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Chronic rhinosinusitis (CRS) can be classified as eosinophilic (eCRS) or non-eosinophilic (neCRS) based on infiltration type. The SWI/SNF complex may be involved in the pathophysiology of CRS.To assess the expression of the SWI/SNF complex in both CRS groups; to correlate blood eosinophil count (BEC), and histopathology eosinophil count (HPEC) with the SWI/SNF expression level in eCRS and neCRS.The study population consisted of 96 patients (68 eCRS, 28 neCRS). Immunohistochemical staining was performed on sinonasal mucosa for assessment of SWI/SNF protein expression. Type of tissue infiltration was assessed in samples obtained from examined groups (HPEC). The diagnostic value of eCRS was 10 cells/HPF (high power field). Complete blood count was analysed in order to calculate BEC.BEC and HPEC correlated negatively with all the SWI/SNF subunits. HPEC and BEC correlated positively with clinical findings (L-M and SNOT-22), while SWI/SNF correlated negatively with clinical findings (L-M and SNOT-22).The SWI/SNF was observed in both eCRS and neCRS, with lower expression in former. The meaning of its negative correlation with BEC, HPEC and clinical findings in eCRS group remains to be understood.Il complesso SWI/SNF nella rinosinusite cronica eosinofila e non eosinofila.La rinosinusite cronica (CRS) può essere classificata come eosinofila (eCRS) o non-eosinofila (neCRS), in base al tipo di infiltrato cellulare. Il complesso SWI/SNF potrebbe avere un ruolo nella fisiopatologia della CRS.Valutare l’espressione del complesso SWI/SNF in entrambi i gruppi di CRS; correlare la conta degli eosinofili nel sangue (BEC) e la conta degli eosinofili nel preparato istopatologico (HPEC) con il livello di espressione SWI/SNF nei gruppi eCRS e neCRS.La popolazione dello studio è composta da 96 pazienti (68-eCRS, 28-neCRS), è stata eseguita la colorazione immunoistochimica sulla mucosa rinosinusale per valutare i livelli di espressione della proteina SWI/SNF, è stato valutato il tipo di infiltrato cellulare nei campioni ottenuti (HPEC). Valore di eosinofili, diagnostico di eCRS: 10 cellule / HPF. È stato analizzato l’emocromo completo per calcolare il BEC.BEC e HPEC sono risultati inversamente correlati con tutte le subunità SWI/SNF e correlati positivamente con i dati clinici (L-M e SNOT-22), mentre SWI/SNF erano correlati negativamente con i risultati clinici (L-M e SNOT-22).Il complesso SWI/SNF è risultato presente sia in eCRS che in neCRS, con un’espressione inferiore nel primo tipo di rinosinusite cronica. Il significato della sua correlazione negativa con BEC, HPEC e risultati clinici nel gruppo eCRS resta da indagare.

La enfermedad de Kimura es un trastorno inflamatorio que afecta principalmente a sujetos de origen asiático. Se manifiesta por la existencia de masas de tejido subcutáneo y subplatismal generalmente en la cabeza y el cuello. Suele acompañarse de linadenopatías, y aumento de los niveles de eosinófilos e IgE en sangre periférica. Comunicamos un caso de enfermedad de Kimura, descubierto en un varón caucasiano, tras una biopsia excisional de una masa cervical.Kimura disease is a chronic inflammatory disorder mainly involving Asians. It often presents as soft-tissue nodes or lymphadenopathy of the head and neck. Commonly associated with increased levels of eosinophils and IgE in peripheral blood. We report a case of Kimura disease in a Caucasian, diagnosed after lymph node and submaxillary gland removal.

La enfermedad de Kimura es un trastorno inflamatorio que afecta principalmente a sujetos de origen asiático. Se manifiesta por la existencia de masas de tejido subcutáneo y subplatismal generalmente en la cabeza y el cuello. Suele acompañarse de linadenopatías, y aumento de los niveles de eosinófilos e IgE en sangre periférica. Comunicamos un caso de enfermedad de Kimura, descubierto en un varón caucasiano, tras una biopsia excisional de una masa cervical. Kimura disease is a chronic inflammatory disorder mainly involving Asians. It often presents as soft-tissue nodes or lymphadenopathy of the head and neck. Commonly associated with increased levels of eosinophils and IgE in peripheral blood. We report a case of Kimura disease in a Caucasian, diagnosed after lymph node and submaxillary gland removal.

espanolLa enfermedad de Kimura es un trastorno inflamatorio que afecta principalmente a sujetos de origen asiatico. Se manifiesta por la existencia de masas de tejido subcutaneo y subplatismal generalmente en la cabeza y el cuello. Suele acompanarse de linadenopatias, y aumento de los niveles de eosinofilos e IgE en sangre periferica. Comunicamos un caso de enfermedad de Kimura, descubierto en un varon caucasiano, tras una biopsia excisional de una masa cervical. EnglishKimura disease is a chronic inflammatory disorder mainly involving Asians. It often presents as soft-tissue nodes or lymphadenopathy of the head and neck. Commonly associated with increased levels of eosinophils and IgE in peripheral blood. We report a case of Kimura disease in a Caucasian, diagnosed after lymph node and submaxillary gland removal.