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Our main objective is to explore the shape and geometry of the limiting curves of the structures that define the escape properties of a particle from a lobular domain in a multiwell potential. For this purpose, we examine the lower umbilical catastrophe D5, for α=1, by calculating the Lyapunov orbit at the entrance of the lobular region as well as the set of incoming asymptotic trajectories to it and the set of successive intersections of this set with a proper surface of section. [ABSTRACT FROM AUTHOR]

The search for water on Mars has long been a theme of intense exploration, as it represents a means of addressing Mars' current climate as well as its evolution in the recent and more distant past. Since the 1970s, several missions have carried instruments to track water in the atmosphere, leading to the conceptualization of a water cycle on Mars characterized by intense seasonal variability in water vapor abundance across the planet. After Mariner 9, Viking, Phobos 2 and Mars Global Surveyor, Mars Express has become the fifth orbiter capable of detecting water vapour, with unique features: measurements by several instruments, each probing a distinct wavelength region from near-infrared to thermal infrared, altitude-dependent profiling of water thanks to solar occultation, and observation in the exosphere of its by-product, hydrogen atoms, which can escape into space, depriving Mars of its primordial water reservoir. Thanks to Mars Express, a new vision of Mars' water cycle and escape processes has emerged. The achievements of Mars Express, as well as the legacy of other missions, which established the foundations of our understanding of Mars' water cycle are presented in this article. [ABSTRACT FROM AUTHOR]

Leaving the nest early to avoid detection by an approaching predator is an often‐cited form of nest defence among ground‐nesting birds, yet has rarely been quantitatively demonstrated. During the breeding season, we recorded Flight‐initiation Distances (FIDs) of incubating, off‐duty and non‐breeding Hooded Plovers Thinornis cucuallatus cucuallatus in Victoria, Australia. Hooded Plovers exhibited longer FIDs when incubating compared with when off‐duty or non‐breeding birds (the latter two categories had similar FIDs). Our study supports the Leave Early to Avoid Detection (LEAD) hypothesis, and demonstrates that so‐called 'passive' defence is in fact an active decision by the incubator to leave nests at distances which exceed those at which birds without nests or off‐duty commence escape. [ABSTRACT FROM AUTHOR]

Preventing escapes from custody is an essential function of prisons and jails. Yet, when these incidents occur, little is known about how often or quickly escapees are recaptured. Drawing on the routine activities framework, this study examines a dataset of 610 prison and jail escapees collected through a comprehensive open-source search protocol. The study uses logistic and Cox regression techniques to determine which factors are associated with being recaptured and the time-to-recapture. Findings indicate that more than 91 percent of escapees were recaptured within 1 year and very few remained on the lam for more than a few days. People who escape from nonsecure facilities (often called walkaways) were less likely to be recaptured and remained out of custody for longer durations than those who escaped from secure facilities or while outside under secure (e.g., transport) or nonsecure (e.g., work release) settings. Jail escapees were also less likely to be recaptured, and were apprehended more slowly, than those who fled from a prison. [ABSTRACT FROM AUTHOR]

Despite enormous efforts being invested in the development of novel therapies for brain malignancies, there remains a dire need for effective treatments, particularly for pediatric glioblastomas. Their poor prognosis has been attributed to the fact that conventional therapies target tumoral cells, but not glioblastoma stem cells (GSCs). GSCs are characterized by self-renewal, tumorigenicity, poor differentiation, and resistance to therapy. These characteristics represent the fundamental tools needed to recapitulate the tumor and result in a relapse. The mechanisms by which GSCs alter metabolic cues and escape elimination by immune cells are discussed in this article, along with potential strategies to harness effector immune cells against GSCs. As cellular immunotherapy is making significant advances in a variety of cancers, leveraging this underexplored reservoir may result in significant improvements in the treatment options for brain malignancies. [ABSTRACT FROM AUTHOR]

Abstract Safety behaviors are core features of anxiety-related disorders, specifically involving behaviors that do not completely terminate aversive situations, but rather prevent the risk of the occurrence of the expected aversive outcome (US). This study aimed to examine the dynamics of defensive reactivity associated with safety behaviors, both before and after their execution, and to investigate changes in these reactions following extensive training. Twenty-four healthy participants underwent a US-avoidance task as an experimental analog to model safety behavior, requiring a button press to avoid the US without terminating the associated warning cue (CS). Two CS+ were used, with one being devalued during a devaluation procedure to assess the formation of avoidance habits. Defensive reactivity was assessed using fear-potentiated startle (FPS) and skin conductance responses (SCR). Participants showed pronounced defensive reactivity to both CS + vs. CS- before the avoidance action, which decreased upon the opportunity to avoid the US. Contrarily, after the avoidance action, a re-emergence of defensive responses was observed as indicated by FPS and increased SCR. Only one participant showed signs of avoidance habit formation. The findings reveal a re-emergence of defensive reactivity following safety behaviors challenging the prevailing belief that relief is the primary sustaining factor of safety behavior.

