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The Indian subcontinent is highly susceptible to natural disasters. To abate the effect of the disasters, the government emanates institutional mechanisms and strategies for disaster preparedness, mitigation and response. Although there is well-established institutional framework in India for disaster management, there is no study that proposes a disaster supply chain structure under the institutional framework and integrates information and digital technologies (IDT) of industry 4.0 within it. The present study overcomes this research gap. It introduces an IDT structure within the institutional framework of India for multi-agency information sharing, coordination and decision making. It formulates a mathematical model and analyses the impact of IDT on the total response time through three scenarios. The results of scenario analysis reveal the significance of IDT on the disaster supply chains and its capability to handle information delays and IDT failure. The present study can be adopted by disaster management institutions to construct and implement better response practices at the operational, planning and strategic levels. Furthermore, the proposed model in the study can be used for vaccination planning, which includes vaccine distribution, monitoring, regulation and effective implmentation as a response against the current pandemic situation caused due to SARS-CoV-2. [ABSTRACT FROM AUTHOR]