1. Raised dsDNA autoantibodies in tuberculosis patients
- Author
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Faheem Shahzad, Atia Ali, Abid Mushtaq, Khursheed Javaid, Afzaal Nazir, Amna Pervez, Mohammad Kashif, Noman Bashir, Afia Abbas, Romeeza Tahir, Shah Jahan, and Nadeem Afzal
- Subjects
autoimmunity ,dsDNA autoantibodies ,tB and tuberculosis ,Diseases of the respiratory system ,RC705-779 - Abstract
Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis. M. tuberculosis can become dormant, resist the hostile environment of the phagosome, and trigger a delayed-type hypersensitivity reaction leading to chronic infection and granuloma formation. In granulomas, destruction of tissues results in the release of intracellular self-antigens that may provoke the development of autoantibodies. Therefore, the present cross-sectional study was conducted to detect anti-dsDNA antibodies in local TB patients. Patients and methods In all, 160 patients were recruited for this comparative study. Anti-dsDNA antibodies were detected by enzyme-linked immunosorbent assay. Independent Student’s t test was used to compare mean anti-dsDNA values between TB patients and healthy individuals. A p value less than or equal to 0.05 was considered as statistically significant. Results Anti-dsDNA antibodies were high in TB patients as compared with healthy controls and the difference between the two groups was statistically significant (P
- Published
- 2019
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