Introduction: Although not yet recognized as an official disorder, Social Media Disorder (SMD) has recently received considerable interest in the research. However, relatively little is known about underlying motives for social media use and to what extent motives show differential associations with SMD symptom severity and SMD diagnosis. The overall aim of the present study was therefore to examine motives for social media use in relation to (1) which motives are most common, (2) associations between motives and both SMD symptom severity and SMD diagnosis, and (3) the effects of sex and age. Methods: Data were collected through a digital survey (n = 1820) and included both high school students (n = 924) and university students (n = 896). Six different motives were assessed, and SMD was measured in relation to both Heavy Involvement and Negative Consequences of social media use. Results: The results showed that the most common social media use motives were Entertainment, Social Maintenance, and Information and Skills. However, it was the three least common motives - Social Compensation, Self-status, and Escape - that were most strongly associated with SMD symptom severity and SMD diagnosis. These three motives explained as much as 42% of the variance in negative consequences of social media use. Only a few small effects of sex or age were found. Discussion: Some social media use motives are much more strongly associated with SMD than others are. This could indicate that prevention and intervention programs should target these motives specifically, rather than focusing on social media use in general. [ABSTRACT FROM AUTHOR]

A number of tourists visit churches on their holiday without being religious or having any religious motivation. If religion is not important for the visit, what is then central to the tourist experience, and how do tourists describe their church visit? In this article, I examine tourists' church visits and the meaning it gives. In a setting characterized through tourism and religion, and with a special focus on the individual church experience, the personal perspective is prioritized. The data for this study have been collected at the church of Santa Cecilia in Rome, where I have interviewed 12 tourists. The findings show that the experience of escape is an important part of the church visit. Further the findings demonstrate tourists' need to find back to themselves, as a contrast to the busier tourist role. While previous studies of visits to religious sites often emphasize religious identity and holiness, this study indicates that religion is unimportant or subordinate to some extent. The findings therefore provide new knowledge about the significance for tourists of visiting churches. [ABSTRACT FROM AUTHOR]

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape. [ABSTRACT FROM AUTHOR]

In the natural world, animals make decisions on an ongoing basis, continuously selecting which action to undertake next. In the lab, however, the neural bases of decision processes have mostly been studied using artificial trial structures. New experimental tools based on the genetic toolkit of model organisms now make it experimentally feasible to monitor and manipulate neural activity in small subsets of neurons during naturalistic behaviors. We thus propose a new approach to investigating decision processes, termed reverse neuroethology. In this approach, experimenters select animal models based on experimental accessibility and then utilize cutting-edge tools such as connectomes and genetically encoded reagents to analyze the flow of information through an animal's nervous system during naturalistic choice behaviors. We describe how the reverse neuroethology strategy has been applied to understand the neural underpinnings of innate, rapid decision making, with a focus on defensive behavioral choices in the vinegar fly Drosophila melanogaster. [ABSTRACT FROM AUTHOR]

Between 1837–1863, the government on the Dutch colony of Curacao registered the escape attempts from all enslaved persons on the island. By combining the structured information of the 'register of runaway slaves' with other sources, it becomes clear that running away during slavery was a multi-faceted phenomenon. The 1,613 registered escape attempts included not only escapees, trying to flee the island, but also a majority of truants who fled temporarily but stayed on the island. Escapees were mostly young men, who normally worked in groups and had to prepare their attempts well, in order to have a chance to escape the island. An analysis of the profiles of truants show that they were a wide range of persons, from pregnant women to elderly people, fleeing alone or in groups. All these people not only needed an opportunity to flee, but also a place to go to. Together, they created a 'maroon landscape', a mental map of opportunities available to enslaved people. Their mental landscape did include locations, people and circumstances on Curacao, but also the sea surrounding it. Moreover, seasonal effects like harvest time and changes abroad altered the 'maroon landscape' continuously and lead to an adjustment of behavior, which is most obvious after the abolition of slavery in nearby Venezuela in 1854. [ABSTRACT FROM AUTHOR]

