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This document is an editorial published in Frontiers in Microbiology in September 2024. It discusses the importance of One Health approaches in addressing antimicrobial resistance (AMR) and zoonotic pathogens' virulence in the food chain. The editorial highlights the need for collaborative efforts across disciplines to monitor and mitigate the risks of AMR and zoonotic infections. It also provides a summary of several research papers included in the journal issue, which cover topics such as surveillance and monitoring of AMR, genetic and molecular mechanisms of AMR and virulence, and the impact of AMR on public health and food safety. Overall, the editorial emphasizes the importance of integrating efforts to protect public health, ensure food security, and promote a resilient global community. [Extracted from the article]