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7 results on '"dos-Santos, Júlio Souza"'

1. B-1 lymphocytes are able to produce IL-10, but is not pathogenic during Leishmania (Leishmania) amazonensis infection

Author

Firmino-Cruz, Luan, Ramos, Tadeu Diniz, da Fonseca-Martins, Alessandra Marcia, Oliveira-Maciel, Diogo, Oliveira-Silva, Gabriel, dos Santos, Júlio Souza, Cavazzoni, Cecília, Morrot, Alexandre, Gomes, Daniel Claudio Oliveira, Vale, André Macedo, Decoté-Ricardo, Debora, Freire-de-Lima, Celio G., and de Matos Guedes, Herbert Leonel

Published
2020
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2. Intradermal Immunization of SARS-CoV-2 Original Strain Trimeric Spike Protein Associated to CpG and AddaS03 Adjuvants, but Not MPL, Provide Strong Humoral and Cellular Response in Mice

Author

Firmino-Cruz, Luan, primary, dos-Santos, Júlio Souza, additional, da Fonseca-Martins, Alessandra Marcia, additional, Oliveira-Maciel, Diogo, additional, Guadagnini-Perez, Gustavo, additional, Roncaglia-Pereira, Victor A., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Vicente Santos, Ana C., additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Rossi-Bergmann, Bartira, additional, Vale, Andre M., additional, Filardy, Alessandra D’Almeida, additional, Silva, Jerson Lima, additional, de Oliveira, Andrea Cheble, additional, Gomes, Andre M. O., additional, and de Matos Guedes, Herbert Leonel, additional

Published
2022
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3. Immunogenicity of SARS-CoV-2 Trimeric Spike Protein Associated to Poly(I:C) Plus Alum

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, da Fonseca-Martins, Alessandra Marcia, additional, Oliveira-Maciel, Diogo, additional, Perez, Gustavo Guadagnini, additional, Roncaglia-Pereira, Victor A., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Santos, Ana C. Vicente, additional, Leandro, Monique dos Santos, additional, Ferreira, Jesuino Rafael Machado, additional, Guimarães-Pinto, Kamila, additional, Conde, Luciana, additional, Rodrigues, Danielle A. S., additional, Silva, Marcus Vinicius de Mattos, additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Ferreira Jr., Orlando C., additional, Mohana Borges, Ronaldo da Silva, additional, Tanuri, Amilcar, additional, Souza, Thiago Moreno L., additional, Rossi-Bergmann, Bartira, additional, Vale, André M., additional, Silva, Jerson Lima, additional, de Oliveira, Andréa Cheble, additional, Filardy, Alessandra D’Almeida, additional, Gomes, Andre M. O., additional, and de Matos Guedes, Herbert Leonel, additional

Published
2022
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4. Immunogenicity of SARS-CoV-2 trimetric spike protein associated to Poly(I:C) plus Alum

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, Fonseca-Martins, Alessandra Marcia da, additional, Oliveira-Maciel, Diogo, additional, Perez, Gustavo Guadagini, additional, Pereira, Victor A. R., additional, Dumard, Carlos H., additional, Guedes-da-Silva, Francisca H., additional, Santos, Ana C. Vicente, additional, Leandro, Monique dos Santos, additional, Machado Ferreira, Jesuino Rafael, additional, Guimarães-Pinto, Kamila, additional, Conde, Luciana, additional, Rodrigues, Danielle A. S., additional, de Mattos Silva, Marcus Vinicius, additional, Alvim, Renata G. F., additional, Lima, Tulio M., additional, Marsili, Federico F., additional, Abreu, Daniel P. B., additional, Ferreira, Orlando, additional, Borges, Ronaldo da Silva Mohana, additional, Tanuri, Amilcar, additional, Souza, Thiago Moreno L., additional, Rossi-Bergamnn, Bartira, additional, Vale, André M., additional, Silva, Jerson Lima, additional, de Oliveira, Andrea Cheble, additional, Filardy, Alessandra D’Almeida, additional, Gomes, Andre M. O., additional, and Leonel de Matos Guedes, Herbert, additional

Published
2021
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5. MPLA and AddaVax® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis

Author

Oliveira-Maciel, Diogo, primary, dos-Santos, Júlio Souza, additional, Oliveira-Silva, Gabriel, additional, Mello, Mirian França de, additional, da Fonseca-Martins, Alessandra Marcia, additional, Carneiro, Monique Pacheco Duarte, additional, Ramos, Tadeu Diniz, additional, Firmino-Cruz, Luan, additional, Gomes, Daniel Claudio Oliveira, additional, Rossi-Bergmann, Bartira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2021
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6. Characterization of Sv129 Mice as a Susceptible Model to Leishmania amazonensis

Author

dos-Santos, Júlio Souza, primary, Firmino-Cruz, Luan, additional, Ramos, Tadeu Diniz, additional, Fonseca-Martins, Alessandra Marcia da, additional, Oliveira-Maciel, Diogo, additional, De-Medeiros, Juliana Valente Rodrigues, additional, Chaves, Suzana Passos, additional, Gomes, Daniel Claudio Oliveira, additional, and de Matos Guedes, Herbert Leonel, additional

Published
2019
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7. MPLA and AddaVax ® Adjuvants Fail to Promote Intramuscular LaAg Vaccine Protectiveness against Experimental Cutaneous Leishmaniasis.

Author

Oliveira-Maciel, Diogo, dos-Santos, Júlio Souza, Oliveira-Silva, Gabriel, Mello, Mirian França de, da Fonseca-Martins, Alessandra Marcia, Carneiro, Monique Pacheco Duarte, Ramos, Tadeu Diniz, Firmino-Cruz, Luan, Gomes, Daniel Claudio Oliveira, Rossi-Bergmann, Bartira, and de Matos Guedes, Herbert Leonel

Subjects
CUTANEOUS leishmaniasis, LEISHMANIASIS, VACCINES, VACCINE effectiveness, IMMUNIZATION, LEISHMANIA
Abstract

There is so far no vaccine approved for human leishmaniasis, mainly because of the lack of appropriate adjuvants. This study aimed to evaluate in mice the capacity of a mixture of monophosphoryl lipid A (MPLA) and AddaVax® adjuvants in enhancing the efficacy of a Leishvacin®-like vaccine comprised of Leishmania amazonensis whole antigens (LaAg). For that, mice were immunized with LaAg plus MPLA/AddaVax® by the intramuscular route (i.m.) prior to challenge with 2 × 105 and 2 × 106 living parasites. Immunization with LaAg alone reduced the lesion growth of the 2 × 105-challenged mice only in the peak of infection, but that was not accompanied by reduced parasite load, and thus not considered protective. Mice given a 2 × 106 -challenge were not protected by LaAg. The association of LaAg with MPLA/AddaVax® was able to enhance the cutaneous hypersensitivity response compared with LaAg alone. Despite this, there was no difference in proliferative cell response to antigen ex vivo. Moreover, regardless of the parasite challenge, association of LaAg with MPL/AddaVax® did not significantly enhance protection in comparison with LaAg alone. This work demonstrated that MPL/AddaVax® is not effective in improving the efficacy of i.m. LaAg vaccine against cutaneous leishmaniasis. [ABSTRACT FROM AUTHOR]

Published
2021
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