10,421 results on '"drug repurposing"'
Search Results
2. An update on drug repurposing in Parkinson’s disease: Preclinical and clinical considerations
3. Immune checkpoint blockade in experimental bacterial infections
4. Pan-genome analysis and drug repurposing strategies for extensively drug-resistant Salmonella Typhi: Subtractive genomics and e-pharmacophore approaches
5. FDA-approved polypeptide PTH 1–34 impedes palmitic acid-mediated osteoblasts dysfunction by promoting its differentiation and thereby improving skeletal health
6. Cyclosporine: Immunosuppressive effects, entwined toxicity, and clinical modulations of an organ transplant drug
7. Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing
8. Computational network analysis of two popular skin cancers provides insights into the molecular mechanisms and reveals common therapeutic targets
9. SR9009 attenuates TGF-β1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells
10. Repurposing mitochondria-targeted therapeutics for kidney diseases
11. Exploration of innovative drug repurposing strategies for combating human protozoan diseases: Advances, challenges, and opportunities
12. Tumour heterogeneity and personalized treatment screening based on single-cell transcriptomics
13. Targeting KRAS G12C and G12S mutations in lung cancer: In silico drug repurposing and antiproliferative assessment on A549 cells
14. Empagliflozin protects the heart from atrial fibrillation in rats through inhibiting the NF-κB/HIF-1α regulatory axis and atrial remodeling
15. Exploring the key structural attributes and chemico-biological interactions of pyridinone-based SARS-CoV-2 3CLpro inhibitors through validated structure-based drug design strategies
16. Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective
17. One arrow two eagles: Multifunctional nano-system for macrophage reprogramming and osteoclastogenesis inhibition against inflammatory osteolysis
18. Searching for the Holy Grail − Highly Potent Bridged Endoperoxides for Targeted Cancer Therapy
19. Discovery of Daclatasvir as a potential PD-L1 inhibitor from drug repurposing
20. Fosamprenavir and Tirofiban to combat COPD and cancer: A drug repurposing strategy integrating virtual screening, MD simulation, and DFT studies
21. Knowledge graph applications and multi-relation learning for drug repurposing: A scoping review
22. Trends in drug repurposing: Advancing cardiovascular disease management in geriatric populations
23. Drug repurposing using artificial intelligence, molecular docking, and hybrid approaches: A comprehensive review in general diseases vs Alzheimer's disease
24. Precision Drug Repurposing (PDR): Patient-level modeling and prediction combining foundational knowledge graph with biobank data
25. Host-targeted antivirals against SARS-CoV-2 in clinical development - Prospect or disappointment?
26. Unraveling the molecular landscape of non-small cell lung cancer: Integrating bioinformatics and statistical approaches to identify biomarkers and drug repurposing
27. IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials
28. ExPDrug: Integration of an interpretable neural network and knowledge graph for pathway-based drug repurposing
29. Leishmaniasis: A multifaceted approach to diagnosis, maladies, drug repurposing and way forward
30. Cys44 of SARS-CoV-2 3CLpro affects its catalytic activity
31. Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
32. Latent space arithmetic on data embeddings from healthy multi-tissue human RNA-seq decodes disease modules
33. MFF-DTA: Multi-scale feature fusion for drug-target affinity prediction
34. Epertinib counteracts multidrug resistance in cancer cells by antagonizing the drug efflux function of ABCB1 and ABCG2
35. DRADTiP: Drug repurposing for aging disease through drug-target interaction prediction
36. SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
37. Discovery of new Glyoxalase I inhibitors by repurposing of FDA-approved drugs: An in silico study
38. Role of ribosomal pathways and comorbidity in COVID-19: Insight from SARS-CoV-2 proteins and host proteins interaction network analysis
39. L-Thyroxine and L-thyroxine-based antimicrobials against Streptococcus pneumoniae and other Gram-positive bacteria
40. Predicting drug response through tumor deconvolution by cancer cell lines
41. Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)
42. Repurposing antiviral drugs targeting the PARP-1 and HER2 pathways with multifaceted impacts through integrated network analysis and molecular mechanics
43. Computer-aided drug repurposing to tackle antibiotic resistance based on topological data analysis
44. Lansoprazole as a potent HDAC2 inhibitor for treatment of colorectal cancer: An in-silico analysis and experimental validation
45. An effective multi-task learning framework for drug repurposing based on graph representation learning
46. RDKG-115: Assisting drug repurposing and discovery for rare diseases by trimodal knowledge graph embedding
47. Predicting new drug indications based on double variational autoencoders
48. Tenofovir alone or combined with doxorubicin abrogates DMBA-induced mammary cell carcinoma: An insight into its modulatory impact on oxidative/Notch/apoptotic signaling
49. DTSEA: A network-based drug target set enrichment analysis method for drug repurposing against COVID-19
50. Application of the PHENotype SIMulator for rapid identification of potential candidates in effective COVID-19 drug repurposing
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