1. Midbrain and pons MRI shape analysis and its clinical and CSF correlates in degenerative parkinsonisms: a pilot study
- Author
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C. Painous, S. Pascual-Diaz, E. Muñoz-Moreno, V. Sánchez, JC. Pariente, A. Prats-Galino, M. Soto, M. Fernández, A. Pérez-Soriano, A. Camara, E. Muñoz, F. Valldeoriola, N. Caballol, C. Pont-Sunyer, N. Martin, M. Basora, M. Tio, J. Rios, MJ. Martí, N. Bargalló, Y. Compta, [Painous C] Parkinson’s Disease & Movement Disorders Unit, Parkinson’s Disease and Other Degenerative Movement Disorders Team, Neurology Service, Hospital Clínic de Barcelona, IDIBAPS, CIBERNED (CB06/05/0018-ISCIII), ERN-RND, Institut Clínic de Neurociències (UBNeuro), Department of Medicine, School of Medicine, Universitat de Barcelona, Catalonia, Barcelona, Spain. Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Institut de Neurociències, Hospital Clínic de Barcelona, Institut de Neurociències (UBNeuro), Universitat de Barcelona, Catalonia, Barcelona, Spain. [Pascual-Diaz S] Magnetic Resonance Imaging Core Facility, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. Laboratory of Surgical Neuroanatomy (LSNA), Universitat de Barcelona, Barcelona, Spain. [Muñoz-Moreno E, Pariente JC] Magnetic Resonance Imaging Core Facility, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. [Sánchez V] Centre de Diagnostic Per La Imatge (CDIC), Hospital Clinic, Barcelona, Spain. [Prats-Galino A] Centre de Diagnostic Per La Imatge (CDIC), Hospital Clinic, Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. [Pont-Sunyer C] Neurology Unit, Hospital General de Granollers, Universitat Internacional de Catalunya, Granollers, Spain, and Hospital General de Granollers
- Subjects
Investigative Techniques::Chemistry Techniques, Analytical::Spectrum Analysis::Magnetic Resonance Spectroscopy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Nervous System Diseases::Autonomic Nervous System Diseases::Primary Dysautonomias::Multiple System Atrophy [DISEASES] ,Steele-Richardson-Olszewski, Síndrome de ,Ressonància magnètica ,técnicas de investigación::técnicas de química analítica::análisis espectral::espectroscopia de resonancia magnética [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos [ENFERMEDADES] ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Parkinson, Malaltia de ,enfermedades del sistema nervioso::enfermedades del sistema nervioso autónomo::disautonomías primarias::atrofia de múltiples sistemas [ENFERMEDADES] ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders [DISEASES] - Abstract
Objectives To conduct brainstem MRI shape analysis across neurodegenerative parkinsonisms and control subjects (CS), along with its association with clinical and cerebrospinal fluid (CSF) correlates. Methodology We collected demographic and clinical variables, performed planimetric and shape MRI analyses, and determined CSF neurofilament-light chain (NfL) levels in 84 participants: 11 CS, 12 with Parkinson’s disease (PD), 26 with multiple system atrophy (MSA), 21 with progressive supranuclear palsy (PSP), and 14 with corticobasal degeneration (CBD). Results MSA featured the most extensive and significant brainstem shape narrowing (that is, atrophy), mostly in the pons. CBD presented local atrophy in several small areas in the pons and midbrain compared to PD and CS. PSP presented local atrophy in small areas in the posterior and upper midbrain as well as the rostral pons compared to MSA. Our findings of planimetric MRI measurements and CSF NfL levels replicated those from previous literature. Brainstem shape atrophy correlated with worse motor state in all parkinsonisms and with higher NfL levels in MSA, PSP, and PD. Conclusion Atypical parkinsonisms present different brainstem shape patterns which correlate with clinical severity and neuronal degeneration. In MSA, shape analysis could be further explored as a potential diagnostic biomarker. By contrast, shape analysis appears to have a rather limited discriminant value in PSP. Key Points • Atypical parkinsonisms present different brainstem shape patterns. • Shape patterns correlate with clinical severity and neuronal degeneration. • In MSA, shape analysis could be further explored as a potential diagnostic biomarker.
- Published
- 2023