Characterizing the abundance of atmospheric hydrogen (H) at Mars is critical for determining the current and, subsequently, the primordial water content on the planet. At present, the atmospheric abundance of Martian H is not directly measured but is simulated using proprietary models that are constrained with observations of H Lyman‐α emission brightness, as well as with observations of other atmospheric parameters, such as temperature and Solar UV irradiance. Publicly available brightness measurements require further processing to have scientific utility. To make the data needed to model H abundances and escape rates more accessible to the community, we use H Lyman‐α emissions made with the Mars Atmosphere and Volatile Evolution (MAVEN) mission. The near decade‐spanning data set is reduced to obtain disk‐pointed averages of the H brightness in the upper atmosphere of Mars and then analyzed for statistical trends across multiple variables. The H Lyman‐α emission brightness is found to be dependent on Solar illumination, Solar cycle, and season. The resulting data trends are used to derive empirical fits to build a predictive framework for future observations or an extrapolative tool for estimates of water content at previous epochs. Data that was intentionally not included in the empirical derivations are used to validate the predictions successfully to within 18% accuracy, on average. This first‐of‐its kind predictive model for H brightness is presented to the community and can be used with atmospheric models to further derive and interpret the abundances and escape rate of H atoms at Mars. Plain Language Summary: The upper atmosphere of Mars contains Hydrogen atoms that can escape into outer space. Since these atoms originate from water, understanding the abundance and variation of these atoms is important to understanding water escape from Mars. There are no direct measurements of H abundances in the upper atmosphere of Mars. However, H atoms emit UV photons, and these photons can be measured and used with models to derive H atom abundances. This work investigates the UV photon emissions of H atoms from the upper atmosphere of Mars using a 9‐year data set by converting the data into scientifically useable form and studying the trends with time. A predictive model is developed to successfully replicate the trends in the UV emissions of H atoms according to illumination, seasonal, and Solar activity conditions. This predictive model can be used with other tools and observed quantities to derive H abundances to infer the present and evolving water content at Mars. Key Points: Nine years of H Ly‐α brightness measurements are found to depend on Solar cycle, illumination, and Martian seasonStatistical fits for H Ly‐α brightness across independent variables are empirically derivedA predictive tool for atmospheric H brightness at Mars is developed and shared with the community [ABSTRACT FROM AUTHOR]

Copyright of Turkish Studies - Language & Literature is the property of Electronic Turkish Studies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Context: Semiarid environments, such as the Patagonian shrublands, are characterised by having shrubby patches surrounded by grasses with different ecophysiological strategies to tolerate long dry periods. Aims: We hypothesised that coexisting grasses of the Patagonian rangeland, already classified as drought-escaping or drought-tolerant, have different traits according to the season and the annual rainfall events. Methods: Two dominant native grasses were selected: Pappostipa speciosa (evergreen) and Poa ligularis (deciduous). Samples were collected in the four seasons for the term of 1 year. Rainfall events and soil water content of each season were determined. Spring was the wettest season and autumn the driest. Physiological (relative water content, pigments, hormones), biochemical (polyphenols, antioxidant activity) and morphological traits were measured in the four seasons. Key results: P. speciosa was characterised by keeping evergreen leaves with high production of polyphenols as secondary metabolites with high antioxidant capacity during the dry autumn and winter seasons. P. ligularis was characterised by high contents of gibberellin (GA1), auxin (IAA), total phenols, total flavonoids and tartaric acid esters, and high antioxidant capacity in roots during the autumn dry season. In addition, P. ligularis leaves had higher content of carotenoids and polyphenols than P. speciosa during the summer dry season. Conclusions: The major adaptive strategy to tolerate dry periods is the high activity of the secondary metabolism, mainly in leaves in P. speciosa (a drought-tolerant grass) and in roots in P. ligularis (a drought-escaping grass). Implications: Rainfall variations during a year can affect the phenological growth stages and the metabolism of two native grasses from Argentina characterised by different drought resistance mechanisms. The major adaptive strategy against the dry period is the high activity of secondary metabolism; mainly in leaves for the drought-tolerant grass Pappostipa speciosa , and in roots for the drought-escaping grass Poa ligularis. Photographs by Ana M. Cenzano. [ABSTRACT FROM AUTHOR]

Bacteriophages have been used across various fields, and the utilization of CRISPR/Cas-based genome editing technology can accelerate the research and applications of bacteriophages. However, some bacteriophages can escape from the cleavage of Cas protein, such as Cas9, and decrease the efficiency of genome editing. This study focuses on the bacteriophage T7, which is widely utilized but whose mechanism of evading the cleavage of CRISPR/Cas9 has not been elucidated. First, we test the escape rates of T7 phage at different cleavage sites, ranging from 10-2 to 10-5. The sequencing results show that DNA point mutations and microhomology-mediated end joining (MMEJ) at the target sites are the main causes. Next, we indicate the existence of the hotspot DNA region of MMEJ and successfully reduce MMEJ events by designing targeted sites that bypass the hotspot DNA region. Moreover, we also knock out the ATP-dependent DNA ligase 1.3 gene, which may be involved in the MMEJ event, and the frequency of MMEJ at 4.3 is reduced from 83% to 18%. Finally, the genome editing efficiency in T7 Δ1.3 increases from 20% to 100%. This study reveals the mechanism of T7 phage evasion from the cleavage of CRISPR/Cas9 and demonstrates that the special design of editing sites or the deletion of key gene 1.3 can reduce MMEJ events and enhance gene editing efficiency. These findings will contribute to advancing CRISPR/Cas-based tools for efficient genome editing in phages and provide a theoretical foundation for the broader application of phages.

