1. Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications
- Author
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Valentina Villalobos Coa, Lissette Jiménez, Vito Lubes, Giuseppe Lubes, Carlos Ciangherotti, Edgar Del Carpio, and Lino Hernández
- Subjects
Lac, lactate ,BEOV, bis(ethylmaltolate)oxovanadium(IV) ,6-mepic, 6-methylpicolinic acid ,DMF, N,N-dimethylformamide ,salVal, N-salicylidene-l-valinate ,01 natural sciences ,GlyTyr, glycyltyrosine ,PTP1B, protein tyrosine phosphatase 1B ,GlyAla, glycylalanine ,HisGlyGly, histidylglycylglycine ,Glu, glutamic acid ,Im, imidazole ,chemistry.chemical_classification ,G, Gauss ,T, Tesla ,Bioinorganic chemistry ,salophen, N,N′-bis(salicylidene)-o-phenylenediamine ,Pro, proline ,Pro-Ala, prolylalanine ,Ox, oxalate ,GlyGlyCys, glycylglycylcysteine ,THF, tetrahydrofuran ,acac, acetylacetone ,Antiparasitic ,dmpp, 1,2-dimethyl-3-hydroxy-4-pyridinonate ,Ser, serine ,Vanadium ,hpno, 2-hydroxypyridine-N-oxide ,Article ,Sal-Ala, N-salicylidene-l-alaninate ,Ala, alanine ,Inorganic Chemistry ,MeCN, acetonitrile ,GlyGly, glycylglycine ,Antidiabetics ,SARS, severe acute respiratory syndrome ,hTf, transferring ,010405 organic chemistry ,py, pyridine ,2,2′-bipy, 2,2-bipyridine ,0104 chemical sciences ,chemistry ,Ala-Gly, alanylglycine ,NEP, neutral endopeptidas ,Cys, cysteine ,NADH and NAD+, nicotinamide adenine dinucleotide ,l.m.m., low molecular mass ,VanSer, Schiff base formed from o-vanillin and l-serine ,Pic, picolinic acid ,DNA, deoxyribonucleic acid ,Biotransformation ,Materials Chemistry ,GlyVal, glycylvaline ,biology ,Gly, glycine ,Amino acid ,HIV, human immunodeficiency virus ,HSA, albumin ,Biochemistry ,GlyGlyHis, glycylglycylhistidine ,Amino acids ,Chemical speciation ,Antitumors ,sal-l-Phe, N-salicylidene-l-tryptophanate ,medicine.symptom ,L-Glu(γ)HXM, l-glutamic acid γ-monohydroxamate ,PI3K, phosphoinositide 3-kinase ,EPR, Electron Paramagnetic Resonance ,Cyt, citrate ,medicine.drug_class ,Thr, threonine ,Vanadium complexes ,chemistry.chemical_element ,dhp, 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone ,NMR, Nuclear Magnetic Resonance ,Asp, aspartic acid ,010402 general chemistry ,Cofactor ,Ala-His, alanylhistidine ,GlyPhe, glycylphenylalanine ,mal, maltol ,Ad, adenosine ,salGlyGly, N-salicylideneglycylglycinate ,medicine ,Physical and Theoretical Chemistry ,LD50, the amount of a toxic agent (such as a poison, virus, or radiation) that is sufficient to kill 50 percent of population of animals ,γ-PGA, poly-γ-glutamic acid ,His, histidine ,VBPO, vanadium bromoperoxidases ,Ig, immunoglobulins ,saltrp, N-salicylidene-l-tryptophanate ,salTrp, N-salicylidene-L tryptophanate ,SalGly, salicylglycine ,Enzyme ,Mechanism of action ,RNA, ribonucleic acid ,biology.protein ,dipic, dipicolinic acid ,SalGlyAla, salicylglycylalanine ,GlyGlyGly, glycylglycylglycine ,Ala-Ser, alanylserine ,Hb, hemoglobin ,salSer, N-salicylideneserinate - Abstract
Highlights • Vanadium history and industrial applications. • Recent research on metal vanadium complexes with amino acids. • Vanadium complexes with amino acids and their properties. • Vanadium complexes are promising candidates as metallopharmaceuticals., In the last 30 years, since the discovery that vanadium is a cofactor found in certain enzymes of tunicates and possibly in mammals, different vanadium-based drugs have been developed targeting to treat different pathologies. So far, the in vitro studies of the insulin mimetic, antitumor and antiparasitic activity of certain compounds of vanadium have resulted in a great boom of its inorganic and bioinorganic chemistry. Chemical speciation studies of vanadium with amino acids under controlled conditions or, even in blood plasma, are essential for the understanding of the biotransformation of e.g. vanadium antidiabetic complexes at the physiological level, providing clues of their mechanism of action. The present article carries out a bibliographical research emphaticizing the chemical speciation of the vanadium with different amino acids and reviewing also some other important aspects such as its chemistry and therapeutical applications of several vanadium complexes.
- Published
- 2018
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