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We provide a proof of principle for an evolutionary systems theory (EST) of depression. This theory suggests that normative depressive symptoms counter socioenvironmental volatility by increasing interpersonal support via social signalling and that this response depends upon the encoding of uncertainty about social contingencies, which can be targeted by neuromodulatory antidepressants. We simulated agents that committed to a series of decisions in a social two-arm bandit task before and after social adversity, which precipitated depressive symptoms. Responses to social adversity were modelled under various combinations of social support and pharmacotherapy. The normative depressive phenotype responded positively to social support and simulated treatments with antidepressants. Attracting social support and administering antidepressants also alleviated anhedonia and social withdrawal, speaking to improvements in interpersonal relationships. These results support the EST of depression by demonstrating that following adversity, normative depressed mood preserved social inclusion with appropriate interpersonal support or pharmacotherapy.

We provide a proof of principle for an evolutionary systems theory (EST) of depression. This theory suggests that normative depressive symptoms counter socioenvironmental volatility by increasing interpersonal support via social signalling and that this response depends upon the encoding of uncertainty about social contingencies, which can be targeted by neuromodulatory antidepressants. We simulated agents that committed to a series of decisions in a social two-arm bandit task before and after social adversity, which precipitated depressive symptoms. Responses to social adversity were modelled under various combinations of social support and pharmacotherapy. The normative depressive phenotype responded positively to social support and simulated treatments with antidepressants. Attracting social support and administering antidepressants also alleviated anhedonia and social withdrawal, speaking to improvements in interpersonal relationships. These results support the EST of depression by demonstrating that following adversity, normative depressed mood preserved social inclusion with appropriate interpersonal support or pharmacotherapy. [ABSTRACT FROM AUTHOR]

Social evolution has reached a point at which the continuation of human life is even at stake. The reason why that is the case lies in dysfunctionalities of the organization of social systems. Those dysfunctionalities came to the fore when hominization was as successful as to cover the whole globe. What social systems could externalize so far, became part of an ever more deteriorating environment on which every system, in turn, has to live on. This system theoretical insight concerns the organization of relations among humans, of relations with nature and of relations with technology.

The purpose of this review was to integrate leading paradigms in psychology and neuroscience with a theory of the embodied, situated human brain, called the Hierarchically Mechanistic Mind (HMM). The HMM describes the brain as a complex adaptive system that functions to minimize the entropy of our sensory and physical states via action-perception cycles generated by hierarchical neural dynamics. First, we review the extant literature on the hierarchical structure of the brain. Next, we derive the HMM from a broader evolutionary systems theory that explains neural structure and function in terms of dynamic interactions across four nested levels of biological causation (i.e., adaptation, phylogeny, ontogeny, and mechanism). We then describe how the HMM aligns with a global brain theory in neuroscience called the free-energy principle, leveraging this theory to mathematically formulate neural dynamics across hierarchical spatiotemporal scales. We conclude by exploring the implications of the HMM for psychological inquiry. [ABSTRACT FROM AUTHOR]

This paper addresses the challenges faced by multiscale formulations of the variational (free energy) approach to dynamics that obtain for large-scale ensembles. We review a framework for modelling complex adaptive control systems for multiscale free energy bounding organism–niche dynamics, thereby integrating the modelling strategies and heuristics of variational neuroethology with a broader perspective on the ecological nestedness of biotic systems. We extend the multiscale variational formulation beyond the action–perception loops of individual organisms by appealing to the variational approach to niche construction to explain the dynamics of coupled systems constituted by organisms and their ecological niche. We suggest that the statistical robustness of living systems is inherited, in part, from their eco-niches, as niches help coordinate dynamical patterns across larger spatiotemporal scales. We call this approach variational ecology. We argue that, when applied to cultural animals such as humans, variational ecology enables us to formulate not just a physics of individual minds, but also a physics of interacting minds across spatial and temporal scales – a physics of sentient systems that range from cells to societies. • We extend the multiscale variational free energy approach to large-scale ensembles. • We integrate multiscale modelling with a broad perspective on ecological nestedness. • We argue that the statistical robustness of living systems is ecologically inherited. • We propose variational ecology as a physics of sentient systems. [ABSTRACT FROM AUTHOR]

This article presents a unifying theory of the embodied, situated human brain called the Hierarchically Mechanistic Mind (HMM). The HMM describes the brain as a complex adaptive system that actively minimises the decay of our sensory and physical states by producing self-fulfilling action-perception cycles via dynamical interactions between hierarchically organised neurocognitive mechanisms. This theory synthesises the free-energy principle (FEP) in neuroscience with an evolutionary systems theory of psychology that explains our brains, minds, and behaviour by appealing to Tinbergen's four questions: adaptation , phylogeny , ontogeny , and mechanism. After leveraging the FEP to formally define the HMM across different spatiotemporal scales, we conclude by exploring its implications for theorising and research in the sciences of the mind and behaviour. • We present an interdisciplinary theory of the embodied, situated human brain called the Hierarchically Mechanistic Mind (HMM). • We describe the HMM as a model of neural architecture. • We explore how the HMM synthesises the free-energy principle in neuroscience with an evolutionary systems theory of psychology. • We translate our model into a new heuristic for theorising and research in neuroscience and psychology. [ABSTRACT FROM AUTHOR]

The free-energy principle (FEP) is a formal model of neuronal processes that is widely recognised in neuroscience as a unifying theory of the brain and biobehaviour. More recently, however, it has been extended beyond the brain to explain the dynamics of living systems, and their unique capacity to avoid decay. The aim of this review is to synthesise these advances with a meta-theoretical ontology of biological systems called variational neuroethology, which integrates the FEP with Tinbergen's four research questions to explain biological systems across spatial and temporal scales. We exemplify this framework by applying it to Homo sapiens, before translating variational neuroethology into a systematic research heuristic that supplies the biological, cognitive, and social sciences with a computationally tractable guide to discovery. [ABSTRACT FROM AUTHOR]

Throughout this model for studying the genesis and development of societies and world‐views, Time‐Space‐Technics applies evolutionary systems theory. The model utilizes a number of integrative principles omnipresent throughout the phenomenal world; they interact with human agency in organizing all cultures and societies so as to result in a wide variety of conceptual and behavioural isomorphisms. Special attention is paid both to processes of equilibration between a system and its environment, and to factors responsible for fracturing a system's equilibrium, quantizing it to a different level of societal organization, accompanied by either the emergence of new properties or the loss of existing parameters. These major quantum shifts, which have appeared periodically in global history, are correlated with the emergence of new paradigms of reality, or world‐views. Application of this systems model in our present transformative era makes it possible to foresee issues that constitute bifurcation points ahead. Those issues will challenge humanity to avoid environmental and societal crashes on a global scale. Conversely, proactive measures can attain a new level of planetary organization and integration, with its unique world‐view. [ABSTRACT FROM PUBLISHER]