Abstract Background X-chromosome inactivation (XCI) is an epigenetic process that occurs during early development in mammalian females by randomly silencing one of two copies of the X chromosome in each cell. The preferential inactivation of either the maternal or paternal copy of the X chromosome in a majority of cells results in a skewed or non-random pattern of X inactivation and is observed in over 25% of adult females. Identifying skewed X inactivation is of clinical significance in patients with suspected rare genetic diseases due to the possibility of biased expression of disease-causing genes present on the active X chromosome. The current clinical test for the detection of skewed XCI relies on the methylation status of the methylation-sensitive restriction enzyme (Hpall) binding site present in proximity of short tandem polymorphic repeats on the androgen receptor (AR) gene. This approach using one locus results in uninformative or inconclusive data for 10–20% of tests. Further, recent studies have shown inconsistency between methylation of the AR locus and the state of inactivation of the X chromosome. Herein, we develop a method for estimating X inactivation status, using exome and transcriptome sequencing data derived from blood in 227 female samples. We built a reference model for evaluation of XCI in 135 females from the GTEx consortium. We tested and validated the model on 11 female individuals with different types of undiagnosed rare genetic disorders who were clinically tested for X-skew using the AR gene assay and compared results to our outlier-based analysis technique. Results In comparison to the AR clinical test for identification of X inactivation, our method was concordant with the AR method in 9 samples, discordant in 1, and provided a measure of X inactivation in 1 sample with uninformative clinical results. We applied this method on an additional 81 females presenting to the clinic with phenotypes consistent with different hereditary disorders without a known genetic diagnosis. Conclusions This study presents the use of transcriptome and exome sequencing data to provide an accurate and complete estimation of X-inactivation and skew status in a cohort of female patients with different types of suspected rare genetic disease.

A six‐fold typology of ideal trips was developed in this study by listening to the voices of residents of Southeast Queensland, Australia, who identified what they felt a dream vacation encompassed. The study represents one of the first of its kind to explore this phenomenon from the tourists' perspective. The typology encompassed 16 styles of holiday. The six types included destination‐exclusive holidays, personal growth, exploration, escape, hedonism and attraction or activity specific holidays. The study concludes that more empirical research into this phenomenon is desired before comprehensive theory development can occur, for existing theories and models used to study ideal holidays tend to be fragmented and often contradictory. [ABSTRACT FROM AUTHOR]

Recently, there has been a lot of talk about the topic of servants, their rights and duties has become widespread and has become a matter of debate in our society. Because it has implications for the individual, the family and the community, the topic of insurance for the escape of servants is an important topic in this section, especially as it relates to the family. The scientific approach in this research has been to extrapolate the opinions of scholars on the matter, draw on the original sources of research, and attribute the texts and opinions of scientists to their books directly. The research aims to outline the provisions on insurance of domestic workers in jurisprudence and the system by: - To indicate what is meant by insurance for the escape of the domestic worker in Islamic jurisprudence, the rights and duties of the employer and the domestic worker, the reasons for the escape of the domestic worker and what is the treatment and the provision for insurance for the escape of the domestic worker in Islamic jurisprudence; The research has been divided into the following issues: the definition of insurance, the definition of escape, Definition of servants, definition of insurance for domestic workers, and the rights and duties of the employer and domestic servants and the reasons for the worker's escape and treatment, and the importance of insurance for the domestic service worker The research recommends holding seminars and conferences and activating lectures in schools and communities on servants' rights and duties. as well as the types of insurance and the provision of insurance on the necessary and necessary things for man to conduct doctrinal and societal studies on the causes of servants' flight and ways of addressing them and propose appropriate solutions for the existence of the right alternative in society. [ABSTRACT FROM AUTHOR]

