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8 results on '"el-Sohly MA"'

4. The iCannTookit: a consensus-based, flexible framework for measuring contemporary cannabis use.

Author

Lorenzetti V, Hindocha C, Petrilli K, Griffiths P, Brown J, Castillo-Carniglia Á, Caulkins JP, Englund A, El Sohly MA, Gage SH, Groshkova T, Gual A, Hammond D, Lawn W, López-Pelayo H, Manthey J, Mokrysz C, Liccardo Pacula R, van Laar M, Vandrey R, Wadsworth E, Winstock A, Hall W, Curran HV, and Freeman TP

Subjects
Analgesics, Cannabinoid Receptor Agonists, Consensus, Humans, Cannabis, Hallucinogens
Published
2022
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5. 5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-perhydro-3,12-ep-oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth-yl}benzene-1,3-diol.

Author

Gul W, Carvalho P, Galal A, Avery MA, and El Sohly MA

Abstract

The title compound, C(22)H(30)O(7), is a fused five-ring system that is of inter-est for its anti-cancer and anti-malarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and per-oxy functionalities has a distorted boat conformation, with a C-O-O-C torsion angle of 42.6 (1)° for the per-oxy group. The seven-membered C(6)O ring has a distorted boat-type conformation, while the seven-membered C(5)O(2) ring has a very distorted chair-type conformation. The structure contains inter-molecular O-H⋯O and O-H⋯(O,O) bonds that link the mol-ecules into sheets parallel to the (100) planes.

Published
2009
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6. Phytochemical analysis of Geigeria alata and Francoeuria crispa essential oils.

Author

Ross SA, el Sayed KA, el Sohly MA, Hamann MT, Abdel-Halim OB, Ahmed AF, and Ahmed MM

Subjects
Animals, Anti-HIV Agents chemistry, Anti-HIV Agents pharmacology, Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic toxicity, Cell Survival drug effects, Gas Chromatography-Mass Spectrometry, HIV drug effects, Humans, Leukemia P388, Mice, Tumor Cells, Cultured, Virus Replication drug effects, Anti-HIV Agents isolation & purification, Antineoplastic Agents, Phytogenic isolation & purification, HIV physiology, Oils, Volatile analysis, Plants, Medicinal, Plants, Toxic
Abstract

Phytochemical analyses of Geigeria alata (Benth. & Hook.) and Francoeuria crispa (Forssk., Cas.) (Asteraceae) essential oils were performed. G. alata oil showed moderate in vitro cytotoxicity (IC50, micrograms/ml against tumor cells; P388: 2.0, A-549: 2.5 and HT-29: 5.0), and also showed weak anti-HIV activity. S-Carvotanacetone, the major component of F. crispa oil (93.0%), was isolated and its structure was elucidated by 2D-NMR analysis.

Published
1997
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7. Biomimetic synthesis of cannabispiran.

Author

El-Feraly FS, Chan YM, El-Sohly MA, and Turner CE

Subjects
Magnetic Resonance Spectroscopy, Methods, Structure-Activity Relationship, Estradiol Congeners, Indans chemical synthesis, Indenes chemical synthesis, Spiro Compounds chemical synthesis
Abstract

Total synthesis of cannabispiran (1) was accomplished by a biomimetic-type cyclization of the bibenzyl 2, using K3Fe(CN)6 or MoCl4.

Published
1979
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