hematology analytes in an alphabetized, user-friendly format. Changes to this edition include Age- and Sex-Related Reference Ranges, Methodologies, Type of Specimen, References, Statistical Basis and Population Sources. - Provides the reference intervals for a wide variety of analytes for children, from neonates to adolescents to young adults - Enhances interpretation of patient results, allows comparison of text results using different methods, and helps optimize patient care - Trusted, vetted source that's been in the market for decades

Manual dirigido a profesionales y estudiantes de las ciencias de la salud. El lector obtendrá conocimientos y habilidades en Medicina Basadas en la Evidencia (MBE) y en el análisis, interpretación y apreciación crítica de los diferentes diseños de investigación clínica, asimismo, podrá adquirir las herramientas básicas mediante el conocimiento de la estructura de los diferentes ensayos clínicos y de la estadística simple en la presentación de los resultados. Así podrá comenzar a realizar su propio proyecto de investigación.

First published in 1986: This book is to help medical, pharmacy, and advanced students in science to understand the growing importance of continuously advancing biochemical concepts in human disease.

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors. - Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing - Includes new case studies that highlight clinical relevance and errors to avoid - Highlights the best titles published within a variety of medical specialties - Reviewed by medical librarians and content specialists, with key selections compiled in their annual list

This book is the first exclusively devoted to the systematic synthesis of diagnostic test accuracy studies. It builds upon the major recent developments in reporting standards, search methods, and, in particular, statistical tools specifically devoted to diagnostic studies. In addition, it borrows extensively from the latest advances in systematic reviews and meta-analyses of intervention studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these approaches is demonstrated in the context of case studies from various clinical disciplines. Diagnosis is central in medical decision-making, and in many other fields of human endeavor, such as education and psychology. The plurality of sources of evidence on diagnostic test accuracy poses a huge challenge for practitioners and researchers, as do the multiple dimensions of evidence validity, which include sensitivity, specificity, predictive values, and likelihood ratios. This book offers an invaluable resource for anyone aiming to improve decision-making processes in diagnosis, classification or risk prognostication, from epidemiologists to biostatisticians, radiologists, laboratory physicians and graduate students, as any physician interested in refining his methodological skills in clinical diagnosis.