The purpose of the study was to do an experimental analysis of academic task refusal for one girl with a developmental disability. Task refusal was analyzed in two experimental analyses. First, an analysis testing if the behavior was maintained by negative reinforcement, and the second, an analysis testing if the behavior was the result of transitioning between academic tasks differing in preference. Task refusal did not occur in the demand condition of the functional analysis, indicating that the behavior was not maintained by escape from demands. Conversely, task refusal occurred solely in the second experimental analysis when transitioning from a high‐preferred to a low‐preferred academic task. In this case, the context of terminating a preferred academic task and transitioning to a less preferred academic task was aversive but not the demand itself. In addition, when an embedded break condition was compared to a no break condition in a multielement design, task refusal was reduced to zero levels. [ABSTRACT FROM AUTHOR]

The purpose of this study is to analyze the antecedents of viewers engagement from social media influencers specifically in relation to YouTube channels, which include feelings of escape, self-improvement, fun, glamourous, connectivity from the audience as well as Overall Perceived image of the influencer. The sample design used in this research is non-probability sampling with purposive sampling technique. The processed data came from 280 respondents and then the data was analyzed using the Structural Equation Modeling (SEM) method. The results of this study indicate that there is a positive influence of escape on fun, there is a positive influence of self improvement on fun, glamorous and connectivity, there is also a positive influence of fun, glamorous and connectivity on overall perceived image and there is a positive influence of overall perceived image on viewers engagement. Likewise, this study found that there is no positive effect of escape on glamorous and connectivity. In general, the results of this study show that fun, glamorous and connectivity, and overall perceived image are important factors that influence viewers engagement. Content that has a positive, authentic and informative overall image tends to attract more attention and is easily understood by viewers. Suggestions for future research, researchers can conduct research on Indonesian youtuber objects that are not included in this study and overseas youtuber objects. and can also conduct research on the impact of escape and self improvement on viewers engagement by adding job occupation variables as moderators. [ABSTRACT FROM AUTHOR]

Group members frequently face violations of group-based expectations by in- and outgroup members' behaviour. Responses to such violations include confronting the violators and escaping from the group. The current article presents a novel, integrative model explaining how and why violations of group-based expectations elicit these reactions. We argue that group members experience violations of expectations as threats to their social selves, which motivates them to react at all. Crucially adding to extant theorising, we argue that how group members react depends on their perceived control, a largely overlooked factor thus far. Herein, we synthesise our model's empirical basis, which spans studies on different violations (violations of ingroup norms, norms for cooperation, and expectations based on political ideology) and different group contexts (e.g., attitude-based lab groups, learning groups, Facebook groups). Moreover, we discuss boundary conditions for the model's applicability and its potential for integration with classic research on social identity management. [ABSTRACT FROM AUTHOR]

Several breakthrough articles have recently confirmed the ability of tumor cells to escape the stable cell cycle arrest imposed by Therapy-Induced Senescence (TIS). Subsequently, accepting the hypothesis that TIS is escapable should encourage serious reassessments of the fundamental roles of senescence in cancer treatment. The potential for escape from TIS undermines the well-established tumor suppressor function of senescence, proposes it as a mechanism of tumor dormancy leading to disease recurrence and invites for further investigation of its unfavorable contribution to cancer therapy outcomes. Moreover, escaping TIS strongly indicates that the elimination of senescent tumor cells, primarily through pharmacological means, is a suitable approach for increasing the efficacy of cancer treatment, one that still requires further exploration. This commentary provides an overview of the recent evidence that unequivocally demonstrated the ability of therapy-induced senescent tumor cells in overcoming the terminal growth arrest fate and provides future perspectives on the roles of TIS in tumor biology. [ABSTRACT FROM AUTHOR]

Secondary minerals in SNC meteorites from Mars exhibit O isotope ratios believed to be consistent with the non-thermal escape of O from the atmosphere. The primary source of the non-thermal O is the dissociative- recombination of O2+ in the ionosphere. I present here the results of a model that accounts for the probability of escape of non-thermal O isotopes due to collisions with overlying CO2, combined with a model for Rayleigh fractionation of the atmosphere remaining as a result of O escape. Previous analyses of MAVEN number density data have shown a strong variability with latitude and season of the heights of the homopause and exobase, with a mean homopause at 110 km and a mean difference of about 60 km. Rayleigh model results demonstrate a dependence on homopause height and on temperature profile and require a more accurate calculation of fractionation factors for the Rayleigh equation. Isothermal temperature profiles yield much smaller variation in 17O with homopause height. These results demonstrate the need for a careful assessment of O isotope enrichment due to non-thermal escape both for the modern atmosphere and for the evolution of the atmosphere over the age of the planet. [ABSTRACT FROM AUTHOR]

The rational design of HIV-1 immunogens to trigger the development of broadly neutralizing antibodies (bNAbs) requires understanding the viral evolutionary pathways influencing this process. An acute HIV-1-infected individual exhibiting >50% plasma neutralization breadth developed neutralizing antibody specificities against the CD4-binding site (CD4bs) and V1V2 regions of Env gp120. Comparison of pseudoviruses derived from early and late autologous env sequences demonstrated the development of >2 log resistance to VRC13 but not to other CD4bs-specific bNAbs. Mapping studies indicated that the V3 and CD4-binding loops of Env gp120 contributed significant ly to developing resistance to the autologous neutralizing response and that the CD4- binding loop (CD4BL) specifically was responsible for the developing resistance to VRC13. Tracking viral evolution during the development of this cross-neutralizing CD4bs response identified amino acid substitutions arising at only 4 of 11 known VRC13 contact sites (K282, T283, K421, and V471). However, each of these mutations was external to the V3 and CD4BL regions conferring resistance to VRC13 and was transient in nature. Rather, complete resistance to VRC13 was achieved through the cooperative expression of a cluster of single amino acid changes within and immediately adjacent to the CD4BL, including a T359I substitution, exchange of a potential N-linked glycosylation (PNLG) site to residue S362 from N363, and a P369L substitution. Collectively, our data characterize complex HIV-1 env evolution in an individual developing resistance to a VRC13-like neutralizing antibody response and identify novel VRC13-associated escape mutations that may be important to inducing VRC13-like bNAbs for lineage-based immunogens. [ABSTRACT FROM AUTHOR]

Copyright of Al-Adab / Al-ādāb is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Mevzu is the property of Ali Sever and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background. The baptized Kalmyks settled in the Middle Volga region and in the Southern Urals contributed to the economic development and defense of Russia’s south-eastern borders. The negative side of the creation of separate Kalmyk settlements was the desire of some of the baptized Kalmyks to return to the Kalmyk Khanate. The purpose of the work is to consider the measures taken by the Russian authorities to prevent the escape of baptized Kalmyks to the Kalmyk Khanate, as well as practical steps aimed at their detention and return in 1737–1771. Materials and methods. The basis of the research source base was the materials of the Joint State Archive of Orenburg Region and the National Archive of the Republic of Kalmykia. The historical-genetic, structural-functional methods of scientific research, the method of critical analysis of historical sources are used. Results. The analyzed sources do not allow us to judge unambiguously the effectiveness of measures aimed at preventing the escape of baptized Kalmyks. The escapes continued until the migration of the Volga Kalmyks to China and the liquidation of the Kalmyk Khanate. At the same time, the total number of fugitives by the end of 1760 did not exceed one per-cent of the total number of baptized Kalmyks settled in the Orenburg province.

IntroductionAlthough not yet recognized as an official disorder, Social Media Disorder (SMD) has recently received considerable interest in the research. However, relatively little is known about underlying motives for social media use and to what extent motives show differential associations with SMD symptom severity and SMD diagnosis. The overall aim of the present study was therefore to examine motives for social media use in relation to (1) which motives are most common, (2) associations between motives and both SMD symptom severity and SMD diagnosis, and (3) the effects of sex and age.MethodsData were collected through a digital survey (n = 1820) and included both high school students (n = 924) and university students (n = 896). Six different motives were assessed, and SMD was measured in relation to both Heavy Involvement and Negative Consequences of social media use.ResultsThe results showed that the most common social media use motives were Entertainment, Social Maintenance, and Information and Skills. However, it was the three least common motives – Social Compensation, Self-status, and Escape – that were most strongly associated with SMD symptom severity and SMD diagnosis. These three motives explained as much as 42% of the variance in negative consequences of social media use. Only a few small effects of sex or age were found.DiscussionSome social media use motives are much more strongly associated with SMD than others are. This could indicate that prevention and intervention programs should target these motives specifically, rather than focusing on social media use in general.

Abstract Characterizing the abundance of atmospheric hydrogen (H) at Mars is critical for determining the current and, subsequently, the primordial water content on the planet. At present, the atmospheric abundance of Martian H is not directly measured but is simulated using proprietary models that are constrained with observations of H Lyman‐α emission brightness, as well as with observations of other atmospheric parameters, such as temperature and Solar UV irradiance. Publicly available brightness measurements require further processing to have scientific utility. To make the data needed to model H abundances and escape rates more accessible to the community, we use H Lyman‐α emissions made with the Mars Atmosphere and Volatile Evolution (MAVEN) mission. The near decade‐spanning data set is reduced to obtain disk‐pointed averages of the H brightness in the upper atmosphere of Mars and then analyzed for statistical trends across multiple variables. The H Lyman‐α emission brightness is found to be dependent on Solar illumination, Solar cycle, and season. The resulting data trends are used to derive empirical fits to build a predictive framework for future observations or an extrapolative tool for estimates of water content at previous epochs. Data that was intentionally not included in the empirical derivations are used to validate the predictions successfully to within 18% accuracy, on average. This first‐of‐its kind predictive model for H brightness is presented to the community and can be used with atmospheric models to further derive and interpret the abundances and escape rate of H atoms at Mars.

The ability to recognize threats and to respond in a timely and appropriate manner carries significant benefits. Depending on the recognition task, this can be cognitively demanding. The zebra jumping spider (Salticus scenicus) is capable of visually recognizing static predator stimuli and reacts via a robust “freeze and retreat,” a potentially innate response in this species. Here, we extend this finding, asking whether the ability of spiderlings to recognize a static predator and to initiate an escape response is common across juvenile salticids, and if so, whether there is species-specific variation of anti-predator responses. We found that captive-reared spiderlings of three European salticid species from different genera (Heliophanus cf. cupreus, Evarcha arcuata, Marpissa muscosa) were able to robustly recognize and retreat from a stationary predator stimulus. Additionally, we found differences in the reaction times between the species as well as different behavioral repertoires associated with the escape response which may reflect species-specific predator avoidance strategies.

The D/H ratio in water on Mars, Rwater, is 4–6× the Earth ratio, signifying past water loss to space. Recently, measurements have revealed high values of the D/H ratio in hydrogen, Ratomic, in the thermosphere during southern summer. Here, we use a photochemical model to explore the potential drivers of Ratomic, testing three: thermospheric temperatures, excess mesospheric water, and changing insolation. We find that Ratomic can achieve values between 15× the Earth ratio (due to water) and 23× the Earth ratio (due to temperature). The effects arise because H escape is diffusion‐limited, while D escape is energy‐limited. Our results underscore how Ratomic reflects mesospheric dynamics, and the need for concurrent measurements of mesospheric water, thermospheric temperatures, and Ratomic to understand seasonal changes in the martian water cycle and atmospheric loss. Plain Language Summary: The high ratio of deuterium (D) to hydrogen (H) measured in water molecules on Mars indicates that much of Mars' past water has escaped to space. Recent measurements of the D/H ratio in the atoms themselves using data from the MAVEN spacecraft have revealed a ratio as high as 100 times the Earth value. In this work, we use a computational model of the Mars atmosphere to explore whether the large values could be caused by seasonal changes in three atmospheric parameters: the upper atmospheric temperature, the presence of extra water vapor in the middle atmosphere, and the incoming solar radiation. We find that temperature and water vapor have comparable effects, with each leading to an atomic D/H ratio similar to those found by MAVEN observations. We also explain how temperature and water affect the dynamics of H and D in the atmosphere to cause the change in the ratio. Key Points: Seasonal increases in exobase temperature or mesospheric water can enhance the upper atmospheric atomic D/H ratio up to 15–23 times VSMOWThe enhancement occurs due to dynamical differences, leading to similarities in D/H ratio but differences in abundance and escapeConcurrent measurements of temperatures, water vapor, and the D/H ratio will enhance our understanding of atmospheric escape from Mars [ABSTRACT FROM AUTHOR]

Interferon-induced transmembrane proteins (IFITMs) are a family of proteins which inhibit infections of various enveloped viruses. While their general mechanism of inhibition seems to be non-specific, involving the tightening of membrane structures to prevent fusion between the viral envelope and cell membrane, numerous studies have underscored the importance of viral envelope proteins in determining the susceptibility of viruses to IFITMs. Mutations in envelope proteins may lead to viral escape from direct interaction with IFITM proteins or result in indirect resistance by modifying the viral entry pathway, allowing the virus to modulate its exposure to IFITMs. In a broader context, the nature of viral envelope proteins and their interaction with IFITMs can play a crucial role in the context of adaptive immunity, leading to viral envelope proteins that are more susceptible to antibody neutralization. The precise mechanisms underlying these observations remain unclear, and further studies in this field could contribute to a better understanding of how IFITMs control viral infections. [ABSTRACT FROM AUTHOR]

Parental mediation to protect children from gaming disorders may have unintended consequences. According to the self-determination theory, parental mediation with psychological control may exacerbate problem behavior. Therefore, investigating the indirect effects of parental controlling mediation on gaming disorders is worthwhile. This study aimed to examine the conditional effect of parental controlling mediation on the relationship between escape motivation and gaming disorder, mediated by daily game time. The following research questions were investigated: whether escape motivation has an indirect effect on gaming disorder through daily game time, and whether parental controlling mediation moderates the relationship between gaming disorder and daily gaming time. The convenience sample included 501 mid-school students (251 male and 250 female) in grades 5–7. The conditional indirect effects model was developed using Hayes's model 14 and Process Macro. The results showed that escape motivation was positively related to gaming disorder through daily game time, and parental controlling mediation had a moderating effect on the relationship between daily game time and gaming disorder. These findings suggest that parental mediation to protect children from excessive gaming may be related to gaming disorder when implemented with psychological control. Higher parental controlling mediation may be a risk factor for gaming disorder even when their children play games less frequently. These findings are discussed in light of the literature. [ABSTRACT FROM AUTHOR]

Theoretically, siRNA has the ability to target any gene of interest, potentially addressing disease targets that are 'undruggable' for small molecules and proteins. Currently, there are six siRNA therapeutics that have been approved for clinical use, and approximately 20 additional candidates have progressed to late stages of clinical investigation. Targeted accumulation and cellular uptake (entry), endolysosomal escape (escape), and in vivo pharmaceutical performance (efficacy) (three 'E' challenges) are the most critical bottlenecks in siRNA drug development. Ligand-conjugated siRNAs are promising platforms that have made a breakthrough in robust extrahepatic delivery. Sophisticated and appropriate chemical modification may bring astounding breakthroughs in the stability and long-term efficacy of siRNA modalities. siRNA therapeutics have gained extensive attention, and to date six siRNAs are approved for clinical use. Despite being investigated for the treatment of metabolic, cardiovascular, infectious, and rare genetic diseases, cancer, and central nervous system (CNS) disorders, there exist several druggability challenges. Here, we provide insightful discussions concerning these challenges, comprising targeted accumulation and cellular uptake ('entry'), endolysosomal escape ('escape'), and in vivo pharmaceutical performance ('efficacy') – the three 'E' challenges – while also shedding light on siRNA drug development. Moreover, we propose several promising strategies that hold great potential in facilitating the clinical translation of siRNA therapeutics, including the exploration of diverse ligand-siRNA conjugates, expansion of potential disease targets, and excavation of novel modification geometries, as well as the development of combination therapies. [ABSTRACT FROM AUTHOR]

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This article illuminates pivotal moments in the lives of eighteen—enslaved and free—African descent peoples listed as mulatto from 1732 to 1803 in New Spain's north frontier. The records consulted reveal that both enslaved and free peoples employed the legal system to petition abuses and request transfers of ownership in places such as San Luis Potosí, Saltillo, Monclova, and San Antonio de Béjar, Texas. Two instances of manumission are detailed below. This article also highlights one escape from a semiliterate enslaved man who voluntarily returned to Saltillo, illuminating emotional ties to friends and family. [ABSTRACT FROM AUTHOR]

The silencing of all but one X chromosome in mammalian cells is a remarkable epigenetic process leading to near dosage equivalence in X-linked gene products between the sexes. However, equally remarkable is the ability of a subset of genes to continue to be expressed from the otherwise inactive X chromosome—in some cases constitutively, while other genes are variable between individuals, tissues or cells. In this review we discuss the advantages and disadvantages of the approaches that have been used to identify escapees. The identity of escapees provides important clues to mechanisms underlying escape from XCI, an arena of study now moving from correlation to functional studies. As most escapees show greater expression in females, the not-so-inactive X chromosome is a substantial contributor to sex differences in humans, and we highlight some examples of such impact. [ABSTRACT FROM AUTHOR]

During threat exposure, survival depends on defensive reactions. Prior works linked large glutamatergic populations in the midbrain periaqueductal gray (PAG) to defensive freezing and flight, and established that the overarching functional organization axis of the PAG is along anatomically-defined columns. Accordingly, broad activation of the dorsolateral column induces flight, while activation of the lateral or ventrolateral (l and vl) columns induces freezing. However, the PAG contains diverse cell types that vary in neurochemistry. How these cell types contribute to defense remains unknown, indicating that targeting sparse, genetically-defined populations may reveal how the PAG generates diverse behaviors. Though prior works showed that broad excitation of the lPAG or vlPAG causes freezing, we found in mice that activation of lateral and ventrolateral PAG (l/vlPAG) cholecystokinin-expressing (CCK) cells selectively caused flight to safer regions within an environment. Furthermore, inhibition of l/vlPAG-CCK cells reduced predator avoidance without altering other defensive behaviors like freezing. Lastly, l/vlPAG-CCK activity decreased when approaching threat and increased during movement to safer locations. These results suggest CCK cells drive threat avoidance states, which are epochs during which mice increase distance from threat and perform evasive escape. Conversely, l/vlPAG pan-neuronal activation promoted freezing, and these cells were activated near threat. Thus, CCK l/vlPAG cells have opposing function and neural activation motifs compared to the broader local ensemble defined solely by columnar boundaries. In addition to the anatomical columnar architecture of the PAG, the molecular identity of PAG cells may confer an additional axis of functional organization, revealing unexplored functional heterogeneity.